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The map label for this gene is emrA [H]

Identifier: 182678991

GI number: 182678991

Start: 2316511

End: 2317716

Strand: Reverse

Name: emrA [H]

Synonym: Bind_2026

Alternate gene names: 182678991

Gene position: 2317716-2316511 (Counterclockwise)

Preceding gene: 182678994

Following gene: 182678990

Centisome position: 55.58

GC content: 58.21

Gene sequence:

>1206_bases
ATGGACGAAGCTTATCACAGTGGTGAGACCGCGGATTTGGTGAAAACCTCGTCCCCGGAGGATCGGTTGCATGCCCGTGT
CAAAAGCGAAGGTCTTGCGCCCGAACGTGACAAGCCGCTGATCGAGGACAACGGCAATGGCGGTTCGCCGCAAAACGACA
AGGCCCGCCAGAAACGGGGTGGCACGGTCAAGCTGGTGGGCTTTCTTGTCGTTGCCGCCTTGGCCTTGGGCGGCGGCTAT
TATTGGTTCACTTCGCGTAATCTCGAATCCACCGACGATGCCTTTACGGATGGCCGGGCGATCAGTGTCGCGCCGCGTGT
GGCGGGGCAGGTCGTGGCCCTCGATGTCACGGATAATCAGTTCGTGCGCAAGGGTGATCCGCTGATCCATATTGATCCGA
GCCAGTTTACGGTCAGCCGTGATTCCGCCCAAGGCAATCTGGATATGGCCAAGGCGCAATTTGCTGGCGAGCAATATGGC
GCCGAGATCGCCCGCAAGAATTATCCGGCTGTGTTGCAACAGTCACAGGCGCAATTGGCGGTCGCGCAGGCCAATCTGTT
CAGGGCGACAGCGGATAATAAACGTCAGAAAAGCCTGCCGAAACAAGCAACGACCCAACAGGAGGTCGATGCCGCCGAGG
CTGCCTACCGCCAGGCCGAGGCTCAAGTGCAATTGGCGCAGGCCCAGGTTTTCCAAAATTCGCCGGTCCCGCAGCGGATT
GGTGTCGCCGACAGCACGGTCGGCCAATTGAAGGGCCAGGTTGAACAGGCACAAGCGCAGCTCGATCAAGCCAATTTGAA
CCTCGACTGGACTGTGGTGCGGGCCCCGCAGGACGGCTGGATCACCAAGCGCAACGTCGAGGTCGGCACTTATGTATCGC
CCGGCCAGCAGATTTTCTCGATTGTGTCGCCGGAAGTCTGGGTCACCGCCAATTTCAAGGAGAACCAGCTTGATCGGATG
CGTGCTGGCCAGCCCGTCAAGATCGAGGTTGATGCCTATCCTCATCTCGACCTTCATGGCCATGTCGATAGCATTCAACT
CGGTTCCGGTTCGAAATTCACGGCTTTCCCGCCGGAAAATGCGACGGGTAATTATGTGAAGATCGTCCAGCGTGTCCCGG
TCAAGATCCTAATCGATAAGGGGCTTGATCCGGAGCAGCCTTTGCCGCTGGGTCTTTCGGTCGTGCCGACGGTCACTTTG
AAATGA

Upstream 100 bases:

>100_bases
CAAAATCAAACAAAGCGAAACACGATTGGCTATTTGGGCCAATGCCATCTCGATGAGCGTTCCTCTGGCTGGATGGCCGC
CACTGAAGATAGGAATTGCG

Downstream 100 bases:

>100_bases
GTGCGGTGGTGGATTCAAACGACCACGCGGACTGGAGGCCATCGCATAATCCGTGGCTGATCGCGGTCGTCGTCACGCTC
GCCGCCTTCATGGAAATTCT

Product: secretion protein HlyD family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MDEAYHSGETADLVKTSSPEDRLHARVKSEGLAPERDKPLIEDNGNGGSPQNDKARQKRGGTVKLVGFLVVAALALGGGY
YWFTSRNLESTDDAFTDGRAISVAPRVAGQVVALDVTDNQFVRKGDPLIHIDPSQFTVSRDSAQGNLDMAKAQFAGEQYG
AEIARKNYPAVLQQSQAQLAVAQANLFRATADNKRQKSLPKQATTQQEVDAAEAAYRQAEAQVQLAQAQVFQNSPVPQRI
GVADSTVGQLKGQVEQAQAQLDQANLNLDWTVVRAPQDGWITKRNVEVGTYVSPGQQIFSIVSPEVWVTANFKENQLDRM
RAGQPVKIEVDAYPHLDLHGHVDSIQLGSGSKFTAFPPENATGNYVKIVQRVPVKILIDKGLDPEQPLPLGLSVVPTVTL
K

Sequences:

