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The map label for this gene is strD [H]

Identifier: 182682167

GI number: 182682167

Start: 1824796

End: 1825518

Strand: Direct

Name: strD [H]

Synonym: XfasM23_1646

Alternate gene names: 182682167

Gene position: 1824796-1825518 (Clockwise)

Preceding gene: 182682166

Following gene: 182682171

Centisome position: 71.96

GC content: 56.57

Gene sequence:

>723_bases
ATGAAAGCACTGATCTTTGCCGCAGGCATCGGTCAGCGCATGCGTCCACTAACAAACTACACGCCAAAGCCACTCTTATG
TGCTGGCGGTGAACCATTGATCGTCTGGAACCTACGCAAACTCGCCGCGTTGGGCATCAGTGAAGTTGTGATCAACACCG
CCTGGCTGAGCGAGCAATTCCCGGAGATCCTCGGAGACGGTCAACGTTTCGGCTTACGCTTGTTCTACAGCAACGAAGGC
TCACTGCCACTGGAAACTGGTGGCGGCATGCTACACGCGCTACCACTGCTGGGCAACGCACCATTCCTCGCAATCAACGG
CGACATATGGACTGATGCCGACCTCACACGCCTACCGACGGAACCAGTAGGCGATGCACATCTCATGCTGGTCAACAACC
CTGAATATCACCCACAAGGCGACTTTGTATTACAAGCAGACAGCAGCGTACTCGACCGCACCCCTGGGATTCCTACATTG
ACTTTTGCCGGACTTGGCATCTACAGATCACAACTGCTGGCCGACTGGCGGAACATCATCGGTGATACGCCCGACACACA
TGCACAACCACCACGCTTCAAGCTTGCGCCACTGTTGCGTGCGGCCATGCGAAGCGGCCGCATCCACGGCACCCACCACC
GCGGCCAATGGACCGACGTTGGTACGCCGCAGCGTCTGCACGCACTAGATACATGGCTAAGATCACCAGAAGCACGCTTC
TAA

Upstream 100 bases:

>100_bases
AAGAAATACTGCCACGCCACCCAACACTCGCACCATTGGCCGAACTGATTGAGCACCGCATCAAACCAGCACTGGCAGCA
CGAATGATCACGGAGTCAAC

Downstream 100 bases:

>100_bases
AAAAGATGAAATTTTCTTCATTTTCCAACACTAAAATGTATGGATCACTCCAATACTCCACTGGCCTGACCTTCGCTGAC
ACACCACTCACAACGTGTTA

Product: nucleotidyl transferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MKALIFAAGIGQRMRPLTNYTPKPLLCAGGEPLIVWNLRKLAALGISEVVINTAWLSEQFPEILGDGQRFGLRLFYSNEG
SLPLETGGGMLHALPLLGNAPFLAINGDIWTDADLTRLPTEPVGDAHLMLVNNPEYHPQGDFVLQADSSVLDRTPGIPTL
TFAGLGIYRSQLLADWRNIIGDTPDTHAQPPRFKLAPLLRAAMRSGRIHGTHHRGQWTDVGTPQRLHALDTWLRSPEARF

Sequences:

>Translated_240_residues
MKALIFAAGIGQRMRPLTNYTPKPLLCAGGEPLIVWNLRKLAALGISEVVINTAWLSEQFPEILGDGQRFGLRLFYSNEG
SLPLETGGGMLHALPLLGNAPFLAINGDIWTDADLTRLPTEPVGDAHLMLVNNPEYHPQGDFVLQADSSVLDRTPGIPTL
TFAGLGIYRSQLLADWRNIIGDTPDTHAQPPRFKLAPLLRAAMRSGRIHGTHHRGQWTDVGTPQRLHALDTWLRSPEARF
>Mature_240_residues
MKALIFAAGIGQRMRPLTNYTPKPLLCAGGEPLIVWNLRKLAALGISEVVINTAWLSEQFPEILGDGQRFGLRLFYSNEG
SLPLETGGGMLHALPLLGNAPFLAINGDIWTDADLTRLPTEPVGDAHLMLVNNPEYHPQGDFVLQADSSVLDRTPGIPTL
TFAGLGIYRSQLLADWRNIIGDTPDTHAQPPRFKLAPLLRAAMRSGRIHGTHHRGQWTDVGTPQRLHALDTWLRSPEARF

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=235, Percent_Identity=27.2340425531915, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI11761619, Length=235, Percent_Identity=27.2340425531915, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=234, Percent_Identity=27.7777777777778, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=130, Percent_Identity=32.3076923076923, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI21355443, Length=120, Percent_Identity=32.5, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644084, Length=120, Percent_Identity=32.5, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 26406; Mature: 26406

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS00639 THIOL_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALIFAAGIGQRMRPLTNYTPKPLLCAGGEPLIVWNLRKLAALGISEVVINTAWLSEQF
CCEEEEECCCCCHHHHHCCCCCCCEEECCCCEEEEEEHHHHHHHCHHHHHHHHHHHHHHH
PEILGDGQRFGLRLFYSNEGSLPLETGGGMLHALPLLGNAPFLAINGDIWTDADLTRLPT
HHHHCCCCEEEEEEEECCCCCCEEECCCCEEEEEECCCCCCEEEECCCEECCCCCCCCCC
EPVGDAHLMLVNNPEYHPQGDFVLQADSSVLDRTPGIPTLTFAGLGIYRSQLLADWRNII
CCCCCEEEEEEECCCCCCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GDTPDTHAQPPRFKLAPLLRAAMRSGRIHGTHHRGQWTDVGTPQRLHALDTWLRSPEARF
CCCCCCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKALIFAAGIGQRMRPLTNYTPKPLLCAGGEPLIVWNLRKLAALGISEVVINTAWLSEQF
CCEEEEECCCCCHHHHHCCCCCCCEEECCCCEEEEEEHHHHHHHCHHHHHHHHHHHHHHH
PEILGDGQRFGLRLFYSNEGSLPLETGGGMLHALPLLGNAPFLAINGDIWTDADLTRLPT
HHHHCCCCEEEEEEEECCCCCCEEECCCCEEEEEECCCCCCEEEECCCEECCCCCCCCCC
EPVGDAHLMLVNNPEYHPQGDFVLQADSSVLDRTPGIPTLTFAGLGIYRSQLLADWRNII
CCCCCEEEEEEECCCCCCCCCEEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
GDTPDTHAQPPRFKLAPLLRAAMRSGRIHGTHHRGQWTDVGTPQRLHALDTWLRSPEARF
CCCCCCCCCCCCCHHHHHHHHHHHCCCEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]