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The map label for this gene is argH

Identifier: 170757234

GI number: 170757234

Start: 2848984

End: 2850306

Strand: Reverse

Name: argH

Synonym: CLD_1895

Alternate gene names: 170757234

Gene position: 2850306-2848984 (Counterclockwise)

Preceding gene: 170754318

Following gene: 170756400

Centisome position: 72.01

GC content: 30.01

Gene sequence:

>1323_bases
ATGAAACTTTGGGGAGGACGTTTTAAGGAAGAAGAAAGTAAACTTATGGAGGATTTTAATAGTTCTCTAAGTTTTGATAA
AAAACTTTATTATGAAGATATAAGAGGAAGCATAGCTCATGTTAAAATGCTTGCAAATCAAAATATAATAAAGGAAGAAG
AAAAAGAAAAAATATTGCTTGGGTTAGAGGAAATATTAAAAGAAATAGATGAAGGAATTTTAAAAATAGAGGGAGACTAT
GAGGATATTCATAGCTTTGTGGAAATAAATTTAATAAATAAAATAGGAAATGTGGGGAAAAAGCTTCATACAGGCAGAAG
TAGAAATGACCAAGTAGCCTTAGATATGAAATTATATGCTAAAAAATCCACGGAAGAAGTAATAGAATGCTTAAAGGAAC
TTATGGACTCTTTAATTAAAGTTGGAAATGAAAATAATTATATTATGCCAGGATATACCCATCTTCAAAGAGCTCAAGTG
GTAACTTTTAGGTATCATTTATTAGCTTATTTTGAAATGTTTAAAAGAGATGAGAAAAGATTAAAAAATGCCTTAGAGAT
TTTAAATGAAAGTCCTTTAGGATCAGGGGCTTTAGCGGGAAGTACTTATAGCATAGATAGAGAATACACTGCTAAGTTAT
TGGGCTTTAGAAAACCGGTAGATAATTTTTTAGATGGAGTTAGTGATAGGGATTATATAATAGAACTTATAAGTAAATTT
TCTATAATAATGATGCATTTAAGTAGATTATCTGAAGAACTTATACTTTGGAGTAGTAGTGAATTTAGGTTCATACAAAT
AGGAGATGCTTATTCCACAGGTAGTAGTATAATGCCTCAGAAGAAAAACCCAGATGGGGCGGAACTTATACGCGGGAAAA
CTGGAAGGGTATATGGGGACTTAATAGGTATATTAACAGTTATGAAATCACTACCATTAGCTTATAATAAAGATATGCAA
GAGGATAAAGAGCCTTTCTTTGATGCAAAAGATACTGTAATAAGCTGTTTAAAAGTAATGGAAGGTATAATATCTACTCT
AAAAGTAAATAAAGAAAATTTAATGAAATCTGTGAAAAAAGGCTTTTTAAATGCCACAGAAGCAGCGGATTATTTAGTAA
ATAAAGGCATGGCTTTTAGAGATGCACATAAAGTTATAGGTGAAATCGTAATATACTGTGAGGATAAAAATTCAGCTATA
GAGGATTTATCCCTAGAAGAATTAAAACAATTCTCAGATCTATTTTGTGAGGATATTTATGGATTTATAGATTATAAGAG
CTCTATAAACAAAGGGATAAAAAAAGAAATGGGATACTCTTAA

Upstream 100 bases:

>100_bases
TTACAGTCATAAAGATGCAGAAGGCTTTATAAATTTATTTGGATTGCCATGCAAAATAAAAGCACTCAAAAATTTCTAGA
CTAAATTGGAGGAACATATT

Downstream 100 bases:

>100_bases
GAAGATTATAATTTTATAGTCTTTAAAGGTTGAAAACTAAAACGAGAAATACTTTTAGTCAATAGATAGTCATAAAATAA
AGAATGCTAATATTAGTTCA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIRGSIAHVKMLANQNIIKEEEKEKILLGLEEILKEIDEGILKIEGDY
EDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYAKKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQV
VTFRYHLLAYFEMFKRDEKRLKNALEILNESPLGSGALAGSTYSIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKTGRVYGDLIGILTVMKSLPLAYNKDMQ
EDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKKGFLNATEAADYLVNKGMAFRDAHKVIGEIVIYCEDKNSAI
EDLSLEELKQFSDLFCEDIYGFIDYKSSINKGIKKEMGYS

Sequences:

>Translated_440_residues
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIRGSIAHVKMLANQNIIKEEEKEKILLGLEEILKEIDEGILKIEGDY
EDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYAKKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQV
VTFRYHLLAYFEMFKRDEKRLKNALEILNESPLGSGALAGSTYSIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKTGRVYGDLIGILTVMKSLPLAYNKDMQ
EDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKKGFLNATEAADYLVNKGMAFRDAHKVIGEIVIYCEDKNSAI
EDLSLEELKQFSDLFCEDIYGFIDYKSSINKGIKKEMGYS
>Mature_440_residues
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIRGSIAHVKMLANQNIIKEEEKEKILLGLEEILKEIDEGILKIEGDY
EDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYAKKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQV
VTFRYHLLAYFEMFKRDEKRLKNALEILNESPLGSGALAGSTYSIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKTGRVYGDLIGILTVMKSLPLAYNKDMQ
EDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKKGFLNATEAADYLVNKGMAFRDAHKVIGEIVIYCEDKNSAI
EDLSLEELKQFSDLFCEDIYGFIDYKSSINKGIKKEMGYS

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=431, Percent_Identity=42.6914153132251, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI68303542, Length=431, Percent_Identity=42.6914153132251, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI68303549, Length=431, Percent_Identity=40.8352668213457, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI68303547, Length=431, Percent_Identity=40.3712296983759, Blast_Score=336, Evalue=2e-92,
Organism=Escherichia coli, GI1790398, Length=437, Percent_Identity=47.8260869565217, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6321806, Length=434, Percent_Identity=45.3917050691244, Blast_Score=365, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221473854, Length=431, Percent_Identity=40.3712296983759, Blast_Score=341, Evalue=5e-94,
Organism=Drosophila melanogaster, GI78706858, Length=431, Percent_Identity=40.3712296983759, Blast_Score=341, Evalue=5e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 50294; Mature: 50294

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIRGSIAHVKMLANQNIIKEEEKEKILL
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
GLEEILKEIDEGILKIEGDYEDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYA
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHH
KKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQVVTFRYHLLAYFEMFKRDEKR
CCCHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNALEILNESPLGSGALAGSTYSIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
HHHHHHHHCCCCCCCCCCCCCCEECCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHH
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKTGRVYGD
HHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHH
LIGILTVMKSLPLAYNKDMQEDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKK
HHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GFLNATEAADYLVNKGMAFRDAHKVIGEIVIYCEDKNSAIEDLSLEELKQFSDLFCEDIY
HCCCHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHH
GFIDYKSSINKGIKKEMGYS
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKLWGGRFKEEESKLMEDFNSSLSFDKKLYYEDIRGSIAHVKMLANQNIIKEEEKEKILL
CCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHH
GLEEILKEIDEGILKIEGDYEDIHSFVEINLINKIGNVGKKLHTGRSRNDQVALDMKLYA
HHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHH
KKSTEEVIECLKELMDSLIKVGNENNYIMPGYTHLQRAQVVTFRYHLLAYFEMFKRDEKR
CCCHHHHHHHHHHHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKNALEILNESPLGSGALAGSTYSIDREYTAKLLGFRKPVDNFLDGVSDRDYIIELISKF
HHHHHHHHCCCCCCCCCCCCCCEECCHHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHH
SIIMMHLSRLSEELILWSSSEFRFIQIGDAYSTGSSIMPQKKNPDGAELIRGKTGRVYGD
HHHHHHHHHHHHHHEEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHH
LIGILTVMKSLPLAYNKDMQEDKEPFFDAKDTVISCLKVMEGIISTLKVNKENLMKSVKK
HHHHHHHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
GFLNATEAADYLVNKGMAFRDAHKVIGEIVIYCEDKNSAIEDLSLEELKQFSDLFCEDIY
HCCCHHHHHHHHHHCCCHHHHHHHHHHHEEEEECCCCCCHHCCCHHHHHHHHHHHHHHHH
GFIDYKSSINKGIKKEMGYS
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA