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The map label for this gene is yeaE [H]

Identifier: 170751660

GI number: 170751660

Start: 5606152

End: 5606991

Strand: Reverse

Name: yeaE [H]

Synonym: Mrad2831_5289

Alternate gene names: 170751660

Gene position: 5606991-5606152 (Counterclockwise)

Preceding gene: 170751661

Following gene: 170751659

Centisome position: 92.25

GC content: 67.86

Gene sequence:

>840_bases
ATGGAGCAGCGCCCGTTTGGTCCCGTGCCGCGCGATGTTGCGGTGATCGGCCAGGGAACCTGGTACATCGACGACGCGCA
CCGGCCCACCGCGGTCGCCGCCCTGCGCCGCGGCCTCGACCTCGGCATGACGCACATCGATACCGCCGAGATGTACGGCG
ACGCCGAGACCGTGGTCGGCGAGGCGATCACCGGTCGGCGCGACGACGTGTTCCTCGTCTCCAAGGTCCTCCCCAGCAAC
GCCTCGCTTGCCGGGACAGTGGCAGCCTGCGAGCGCTCGCTGGCGCGCCTGCGCACCGACAGGCTGGATTGTTACCTATT
GCATTGGCTTGGCTCGCATCCCCTTGAGGATACTTTCGCCGGCTTCGAGCGGCTCCGCGAACAGGGCAAGATCCTGTCCT
GGGGGGTAAGCAACTTCGATGTGTCCAACCTCGAAGCCGCCTGGAAGGCCGGGGGCGAGGGGCGCATCGCCTGCAACCAG
GTTCTCTACCACTTGGAGGAGTGTGCAATCGAGCACGCCGTCCAGCCCTGGTGCGAGGATCACGGCATCGCCGTCGTCGC
CTACAGCCCGTTCGGCCATGGCAGCTTCCCTGGCCCACGAACACCGGGCGGCCGCGTCCTGGATGAGATCGCGGCGAACC
ACGGCGCCACCGCCCGTCATGTCGCGCTCCGGTTCCTCACGCGGAGGCCGTCCACCTTCACGATCCCCAAGGCGTCCAGT
CCCGAGCATACCGCCGACAACGCCAGCGCTGGCCCGCTGCGGCTGACGGAAGACGAGTTCATGCGGATCGACGCAGCGTT
TCCGCGGGGTCCCGGACCGCGCCACCTCCCTATGTTGTAG

Upstream 100 bases:

>100_bases
ACCGCGCGGCTACGACATGTTCGATCACAAGACGGACGGCTGCGTGCGCGCGGTGTTCGCGCCTTAGGCGCACGTGCCGT
CCACGGATGGAGGGAAATGC

Downstream 100 bases:

>100_bases
GCCCGTGATGCCCACTTGATCAGGGCAGATGACCGTCCCGCTGTCTCGAAGCCCCGCCCGGCAGCGGACGATCCCGCCGC
TAGGCGGGGATTCGCGGATC

Product: aldo/keto reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MEQRPFGPVPRDVAVIGQGTWYIDDAHRPTAVAALRRGLDLGMTHIDTAEMYGDAETVVGEAITGRRDDVFLVSKVLPSN
ASLAGTVAACERSLARLRTDRLDCYLLHWLGSHPLEDTFAGFERLREQGKILSWGVSNFDVSNLEAAWKAGGEGRIACNQ
VLYHLEECAIEHAVQPWCEDHGIAVVAYSPFGHGSFPGPRTPGGRVLDEIAANHGATARHVALRFLTRRPSTFTIPKASS
PEHTADNASAGPLRLTEDEFMRIDAAFPRGPGPRHLPML

Sequences:

>Translated_279_residues
MEQRPFGPVPRDVAVIGQGTWYIDDAHRPTAVAALRRGLDLGMTHIDTAEMYGDAETVVGEAITGRRDDVFLVSKVLPSN
ASLAGTVAACERSLARLRTDRLDCYLLHWLGSHPLEDTFAGFERLREQGKILSWGVSNFDVSNLEAAWKAGGEGRIACNQ
VLYHLEECAIEHAVQPWCEDHGIAVVAYSPFGHGSFPGPRTPGGRVLDEIAANHGATARHVALRFLTRRPSTFTIPKASS
PEHTADNASAGPLRLTEDEFMRIDAAFPRGPGPRHLPML
>Mature_279_residues
MEQRPFGPVPRDVAVIGQGTWYIDDAHRPTAVAALRRGLDLGMTHIDTAEMYGDAETVVGEAITGRRDDVFLVSKVLPSN
ASLAGTVAACERSLARLRTDRLDCYLLHWLGSHPLEDTFAGFERLREQGKILSWGVSNFDVSNLEAAWKAGGEGRIACNQ
VLYHLEECAIEHAVQPWCEDHGIAVVAYSPFGHGSFPGPRTPGGRVLDEIAANHGATARHVALRFLTRRPSTFTIPKASS
PEHTADNASAGPLRLTEDEFMRIDAAFPRGPGPRHLPML

