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The map label for this gene is hflC [H]

Identifier: 182678704

GI number: 182678704

Start: 1957926

End: 1958813

Strand: Direct

Name: hflC [H]

Synonym: Bind_1731

Alternate gene names: 182678704

Gene position: 1957926-1958813 (Clockwise)

Preceding gene: 182678703

Following gene: 182678706

Centisome position: 46.95

GC content: 57.88

Gene sequence:

>888_bases
ATGAAATACCCGTCCGGCCTCGCGCTTTCGCTCGTGCTGCTTGTCCTTGTCCTTCTCGGCGGTGGCACGTTCTTCATCGT
GCAGCAGACACAGCAAGCCCTGGTTCTGCGCTTCGGCGAGCCCCTGCCCGGTCGTGGTCTCGTCACCAAGCCTGGCTTGT
ATTTCAAGCTTCCCTCCATCGAAACCGCCGTCTTTCTCGACAATCGTATTCTCGATGTCGAAACCGCGAAACAGGAGGTT
CTTGCTTCCGACAATACGCGCATCGAGGTGGACGCTTTTCTACGCTACAGGATCATTGATCCCTTGCGTTTCTACCAGAG
CGTCGGCTCGGTGGAGCGGGCAGCCAATCAGCTCGGCTACATTTTGAATTCGGCGGTAAGGCGTGTTCTCGGCGAGGCCA
ATCTCACCCAGATCGTGCGTGACGAACGCGCGCAATTAATGGTCAAGATCCGTGATCAGGTCAATCGGGAGGCCGATCGT
CTCGGCGTCACTGTCGTGGATGTCCGCATACGCCGCGCCGACCTGCCACGCCAGATTTCCGAAAAAGTATTCAACCGCAT
GCAGACCGAGCGCGCCCGCGAAGCGGCGGAATATCGGGCACAAGGGTCGGAACAGGCACAAATGATCACCGCCAAAGCCA
ATCGCGATGTGACGATCATCCAGGCCGAAGCACGCCGTCAAGGCGAACAGATTCGCGGCGAAGGCGACGCCCAGCGCGCC
CGTATTTTCGCCGAGGCGTTCGGACGAGACCAGGATTTTTTCGCTTTTTATCGCTCGATGCAGGCCTATGAAACGAGTCT
GAAACCCGACTCGACCAAGCTGGTCATCGATCCAGGGTCCGAGTTTTTCCGTTTTCTCGGAAGCTCTTCAGGACGCGCCG
CACAGTAA

Upstream 100 bases:

>100_bases
AGGGAGCCGTCCAGGGCGTTCTCCCCTATCTGCCGCTCGATCACTTCCAGACCGAGACCAAGGCGCCGGAGACCCGGGCC
CCCAAGGCGGGAGATCAGAA

Downstream 100 bases:

>100_bases
GGGTCTCGAACGCGAGCAGAAGCCCGACACCTTACCGGTATCGGGCTTTTGGGGATTTAAAAGCTTTATTTCGCCTCAGG
CTTGGTCCCGCCGGTTTTCG

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MKYPSGLALSLVLLVLVLLGGGTFFIVQQTQQALVLRFGEPLPGRGLVTKPGLYFKLPSIETAVFLDNRILDVETAKQEV
LASDNTRIEVDAFLRYRIIDPLRFYQSVGSVERAANQLGYILNSAVRRVLGEANLTQIVRDERAQLMVKIRDQVNREADR
LGVTVVDVRIRRADLPRQISEKVFNRMQTERAREAAEYRAQGSEQAQMITAKANRDVTIIQAEARRQGEQIRGEGDAQRA
RIFAEAFGRDQDFFAFYRSMQAYETSLKPDSTKLVIDPGSEFFRFLGSSSGRAAQ

Sequences:

