Click here to switch to the map view.

The map label for this gene is fhuB

Identifier: 170756160

GI number: 170756160

Start: 806277

End: 807317

Strand: Direct

Name: fhuB

Synonym: CLD_0079

Alternate gene names: 170756160

Gene position: 806277-807317 (Clockwise)

Preceding gene: 170755421

Following gene: 170757399

Centisome position: 20.37

GC content: 38.9

Gene sequence:

>1041_bases
ATGAAAAAACCAATGGAGAGGGTAAATATAAACATAAATAAAAAAGATCATATACGGAAGATGTGGTTTATTGTATTGGG
AGGATTAGGATTACTTGCTTTTATTATGATGGTTTCTACAACTAAGGGGGCAGAGAATATCCCCTTAGCTTCCCTATGGG
ATGCTTTATTTCATTTTAATGAGAAGGAAATGAATCATCTTGTTATAGTCAATCTACGTATTCCTCGTGTTATAGCAAGT
GCCTTAGTTGGTGCAGCGCTTGCTGTTTCGGGAGCTATTATGCAAGGAACTACAGGAAATCCCCTTGCTGATTCAGGATT
ATTAGGGTTAAATGCTGGAGCGGCTTTTGCTCTTTCTATATGTTTTGCCTTCTTTCCTGGAATGAAATATATCCATATTA
TTTTATTCTCCTTTTTAGGAGCAGCTTTTGGAGCTGCATTAGTTAATGGTATTGCTTCTATGAAAAGAGGTGGACAAACA
CCTATTCGTCTTGTATTGGCAGGGGCAGCTGTTAGTACACTGCTTGTGGCCATGAGCCAAGGAATTGCCCTTTATTTTAA
TGTGGCTCAAAGCATTATGTTTTGGACCGTTGGTGGTGTTGCAGGTTCCAATTGGGAACAGGTTAGGATAATGCTTCCGT
GGATAATAGGAGGTCTCATAGGATCGGTGGCATTATCGCCTTATATTTCTATTTTAAGCTTAGGCCAGGATGTTGCAAAG
GGATTGGGAATAAATATAAAGGTAGTAAATGTACTCTCTTCAATTATAGTTCTTATATTGGTAGGAGCTTCAGTATCTGT
AGTAGGTTCAGTTGGATTTGTGGGATTGATTGTTCCTCATATTGCACGTTTTTTTGTTGGGATGGATTATAAACTAATTA
TTCCTTCTACAGCAGTAATGGGAGCTTTGCTGGTAGTATTGGCTGACCTAGGAGCGAGAACTTTAAACCCTCCCTTTGAA
ACTCCCATAGGAGCTATAATTTCTCTCATAGGTGTGCCATTATTTCTAAACTTGGCTCGTAGGCAAAGGAGTGCAATGTA
A

Upstream 100 bases:

>100_bases
AATAAACTTTCATTGGCAATTTAAATGTAATCTAAATGGAAGTTATCCATTGGTTTGGCATAATAAGAATAGTTTACAGT
AATAAGGAGGTAGCAGTTAT

Downstream 100 bases:

>100_bases
TGAAAGAACAACAACAAATAATTGAAGCATATAAGCGTAAGGTAGCTATTCGTAATACATTAATTGTAATTGGGTGTGTT
TTATTACTGGCAATTTCTTT

Product: ferrichrome ABC transporter, permease protein FhuB

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKKPMERVNININKKDHIRKMWFIVLGGLGLLAFIMMVSTTKGAENIPLASLWDALFHFNEKEMNHLVIVNLRIPRVIAS
ALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSICFAFFPGMKYIHIILFSFLGAAFGAALVNGIASMKRGGQT
PIRLVLAGAAVSTLLVAMSQGIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGSVALSPYISILSLGQDVAK
GLGINIKVVNVLSSIIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVMGALLVVLADLGARTLNPPFE
TPIGAIISLIGVPLFLNLARRQRSAM

Sequences:

>Translated_346_residues
MKKPMERVNININKKDHIRKMWFIVLGGLGLLAFIMMVSTTKGAENIPLASLWDALFHFNEKEMNHLVIVNLRIPRVIAS
ALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSICFAFFPGMKYIHIILFSFLGAAFGAALVNGIASMKRGGQT
PIRLVLAGAAVSTLLVAMSQGIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGSVALSPYISILSLGQDVAK
GLGINIKVVNVLSSIIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVMGALLVVLADLGARTLNPPFE
TPIGAIISLIGVPLFLNLARRQRSAM
>Mature_346_residues
MKKPMERVNININKKDHIRKMWFIVLGGLGLLAFIMMVSTTKGAENIPLASLWDALFHFNEKEMNHLVIVNLRIPRVIAS
ALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSICFAFFPGMKYIHIILFSFLGAAFGAALVNGIASMKRGGQT
PIRLVLAGAAVSTLLVAMSQGIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGSVALSPYISILSLGQDVAK
GLGINIKVVNVLSSIIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVMGALLVVLADLGARTLNPPFE
TPIGAIISLIGVPLFLNLARRQRSAM

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=294, Percent_Identity=35.7142857142857, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1786805, Length=303, Percent_Identity=33.6633663366337, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790740, Length=295, Percent_Identity=30.8474576271186, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786347, Length=281, Percent_Identity=32.3843416370107, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788004, Length=292, Percent_Identity=32.5342465753425, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786804, Length=306, Percent_Identity=30.3921568627451, Blast_Score=93, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36488; Mature: 36488

Theoretical pI: Translated: 10.85; Mature: 10.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKPMERVNININKKDHIRKMWFIVLGGLGLLAFIMMVSTTKGAENIPLASLWDALFHFN
CCCCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
EKEMNHLVIVNLRIPRVIASALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSI
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCHHHHHHHH
CFAFFPGMKYIHIILFSFLGAAFGAALVNGIASMKRGGQTPIRLVLAGAAVSTLLVAMSQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGSVALSPYISILSLGQDVAK
CHHHHHHHHHHHHHHHCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGINIKVVNVLSSIIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVM
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHH
GALLVVLADLGARTLNPPFETPIGAIISLIGVPLFLNLARRQRSAM
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKPMERVNININKKDHIRKMWFIVLGGLGLLAFIMMVSTTKGAENIPLASLWDALFHFN
CCCCCHHCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCC
EKEMNHLVIVNLRIPRVIASALVGAALAVSGAIMQGTTGNPLADSGLLGLNAGAAFALSI
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCHHHHHHHH
CFAFFPGMKYIHIILFSFLGAAFGAALVNGIASMKRGGQTPIRLVLAGAAVSTLLVAMSQ
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GIALYFNVAQSIMFWTVGGVAGSNWEQVRIMLPWIIGGLIGSVALSPYISILSLGQDVAK
CHHHHHHHHHHHHHHHCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGINIKVVNVLSSIIVLILVGASVSVVGSVGFVGLIVPHIARFFVGMDYKLIIPSTAVM
CCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHH
GALLVVLADLGARTLNPPFETPIGAIISLIGVPLFLNLARRQRSAM
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]