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The map label for this gene is lacA [H]

Identifier: 170755507

GI number: 170755507

Start: 2301246

End: 2301860

Strand: Reverse

Name: lacA [H]

Synonym: CLD_2478

Alternate gene names: 170755507

Gene position: 2301860-2301246 (Counterclockwise)

Preceding gene: 170755408

Following gene: 170754582

Centisome position: 58.15

GC content: 32.52

Gene sequence:

>615_bases
ATGAATCAGAAAGATAGAATGTTAGCAGGGCTTCCATATAAAGCGTGCTTAGATGGATTACCAGAAGAACGAATGGCAAA
TAAAAAGAAAATTTATGAGTATAACCATTGCTTCCCAGATGAACATGAAAAAATCCATAAATTAATAAGAGATATTCTTG
GAAAAGCAGGTGCAGATGTACATATAGAGGCACCCTTTTATTGTGATTATGGAAAGAATATTCAGGTTGGAGATAACTTT
TTTGCAAATTACAACTGTACAATTCTAGATGTGGGAAAAGTAATTATAGGTAATAATGTACAATTTGCTCCAAATGTTTC
TTTGTATACAGCAGGTCATCCCATACATCCTGATTCACGAAATTCTGGATATGAATATGGAATTGGTATAACAATAGGAG
ATAATGTGTGGCTGGGAGGAAATGTTGTTGTAAATCCTGGAGTTCATATTGGAAATAACGTTGTTATTGGTTCGGGAAGT
GTTGTTACAAAAGACATTCCAGACAATGTGATAGCAATAGGAAATCCATGTAAAGTTATTCGTGAAATTACAGAAGAAGA
TCGTAAGTATTATTATAAAAATTATGAATTTGATGTTGATGATTATAAGGAATAG

Upstream 100 bases:

>100_bases
AATGAGTTCTAGTATCCCTTTCAAAATGTTATAATGTAAGTTAAAAGATAAAGTGAAATTTATTTTCAATATTAATATAA
TGTGGAAGGTGGAGACAATT

Downstream 100 bases:

>100_bases
TTTATTTACAAATTAAAATTATTTATGCAATGGGGTGAGAAAATGATTTTAGCCATAGAATGTTTTATTGCATGTGTACT
ATTTACTCTTATGATTTTAC

Product: O-acetyltransferase family protein

Products: NA

Alternate protein names: GAT; Thiogalactoside acetyltransferase [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MNQKDRMLAGLPYKACLDGLPEERMANKKKIYEYNHCFPDEHEKIHKLIRDILGKAGADVHIEAPFYCDYGKNIQVGDNF
FANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSRNSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGS
VVTKDIPDNVIAIGNPCKVIREITEEDRKYYYKNYEFDVDDYKE

Sequences:

>Translated_204_residues
MNQKDRMLAGLPYKACLDGLPEERMANKKKIYEYNHCFPDEHEKIHKLIRDILGKAGADVHIEAPFYCDYGKNIQVGDNF
FANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSRNSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGS
VVTKDIPDNVIAIGNPCKVIREITEEDRKYYYKNYEFDVDDYKE
>Mature_204_residues
MNQKDRMLAGLPYKACLDGLPEERMANKKKIYEYNHCFPDEHEKIHKLIRDILGKAGADVHIEAPFYCDYGKNIQVGDNF
FANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSRNSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGS
VVTKDIPDNVIAIGNPCKVIREITEEDRKYYYKNYEFDVDDYKE

Specific function: May assist cellular detoxification by acetylating non- metabolizable pyranosides, thereby preventing their reentry into the cell [H]

COG id: COG0110

COG function: function code R; Acetyltransferase (isoleucine patch superfamily)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Escherichia coli, GI1786537, Length=198, Percent_Identity=49.4949494949495, Blast_Score=208, Evalue=2e-55,
Organism=Escherichia coli, GI1786664, Length=182, Percent_Identity=47.2527472527472, Blast_Score=189, Evalue=9e-50,
Organism=Escherichia coli, GI1788367, Length=141, Percent_Identity=31.2056737588652, Blast_Score=65, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322243, Length=188, Percent_Identity=53.1914893617021, Blast_Score=194, Evalue=1e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00132 Hexapep [H]

EC number: =2.3.1.18 [H]

Molecular weight: Translated: 22874; Mature: 22874

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKDRMLAGLPYKACLDGLPEERMANKKKIYEYNHCFPDEHEKIHKLIRDILGKAGADV
CCCCCCEEECCCHHHHHCCCCHHHHCCHHHEEECCCCCCCHHHHHHHHHHHHHCCCCCCE
HIEAPFYCDYGKNIQVGDNFFANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSR
EEECCEEECCCCEEEECCCEEECCCEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCC
NSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGSVVTKDIPDNVIAIGNPCKVI
CCCEEEEEEEEECCCEEECCEEEECCCEEECCEEEEECCCEEEECCCCCEEEECCHHHHH
REITEEDRKYYYKNYEFDVDDYKE
HHHHHHHHHEECCCCEECCCCCCC
>Mature Secondary Structure
MNQKDRMLAGLPYKACLDGLPEERMANKKKIYEYNHCFPDEHEKIHKLIRDILGKAGADV
CCCCCCEEECCCHHHHHCCCCHHHHCCHHHEEECCCCCCCHHHHHHHHHHHHHCCCCCCE
HIEAPFYCDYGKNIQVGDNFFANYNCTILDVGKVIIGNNVQFAPNVSLYTAGHPIHPDSR
EEECCEEECCCCEEEECCCEEECCCEEEEECCEEEECCCEEECCCEEEEECCCCCCCCCC
NSGYEYGIGITIGDNVWLGGNVVVNPGVHIGNNVVIGSGSVVTKDIPDNVIAIGNPCKVI
CCCEEEEEEEEECCCEEECCEEEECCCEEECCEEEEECCCEEEECCCCCEEEECCHHHHH
REITEEDRKYYYKNYEFDVDDYKE
HHHHHHHHHEECCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3922433; 3901000; 9278503; 6444453; 11937062 [H]