>Translated_295_residues
MKYPSGLALSLVLLVLVLLGGGTFFIVQQTQQALVLRFGEPLPGRGLVTKPGLYFKLPSIETAVFLDNRILDVETAKQEV
LASDNTRIEVDAFLRYRIIDPLRFYQSVGSVERAANQLGYILNSAVRRVLGEANLTQIVRDERAQLMVKIRDQVNREADR
LGVTVVDVRIRRADLPRQISEKVFNRMQTERAREAAEYRAQGSEQAQMITAKANRDVTIIQAEARRQGEQIRGEGDAQRA
RIFAEAFGRDQDFFAFYRSMQAYETSLKPDSTKLVIDPGSEFFRFLGSSSGRAAQ
>Mature_295_residues
MKYPSGLALSLVLLVLVLLGGGTFFIVQQTQQALVLRFGEPLPGRGLVTKPGLYFKLPSIETAVFLDNRILDVETAKQEV
LASDNTRIEVDAFLRYRIIDPLRFYQSVGSVERAANQLGYILNSAVRRVLGEANLTQIVRDERAQLMVKIRDQVNREADR
LGVTVVDVRIRRADLPRQISEKVFNRMQTERAREAAEYRAQGSEQAQMITAKANRDVTIIQAEARRQGEQIRGEGDAQRA
RIFAEAFGRDQDFFAFYRSMQAYETSLKPDSTKLVIDPGSEFFRFLGSSSGRAAQ

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI38016911, Length=154, Percent_Identity=27.9220779220779, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7305503, Length=187, Percent_Identity=26.2032085561497, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1790617, Length=312, Percent_Identity=33.0128205128205, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI1786697, Length=299, Percent_Identity=25.4180602006689, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI193209764, Length=201, Percent_Identity=28.8557213930348, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17569493, Length=201, Percent_Identity=28.8557213930348, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25153583, Length=173, Percent_Identity=27.7456647398844, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71987612, Length=173, Percent_Identity=27.7456647398844, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71987621, Length=173, Percent_Identity=27.7456647398844, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71989948, Length=156, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71989955, Length=156, Percent_Identity=30.7692307692308, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32566490, Length=154, Percent_Identity=30.5194805194805, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569499, Length=182, Percent_Identity=28.5714285714286, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17569497, Length=205, Percent_Identity=27.3170731707317, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32564147, Length=194, Percent_Identity=26.2886597938144, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17570161, Length=179, Percent_Identity=27.3743016759777, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193210507, Length=179, Percent_Identity=27.3743016759777, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45550506, Length=190, Percent_Identity=27.3684210526316, Blast_Score=78, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281365664, Length=173, Percent_Identity=27.7456647398844, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI45556022, Length=176, Percent_Identity=30.1136363636364, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24657857, Length=173, Percent_Identity=27.7456647398844, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI62484448, Length=173, Percent_Identity=27.7456647398844, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI62484274, Length=173, Percent_Identity=27.7456647398844, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18860517, Length=156, Percent_Identity=30.1282051282051, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 33238; Mature: 33238

Theoretical pI: Translated: 10.02; Mature: 10.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYPSGLALSLVLLVLVLLGGGTFFIVQQTQQALVLRFGEPLPGRGLVTKPGLYFKLPSI
CCCCCHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCCCCCCCCEECCCCEEECCCC
ETAVFLDNRILDVETAKQEVLASDNTRIEVDAFLRYRIIDPLRFYQSVGSVERAANQLGY
CEEEEECCCEEEHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILNSAVRRVLGEANLTQIVRDERAQLMVKIRDQVNREADRLGVTVVDVRIRRADLPRQIS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCEEEEEEEEHHHCCCHHHH
EKVFNRMQTERAREAAEYRAQGSEQAQMITAKANRDVTIIQAEARRQGEQIRGEGDAQRA
HHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCEEEEEHHHHHCCHHHCCCCCHHHH
RIFAEAFGRDQDFFAFYRSMQAYETSLKPDSTKLVIDPGSEFFRFLGSSSGRAAQ
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKYPSGLALSLVLLVLVLLGGGTFFIVQQTQQALVLRFGEPLPGRGLVTKPGLYFKLPSI
CCCCCHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCCCCCCCCEECCCCEEECCCC
ETAVFLDNRILDVETAKQEVLASDNTRIEVDAFLRYRIIDPLRFYQSVGSVERAANQLGY
CEEEEECCCEEEHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILNSAVRRVLGEANLTQIVRDERAQLMVKIRDQVNREADRLGVTVVDVRIRRADLPRQIS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHCEEEEEEEEHHHCCCHHHH
EKVFNRMQTERAREAAEYRAQGSEQAQMITAKANRDVTIIQAEARRQGEQIRGEGDAQRA
HHHHHHHHHHHHHHHHHHHHCCCCHHHEEEECCCCCEEEEEHHHHHCCHHHCCCCCHHHH
RIFAEAFGRDQDFFAFYRSMQAYETSLKPDSTKLVIDPGSEFFRFLGSSSGRAAQ
HHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]