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The map label for this gene is groL

Identifier: 182678711

GI number: 182678711

Start: 1965730

End: 1967376

Strand: Direct

Name: groL

Synonym: Bind_1738

Alternate gene names: 182678711

Gene position: 1965730-1967376 (Clockwise)

Preceding gene: 182678710

Following gene: 182678712

Centisome position: 47.14

GC content: 61.81

Gene sequence:

>1647_bases
ATGGCAGCCAAAGACGTCCGTTTCTCGTCTGATGCCCGCGATCGTATGCTGCGCGGCGTCGAGATCCTGGCCAATGCGGT
CAAGGTCACCCTCGGCCCCAAAGGCCGTAACGTCGTCATCGAAAAATCCTTCGGTGCGCCGCGCATCACCAAGGACGGCG
TGAGCGTCGCCAAGGAGATCGAACTCGCCGACAAGTTCGAAAATCTCGGTGCGCAGCTCGTGCGCGAAGTCGCTTCCAAG
CAGAACGATGCGGCTGGCGACGGCACCACCACCGCCACCATTCTCGCCGCTTCCATCGTCAAGGAAGGCACCAAGGCGGT
CGCCGCCGGCCTCAACCCGATGGATCTGAAGCGCGGCATCGACCACGCCGTCGAAGCGATCGTCGCCGACCTCAAGGCTA
ATTCCAAGAAGGTCACCTCGAACGACGAAATCGCCCAGGTCGGCACGATTTCGGCCAATGGCGACAAGTCCGTCGGCGAC
ATGATCTCGACCGCCATGCAGAAGGTCGGCAACGAGGGTGTCATCACCGTCGAGGAAGCCAAGAGCCTCGAGACCGAGCT
CGATGTCGTCGAAGGCATGCAGTTCGATCGCGGCTATCTCTCCCCCTACTTCATCACCAATGCCGAGAAGATGATCGCCG
AGCTCGAGGATCCCTATATCCTCGTCCACGAGAAAAAGCTCTCCTCGCTGCAAGCCATGCTGCCGGTGCTCGAAGCCGTC
GTGCAGACCGGCAAGCCGCTCGTCATCATCGCTGAGGACGTCGAAGGTGAGGCTCTTGCCACGCTCGTCGTCAACAAGCT
GCGCGGTGGCCTCAAGGTCGCGGCCGTCAAGGCTCCGGGCTTCGGTGATCGCCGCAAGGCCATGCTCGAAGACATCGCCA
TCCTGACCGGCGGCACCCTGATCTCCGAAGAGCTCGGCATCAAGCTCGAGAACGTCACGCTTGCCATGCTCGGCCGCGCC
AAGCGCATCCGCATCGACAAGGAAGCCACGACGATCATCGATGGCGCCGGCAACAAGGACGACATCGAGGGCCGTATCTC
CCAGATCAAGGCTCAGATCGCCGAGACCACTTCCGATTACGATCGTGAAAAGATGCAGGAGCGTCTCGCCAAGCTCGCTG
GCGGCGTCGCCGTGCTGCGTGTCGGCGGCTCGACCGAAGTCGAAGTGAAGGAAAAGAAGGACCGCGTCGACGACGCGCTC
AACGCGACCCGCGCTGCGGTCGAAGAAGGCGTTTCCCCCGGTGGTGGTGTCGCTCTTCTCCGCGCGATCAAGGCGCTCGA
AAACCTGCCTACGGATAATTCCGACCAGAAGGCTGGTATCGAAATCGTCCGCAAGGCGATCCAGACCCCGGCTAAGCAGA
TCGTCGACAATTCCGGCGGCGACGGCGCGGTCGTGGTTGGCAAGCTGCTCGAGTCGAACGAATATGCTTTCGGCTACAAT
GCCCAGACCGGCGAATATGGCGACATGGTCAAGCTCGGCATTATCGACCCGACCAAGGTTGTCCGCACGGCGCTCCAAGA
TGCGGCTTCCATTGCCGGCCTCCTGATCACCACCGAGGCGACGATCACCGAAGCGCCGAAGAAGGAAGCTCCGCTTCCTC
CGATGGGCGGTGGCGGCATGGGCGGCATGGGCGGTATGGATTTCTAA

Upstream 100 bases:

>100_bases
TCATGAAGGAGAGCGACATTCTCGGTGTCGTTGGCTGAGTCCTCCCAAGAGCCTCATCTTTTCTCAATAAATTCCGCGAA
AGCGATTCAGGAGTTTCAAC

Downstream 100 bases:

>100_bases
GCCCAGTCATAGCCCTCGATTTTTCAGGACCTCGGCTTCGGCCGGGGTCTTTTTTTGTCTGTTCTCCTGTCTCCGCTCCA
GTTTTTCGGTCAAATCCTAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAAKDVRFSSDARDRMLRGVEILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELADKFENLGAQLVREVASK
QNDAAGDGTTTATILAASIVKEGTKAVAAGLNPMDLKRGIDHAVEAIVADLKANSKKVTSNDEIAQVGTISANGDKSVGD
MISTAMQKVGNEGVITVEEAKSLETELDVVEGMQFDRGYLSPYFITNAEKMIAELEDPYILVHEKKLSSLQAMLPVLEAV
VQTGKPLVIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTLISEELGIKLENVTLAMLGRA
KRIRIDKEATTIIDGAGNKDDIEGRISQIKAQIAETTSDYDREKMQERLAKLAGGVAVLRVGGSTEVEVKEKKDRVDDAL
NATRAAVEEGVSPGGGVALLRAIKALENLPTDNSDQKAGIEIVRKAIQTPAKQIVDNSGGDGAVVVGKLLESNEYAFGYN
AQTGEYGDMVKLGIIDPTKVVRTALQDAASIAGLLITTEATITEAPKKEAPLPPMGGGGMGGMGGMDF

Sequences:

>Translated_548_residues
MAAKDVRFSSDARDRMLRGVEILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELADKFENLGAQLVREVASK
QNDAAGDGTTTATILAASIVKEGTKAVAAGLNPMDLKRGIDHAVEAIVADLKANSKKVTSNDEIAQVGTISANGDKSVGD
MISTAMQKVGNEGVITVEEAKSLETELDVVEGMQFDRGYLSPYFITNAEKMIAELEDPYILVHEKKLSSLQAMLPVLEAV
VQTGKPLVIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTLISEELGIKLENVTLAMLGRA
KRIRIDKEATTIIDGAGNKDDIEGRISQIKAQIAETTSDYDREKMQERLAKLAGGVAVLRVGGSTEVEVKEKKDRVDDAL
NATRAAVEEGVSPGGGVALLRAIKALENLPTDNSDQKAGIEIVRKAIQTPAKQIVDNSGGDGAVVVGKLLESNEYAFGYN
AQTGEYGDMVKLGIIDPTKVVRTALQDAASIAGLLITTEATITEAPKKEAPLPPMGGGGMGGMGGMDF
>Mature_547_residues
AAKDVRFSSDARDRMLRGVEILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELADKFENLGAQLVREVASKQ
NDAAGDGTTTATILAASIVKEGTKAVAAGLNPMDLKRGIDHAVEAIVADLKANSKKVTSNDEIAQVGTISANGDKSVGDM
ISTAMQKVGNEGVITVEEAKSLETELDVVEGMQFDRGYLSPYFITNAEKMIAELEDPYILVHEKKLSSLQAMLPVLEAVV
QTGKPLVIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTLISEELGIKLENVTLAMLGRAK
RIRIDKEATTIIDGAGNKDDIEGRISQIKAQIAETTSDYDREKMQERLAKLAGGVAVLRVGGSTEVEVKEKKDRVDDALN
ATRAAVEEGVSPGGGVALLRAIKALENLPTDNSDQKAGIEIVRKAIQTPAKQIVDNSGGDGAVVVGKLLESNEYAFGYNA
QTGEYGDMVKLGIIDPTKVVRTALQDAASIAGLLITTEATITEAPKKEAPLPPMGGGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=56.0606060606061, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=56.0606060606061, Blast_Score=585, Evalue=1e-167,
Organism=Homo sapiens, GI5453607, Length=533, Percent_Identity=21.7636022514071, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=66.4150943396226, Blast_Score=689, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=54.820415879017, Blast_Score=573, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=53.0805687203791, Blast_Score=224, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=57.7946768060836, Blast_Score=605, Evalue=1e-174,
Organism=Saccharomyces cerevisiae, GI6322524, Length=123, Percent_Identity=28.4552845528455, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=57.3863636363636, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=57.3863636363636, Blast_Score=602, Evalue=1e-172,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=54.7348484848485, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=54.7348484848485, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=54.7348484848485, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI17864606, Length=549, Percent_Identity=46.2659380692168, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24584129, Length=529, Percent_Identity=38.3742911153119, Blast_Score=350, Evalue=1e-96,
Organism=Drosophila melanogaster, GI19921262, Length=529, Percent_Identity=38.3742911153119, Blast_Score=350, Evalue=1e-96,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_BEII9 (B2ICU4)

Other databases:

- EMBL:   CP001016
- RefSeq:   YP_001832857.1
- GeneID:   6200696
- GenomeReviews:   CP001016_GR
- KEGG:   bid:Bind_1738
- HOGENOM:   HBG625289
- OMA:   NSDTSIG
- ProtClustDB:   CLSK2516817
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57713; Mature: 57582

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVRFSSDARDRMLRGVEILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEI
CCCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELADKFENLGAQLVREVASKQNDAAGDGTTTATILAASIVKEGTKAVAAGLNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DHAVEAIVADLKANSKKVTSNDEIAQVGTISANGDKSVGDMISTAMQKVGNEGVITVEEA
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEHHH
KSLETELDVVEGMQFDRGYLSPYFITNAEKMIAELEDPYILVHEKKLSSLQAMLPVLEAV
HHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHH
VQTGKPLVIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
ISEELGIKLENVTLAMLGRAKRIRIDKEATTIIDGAGNKDDIEGRISQIKAQIAETTSDY
HHHHHCCEEEEEHHEECCCCCEEEECCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKMQERLAKLAGGVAVLRVGGSTEVEVKEKKDRVDDALNATRAAVEEGVSPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAIKALENLPTDNSDQKAGIEIVRKAIQTPAKQIVDNSGGDGAVVVGKLLESNEYAFGYN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCCCCEEEEHHHCCCCEEEECC
AQTGEYGDMVKLGIIDPTKVVRTALQDAASIAGLLITTEATITEAPKKEAPLPPMGGGGM
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEEECCHHHCCCCCCCCCCCCCCCCCC
GGMGGMDF
CCCCCCCC
>Mature Secondary Structure 
AAKDVRFSSDARDRMLRGVEILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCHHHHHHHHHH
ELADKFENLGAQLVREVASKQNDAAGDGTTTATILAASIVKEGTKAVAAGLNPMDLKRGI
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DHAVEAIVADLKANSKKVTSNDEIAQVGTISANGDKSVGDMISTAMQKVGNEGVITVEEA
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEHHH
KSLETELDVVEGMQFDRGYLSPYFITNAEKMIAELEDPYILVHEKKLSSLQAMLPVLEAV
HHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHH
VQTGKPLVIIAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGTL
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCH
ISEELGIKLENVTLAMLGRAKRIRIDKEATTIIDGAGNKDDIEGRISQIKAQIAETTSDY
HHHHHCCEEEEEHHEECCCCCEEEECCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
DREKMQERLAKLAGGVAVLRVGGSTEVEVKEKKDRVDDALNATRAAVEEGVSPGGGVALL
HHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAIKALENLPTDNSDQKAGIEIVRKAIQTPAKQIVDNSGGDGAVVVGKLLESNEYAFGYN
HHHHHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCCCCCEEEEHHHCCCCEEEECC
AQTGEYGDMVKLGIIDPTKVVRTALQDAASIAGLLITTEATITEAPKKEAPLPPMGGGGM
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEEECCHHHCCCCCCCCCCCCCCCCCC
GGMGGMDF
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA