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The map label for this gene is mutS2 [H]

Identifier: 170755268

GI number: 170755268

Start: 753423

End: 755318

Strand: Direct

Name: mutS2 [H]

Synonym: CLD_0127

Alternate gene names: 170755268

Gene position: 753423-755318 (Clockwise)

Preceding gene: 170756867

Following gene: 170755579

Centisome position: 19.03

GC content: 27.95

Gene sequence:

>1896_bases
ATGAATAAAGCAGCATTAGAAAAATTACATTATTATGAATTAAAAGAAACGATAAAAGAATATTGCGTCAGCGGATTAGG
AAAAAGATTAATAGATAAATTAGAACCTAGTAGTAATATAAAGATTGTAAATCAAAGACTAGATGAAACATCTGAGGGAA
GAAGATTATTAGATGTCTCTTATAATATACCATTAGAGGGTATTTTTAATATATTACCCCTTATTGAAAAAATTGAAAAA
GGAGCATCTTTAGAACCGACTGATTTGACTATGATGTCAAATTTTTTAAGAGGATGTAGGAAAGTTAAGTTATTCATAAA
AGACAAAGAGGGATATGCCCCTACATTGAGCGCTTATGGAGAGAATATTTGTGATTTGAGTTATATTGAAGAGGAAATAA
ATAGATCAATTAGAGGTAGTGTAGTTGACTCAAATGCTAGTAAGGAACTTAAAAAAATAAGAAGAAATATTGACATATGT
GAAAGTAGGATAAAGGAAAAATTAGATAAGTTCCTTAGAAATAGTGCAAATAAAGAGTATATTCAAGAATTCTTTATTAG
TCAGCGTGATGGAAAACATACGATTGCAATTAAGGCAGCACATAAAAATAAAGTTCAAGGAACTATCGTTGAAACGTCTT
CAAAGGGAACAACAGTGTTTATGGAGCCAAATGTTATTTCAAAGCATACAAGTGAATTAGCAGTATTAAAAGCAGAAGAA
AGTGTGGAAGAATACAAAATCCTAGCTACTTTAACAGAGATGCTTTTTGAAAGAATAAAAGATTTGAAGATGAATGTTGA
TGTTATATCTGAATATGATATGATTTGGGCAAAAGCTAAATATAGTAAAGTGATAAATGGAATTAAGCCTAAACTAAATG
ACTATGGATATATAAAAATAATTAAAGGGAAATATCCTCTTATTAAAGATAGTATACCTTTAGACTTTGAAATTGGAAAA
GATTATAGAGGATTAATAATAACAGGACCAAACGCAGGTGGTAAAACAATAGTATTAAAGACAATTGGGTTATTAACATT
AGCAATACAATCTGGATTCCATATAGAAGCTGAGGAAGGAACAGAATTTTCAGTATTTAAAAAGTTATTTGTTGATATTG
GAGATAATCAAAGTGTTGAAAATGCATTAAGTACATTTTCATCTCATGTAAAAAATCTAGCTGAAATAATTAGAGAAAGT
ACAAAATCAACATTACTATTGTTTGATGAAATCGGTAGTGGAACAGAACCAAATGAGGGATCCGCTTTGGCTATTGCAAT
ATTAGAAGAATTGTATCACAAGGGCTCTATAACTATATCAACTACTCATTATGGAGAAATAAAAAACTTTTCAAAAGAAC
ATCCTGATTTTGAAAATGCAGCTATGGAATTTGAGAAAGAAACTTTAGAACCATTATATAAGCTTAGCATAGGAAAAGTA
GGAGATAGTAATGCTTTATATATTTCTAAAAAGATGGGATTATATGATTCAATTATTGATAGAGCAAGAAAGTATATGGA
TACAAAAAGTTATAATTATAACTTAATAGAAGACAGCAAGATTATAAAAAATAAAGAGTTACAAGCAGAGGAAGATTTTT
ATGAATACTCTGTAGGGGATAAAGTTATTCTTTTAGAAAATAATGAATCAGCTATTGTATATAAAGAAAGAGATAGATTA
AATAATGTGACTATACTATATAATAAAGAATTTATTGACGTTAACTATAAAAGAATAAAACTAGAATTAAAGGCAAGTGA
ACTTTATCCAGAGGGGTATGACCTAAATCAGTTATTTATAAGTTATAAGGAAAGAAAGTTAGAAAAAGATATTAAGAGGG
GATCTAAAAAAGCATTAAAAAGAATAAAAAAAGAAACTTTAAAACGTTCTAAATAA

Upstream 100 bases:

>100_bases
GTGGGAGTATCCATAGCTTTTTTTATTATATAAAAATAGAAATCTATCAGGATTTCGTAGACTTGTATTGTAATAAAAAA
TACAAGGAGAGACCATTGAG

Downstream 100 bases:

>100_bases
TATTTATTAAACCTGTAGGCAATTTAATTAAAGATATAAATGGCAATATTAGTAGTTATGTCATTGGCAGATTTATTGGT
ATCTTTGCATCTTATACGGC

Product: MutS domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVSYNIPLEGIFNILPLIEKIEK
GASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYGENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDIC
ESRIKEKLDKFLRNSANKEYIQEFFISQRDGKHTIAIKAAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKIIKGKYPLIKDSIPLDFEIGK
DYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEGTEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRES
TKSTLLLFDEIGSGTEPNEGSALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGDKVILLENNESAIVYKERDRL
NNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFISYKERKLEKDIKRGSKKALKRIKKETLKRSK

Sequences:

>Translated_631_residues
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVSYNIPLEGIFNILPLIEKIEK
GASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYGENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDIC
ESRIKEKLDKFLRNSANKEYIQEFFISQRDGKHTIAIKAAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKIIKGKYPLIKDSIPLDFEIGK
DYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEGTEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRES
TKSTLLLFDEIGSGTEPNEGSALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGDKVILLENNESAIVYKERDRL
NNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFISYKERKLEKDIKRGSKKALKRIKKETLKRSK
>Mature_631_residues
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVSYNIPLEGIFNILPLIEKIEK
GASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYGENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDIC
ESRIKEKLDKFLRNSANKEYIQEFFISQRDGKHTIAIKAAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKIIKGKYPLIKDSIPLDFEIGK
DYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEGTEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRES
TKSTLLLFDEIGSGTEPNEGSALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGDKVILLENNESAIVYKERDRL
NNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFISYKERKLEKDIKRGSKKALKRIKKETLKRSK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=319, Percent_Identity=28.2131661442006, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI36949366, Length=266, Percent_Identity=28.9473684210526, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI26638666, Length=324, Percent_Identity=27.1604938271605, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI4505253, Length=324, Percent_Identity=27.1604938271605, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI26638664, Length=325, Percent_Identity=27.0769230769231, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI4557761, Length=294, Percent_Identity=26.8707482993197, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI4504191, Length=276, Percent_Identity=25.3623188405797, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI262231786, Length=245, Percent_Identity=28.9795918367347, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI1789089, Length=264, Percent_Identity=26.1363636363636, Blast_Score=104, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17534743, Length=307, Percent_Identity=25.4071661237785, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17508445, Length=336, Percent_Identity=25.5952380952381, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI17508447, Length=220, Percent_Identity=28.6363636363636, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17539736, Length=254, Percent_Identity=24.8031496062992, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=552, Percent_Identity=23.9130434782609, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6319935, Length=382, Percent_Identity=26.9633507853403, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6320302, Length=284, Percent_Identity=25.7042253521127, Blast_Score=94, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321912, Length=248, Percent_Identity=23.3870967741935, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321109, Length=241, Percent_Identity=26.9709543568465, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664545, Length=299, Percent_Identity=27.0903010033445, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24584320, Length=204, Percent_Identity=25.9803921568627, Blast_Score=77, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF05192 MutS_III; PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 72116; Mature: 72116

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCEEEEEE
YNIPLEGIFNILPLIEKIEKGASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYG
ECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCC
ENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDICESRIKEKLDKFLRNSANKEY
CCCCHHHHHHHHHCHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IQEFFISQRDGKHTIAIKAAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
HHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEECCCHHHHCCCCEEEEECHH
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
IKGKYPLIKDSIPLDFEIGKDYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEG
EECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHCCCEEECCCC
TEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRESTKSTLLLFDEIGSGTEPNEG
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
SALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
CCHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGD
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCCCHHHHHHCCCCC
KVILLENNESAIVYKERDRLNNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFI
EEEEEECCCCEEEEECCCCCCCEEEEEECEEEECCEEEEEEEEEHHHCCCCCCCHHHHHH
SYKERKLEKDIKRGSKKALKRIKKETLKRSK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKAALEKLHYYELKETIKEYCVSGLGKRLIDKLEPSSNIKIVNQRLDETSEGRRLLDVS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCEEEEEE
YNIPLEGIFNILPLIEKIEKGASLEPTDLTMMSNFLRGCRKVKLFIKDKEGYAPTLSAYG
ECCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEEECCCCCCCCHHHCC
ENICDLSYIEEEINRSIRGSVVDSNASKELKKIRRNIDICESRIKEKLDKFLRNSANKEY
CCCCHHHHHHHHHCHHHCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IQEFFISQRDGKHTIAIKAAHKNKVQGTIVETSSKGTTVFMEPNVISKHTSELAVLKAEE
HHHHHHCCCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEECCCHHHHCCCCEEEEECHH
SVEEYKILATLTEMLFERIKDLKMNVDVISEYDMIWAKAKYSKVINGIKPKLNDYGYIKI
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEE
IKGKYPLIKDSIPLDFEIGKDYRGLIITGPNAGGKTIVLKTIGLLTLAIQSGFHIEAEEG
EECCCCCCCCCCCCEEEECCCCCEEEEECCCCCCCEEEEHHHHHHHHHHHCCCEEECCCC
TEFSVFKKLFVDIGDNQSVENALSTFSSHVKNLAEIIRESTKSTLLLFDEIGSGTEPNEG
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCC
SALAIAILEELYHKGSITISTTHYGEIKNFSKEHPDFENAAMEFEKETLEPLYKLSIGKV
CCHHHHHHHHHHHCCCEEEEEECCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
GDSNALYISKKMGLYDSIIDRARKYMDTKSYNYNLIEDSKIIKNKELQAEEDFYEYSVGD
CCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCEEECCCHHHCCCCCCCHHHHHHCCCCC
KVILLENNESAIVYKERDRLNNVTILYNKEFIDVNYKRIKLELKASELYPEGYDLNQLFI
EEEEEECCCCEEEEECCCCCCCEEEEEECEEEECCEEEEEEEEEHHHCCCCCCCHHHHHH
SYKERKLEKDIKRGSKKALKRIKKETLKRSK
HHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA