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The map label for this gene is degP [H]

Identifier: 182678706

GI number: 182678706

Start: 1960109

End: 1961677

Strand: Direct

Name: degP [H]

Synonym: Bind_1733

Alternate gene names: 182678706

Gene position: 1960109-1961677 (Clockwise)

Preceding gene: 182678704

Following gene: 182678710

Centisome position: 47.0

GC content: 60.8

Gene sequence:

>1569_bases
ATGGGTTTGGCCCGCAGGTTCCTTCCCGTTTCCTTCCCCCTACCGGTACGACCCGCGCGAGGCCGGGCGCTGCGCTTCGG
CTCAAGCCTCGCACTGAGCCTCACTTCGGGACTCATGCTGGCCACGACCTCTTTGCCGCCTTTTACCTTGGTCGAGGCAC
AAGCGCGCGGACCAGAATCCCTGGCCGATCTCTCGGCTGCCGTCAGCGATGCGGTCGTCAATATTTCCGCGACGCAGACC
GTGGACGAAAAGCGCCCCGGCAATGGGCCACAGCTTGAGCCAGGCACGCCGTTCGACGATCTGTTCGAGGAATTTTTCCG
TCGCCGGCAGCAGCGTGGCGGTGGTGGGGGTGGCGGTGCCGTTCCGCGCCCGCATGAGCGCCGCTCGAATTCGCTGGGCT
CTGGCTTCGTCATCGATCCGGCCGGCATCATCATCACCAATAATCACGTCATCGCCGATGCCAATGAGGTGACGGTCATC
TTTACCGATGGTCAAAAGCTCAAGGCGCAGGTCCTCGGCAAGGATGCGAAGGTCGATGTGGCTGTCCTCAAGGTCAAGCC
GGAGAAGCCCCTGAAGGCCGTTAAATTCGGCGACAGTGAAGTCATGCGGGTCGGTGATTGGGTCATTGCCGTCGGCAATC
CCTTCGGGCTCGGCGGCACGGTGACGGCGGGCATTGTTTCGGCGCGCAACCGCAACATCGATTCCGGCCCTTACGACAAT
TATATCCAGACCGATGCAGCCATCAACAAGGGGAATTCCGGTGGCCCCTTGTTCAATATGGCCGGTGAGGTGATCGGTAT
TAATACAGCGATCCTGTCGCCCTCCGGCGGCTCGATCGGCATCGGTTTCGCGACGCCTGCGTCCATGGTCGTTCCGATTG
TGGAGCAATTGCAGAAATTTGGCGAAACACGCCGGGGCTGGCTTGGCGTGCGCATCCAGAATGTCGATGACACCATCGCC
GAAAGCCTCAATCTCGGCACGGCGCGCGGCGCGTTGATCGCCGGCGTGGACGACAAGGGACCGGCCAAGTCGGCTGGCCT
CTCCGCTGGCGACGTCATCGTCAAATTCGATGGCACTGCAATCAAGGAATCGCGTGATCTGCCCAAGCTCGTCGCCATGG
CCGCCGTCGGCAAGGACGTGCCGGTCGTCCTGATCCGTCAGGGCAAGGAGATCACCAAAAACGTGAAGCTCGGCCGTCTC
GAGGACAATGAGAAACAGGCCTCGCTCAATACGCCCGATCGCGACGAAAGCGCGCTCGGCTCAGCGAGCCAGCGTGTCCT
GGGGATGAGCCTGTCTGCGCTGACCGACGAAGCTCGGCAGAAATTCGCGATCCGCGACACTGTCGCATCGGGCGTCGTCA
TCACCGATGTCGATCCTGAATCGGCGGCGGCGGAAAAACATATTCAGCCGGGTGAACTGGTCGTCGAAATCAATCAGGAC
GCGGTGAAGACACCGGCCGAGATCAACAAGAAATTGCAGAGCCTGAAGGAGCAAGGCAAGAAATCAGCTTTGCTGCTCGT
CTCCAACGGACAGGGTGAAGTGCGTTTCGTCGCTCTTGCCATTCCTTGA

Upstream 100 bases:

>100_bases
TCTACACTATTAAAAAAGCCGTTCTTTCCCTTCAGAGCCTGGCTCGATTGCAAAAGCCTCAACGAGACGAGGCGTCACGT
CACGATCGGAGATCATTTCC

Downstream 100 bases:

>100_bases
AACGTCATTCCGTAACCGGCACCGGAAGCGATTTGACTTTTCCGTATTTCCTTGGAGCCGAGGTGGATCATCCGCCTCGG
CTCAATTTTATGGTCCGACA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MGLARRFLPVSFPLPVRPARGRALRFGSSLALSLTSGLMLATTSLPPFTLVEAQARGPESLADLSAAVSDAVVNISATQT
VDEKRPGNGPQLEPGTPFDDLFEEFFRRRQQRGGGGGGGAVPRPHERRSNSLGSGFVIDPAGIIITNNHVIADANEVTVI
FTDGQKLKAQVLGKDAKVDVAVLKVKPEKPLKAVKFGDSEVMRVGDWVIAVGNPFGLGGTVTAGIVSARNRNIDSGPYDN
YIQTDAAINKGNSGGPLFNMAGEVIGINTAILSPSGGSIGIGFATPASMVVPIVEQLQKFGETRRGWLGVRIQNVDDTIA
ESLNLGTARGALIAGVDDKGPAKSAGLSAGDVIVKFDGTAIKESRDLPKLVAMAAVGKDVPVVLIRQGKEITKNVKLGRL
EDNEKQASLNTPDRDESALGSASQRVLGMSLSALTDEARQKFAIRDTVASGVVITDVDPESAAAEKHIQPGELVVEINQD
AVKTPAEINKKLQSLKEQGKKSALLLVSNGQGEVRFVALAIP

Sequences:

>Translated_522_residues
MGLARRFLPVSFPLPVRPARGRALRFGSSLALSLTSGLMLATTSLPPFTLVEAQARGPESLADLSAAVSDAVVNISATQT
VDEKRPGNGPQLEPGTPFDDLFEEFFRRRQQRGGGGGGGAVPRPHERRSNSLGSGFVIDPAGIIITNNHVIADANEVTVI
FTDGQKLKAQVLGKDAKVDVAVLKVKPEKPLKAVKFGDSEVMRVGDWVIAVGNPFGLGGTVTAGIVSARNRNIDSGPYDN
YIQTDAAINKGNSGGPLFNMAGEVIGINTAILSPSGGSIGIGFATPASMVVPIVEQLQKFGETRRGWLGVRIQNVDDTIA
ESLNLGTARGALIAGVDDKGPAKSAGLSAGDVIVKFDGTAIKESRDLPKLVAMAAVGKDVPVVLIRQGKEITKNVKLGRL
EDNEKQASLNTPDRDESALGSASQRVLGMSLSALTDEARQKFAIRDTVASGVVITDVDPESAAAEKHIQPGELVVEINQD
AVKTPAEINKKLQSLKEQGKKSALLLVSNGQGEVRFVALAIP
>Mature_521_residues
GLARRFLPVSFPLPVRPARGRALRFGSSLALSLTSGLMLATTSLPPFTLVEAQARGPESLADLSAAVSDAVVNISATQTV
DEKRPGNGPQLEPGTPFDDLFEEFFRRRQQRGGGGGGGAVPRPHERRSNSLGSGFVIDPAGIIITNNHVIADANEVTVIF
TDGQKLKAQVLGKDAKVDVAVLKVKPEKPLKAVKFGDSEVMRVGDWVIAVGNPFGLGGTVTAGIVSARNRNIDSGPYDNY
IQTDAAINKGNSGGPLFNMAGEVIGINTAILSPSGGSIGIGFATPASMVVPIVEQLQKFGETRRGWLGVRIQNVDDTIAE
SLNLGTARGALIAGVDDKGPAKSAGLSAGDVIVKFDGTAIKESRDLPKLVAMAAVGKDVPVVLIRQGKEITKNVKLGRLE
DNEKQASLNTPDRDESALGSASQRVLGMSLSALTDEARQKFAIRDTVASGVVITDVDPESAAAEKHIQPGELVVEINQDA
VKTPAEINKKLQSLKEQGKKSALLLVSNGQGEVRFVALAIP

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=279, Percent_Identity=34.0501792114695, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI4506141, Length=260, Percent_Identity=33.8461538461538, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI24308541, Length=252, Percent_Identity=34.1269841269841, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI7019477, Length=276, Percent_Identity=36.9565217391304, Blast_Score=132, Evalue=8e-31,
Organism=Escherichia coli, GI1786356, Length=366, Percent_Identity=39.0710382513661, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789629, Length=469, Percent_Identity=35.181236673774, Blast_Score=231, Evalue=1e-61,
Organism=Escherichia coli, GI1789630, Length=271, Percent_Identity=36.1623616236162, Blast_Score=164, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24646839, Length=289, Percent_Identity=32.5259515570934, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 54761; Mature: 54630

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLARRFLPVSFPLPVRPARGRALRFGSSLALSLTSGLMLATTSLPPFTLVEAQARGPES
CCCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEHHCCEEEEECCCCCEEEEEECCCCCHH
LADLSAAVSDAVVNISATQTVDEKRPGNGPQLEPGTPFDDLFEEFFRRRQQRGGGGGGGA
HHHHHHHHHHHEEEEEECCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
VPRPHERRSNSLGSGFVIDPAGIIITNNHVIADANEVTVIFTDGQKLKAQVLGKDAKVDV
CCCCHHHHCCCCCCCEEECCCCEEEECCEEEECCCCEEEEEECCCCEEHHHCCCCCCEEE
AVLKVKPEKPLKAVKFGDSEVMRVGDWVIAVGNPFGLGGTVTAGIVSARNRNIDSGPYDN
EEEEECCCCCCCEEECCCHHEEEECCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCC
YIQTDAAINKGNSGGPLFNMAGEVIGINTAILSPSGGSIGIGFATPASMVVPIVEQLQKF
EEECCHHCCCCCCCCCHHCCCCCEEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHH
GETRRGWLGVRIQNVDDTIAESLNLGTARGALIAGVDDKGPAKSAGLSAGDVIVKFDGTA
HHHCCCEEEEEEECCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCE
IKESRDLPKLVAMAAVGKDVPVVLIRQGKEITKNVKLGRLEDNEKQASLNTPDRDESALG
ECCCCCCHHHHHHHHCCCCCCEEEEECCCHHHHCCEECCCCCCCCCCCCCCCCCCHHHHC
SASQRVLGMSLSALTDEARQKFAIRDTVASGVVITDVDPESAAAEKHIQPGELVVEINQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCEEEEECCC
AVKTPAEINKKLQSLKEQGKKSALLLVSNGQGEVRFVALAIP
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECC
>Mature Secondary Structure 
GLARRFLPVSFPLPVRPARGRALRFGSSLALSLTSGLMLATTSLPPFTLVEAQARGPES
CCCCCCCCCCCCCCCCCCCCCEEECCCCEEEEHHCCEEEEECCCCCEEEEEECCCCCHH
LADLSAAVSDAVVNISATQTVDEKRPGNGPQLEPGTPFDDLFEEFFRRRQQRGGGGGGGA
HHHHHHHHHHHEEEEEECCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
VPRPHERRSNSLGSGFVIDPAGIIITNNHVIADANEVTVIFTDGQKLKAQVLGKDAKVDV
CCCCHHHHCCCCCCCEEECCCCEEEECCEEEECCCCEEEEEECCCCEEHHHCCCCCCEEE
AVLKVKPEKPLKAVKFGDSEVMRVGDWVIAVGNPFGLGGTVTAGIVSARNRNIDSGPYDN
EEEEECCCCCCCEEECCCHHEEEECCEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCC
YIQTDAAINKGNSGGPLFNMAGEVIGINTAILSPSGGSIGIGFATPASMVVPIVEQLQKF
EEECCHHCCCCCCCCCHHCCCCCEEEEEEEEECCCCCEEEEECCCCHHHHHHHHHHHHHH
GETRRGWLGVRIQNVDDTIAESLNLGTARGALIAGVDDKGPAKSAGLSAGDVIVKFDGTA
HHHCCCEEEEEEECCCHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCE
IKESRDLPKLVAMAAVGKDVPVVLIRQGKEITKNVKLGRLEDNEKQASLNTPDRDESALG
ECCCCCCHHHHHHHHCCCCCCEEEEECCCHHHHCCEECCCCCCCCCCCCCCCCCCHHHHC
SASQRVLGMSLSALTDEARQKFAIRDTVASGVVITDVDPESAAAEKHIQPGELVVEINQD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCEEEEECCC
AVKTPAEINKKLQSLKEQGKKSALLLVSNGQGEVRFVALAIP
CCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]