Specific function: Unknown

COG id: COG0656

COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI223468663, Length=282, Percent_Identity=29.7872340425532, Blast_Score=104, Evalue=7e-23,
Organism=Homo sapiens, GI291291012, Length=263, Percent_Identity=30.4182509505703, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI310109922, Length=267, Percent_Identity=29.5880149812734, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI4502049, Length=282, Percent_Identity=29.0780141843972, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI5174695, Length=293, Percent_Identity=28.6689419795222, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI5453543, Length=284, Percent_Identity=28.169014084507, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI45446745, Length=284, Percent_Identity=28.169014084507, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4503285, Length=284, Percent_Identity=28.169014084507, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310109920, Length=284, Percent_Identity=28.169014084507, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI24497585, Length=287, Percent_Identity=26.8292682926829, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI24497577, Length=289, Percent_Identity=25.9515570934256, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI5174391, Length=289, Percent_Identity=25.9515570934256, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788081, Length=268, Percent_Identity=45.5223880597015, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1786400, Length=255, Percent_Identity=28.2352941176471, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI87082198, Length=267, Percent_Identity=26.9662921348315, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788070, Length=314, Percent_Identity=25.1592356687898, Blast_Score=84, Evalue=7e-18,
Organism=Escherichia coli, GI1787674, Length=278, Percent_Identity=29.136690647482, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081735, Length=214, Percent_Identity=29.4392523364486, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17564128, Length=292, Percent_Identity=29.4520547945205, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17552492, Length=283, Percent_Identity=27.5618374558304, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17537077, Length=289, Percent_Identity=28.0276816608997, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17537075, Length=304, Percent_Identity=28.2894736842105, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561300, Length=285, Percent_Identity=26.6666666666667, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17561298, Length=276, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538386, Length=274, Percent_Identity=25.9124087591241, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17566692, Length=283, Percent_Identity=25.7950530035336, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17550248, Length=284, Percent_Identity=24.6478873239437, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320079, Length=269, Percent_Identity=27.1375464684015, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI45553081, Length=282, Percent_Identity=26.9503546099291, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24644950, Length=291, Percent_Identity=28.5223367697594, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24663317, Length=288, Percent_Identity=26.7361111111111, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281366140, Length=253, Percent_Identity=27.6679841897233, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24662789, Length=278, Percent_Identity=28.0575539568345, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24657054, Length=265, Percent_Identity=26.0377358490566, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20129731, Length=283, Percent_Identity=28.2685512367491, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001395
- InterPro:   IPR020471
- InterPro:   IPR023210 [H]

Pfam domain/function: PF00248 Aldo_ket_red [H]

EC number: NA

Molecular weight: Translated: 30438; Mature: 30438

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQRPFGPVPRDVAVIGQGTWYIDDAHRPTAVAALRRGLDLGMTHIDTAEMYGDAETVVG
CCCCCCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHCHHCCCHHCCHHHHHCCHHHHHH
EAITGRRDDVFLVSKVLPSNASLAGTVAACERSLARLRTDRLDCYLLHWLGSHPLEDTFA
HHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCHHHHHH
GFERLREQGKILSWGVSNFDVSNLEAAWKAGGEGRIACNQVLYHLEECAIEHAVQPWCED
HHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
HGIAVVAYSPFGHGSFPGPRTPGGRVLDEIAANHGATARHVALRFLTRRPSTFTIPKASS
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCC
PEHTADNASAGPLRLTEDEFMRIDAAFPRGPGPRHLPML
CCCCCCCCCCCCEEECHHHHEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MEQRPFGPVPRDVAVIGQGTWYIDDAHRPTAVAALRRGLDLGMTHIDTAEMYGDAETVVG
CCCCCCCCCCCCEEEEECCEEEEECCCCHHHHHHHHHCHHCCCHHCCHHHHHCCHHHHHH
EAITGRRDDVFLVSKVLPSNASLAGTVAACERSLARLRTDRLDCYLLHWLGSHPLEDTFA
HHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEHHCCCCHHHHHH
GFERLREQGKILSWGVSNFDVSNLEAAWKAGGEGRIACNQVLYHLEECAIEHAVQPWCED
HHHHHHHCCCEEEECCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
HGIAVVAYSPFGHGSFPGPRTPGGRVLDEIAANHGATARHVALRFLTRRPSTFTIPKASS
CCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEECCCCCC
PEHTADNASAGPLRLTEDEFMRIDAAFPRGPGPRHLPML
CCCCCCCCCCCCEEECHHHHEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]