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The map label for this gene is kanC [H]

Identifier: 170755975

GI number: 170755975

Start: 2287233

End: 2288372

Strand: Reverse

Name: kanC [H]

Synonym: CLD_2491

Alternate gene names: 170755975

Gene position: 2288372-2287233 (Counterclockwise)

Preceding gene: 170756069

Following gene: 170755171

Centisome position: 57.81

GC content: 26.05

Gene sequence:

>1140_bases
ATGTATATGAATTTAGCACAAAAAATTAATGATGATTATTATCATCCAGAGGTTAAACTTGAAACAAACTTATTAGAATC
ATCTCCAATATATTTAGGGTGCAATATATGGAGAGAAAGTCTATTAGAAAAGATGATAGATTTAAATACAGATAAGTTTT
TCTTAATTACAGACGATATTGTATATAATTTGTTTGGAAAAGAACTATTGGAATATATGAATAGAAAAGTTTCAGTAAAA
TTAATTAAATTGCCATCAGGTGAAAAACATAAAAATATAAAAGTGTTTAATGATTTAATGGAAGATTTATTTGATAACAA
TGTAACTAAAAGTTCAATTTTAATTTCATTAGGTGGAGGTGTTGTAGGGAATATTACAGGATTGGCTGCTGCTTTAGCAT
TTAGAGGTATTAGATTTTTTCATATACCTACAACTTTTATGTCTCAGACTGATAGCATTCTTAGCAGAAAACAAGGGATT
AATTCTTTTTATGGTAAGAATATGATTGGATCATATTATACACCTTTATTTAATTTTATAGATACTTCATTTTTAACATT
TGATAGTGAAAGATTTATAAGAGGTAGCTTTGTTGAAACTGTTAAAAATGGATTCATATATAATGCAGATTTTTTAAATA
AACTTAAATCAGTAATTAAAAATGATTTTAATGTTAACCAAGAAGGCATTTTTAATTTAGTAAAAATGAGTATTGAATCA
AAGTTACCAATAATGAAAGCAGATCCAACTGAAAAGGGTTTAGCTATGATTCTAGAGTATGGTCATACCGTTGGACATGC
AATAGAAAAGCTTTCATATGGAAAACTATCACATGGAGAAAGTGTATCAATTGGTATGATGGTTGCTGCTCGTATAAGTG
AAAAACTTGGTTACTTAAGTAAACAAGATGTTAAGGAGCATATGGATATATTATCAGCATTGAAAACACCTACAAAAATT
CCTTCAAATATAAAAATTTCTGACATAATTGATAGAATAAAATTAGATAATAAAAAGGATATAAATGGTATAAGGTTTGT
TGTTCTTCAAAATATAGGAAAATGTATAAATACTGATGGTAGTTATATGATTAAAGTTCCTTTTAATATAATCAATGATG
CTATAGAAGAAACTTGTTAA

Upstream 100 bases:

>100_bases
GAAGGAGTGATGTTTTAATTTAAAATATTAATAGATTGCTTTGTTTGTCAGAGTAGTTTTGTTAAAAAACATATTATATA
AATAAACAGGAGGAATGAAA

Downstream 100 bases:

>100_bases
TTTTAGTGAATTTATTATAAAAATATACTACATTTAGAAGCTTAAAAAAGGATATTTGATTTCAAAATTTAAAGGAGGAG
AATATGTTAAAGTTTGCTTA

Product: putative 3-dehydroquinate synthase

Products: dehydroquinate +phosphate [C]

Alternate protein names: DOI synthase; DOIS [H]

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MYMNLAQKINDDYYHPEVKLETNLLESSPIYLGCNIWRESLLEKMIDLNTDKFFLITDDIVYNLFGKELLEYMNRKVSVK
LIKLPSGEKHKNIKVFNDLMEDLFDNNVTKSSILISLGGGVVGNITGLAAALAFRGIRFFHIPTTFMSQTDSILSRKQGI
NSFYGKNMIGSYYTPLFNFIDTSFLTFDSERFIRGSFVETVKNGFIYNADFLNKLKSVIKNDFNVNQEGIFNLVKMSIES
KLPIMKADPTEKGLAMILEYGHTVGHAIEKLSYGKLSHGESVSIGMMVAARISEKLGYLSKQDVKEHMDILSALKTPTKI
PSNIKISDIIDRIKLDNKKDINGIRFVVLQNIGKCINTDGSYMIKVPFNIINDAIEETC

Sequences:

