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The map label for this gene is gluP [H]

Identifier: 170756233

GI number: 170756233

Start: 497551

End: 498576

Strand: Direct

Name: gluP [H]

Synonym: CLD_0351

Alternate gene names: 170756233

Gene position: 497551-498576 (Clockwise)

Preceding gene: 170755695

Following gene: 170757015

Centisome position: 12.57

GC content: 25.24

Gene sequence:

>1026_bases
GTGATTGGTATAGATAATTTTATAAAAGACATTATAGAAAAGCTTATGAGTACAAACAATTACAATGTTATGGAGATAAA
TACTAATACAGGACTAGAGAGTAATTGGATAGCTGTTAAAGATAAAGAAGATTTTTATAATGTATTAATTTTTTCTAGTA
ACTTTGCAATAAAAAATTTAGATAAGGAATATATAGAAGAGTATATTAAGTCTTTGCTTGTGGATAAACCCATAAATTTA
AACATAGCTATACTAATGGATGAAGAAATAGATGGCTCTTTTATTAATTCTTTAGATAGTAATTTAATTAAAGATATTTC
TTTTATAGTGGATTATAATAATAGAAATATAGTATATGCGGGAGAAGGCACTAGAAATATTGTAGAAAACATAGTAAGTG
TTCCAGAGCAAAGAGAAAATATTTATTATAATGAAAATGATGCAAATAGCAATAAGAAAGCTACTATTACTAAAATAATA
ATAGGTATAAATATTTTTATGTATCTAATAACAGCTTTTTTATCAGGAAGTATATTTACTAGTGATATTAAAGTACTAAT
ATTTCTAGGAGCAAAAGTAAATTCTTTTATAAATAATGGAGAATATTATAGACTAATAACAGCAATGTTTTTACATGGAG
GATTAATACATTTAGCATTAAATATGTATGCATTAAATGCTATAGGTCCATTGGTAGAAATTTATTTTGGTAAAGCAAAA
TATTTAATTATTTATTTTATATCTGGAATATTAAGTTCTTATTTTAGTTATTTATTTTCATCTTCAGTGTCCATAGGGGC
TTCAGGAGCTATATTTGGTATATTAGGAGCTACTTTAATAATAGCTTATACAAATAGGAAAAAAGGCGGGAAAGAATTTT
TAAATAATATAATATCAGTTATAGTTGTTAACTTAATACTAGGGTTTTCTATCCCCAATGTGGATAACTTTGGACATATC
GGTGGATTGATTGGAGGAGTAATTATAACATTTGTTCTTTTTTTATCCGATGACTACCCGCTCTAA

Upstream 100 bases:

>100_bases
TAAATTATATGTTGTGCTTATTTGTATAATAATATATATTGGGTAATAGAAAGAAAATTTTTTAATGGTGTCTAAAAGTA
ATTATTATTTTTATTAGGAT

Downstream 100 bases:

>100_bases
TACTCCCATCGCACTCTGTGAAAGCGATTCGCACCAAATCGAAGATTTTGGATTCTCTGCTTTTCTTCAAAGTGGGAGTA
AAGAGCGGCTACGTCTCTGG

Product: putative membrane associated peptidase

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MIGIDNFIKDIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNLDKEYIEEYIKSLLVDKPINL
NIAILMDEEIDGSFINSLDSNLIKDISFIVDYNNRNIVYAGEGTRNIVENIVSVPEQRENIYYNENDANSNKKATITKII
IGINIFMYLITAFLSGSIFTSDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKAK
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYTNRKKGGKEFLNNIISVIVVNLILGFSIPNVDNFGHI
GGLIGGVIITFVLFLSDDYPL

Sequences:

>Translated_341_residues
MIGIDNFIKDIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNLDKEYIEEYIKSLLVDKPINL
NIAILMDEEIDGSFINSLDSNLIKDISFIVDYNNRNIVYAGEGTRNIVENIVSVPEQRENIYYNENDANSNKKATITKII
IGINIFMYLITAFLSGSIFTSDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKAK
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYTNRKKGGKEFLNNIISVIVVNLILGFSIPNVDNFGHI
GGLIGGVIITFVLFLSDDYPL
>Mature_341_residues
MIGIDNFIKDIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNLDKEYIEEYIKSLLVDKPINL
NIAILMDEEIDGSFINSLDSNLIKDISFIVDYNNRNIVYAGEGTRNIVENIVSVPEQRENIYYNENDANSNKKATITKII
IGINIFMYLITAFLSGSIFTSDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKAK
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYTNRKKGGKEFLNNIISVIVVNLILGFSIPNVDNFGHI
GGLIGGVIITFVLFLSDDYPL

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Caenorhabditis elegans, GI133901888, Length=141, Percent_Identity=34.7517730496454, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115532986, Length=146, Percent_Identity=34.2465753424658, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 38058; Mature: 38058

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIDNFIKDIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNL
CCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCCCHHCC
DKEYIEEYIKSLLVDKPINLNIAILMDEEIDGSFINSLDSNLIKDISFIVDYNNRNIVYA
CHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHEEEECCCEEEEE
GEGTRNIVENIVSVPEQRENIYYNENDANSNKKATITKIIIGINIFMYLITAFLSGSIFT
CCCHHHHHHHHHHCCCHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEC
SDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKAK
CCEEEEEEECCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHH
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYTNRKKGGKEFLNNIISV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHH
IVVNLILGFSIPNVDNFGHIGGLIGGVIITFVLFLSDDYPL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIGIDNFIKDIIEKLMSTNNYNVMEINTNTGLESNWIAVKDKEDFYNVLIFSSNFAIKNL
CCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEECCCCEEEEEEEECCCCHHCC
DKEYIEEYIKSLLVDKPINLNIAILMDEEIDGSFINSLDSNLIKDISFIVDYNNRNIVYA
CHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHEEEECCCEEEEE
GEGTRNIVENIVSVPEQRENIYYNENDANSNKKATITKIIIGINIFMYLITAFLSGSIFT
CCCHHHHHHHHHHCCCHHCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEC
SDIKVLIFLGAKVNSFINNGEYYRLITAMFLHGGLIHLALNMYALNAIGPLVEIYFGKAK
CCEEEEEEECCHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHH
YLIIYFISGILSSYFSYLFSSSVSIGASGAIFGILGATLIIAYTNRKKGGKEFLNNIISV
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHH
IVVNLILGFSIPNVDNFGHIGGLIGGVIITFVLFLSDDYPL
HHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]