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The map label for this gene is purM [H]

Identifier: 182682171

GI number: 182682171

Start: 1828725

End: 1829831

Strand: Direct

Name: purM [H]

Synonym: XfasM23_1650

Alternate gene names: 182682171

Gene position: 1828725-1829831 (Clockwise)

Preceding gene: 182682167

Following gene: 182682172

Centisome position: 72.12

GC content: 55.47

Gene sequence:

>1107_bases
ATGCACCCTGTTAACATTACCAAGGATTTCCGATCAAGCTGCCGCCTCCCCGTGACAACTCCCCCCCCCCCCAGCACGAC
ACCACTGACCTATCGCGATGCCGGAGTCGACATCGACGCTGGTAATGCACTTGTCGAACGGATCAAGCCGTTGGTGAAAC
GCACCTTCCGGCCCGAAGTCATGAGTGGACTGGGAGGCTTTGGTGCATTGTTCAACCTAGCAGGCAAATACAAAGAACCT
GTGTTGGTCTCCGGAACGGACGGAGTTGGCACCAAATTGAAGTTGGCACAGCAACTGAACCGACACAATACGATCGGCAT
TGATTTAGTAGCGATGTGCGTTAACGACGTCCTGGTACAGGGCGCCGAACCCTTGTTCTTCCTGGACTACTTTGCAACCG
GCAAACTTGATATAGACACCGCCACGGCAGTCATCAGCGGTATCGCACTAGGCTGCGAGCAATCCGGCTGCGCACTGATC
GGCGGTGAAACCGCCGAAATGCCAGACATGTATCCACCCGGAGAATACGATCTAGCAGGCTTCTGTGTCGCTGCTGTCGA
AAAATCTCAACTCCTGGATGGCAGCCAAGTACGCGAAGACGATGTCCTCATCGGCATTGCCTCCTCAGGTCCACACTCAA
ATGGCTATTCATTGATCCGACGTATCTATGAGCGTGCCGGATCACCTGCCGACCTGGATATCCACGGAACCCGCCTAATC
GACACATTAATGGCGCCCACCGCGTTATACGTCAAACCAATACTGAAACTTCTACACACCCACAGCGACGCAATCCACGC
AATGGCCCACATCACCGGCGGCGGCTTGACAGAGAACATCATCCGCGTGATTCCACCCAACCTGGGTTTGCGCATTGATG
CCAACGCGTGGACACAACCGCCCGTGTTCCAATGGCTACAGCGCGAAGGCGCGCTAGCCGATACCGAAATGTGGCGCACT
TTTAACTGTGGCATCGGCTTCGTATTAGTCGCCACACCCAACCAGGTAGCCCCCCTGGGACAAGCACTTGACAACCAAGG
CTTGGCACACTGGCAGATAGGCCGGGTCGTTACCCCTGTTGACAATGAGCGGGTACACATCGGCTGA

Upstream 100 bases:

>100_bases
CACAAAGCAATGAACAGAAAAAAACGGTAACGCATTGATAATTCCATGGCATGGGATATGCAGAATAGAGATTGTTGCCC
GAAATAAGGCATTGCCGCCA

Downstream 100 bases:

>100_bases
AGTGACAACAACAGAGACATCCACACCACACACCACTGCGGTATCCCTGCTGCCTCAGCATCGACCTCATCCCTACCTCA
CAACAACACGTGATCTTGCT

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MHPVNITKDFRSSCRLPVTTPPPPSTTPLTYRDAGVDIDAGNALVERIKPLVKRTFRPEVMSGLGGFGALFNLAGKYKEP
VLVSGTDGVGTKLKLAQQLNRHNTIGIDLVAMCVNDVLVQGAEPLFFLDYFATGKLDIDTATAVISGIALGCEQSGCALI
GGETAEMPDMYPPGEYDLAGFCVAAVEKSQLLDGSQVREDDVLIGIASSGPHSNGYSLIRRIYERAGSPADLDIHGTRLI
DTLMAPTALYVKPILKLLHTHSDAIHAMAHITGGGLTENIIRVIPPNLGLRIDANAWTQPPVFQWLQREGALADTEMWRT
FNCGIGFVLVATPNQVAPLGQALDNQGLAHWQIGRVVTPVDNERVHIG

Sequences:

>Translated_368_residues
MHPVNITKDFRSSCRLPVTTPPPPSTTPLTYRDAGVDIDAGNALVERIKPLVKRTFRPEVMSGLGGFGALFNLAGKYKEP
VLVSGTDGVGTKLKLAQQLNRHNTIGIDLVAMCVNDVLVQGAEPLFFLDYFATGKLDIDTATAVISGIALGCEQSGCALI
GGETAEMPDMYPPGEYDLAGFCVAAVEKSQLLDGSQVREDDVLIGIASSGPHSNGYSLIRRIYERAGSPADLDIHGTRLI
DTLMAPTALYVKPILKLLHTHSDAIHAMAHITGGGLTENIIRVIPPNLGLRIDANAWTQPPVFQWLQREGALADTEMWRT
FNCGIGFVLVATPNQVAPLGQALDNQGLAHWQIGRVVTPVDNERVHIG
>Mature_368_residues
MHPVNITKDFRSSCRLPVTTPPPPSTTPLTYRDAGVDIDAGNALVERIKPLVKRTFRPEVMSGLGGFGALFNLAGKYKEP
VLVSGTDGVGTKLKLAQQLNRHNTIGIDLVAMCVNDVLVQGAEPLFFLDYFATGKLDIDTATAVISGIALGCEQSGCALI
GGETAEMPDMYPPGEYDLAGFCVAAVEKSQLLDGSQVREDDVLIGIASSGPHSNGYSLIRRIYERAGSPADLDIHGTRLI
DTLMAPTALYVKPILKLLHTHSDAIHAMAHITGGGLTENIIRVIPPNLGLRIDANAWTQPPVFQWLQREGALADTEMWRT
FNCGIGFVLVATPNQVAPLGQALDNQGLAHWQIGRVVTPVDNERVHIG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=54.0462427745665, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=54.0462427745665, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=54.0462427745665, Blast_Score=360, Evalue=2e-99,
Organism=Escherichia coli, GI1788845, Length=342, Percent_Identity=60.233918128655, Blast_Score=410, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567511, Length=350, Percent_Identity=43.7142857142857, Blast_Score=261, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6321203, Length=340, Percent_Identity=47.6470588235294, Blast_Score=307, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24582400, Length=269, Percent_Identity=47.2118959107807, Blast_Score=241, Evalue=4e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 39532; Mature: 39532

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPVNITKDFRSSCRLPVTTPPPPSTTPLTYRDAGVDIDAGNALVERIKPLVKRTFRPEV
CCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHCCHHH
MSGLGGFGALFNLAGKYKEPVLVSGTDGVGTKLKLAQQLNRHNTIGIDLVAMCVNDVLVQ
HHCCCHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GAEPLFFLDYFATGKLDIDTATAVISGIALGCEQSGCALIGGETAEMPDMYPPGEYDLAG
CCCCEEEEEECCCCCEECHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHH
FCVAAVEKSQLLDGSQVREDDVLIGIASSGPHSNGYSLIRRIYERAGSPADLDIHGTRLI
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECHHHHH
DTLMAPTALYVKPILKLLHTHSDAIHAMAHITGGGLTENIIRVIPPNLGLRIDANAWTQP
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHEECCCCCCEEECCCCCCCC
PVFQWLQREGALADTEMWRTFNCGIGFVLVATPNQVAPLGQALDNQGLAHWQIGRVVTPV
HHHHHHHHCCCCCHHHHHEEECCCCEEEEEECCCCCCHHHHHHHCCCCCEEEECEEECCC
DNERVHIG
CCCEEECC
>Mature Secondary Structure
MHPVNITKDFRSSCRLPVTTPPPPSTTPLTYRDAGVDIDAGNALVERIKPLVKRTFRPEV
CCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCCCEECCCHHHHHHHHHHHHHHCCHHH
MSGLGGFGALFNLAGKYKEPVLVSGTDGVGTKLKLAQQLNRHNTIGIDLVAMCVNDVLVQ
HHCCCHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GAEPLFFLDYFATGKLDIDTATAVISGIALGCEQSGCALIGGETAEMPDMYPPGEYDLAG
CCCCEEEEEECCCCCEECHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHH
FCVAAVEKSQLLDGSQVREDDVLIGIASSGPHSNGYSLIRRIYERAGSPADLDIHGTRLI
HHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECHHHHH
DTLMAPTALYVKPILKLLHTHSDAIHAMAHITGGGLTENIIRVIPPNLGLRIDANAWTQP
HHHHCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHEECCCCCCEEECCCCCCCC
PVFQWLQREGALADTEMWRTFNCGIGFVLVATPNQVAPLGQALDNQGLAHWQIGRVVTPV
HHHHHHHHCCCCCHHHHHEEECCCCEEEEEECCCCCCHHHHHHHCCCCCEEEECEEECCC
DNERVHIG
CCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]