Click here to switch to the map view.

The map label for this gene is lpd [H]

Identifier: 182678484

GI number: 182678484

Start: 1708860

End: 1710302

Strand: Direct

Name: lpd [H]

Synonym: Bind_1508

Alternate gene names: 182678484

Gene position: 1708860-1710302 (Clockwise)

Preceding gene: 182678483

Following gene: 182678485

Centisome position: 40.98

GC content: 58.7

Gene sequence:

>1443_bases
ATGGCCGCAGCCTATGACGTTCTCATCATTGGCGGCGGACCCGGCGGCTATGTCACCGCCATCAGGTCCGCCCAGCTCGG
GCTTAAAACCGCCGTTGTCGAACGCGAACACCTCGGCGGCATTTGCCTCAACTGGGGCTGCATCCCGACTAAGGCTTTGC
TGCGCTCAGCGGAAATCTATCACTATCTGCAGCATCCCAAGGACTATGGCCTGACGATCGAGGGCAAGATCGGCTTTGAT
CCGGCGGCCGTGGTCAAGCGTTCGCGCGGGGTTTCGGCGCAGCTCAATGGCGGCGTTGGCTTTCTTCTCAAGAAGAACAA
GGTCGATGTGATCTGGGGCGAGGCGACGATCACCAAAGTTGGCGAAGTCACTGTCGCGGCGACCAAAAAGACCATCGTCC
AGCCGCAAAACCCGATCCCCAAGGGTGTCCTGGGGGAGGGCACCTATAGCGCCAAGAACATTATCGTGGCGACGGGCGCG
CGTCCCCGCGTGCTGCCGGGTCTCGAGCCCGATGGCAAGACGATCTGGACCTATTTCGAGGCCATGGTGCCCGAAAGCTT
CCCCAAAAGCCTGATCGTGATGGGATCGGGTGCGATCGGGATCGAATTCGCCTCGTTCTATCATACGATGGGCGCCGAGG
TGACGGTGGTCGAAGTGCTGCCGCAGATCATGCCGGTCGAGGATGCCGAAATCGCCGGCCTTGCCCGCAAACAGTTCGAA
AAACAAGGCATCAAGATCCTCACCGGCACCAAGGTGACGAAGATCGAGAAAAACGCGCAAGGTCTTACTGCCACTTTGGA
AGATTCCAAGGGAGCGATTTCGACGCTATCCGCCGAGAAAATGATTTCGGCGGTGGGCGTCGTCGGCAATTCTGAAAACC
TTGGCCTCGAAAAATTGGGCGTCAAGATCGATCGCGGCATTATCAGCGTCGATGGGTTCGGTCGCACCAATGTTCCAGGC
ATTTTTGCCATTGGCGATGTGGCCGGACCGCCCATGCTGGCGCATAAGGCCGAGCATGAGGGTGTCATCTGCGTCGAGGC
GATCAAGGGCCTGCATCCCCATCCCATGGACAAGAGCATGATCCCCGGCTGTACCTATTGCCAGCCGCAGGTTGCTTCCG
TCGGCTTGACAGAGGCCAAGGCGAAGGAAGCGGGCTACACGGTCAAGGTCGGGCGTTTCCCCTTCGTCGGTAACGGCAAG
GCCATCGCCCTCGGCGAGCCGGATGGTCTCATCAAGACGATCTTCGACGCCAAGACGGGTAAGCTTTTGGGCGCGCATAT
GGTCGGCGCCGAGGTTACCGAATTGATTCAAGGCTTTGTCGTCGCAATGAATCTGGAGACGACCGAGGAAGAGCTGATGC
ATACGGTCTTCCCGCATCCGACCCTCTCCGAAATGATGCATGAGAGCGTGCTTGATGCTTACGGCCGAGTGATCCATATG
TAG

Upstream 100 bases:

>100_bases
GGGCGCCTTCAAGAGCCTGATCGAAAACCCGATGGGCATGCTCGTTTGAGCCTTCCCATCGTATCGATCGGAATCATGCA
TTTTAGGGAGGAAGGTTGCC

Downstream 100 bases:

>100_bases
AAAATCAAAGGGGCGCGAAAAGCGCCCCTTGTTCAATGAATAACGAAATAAGGGAACGTCGCCGATGCCGCCTTTAGCCG
ATGCTTCTACCGAGACTTTG

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MAAAYDVLIIGGGPGGYVTAIRSAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEIYHYLQHPKDYGLTIEGKIGFD
PAAVVKRSRGVSAQLNGGVGFLLKKNKVDVIWGEATITKVGEVTVAATKKTIVQPQNPIPKGVLGEGTYSAKNIIVATGA
RPRVLPGLEPDGKTIWTYFEAMVPESFPKSLIVMGSGAIGIEFASFYHTMGAEVTVVEVLPQIMPVEDAEIAGLARKQFE
KQGIKILTGTKVTKIEKNAQGLTATLEDSKGAISTLSAEKMISAVGVVGNSENLGLEKLGVKIDRGIISVDGFGRTNVPG
IFAIGDVAGPPMLAHKAEHEGVICVEAIKGLHPHPMDKSMIPGCTYCQPQVASVGLTEAKAKEAGYTVKVGRFPFVGNGK
AIALGEPDGLIKTIFDAKTGKLLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTVFPHPTLSEMMHESVLDAYGRVIHM

Sequences:

>Translated_480_residues
MAAAYDVLIIGGGPGGYVTAIRSAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEIYHYLQHPKDYGLTIEGKIGFD
PAAVVKRSRGVSAQLNGGVGFLLKKNKVDVIWGEATITKVGEVTVAATKKTIVQPQNPIPKGVLGEGTYSAKNIIVATGA
RPRVLPGLEPDGKTIWTYFEAMVPESFPKSLIVMGSGAIGIEFASFYHTMGAEVTVVEVLPQIMPVEDAEIAGLARKQFE
KQGIKILTGTKVTKIEKNAQGLTATLEDSKGAISTLSAEKMISAVGVVGNSENLGLEKLGVKIDRGIISVDGFGRTNVPG
IFAIGDVAGPPMLAHKAEHEGVICVEAIKGLHPHPMDKSMIPGCTYCQPQVASVGLTEAKAKEAGYTVKVGRFPFVGNGK
AIALGEPDGLIKTIFDAKTGKLLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTVFPHPTLSEMMHESVLDAYGRVIHM
>Mature_479_residues
AAAYDVLIIGGGPGGYVTAIRSAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEIYHYLQHPKDYGLTIEGKIGFDP
AAVVKRSRGVSAQLNGGVGFLLKKNKVDVIWGEATITKVGEVTVAATKKTIVQPQNPIPKGVLGEGTYSAKNIIVATGAR
PRVLPGLEPDGKTIWTYFEAMVPESFPKSLIVMGSGAIGIEFASFYHTMGAEVTVVEVLPQIMPVEDAEIAGLARKQFEK
QGIKILTGTKVTKIEKNAQGLTATLEDSKGAISTLSAEKMISAVGVVGNSENLGLEKLGVKIDRGIISVDGFGRTNVPGI
FAIGDVAGPPMLAHKAEHEGVICVEAIKGLHPHPMDKSMIPGCTYCQPQVASVGLTEAKAKEAGYTVKVGRFPFVGNGKA
IALGEPDGLIKTIFDAKTGKLLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTVFPHPTLSEMMHESVLDAYGRVIHM

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=485, Percent_Identity=38.3505154639175, Blast_Score=289, Evalue=5e-78,
Organism=Homo sapiens, GI50301238, Length=478, Percent_Identity=29.7071129707113, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI22035672, Length=492, Percent_Identity=29.0650406504065, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI33519430, Length=473, Percent_Identity=26.8498942917548, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI33519428, Length=473, Percent_Identity=26.8498942917548, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI33519426, Length=473, Percent_Identity=26.8498942917548, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI148277065, Length=473, Percent_Identity=26.8498942917548, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI148277071, Length=473, Percent_Identity=26.8498942917548, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI291045266, Length=445, Percent_Identity=26.7415730337079, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI291045268, Length=441, Percent_Identity=25.8503401360544, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1786307, Length=467, Percent_Identity=38.1156316916488, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI87082354, Length=484, Percent_Identity=27.4793388429752, Blast_Score=168, Evalue=6e-43,
Organism=Escherichia coli, GI1789915, Length=457, Percent_Identity=28.6652078774617, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI87081717, Length=478, Percent_Identity=26.3598326359833, Blast_Score=136, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI32565766, Length=483, Percent_Identity=39.3374741200828, Blast_Score=300, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI71983419, Length=478, Percent_Identity=28.0334728033473, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71983429, Length=478, Percent_Identity=28.0334728033473, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=23.9085239085239, Blast_Score=118, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI71982272, Length=498, Percent_Identity=25.1004016064257, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17559934, Length=188, Percent_Identity=32.9787234042553, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6321091, Length=482, Percent_Identity=38.1742738589212, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6325240, Length=490, Percent_Identity=30, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6325166, Length=484, Percent_Identity=29.5454545454545, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI21358499, Length=483, Percent_Identity=38.7163561076605, Blast_Score=303, Evalue=1e-82,
Organism=Drosophila melanogaster, GI24640549, Length=483, Percent_Identity=27.1221532091097, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24640553, Length=483, Percent_Identity=27.1221532091097, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24640551, Length=483, Percent_Identity=27.1221532091097, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI17737741, Length=491, Percent_Identity=26.0692464358452, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 50855; Mature: 50724

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAAYDVLIIGGGPGGYVTAIRSAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEIY
CCCEEEEEEEECCCCCCEEEEHHHHCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
HYLQHPKDYGLTIEGKIGFDPAAVVKRSRGVSAQLNGGVGFLLKKNKVDVIWGEATITKV
HHHHCCCCCCEEEEECCCCCHHHHHHHCCCCEEEECCCEEEEEECCCEEEEECCEEEEEC
GEVTVAATKKTIVQPQNPIPKGVLGEGTYSAKNIIVATGARPRVLPGLEPDGKTIWTYFE
CCEEEEECHHHEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHH
AMVPESFPKSLIVMGSGAIGIEFASFYHTMGAEVTVVEVLPQIMPVEDAEIAGLARKQFE
HHCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHH
KQGIKILTGTKVTKIEKNAQGLTATLEDSKGAISTLSAEKMISAVGVVGNSENLGLEKLG
HCCCEEEECCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCCHHHHC
VKIDRGIISVDGFGRTNVPGIFAIGDVAGPPMLAHKAEHEGVICVEAIKGLHPHPMDKSM
EEEECCEEEECCCCCCCCCEEEEECCCCCCCHHHCCCCCCCEEEEHHHCCCCCCCCCCCC
IPGCTYCQPQVASVGLTEAKAKEAGYTVKVGRFPFVGNGKAIALGEPDGLIKTIFDAKTG
CCCCCCCCCCHHHCCCCHHHHHHCCCEEEECCEEEECCCCEEEECCCCCHHHHHHCCCCC
KLLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTVFPHPTLSEMMHESVLDAYGRVIHM
CEEEHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure 
AAAYDVLIIGGGPGGYVTAIRSAQLGLKTAVVEREHLGGICLNWGCIPTKALLRSAEIY
CCEEEEEEEECCCCCCEEEEHHHHCCHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHH
HYLQHPKDYGLTIEGKIGFDPAAVVKRSRGVSAQLNGGVGFLLKKNKVDVIWGEATITKV
HHHHCCCCCCEEEEECCCCCHHHHHHHCCCCEEEECCCEEEEEECCCEEEEECCEEEEEC
GEVTVAATKKTIVQPQNPIPKGVLGEGTYSAKNIIVATGARPRVLPGLEPDGKTIWTYFE
CCEEEEECHHHEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHH
AMVPESFPKSLIVMGSGAIGIEFASFYHTMGAEVTVVEVLPQIMPVEDAEIAGLARKQFE
HHCCCCCCCEEEEEECCCCEEHHHHHHHHCCCCEEHHHHHHHHCCCCCCHHHHHHHHHHH
KQGIKILTGTKVTKIEKNAQGLTATLEDSKGAISTLSAEKMISAVGVVGNSENLGLEKLG
HCCCEEEECCEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHHEECCCCCCCHHHHC
VKIDRGIISVDGFGRTNVPGIFAIGDVAGPPMLAHKAEHEGVICVEAIKGLHPHPMDKSM
EEEECCEEEECCCCCCCCCEEEEECCCCCCCHHHCCCCCCCEEEEHHHCCCCCCCCCCCC
IPGCTYCQPQVASVGLTEAKAKEAGYTVKVGRFPFVGNGKAIALGEPDGLIKTIFDAKTG
CCCCCCCCCCHHHCCCCHHHHHHCCCEEEECCEEEECCCCEEEECCCCCHHHHHHCCCCC
KLLGAHMVGAEVTELIQGFVVAMNLETTEEELMHTVFPHPTLSEMMHESVLDAYGRVIHM
CEEEHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]