>Translated_401_residues
MDEAYHSGETADLVKTSSPEDRLHARVKSEGLAPERDKPLIEDNGNGGSPQNDKARQKRGGTVKLVGFLVVAALALGGGY
YWFTSRNLESTDDAFTDGRAISVAPRVAGQVVALDVTDNQFVRKGDPLIHIDPSQFTVSRDSAQGNLDMAKAQFAGEQYG
AEIARKNYPAVLQQSQAQLAVAQANLFRATADNKRQKSLPKQATTQQEVDAAEAAYRQAEAQVQLAQAQVFQNSPVPQRI
GVADSTVGQLKGQVEQAQAQLDQANLNLDWTVVRAPQDGWITKRNVEVGTYVSPGQQIFSIVSPEVWVTANFKENQLDRM
RAGQPVKIEVDAYPHLDLHGHVDSIQLGSGSKFTAFPPENATGNYVKIVQRVPVKILIDKGLDPEQPLPLGLSVVPTVTL
K
>Mature_401_residues
MDEAYHSGETADLVKTSSPEDRLHARVKSEGLAPERDKPLIEDNGNGGSPQNDKARQKRGGTVKLVGFLVVAALALGGGY
YWFTSRNLESTDDAFTDGRAISVAPRVAGQVVALDVTDNQFVRKGDPLIHIDPSQFTVSRDSAQGNLDMAKAQFAGEQYG
AEIARKNYPAVLQQSQAQLAVAQANLFRATADNKRQKSLPKQATTQQEVDAAEAAYRQAEAQVQLAQAQVFQNSPVPQRI
GVADSTVGQLKGQVEQAQAQLDQANLNLDWTVVRAPQDGWITKRNVEVGTYVSPGQQIFSIVSPEVWVTANFKENQLDRM
RAGQPVKIEVDAYPHLDLHGHVDSIQLGSGSKFTAFPPENATGNYVKIVQRVPVKILIDKGLDPEQPLPLGLSVVPTVTL
K

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788711, Length=349, Percent_Identity=34.3839541547278, Blast_Score=172, Evalue=5e-44,
Organism=Escherichia coli, GI1789041, Length=355, Percent_Identity=30.7042253521127, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790519, Length=320, Percent_Identity=31.5625, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI87081951, Length=327, Percent_Identity=27.82874617737, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1789637, Length=353, Percent_Identity=26.3456090651558, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790024, Length=307, Percent_Identity=28.9902280130293, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790012, Length=298, Percent_Identity=25.503355704698, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1787013, Length=286, Percent_Identity=27.972027972028, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 43538; Mature: 43538

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEAYHSGETADLVKTSSPEDRLHARVKSEGLAPERDKPLIEDNGNGGSPQNDKARQKRG
CCCCCCCCCCHHEEECCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCHHHHHCC
GTVKLVGFLVVAALALGGGYYWFTSRNLESTDDAFTDGRAISVAPRVAGQVVALDVTDNQ
CEEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHCCCCEEEECCCCCCEEEEEEECCCC
FVRKGDPLIHIDPSQFTVSRDSAQGNLDMAKAQFAGEQYGAEIARKNYPAVLQQSQAQLA
HHHCCCCEEEECCCCEEEECCCCCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
VAQANLFRATADNKRQKSLPKQATTQQEVDAAEAAYRQAEAQVQLAQAQVFQNSPVPQRI
HHHHHHHCCCCCCHHHHCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHC
GVADSTVGQLKGQVEQAQAQLDQANLNLDWTVVRAPQDGWITKRNVEVGTYVSPGQQIFS
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECEEECCEECCHHHHHH
IVSPEVWVTANFKENQLDRMRAGQPVKIEVDAYPHLDLHGHVDSIQLGSGSKFTAFPPEN
HCCCCEEEEECCCHHHHHHHHCCCCEEEEECCCCCCEECCCCCEEEECCCCEEEECCCCC
ATGNYVKIVQRVPVKILIDKGLDPEQPLPLGLSVVPTVTLK
CCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCEECCEEEEC
>Mature Secondary Structure
MDEAYHSGETADLVKTSSPEDRLHARVKSEGLAPERDKPLIEDNGNGGSPQNDKARQKRG
CCCCCCCCCCHHEEECCCCHHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCHHHHHCC
GTVKLVGFLVVAALALGGGYYWFTSRNLESTDDAFTDGRAISVAPRVAGQVVALDVTDNQ
CEEEHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHCCCCEEEECCCCCCEEEEEEECCCC
FVRKGDPLIHIDPSQFTVSRDSAQGNLDMAKAQFAGEQYGAEIARKNYPAVLQQSQAQLA
HHHCCCCEEEECCCCEEEECCCCCCCCHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
VAQANLFRATADNKRQKSLPKQATTQQEVDAAEAAYRQAEAQVQLAQAQVFQNSPVPQRI
HHHHHHHCCCCCCHHHHCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHC
GVADSTVGQLKGQVEQAQAQLDQANLNLDWTVVRAPQDGWITKRNVEVGTYVSPGQQIFS
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECEEECCEECCHHHHHH
IVSPEVWVTANFKENQLDRMRAGQPVKIEVDAYPHLDLHGHVDSIQLGSGSKFTAFPPEN
HCCCCEEEEECCCHHHHHHHHCCCCEEEEECCCCCCEECCCCCEEEECCCCEEEECCCCC
ATGNYVKIVQRVPVKILIDKGLDPEQPLPLGLSVVPTVTLK
CCCHHHHHHHHCCEEEEEECCCCCCCCCCCCCEECCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]