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The map label for this gene is era [H]

Identifier: 182679392

GI number: 182679392

Start: 2782446

End: 2783396

Strand: Reverse

Name: era [H]

Synonym: Bind_2440

Alternate gene names: 182679392

Gene position: 2783396-2782446 (Counterclockwise)

Preceding gene: 182679393

Following gene: 182679390

Centisome position: 66.75

GC content: 56.68

Gene sequence:

>951_bases
GTGACAACGCCCGAACCAATCACCCGCTGCGGCTTCGTTGCCTTGATCGGTGCACCCAATGCCGGGAAATCGACTCTCAT
CAACCGGCTTGTCGGCGCCAAAATCTCGATCGTCTCACGCAAGGTACAGACGACGCGCTGCCTTGTGCGTGGCATTGCGA
CCGAGGGCGCTTCCCAAATCATCTTCGTTGATACACCAGGGATTTTCGCGCCGAAACGTCGGCTCGACCAGGCCATGGTG
ACTTCAGCCTGGGGCGGGGCGGGTGATGCCGATGTCGTGGCTTTGCTGGTCGATGCCCGCAAGGGGATCGATGAGGAAGT
CGAGGCGATTTTGGCGAAGTTGCCGCAAGTCCGCGCCAAGAAATTATTGGTTCTGAATAAGATTGATACAATCGAGCCAC
CGCGTCTTCTCGCTTTGGCGGCCGACCTCAATGCTCGCATTGATTTCTCCGAAACTTTTATGATCTCGGCTTTGCGCGGC
CACGGAGTCGACAAGCTCAAAAACCTGCTCGGCGAGATGATGAAGGAAGGGCCTTGGCTCTATCCCGAGGATCAGATTTC
CGATGCTCCTTTGCGGATGCTTGCGGCCGAGATTACGCGCGAGAAGATTTTCGAACGCCTGCATGATGAATTGCCCTATC
AATCGACCGTCGAAACCGTGCTTTGGAAGGATCTGCCGGACGGATCAGCGCGGATCGAACAGACGATTTATGTCATGCGC
GAGGGGCATAAGAAAATCGTCATCGGAGAAGGCGGGCGCACAATCAAGGCGATCGGCCAGGCGGCGCGCAAGGACATTGC
CGAGGCGGCTGAACAGAACGTGCATCTGTTTCTCTTCGTAAAGGTGCGCGAGAACTGGACCGATGATCCCGAACGCTATC
GCGAAATGGGCCTCGAATTCCCTCACGGCTCCAAATCGAGCACGGCGAAATCCGGGACGCGCTCGAAATAA

Upstream 100 bases:

>100_bases
ATGCACAGGCCAAAGGGCCGTCCAAACGGCTTGCCGAACAGGCGGCGGCGGCGCATTTTATCGAGCGCGAGGGCATTCAG
GAAAAACAGAAGGGCGCCGC

Downstream 100 bases:

>100_bases
TCGTCAACGGTATGCAAGACACATCAGGCGCAGCCAAGGTTGCGCCTGATTTCATGCTCAATTCGTTTTTAAGCGTTCAG
CACAATTCAAAAGCCGTCCA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MTTPEPITRCGFVALIGAPNAGKSTLINRLVGAKISIVSRKVQTTRCLVRGIATEGASQIIFVDTPGIFAPKRRLDQAMV
TSAWGGAGDADVVALLVDARKGIDEEVEAILAKLPQVRAKKLLVLNKIDTIEPPRLLALAADLNARIDFSETFMISALRG
HGVDKLKNLLGEMMKEGPWLYPEDQISDAPLRMLAAEITREKIFERLHDELPYQSTVETVLWKDLPDGSARIEQTIYVMR
EGHKKIVIGEGGRTIKAIGQAARKDIAEAAEQNVHLFLFVKVRENWTDDPERYREMGLEFPHGSKSSTAKSGTRSK

Sequences:

>Translated_316_residues
MTTPEPITRCGFVALIGAPNAGKSTLINRLVGAKISIVSRKVQTTRCLVRGIATEGASQIIFVDTPGIFAPKRRLDQAMV
TSAWGGAGDADVVALLVDARKGIDEEVEAILAKLPQVRAKKLLVLNKIDTIEPPRLLALAADLNARIDFSETFMISALRG
HGVDKLKNLLGEMMKEGPWLYPEDQISDAPLRMLAAEITREKIFERLHDELPYQSTVETVLWKDLPDGSARIEQTIYVMR
EGHKKIVIGEGGRTIKAIGQAARKDIAEAAEQNVHLFLFVKVRENWTDDPERYREMGLEFPHGSKSSTAKSGTRSK
>Mature_315_residues
TTPEPITRCGFVALIGAPNAGKSTLINRLVGAKISIVSRKVQTTRCLVRGIATEGASQIIFVDTPGIFAPKRRLDQAMVT
SAWGGAGDADVVALLVDARKGIDEEVEAILAKLPQVRAKKLLVLNKIDTIEPPRLLALAADLNARIDFSETFMISALRGH
GVDKLKNLLGEMMKEGPWLYPEDQISDAPLRMLAAEITREKIFERLHDELPYQSTVETVLWKDLPDGSARIEQTIYVMRE
GHKKIVIGEGGRTIKAIGQAARKDIAEAAEQNVHLFLFVKVRENWTDDPERYREMGLEFPHGSKSSTAKSGTRSK

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=322, Percent_Identity=32.2981366459627, Blast_Score=141, Evalue=9e-34,
Organism=Escherichia coli, GI1788919, Length=296, Percent_Identity=41.8918918918919, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI87082120, Length=179, Percent_Identity=31.8435754189944, Blast_Score=68, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24646434, Length=314, Percent_Identity=29.2993630573248, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34850; Mature: 34719

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPEPITRCGFVALIGAPNAGKSTLINRLVGAKISIVSRKVQTTRCLVRGIATEGASQI
CCCCCCHHHCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
IFVDTPGIFAPKRRLDQAMVTSAWGGAGDADVVALLVDARKGIDEEVEAILAKLPQVRAK
EEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHH
KLLVLNKIDTIEPPRLLALAADLNARIDFSETFMISALRGHGVDKLKNLLGEMMKEGPWL
HHHHHHCCCCCCCCHHEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
YPEDQISDAPLRMLAAEITREKIFERLHDELPYQSTVETVLWKDLPDGSARIEQTIYVMR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHEE
EGHKKIVIGEGGRTIKAIGQAARKDIAEAAEQNVHLFLFVKVRENWTDDPERYREMGLEF
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHCCCCC
PHGSKSSTAKSGTRSK
CCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPEPITRCGFVALIGAPNAGKSTLINRLVGAKISIVSRKVQTTRCLVRGIATEGASQI
CCCCCHHHCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEE
IFVDTPGIFAPKRRLDQAMVTSAWGGAGDADVVALLVDARKGIDEEVEAILAKLPQVRAK
EEEECCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHH
KLLVLNKIDTIEPPRLLALAADLNARIDFSETFMISALRGHGVDKLKNLLGEMMKEGPWL
HHHHHHCCCCCCCCHHEEEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCC
YPEDQISDAPLRMLAAEITREKIFERLHDELPYQSTVETVLWKDLPDGSARIEQTIYVMR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHEE
EGHKKIVIGEGGRTIKAIGQAARKDIAEAAEQNVHLFLFVKVRENWTDDPERYREMGLEF
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHCCCCC
PHGSKSSTAKSGTRSK
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA