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The map label for this gene is dctB [H]

Identifier: 182678130

GI number: 182678130

Start: 1325220

End: 1326593

Strand: Direct

Name: dctB [H]

Synonym: Bind_1145

Alternate gene names: 182678130

Gene position: 1325220-1326593 (Clockwise)

Preceding gene: 182678129

Following gene: 182678131

Centisome position: 31.78

GC content: 59.9

Gene sequence:

>1374_bases
ATGACCGCGAGCGCGGGAACCGGCGAGGACATGCCTTTCGATCCCGATGTGGATACCGAGCGCATGTGGCTCAACGTCGT
GCGCAAGATGGATGAAACCTGGGCTGAGCTCCTGACGCAACAAGCCGAGCTCGAGCGTAAAAATAATGAATTGGAAGAGA
CCCAAGCCTTCATGGCTGGCGTGCTTGATTCCATGTCTGATCTTTTGATGGCCTGCGATCGGCAATTGACCATCGTGCGG
ACCAATATCGCGGCCGAACGCCTGTTCGCGGTATCTGGTCGGCGTCTCGCTGGTATGACGCTCGAGACGCTGATTGCTCC
GGCATCGCCGGGGACGATCCAGGATCTGCGTGCGGTCATCGCCCAAAAGACCCGGTTAGAGGATCAAGAATATATCTTTG
AGAGCCCGCAGGGTGATCTGCCTTTTGCTGTCAATGGCAGTCTTCGCTTTGATCCACGTGGCCGTGTCACCGGGCTCGTT
CTCGTGGCGCGACCGGTCGGCGAATTGCGCAAGGCCTATCGCGATCTTGCGGCCACTCATCGCAGTCTGCAGGACACGCA
AGCGCAGCTTGTCCAGGCGGAGAAAATGGCCTCGCTCGGTCGGCTCGTTGCCGGCGTGGCGCATGAGTTGAACAATCCGA
TCTCCTTTGTCTATGGCAATGCGCATACATTGCACCGTTATGCCCGGCGCCTAGCGGCCTATCTCGATGCGCTGCATGCT
CTTCCCGCCTCGCCGCAGCTTGCCGAACAGCGCCAGACCTTGCGGATCGATATGATCATGACCGAGTTGGAAGGTGTTTT
GGCCGGGATTGTCGACGGAGCGGAACGGGTGCGTGACATTGTGGCCGATCTGCGTCGTTTTTCTTCTGATCGACGTGACG
GCCGGGCGCCTTTCGACCTTGAGCCCGTGGCCACGACGGCGCTTGGCTGGGTCTTGGCGGCAGCGCCCCCGGGCATCGTC
TTAGAGCTCCAGATCGAAGGGCCGCTTGACGTTTTTGGCCATTCCGGTCAAATCCACCAGGTGGTCATGAACCTTGTGCA
AAATGCCGTCGATGCCATGGAAGCCCTGCCGGAAGGAGCAAAGCGTTCTCTCGAAATCAGCGGGGGCCGACGGGAAGACC
ATGCGTGGCTGGCCGTGCGGGACACGGGGCCGGGTATCGCGCCCGACGTCATGGAGCGGATGTTTGATCCCTTTTTCACC
ACCAAGCCGGTCGGCAAGGGGACCGGGCTCGGGCTCGCCATCAGCTATCGGATCCTTCAGGAACATGGCGGTACGTTGAT
GGCGGCCAATCATCCGGAGGGGGGCGCGATCATGACGATCGAATTGCCGGCACAGCTCCTGGACCAAGGTGAAGGCCCTT
TGATGAAATCATGA

Upstream 100 bases:

>100_bases
CTTTCCGCGCGGTTTCGGGGCATAGAAAAATGATTCTTCTTAGGTCTTCTTGCTGATTCCCTTCATGAAAAGGTGATGCG
ACGAACCCGGGAGCAAGAAT

Downstream 100 bases:

>100_bases
AAGGGCCTTCATTCATCGAATACGCTTTTCTTGACACGAAGCGAACGGGCTTCACTTGAAAATGCTCTAGTATCCGCCCT
CACTGGACCGTGAGGTGTCA

Product: PAS/PAC sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTASAGTGEDMPFDPDVDTERMWLNVVRKMDETWAELLTQQAELERKNNELEETQAFMAGVLDSMSDLLMACDRQLTIVR
TNIAAERLFAVSGRRLAGMTLETLIAPASPGTIQDLRAVIAQKTRLEDQEYIFESPQGDLPFAVNGSLRFDPRGRVTGLV
LVARPVGELRKAYRDLAATHRSLQDTQAQLVQAEKMASLGRLVAGVAHELNNPISFVYGNAHTLHRYARRLAAYLDALHA
LPASPQLAEQRQTLRIDMIMTELEGVLAGIVDGAERVRDIVADLRRFSSDRRDGRAPFDLEPVATTALGWVLAAAPPGIV
LELQIEGPLDVFGHSGQIHQVVMNLVQNAVDAMEALPEGAKRSLEISGGRREDHAWLAVRDTGPGIAPDVMERMFDPFFT
TKPVGKGTGLGLAISYRILQEHGGTLMAANHPEGGAIMTIELPAQLLDQGEGPLMKS

Sequences:

>Translated_457_residues
MTASAGTGEDMPFDPDVDTERMWLNVVRKMDETWAELLTQQAELERKNNELEETQAFMAGVLDSMSDLLMACDRQLTIVR
TNIAAERLFAVSGRRLAGMTLETLIAPASPGTIQDLRAVIAQKTRLEDQEYIFESPQGDLPFAVNGSLRFDPRGRVTGLV
LVARPVGELRKAYRDLAATHRSLQDTQAQLVQAEKMASLGRLVAGVAHELNNPISFVYGNAHTLHRYARRLAAYLDALHA
LPASPQLAEQRQTLRIDMIMTELEGVLAGIVDGAERVRDIVADLRRFSSDRRDGRAPFDLEPVATTALGWVLAAAPPGIV
LELQIEGPLDVFGHSGQIHQVVMNLVQNAVDAMEALPEGAKRSLEISGGRREDHAWLAVRDTGPGIAPDVMERMFDPFFT
TKPVGKGTGLGLAISYRILQEHGGTLMAANHPEGGAIMTIELPAQLLDQGEGPLMKS
>Mature_456_residues
TASAGTGEDMPFDPDVDTERMWLNVVRKMDETWAELLTQQAELERKNNELEETQAFMAGVLDSMSDLLMACDRQLTIVRT
NIAAERLFAVSGRRLAGMTLETLIAPASPGTIQDLRAVIAQKTRLEDQEYIFESPQGDLPFAVNGSLRFDPRGRVTGLVL
VARPVGELRKAYRDLAATHRSLQDTQAQLVQAEKMASLGRLVAGVAHELNNPISFVYGNAHTLHRYARRLAAYLDALHAL
PASPQLAEQRQTLRIDMIMTELEGVLAGIVDGAERVRDIVADLRRFSSDRRDGRAPFDLEPVATTALGWVLAAAPPGIVL
ELQIEGPLDVFGHSGQIHQVVMNLVQNAVDAMEALPEGAKRSLEISGGRREDHAWLAVRDTGPGIAPDVMERMFDPFFTT
KPVGKGTGLGLAISYRILQEHGGTLMAANHPEGGAIMTIELPAQLLDQGEGPLMKS

Specific function: Member of the two-component regulatory system dctB/dctD involved in the transport of C4-dicarboxylates. DctB functions as a membrane-associated protein kinase that phosphorylates dctD in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=400, Percent_Identity=25.5, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1790436, Length=268, Percent_Identity=27.9850746268657, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1788393, Length=154, Percent_Identity=32.4675324675325, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790300, Length=400, Percent_Identity=26.25, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081816, Length=252, Percent_Identity=26.984126984127, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=29.0836653386454, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1789808, Length=193, Percent_Identity=30.5699481865285, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790346, Length=121, Percent_Identity=31.404958677686, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR017055
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49921; Mature: 49790

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASAGTGEDMPFDPDVDTERMWLNVVRKMDETWAELLTQQAELERKNNELEETQAFMAG
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VLDSMSDLLMACDRQLTIVRTNIAAERLFAVSGRRLAGMTLETLIAPASPGTIQDLRAVI
HHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHH
AQKTRLEDQEYIFESPQGDLPFAVNGSLRFDPRGRVTGLVLVARPVGELRKAYRDLAATH
HHHHCCCCHHHHHCCCCCCCCEEECCCEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHH
RSLQDTQAQLVQAEKMASLGRLVAGVAHELNNPISFVYGNAHTLHRYARRLAAYLDALHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
LPASPQLAEQRQTLRIDMIMTELEGVLAGIVDGAERVRDIVADLRRFSSDRRDGRAPFDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EPVATTALGWVLAAAPPGIVLELQIEGPLDVFGHSGQIHQVVMNLVQNAVDAMEALPEGA
CHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
KRSLEISGGRREDHAWLAVRDTGPGIAPDVMERMFDPFFTTKPVGKGTGLGLAISYRILQ
HCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
EHGGTLMAANHPEGGAIMTIELPAQLLDQGEGPLMKS
HCCCEEEEECCCCCCEEEEEECCHHHHCCCCCCCCCC
>Mature Secondary Structure 
TASAGTGEDMPFDPDVDTERMWLNVVRKMDETWAELLTQQAELERKNNELEETQAFMAG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
VLDSMSDLLMACDRQLTIVRTNIAAERLFAVSGRRLAGMTLETLIAPASPGTIQDLRAVI
HHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCHHHHHHHHH
AQKTRLEDQEYIFESPQGDLPFAVNGSLRFDPRGRVTGLVLVARPVGELRKAYRDLAATH
HHHHCCCCHHHHHCCCCCCCCEEECCCEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHH
RSLQDTQAQLVQAEKMASLGRLVAGVAHELNNPISFVYGNAHTLHRYARRLAAYLDALHA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
LPASPQLAEQRQTLRIDMIMTELEGVLAGIVDGAERVRDIVADLRRFSSDRRDGRAPFDL
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
EPVATTALGWVLAAAPPGIVLELQIEGPLDVFGHSGQIHQVVMNLVQNAVDAMEALPEGA
CHHHHHHHHHHHHCCCCCEEEEEEECCCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHH
KRSLEISGGRREDHAWLAVRDTGPGIAPDVMERMFDPFFTTKPVGKGTGLGLAISYRILQ
HCEEEECCCCCCCCEEEEEECCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
EHGGTLMAANHPEGGAIMTIELPAQLLDQGEGPLMKS
HCCCEEEEECCCCCCEEEEEECCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2134335; 2793824; 11481431; 2551890; 2695394 [H]