>Translated_379_residues
MYMNLAQKINDDYYHPEVKLETNLLESSPIYLGCNIWRESLLEKMIDLNTDKFFLITDDIVYNLFGKELLEYMNRKVSVK
LIKLPSGEKHKNIKVFNDLMEDLFDNNVTKSSILISLGGGVVGNITGLAAALAFRGIRFFHIPTTFMSQTDSILSRKQGI
NSFYGKNMIGSYYTPLFNFIDTSFLTFDSERFIRGSFVETVKNGFIYNADFLNKLKSVIKNDFNVNQEGIFNLVKMSIES
KLPIMKADPTEKGLAMILEYGHTVGHAIEKLSYGKLSHGESVSIGMMVAARISEKLGYLSKQDVKEHMDILSALKTPTKI
PSNIKISDIIDRIKLDNKKDINGIRFVVLQNIGKCINTDGSYMIKVPFNIINDAIEETC
>Mature_379_residues
MYMNLAQKINDDYYHPEVKLETNLLESSPIYLGCNIWRESLLEKMIDLNTDKFFLITDDIVYNLFGKELLEYMNRKVSVK
LIKLPSGEKHKNIKVFNDLMEDLFDNNVTKSSILISLGGGVVGNITGLAAALAFRGIRFFHIPTTFMSQTDSILSRKQGI
NSFYGKNMIGSYYTPLFNFIDTSFLTFDSERFIRGSFVETVKNGFIYNADFLNKLKSVIKNDFNVNQEGIFNLVKMSIES
KLPIMKADPTEKGLAMILEYGHTVGHAIEKLSYGKLSHGESVSIGMMVAARISEKLGYLSKQDVKEHMDILSALKTPTKI
PSNIKISDIIDRIKLDNKKDINGIRFVVLQNIGKCINTDGSYMIKVPFNIINDAIEETC

Specific function: Catalyzes the intramolecular carbocycle formation from D-glucose-6-phosphate to 2-deoxy-scyllo-inosose (DOI) [H]

COG id: COG0337

COG function: function code E; 3-dehydroquinate synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dehydroquinate synthase family. DOI synthase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789791, Length=306, Percent_Identity=31.6993464052288, Blast_Score=161, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320332, Length=319, Percent_Identity=28.8401253918495, Blast_Score=138, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016303
- InterPro:   IPR002658 [H]

Pfam domain/function: PF01761 DHQ_synthase [H]

EC number: 4.2.3.4 [C]

Molecular weight: Translated: 42906; Mature: 42906

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYMNLAQKINDDYYHPEVKLETNLLESSPIYLGCNIWRESLLEKMIDLNTDKFFLITDDI
CCCCHHHHCCCCCCCCCEEEEECHHCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEHHH
VYNLFGKELLEYMNRKVSVKLIKLPSGEKHKNIKVFNDLMEDLFDNNVTKSSILISLGGG
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCC
VVGNITGLAAALAFRGIRFFHIPTTFMSQTDSILSRKQGINSFYGKNMIGSYYTPLFNFI
CHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHH
DTSFLTFDSERFIRGSFVETVKNGFIYNADFLNKLKSVIKNDFNVNQEGIFNLVKMSIES
HHHHEEECCCHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KLPIMKADPTEKGLAMILEYGHTVGHAIEKLSYGKLSHGESVSIGMMVAARISEKLGYLS
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
KQDVKEHMDILSALKTPTKIPSNIKISDIIDRIKLDNKKDINGIRFVVLQNIGKCINTDG
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
SYMIKVPFNIINDAIEETC
CEEEEECHHHHHHHHHHCC
>Mature Secondary Structure
MYMNLAQKINDDYYHPEVKLETNLLESSPIYLGCNIWRESLLEKMIDLNTDKFFLITDDI
CCCCHHHHCCCCCCCCCEEEEECHHCCCCEEEEHHHHHHHHHHHHHHCCCCEEEEEEHHH
VYNLFGKELLEYMNRKVSVKLIKLPSGEKHKNIKVFNDLMEDLFDNNVTKSSILISLGGG
HHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCC
VVGNITGLAAALAFRGIRFFHIPTTFMSQTDSILSRKQGINSFYGKNMIGSYYTPLFNFI
CHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHH
DTSFLTFDSERFIRGSFVETVKNGFIYNADFLNKLKSVIKNDFNVNQEGIFNLVKMSIES
HHHHEEECCCHHHHHHHHHHHHCCCEECHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
KLPIMKADPTEKGLAMILEYGHTVGHAIEKLSYGKLSHGESVSIGMMVAARISEKLGYLS
CCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
KQDVKEHMDILSALKTPTKIPSNIKISDIIDRIKLDNKKDINGIRFVVLQNIGKCINTDG
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCC
SYMIKVPFNIINDAIEETC
CEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: Co2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.033 {3-deoxy-D-arabino-heptulosonic} [C]

Substrates: @DEOX04.txt*phospho-deoxy-arabino-heptulosonate! [C]

Specific reaction: @DEOX04.txt*phospho-deoxy-arabino-heptulosonate! = dehydroquinate +phosphate [C]

General reaction: elimination (P-O bond cleavage [C]

Inhibitor: 3-deoxy-D-arabino-heoptulosonic acid; 3-deoxy-D-arabino-heptulosonic acid7-homophosphate [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA