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The map label for this gene is ppi [H]

Identifier: 182679293

GI number: 182679293

Start: 2674677

End: 2675132

Strand: Reverse

Name: ppi [H]

Synonym: Bind_2337

Alternate gene names: 182679293

Gene position: 2675132-2674677 (Counterclockwise)

Preceding gene: 182679294

Following gene: 182679292

Centisome position: 64.15

GC content: 56.8

Gene sequence:

>456_bases
ATGGCGGAAGCCGGCAATACGCTGACCCTTGAAACCACGAAGGGACCCGTGGTGATCGAGATGCGGCCTGATCTAGCACC
CAATCATGTCGCGCATATCAAGAAGCTTGTCGAAGAGAAGTTCTACGACGGCATCGTGTTTCATCGCGTTATCGATGGGT
TCATGGCGCAAACGGGCTGCCCGCACGGCACCGGCACGGGCGGCTCGAAATATCCTGACCTGAAGCAGGAATTCAATGCC
GAGCCGCATGTGCGTGGCACGGTCTCCATGGCGCGCGCGGCGAATCCTGATTCCGCCAATTCGCAATTCTTCATCTGCTT
TGCTGACGCCCGCTTCCTCGACAAAAATTATACGGTCTGGGGCAAGGTCGTTTCCGGGATGGAGAATGTCGACAAGATCA
AGCGCGGTGAGCCGGTGCGCGATCCCGACAAAATTATTTCCGCGACCCTGAGCTAA

Upstream 100 bases:

>100_bases
GCTTTAAAATTCCGGACACAGGCCTGCTTGATGTGGTTTACCTTCGTTGATGCATCGGCTATTGCAGACGTGAATTTATT
GACGAACGCAGGAGTTCCCG

Downstream 100 bases:

>100_bases
TCACAAAGGCTGTTCTCGTGCGGTTCGCCCGAGAAGGGCGGATCGCCATCCACCATGCGCGTCGATCTTTTCGATTTCGA
TCTGCCACCGGAGCGCATCG

Product: peptidyl-prolyl cis-trans isomerase cyclophilin type

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 151; Mature: 150

Protein sequence:

>151_residues
MAEAGNTLTLETTKGPVVIEMRPDLAPNHVAHIKKLVEEKFYDGIVFHRVIDGFMAQTGCPHGTGTGGSKYPDLKQEFNA
EPHVRGTVSMARAANPDSANSQFFICFADARFLDKNYTVWGKVVSGMENVDKIKRGEPVRDPDKIISATLS

Sequences:

>Translated_151_residues
MAEAGNTLTLETTKGPVVIEMRPDLAPNHVAHIKKLVEEKFYDGIVFHRVIDGFMAQTGCPHGTGTGGSKYPDLKQEFNA
EPHVRGTVSMARAANPDSANSQFFICFADARFLDKNYTVWGKVVSGMENVDKIKRGEPVRDPDKIISATLS
>Mature_150_residues
AEAGNTLTLETTKGPVVIEMRPDLAPNHVAHIKKLVEEKFYDGIVFHRVIDGFMAQTGCPHGTGTGGSKYPDLKQEFNAE
PHVRGTVSMARAANPDSANSQFFICFADARFLDKNYTVWGKVVSGMENVDKIKRGEPVRDPDKIISATLS

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=134, Percent_Identity=39.5522388059701, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI7706339, Length=128, Percent_Identity=35.15625, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI22547212, Length=151, Percent_Identity=38.4105960264901, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI7657473, Length=151, Percent_Identity=38.4105960264901, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI22547215, Length=151, Percent_Identity=38.4105960264901, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI64276486, Length=121, Percent_Identity=38.0165289256198, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI24308049, Length=134, Percent_Identity=35.8208955223881, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI5031987, Length=129, Percent_Identity=38.7596899224806, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI20911035, Length=138, Percent_Identity=36.9565217391304, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI10863927, Length=130, Percent_Identity=37.6923076923077, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1789763, Length=142, Percent_Identity=40.8450704225352, Blast_Score=88, Evalue=2e-19,
Organism=Escherichia coli, GI1786736, Length=145, Percent_Identity=37.9310344827586, Blast_Score=86, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI71980594, Length=132, Percent_Identity=40.1515151515151, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=132, Percent_Identity=40.1515151515151, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17539496, Length=135, Percent_Identity=37.037037037037, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17506311, Length=154, Percent_Identity=35.7142857142857, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71997782, Length=125, Percent_Identity=40, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17539498, Length=147, Percent_Identity=36.0544217687075, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=132, Percent_Identity=32.5757575757576, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=148, Percent_Identity=31.7567567567568, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=135, Percent_Identity=35.5555555555556, Blast_Score=66, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI32563659, Length=138, Percent_Identity=33.3333333333333, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17566266, Length=136, Percent_Identity=32.3529411764706, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17552780, Length=129, Percent_Identity=35.6589147286822, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6320359, Length=129, Percent_Identity=37.2093023255814, Blast_Score=62, Evalue=4e-11,
Organism=Drosophila melanogaster, GI17986117, Length=155, Percent_Identity=39.3548387096774, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19922376, Length=142, Percent_Identity=33.0985915492958, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24652460, Length=135, Percent_Identity=36.2962962962963, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45549139, Length=145, Percent_Identity=36.551724137931, Blast_Score=76, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24664125, Length=129, Percent_Identity=37.984496124031, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357783, Length=129, Percent_Identity=37.984496124031, Blast_Score=73, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17647301, Length=130, Percent_Identity=36.9230769230769, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21357249, Length=119, Percent_Identity=35.2941176470588, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI19922912, Length=155, Percent_Identity=41.9354838709677, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17136360, Length=130, Percent_Identity=32.3076923076923, Blast_Score=63, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 16565; Mature: 16434

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAGNTLTLETTKGPVVIEMRPDLAPNHVAHIKKLVEEKFYDGIVFHRVIDGFMAQTGC
CCCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
PHGTGTGGSKYPDLKQEFNAEPHVRGTVSMARAANPDSANSQFFICFADARFLDKNYTVW
CCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCEECCCCCCHH
GKVVSGMENVDKIKRGEPVRDPDKIISATLS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
AEAGNTLTLETTKGPVVIEMRPDLAPNHVAHIKKLVEEKFYDGIVFHRVIDGFMAQTGC
CCCCCEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCC
PHGTGTGGSKYPDLKQEFNAEPHVRGTVSMARAANPDSANSQFFICFADARFLDKNYTVW
CCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHHCCCCCCCCCEEEEEEECCEECCCCCCHH
GKVVSGMENVDKIKRGEPVRDPDKIISATLS
HHHHHHHHHHHHHHCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA