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The map label for this gene is pyrC

Identifier: 170755484

GI number: 170755484

Start: 3517627

End: 3518817

Strand: Reverse

Name: pyrC

Synonym: CLD_1292

Alternate gene names: 170755484

Gene position: 3518817-3517627 (Counterclockwise)

Preceding gene: 170757312

Following gene: 170757462

Centisome position: 88.9

GC content: 29.81

Gene sequence:

>1191_bases
ATGAATGAATTACTAATTAAAAATATTAATATAATAGATTGGTGTCAAAACTTCCATGGAGATGTTTATATAAAAAACGG
AATTATAGAAGAATTAGGAAAAGATTTAAATAAAAATTGTGAAATATTTGATGGAAGAGGATTAACTCTTCTTCCATCTT
TCATAGATATGCATGCCCACTTTAGAGATCCAGGTTTTACATATAAAGAAGATATATTAACAGGGAGCAGAGCTGCAGTA
AAGGGTGGGTATACTATGGTAAATTTAATGGCCAATACTAAACCTATATGTAGCTCTAATAAAGAAGTAGAGTATGTTTT
AGAAAAAGGAAAAGAGATAGGATTAGTAGATATCCACCAATGTATGTCCATTACAAAAGATTTTTCTGGAGATGATATAA
GCCATCTAGATTCTATAGATAAGAAAGTAAAAATAATATCAGAAGATGGAAAAGATGTAATGAATACAAGGGTATTAATA
GAGGCTATGTTTAAAGCTAAAGAAAAAGATCTTATAGTAATGTGCCACTCAGAAGAGCATGATGTAACAAATTTGGATAC
TAGGCTTTCAGAAAATTTAATGACTTGGAGAAACATAGCACTTTCAGAATTTACAGCCTGTAAGGTTCATATAGCGCATG
TAAGCACTAAAGAATCTATGGAATATATAAAGGATGCGAAAAAGAAAGGTTTAAAAGTAACTTGTGAAGTAGCGCCACAT
CATATAGCACTTACAAATAAAATTTTTTATAGAGTAAATCCACCTTTAAGAGAAGAAGAAGATATAAAGGTATTAATAGA
GGCAATAAAGGAAGATTTAGTAGATTGTATAGGGACGGATCATGCACCTCATAGTAAAGAAGATAAGCTAAAGGGGAGTC
CGGGAATATCAGGAATAGAAACCTCTTTTTCTACATGTTATACAAAGTTAGTTCATAATAATCATATTAGCTTAAGAAAA
CTTTCAAAAATAATGTCTAAAAATCCAGCAGATATTTTAGGTGTAAACAAGGGAGAAATAAAAATAGGAAGAGAAGCAGA
TTTAGTTTTAGTAGATACAAAAGAAGAATATAAAGTAAAATCTGAAGAGTTTCATTCAAAAGGTAAAAATACTCCTATGG
ATGGTATGTGTCTTAAAGGAAGAGTTAAAGTTACATTTAAAGCAGGATGTATAGTATATAGTGAATTTTAA

Upstream 100 bases:

>100_bases
AGTAGATGAAGAAAATGGTGAATATAGATGTAAATATTGTGATGAAATATATTCAGGGGGAGATATAAATAAATTATAAA
ATTTATGGAGGTGTGCACAA

Downstream 100 bases:

>100_bases
TAGAAAAAGAAAGGATGAATAAATTGATTATAGATAAATTGTATGAAAACGTAGAGAAAAAAGGATGTGTTTGTGTAGGC
CTTGATACGGATATAAGTTA

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MNELLIKNINIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAHFRDPGFTYKEDILTGSRAAV
KGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQCMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLI
EAMFKAKEKDLIVMCHSEEHDVTNLDTRLSENLMTWRNIALSEFTACKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIETSFSTCYTKLVHNNHISLRK
LSKIMSKNPADILGVNKGEIKIGREADLVLVDTKEEYKVKSEEFHSKGKNTPMDGMCLKGRVKVTFKAGCIVYSEF

Sequences:

>Translated_396_residues
MNELLIKNINIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAHFRDPGFTYKEDILTGSRAAV
KGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQCMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLI
EAMFKAKEKDLIVMCHSEEHDVTNLDTRLSENLMTWRNIALSEFTACKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIETSFSTCYTKLVHNNHISLRK
LSKIMSKNPADILGVNKGEIKIGREADLVLVDTKEEYKVKSEEFHSKGKNTPMDGMCLKGRVKVTFKAGCIVYSEF
>Mature_396_residues
MNELLIKNINIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAHFRDPGFTYKEDILTGSRAAV
KGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQCMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLI
EAMFKAKEKDLIVMCHSEEHDVTNLDTRLSENLMTWRNIALSEFTACKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIETSFSTCYTKLVHNNHISLRK
LSKIMSKNPADILGVNKGEIKIGREADLVLVDTKEEYKVKSEEFHSKGKNTPMDGMCLKGRVKVTFKAGCIVYSEF

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=387, Percent_Identity=28.1653746770026, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI4503379, Length=448, Percent_Identity=23.6607142857143, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI4503051, Length=450, Percent_Identity=23.3333333333333, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI62422571, Length=450, Percent_Identity=23.3333333333333, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4503375, Length=453, Percent_Identity=23.1788079470199, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI19923821, Length=451, Percent_Identity=24.1685144124169, Blast_Score=91, Evalue=3e-18,
Organism=Escherichia coli, GI1786722, Length=432, Percent_Identity=27.5462962962963, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI87082175, Length=447, Percent_Identity=21.7002237136465, Blast_Score=107, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193204318, Length=365, Percent_Identity=27.1232876712329, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI71989490, Length=442, Percent_Identity=23.9819004524887, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6322218, Length=391, Percent_Identity=24.5524296675192, Blast_Score=109, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24642586, Length=348, Percent_Identity=30.7471264367816, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI18859883, Length=211, Percent_Identity=26.5402843601896, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 44607; Mature: 44607

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNELLIKNINIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAH
CCCCEEECCCHHHHHHCCCCCEEEECCHHHHHHHHHCCCCEEECCCCCEECHHHHHHHHH
FRDPGFTYKEDILTGSRAAVKGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQ
CCCCCCCCHHHHCCCCCHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCEEEHHH
CMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLIEAMFKAKEKDLIVMCHSEEH
HHHHHCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DVTNLDTRLSENLMTWRNIALSEFTACKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
CCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCC
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIE
EEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
TSFSTCYTKLVHNNHISLRKLSKIMSKNPADILGVNKGEIKIGREADLVLVDTKEEYKVK
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCEEEEECHHHHHCC
SEEFHSKGKNTPMDGMCLKGRVKVTFKAGCIVYSEF
HHHHHHCCCCCCCCCEEECCEEEEEEEECEEEEECC
>Mature Secondary Structure
MNELLIKNINIIDWCQNFHGDVYIKNGIIEELGKDLNKNCEIFDGRGLTLLPSFIDMHAH
CCCCEEECCCHHHHHHCCCCCEEEECCHHHHHHHHHCCCCEEECCCCCEECHHHHHHHHH
FRDPGFTYKEDILTGSRAAVKGGYTMVNLMANTKPICSSNKEVEYVLEKGKEIGLVDIHQ
CCCCCCCCHHHHCCCCCHHCCCCCEEEEEEECCCCCCCCCCHHHHHHHCCCCCCEEEHHH
CMSITKDFSGDDISHLDSIDKKVKIISEDGKDVMNTRVLIEAMFKAKEKDLIVMCHSEEH
HHHHHCCCCCCCHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
DVTNLDTRLSENLMTWRNIALSEFTACKVHIAHVSTKESMEYIKDAKKKGLKVTCEVAPH
CCCHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHCCCEEEEEECCC
HIALTNKIFYRVNPPLREEEDIKVLIEAIKEDLVDCIGTDHAPHSKEDKLKGSPGISGIE
EEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHH
TSFSTCYTKLVHNNHISLRKLSKIMSKNPADILGVNKGEIKIGREADLVLVDTKEEYKVK
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEECCCCCEEECCCCCEEEEECHHHHHCC
SEEFHSKGKNTPMDGMCLKGRVKVTFKAGCIVYSEF
HHHHHHCCCCCCCCCEEECCEEEEEEEECEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA