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The map label for this gene is hflK [H]

Identifier: 170750916

GI number: 170750916

Start: 4804812

End: 4805996

Strand: Direct

Name: hflK [H]

Synonym: Mrad2831_4527

Alternate gene names: 170750916

Gene position: 4804812-4805996 (Clockwise)

Preceding gene: 170750915

Following gene: 170750917

Centisome position: 79.05

GC content: 70.97

Gene sequence:

>1185_bases
ATGCCTTGGAGCAATCAGAGCGGCGGCGGGGGCCCGTGGGGCCGGCCCGGCGGCAACGGCGGCGGTCCCTGGGGCGGTGG
CGGTGGCGGCGGCAAGACGCCGCCGAACCTCGAGGACCTGCTCCGGCGCGGGCAGGACCGCCTGCGCGGCCTGATCCCGG
GCGGCGGCGGCTCGGGCGGCGGCTACGGCGGCGGCGGCTCGACCGGCGTCGGCGGCGGCCGCAGCGCGGCGGTCATCGCC
GTCCTGGCCATCGCCATCTGGCTCGCCACCGGTTTCTACACCGTCTACCCGCGCCAGGTCGGCATCGAGACGATCTTCGG
CCGCTATGTCGGCACCAAGGGCGAGGGCCTGCGCTACAACTTCCCCTATCCGATCGGCGGCGTGGTGAAGCCGGATGTCG
GCTCCCAGAACTCGATCCAGATCGGCTTCCGCGCCGGCCCGAACGGCCAGGGCCGCACCCGCGACGTGCCGGACGAGAGC
CTGATGCTCACCGGTGACGAGAACATCGTCGATCTCGACTTCGAGGTGCAGTGGCGCGTCAACCCGCTGAAGGCTTCCGA
CTTCGTGTTCAACCTCCAGAACCCGGAGGGCACCATCAAGGCGATCTCCGAGAGCGCGATGCGCGAGGTGATCGGCCGCC
GCAACATCCAGGCGATCCTCACCAATGATCAGTCGAGCATCGCCCAGGAGGTGAAGGAGATGGTCCAGAAGGCGCTCGAC
GAGTACGGCGCCGGCGTGCGCATCGAGGTGGTGCAGCTCGTCTCGGTCAACCCGCCGCCGGAGGTGCGCCCCGCCTTCAT
CGACGTGAACGCGGCCCAGCAGGACGCCGACACGGCGCAGAACGAGGCCAAGACCTACGCCAGCCGCGAAGTGCCGCAGG
CCCGCGGTAAGGCGTCCCAGATCGTCCAGCAGGCCGAGGCCTACCGGACGAAGGCGACCGCCGACGCCACCGGTCAGGCC
GCGCGCTTCAGCGAGGTCTATGCCTCCTACAAGGCCGCCCCGGCGATCAGCCGCGAGCGGATCTTCCTGGAGACGATGGA
GAAGGTCCTGGGCTCCGTGAACAAGGTGATCATCGACCAGAACGGGACGCAGCCCGGCGGCGCGACCGCGGCCGGCGTGC
TGCCGGTGCTGCCGCTCTCCGAGTTCGGCGCCCGCGCCCAGACCCAGACGGGAGCCGCCCGATGA

Upstream 100 bases:

>100_bases
TCCGGAGGGTCGGGACTAGGCGGGCGAGCGTGGCCGTTCAGGCAGGGGGCGCCGGCCGGGATATGGGCCGGGCGCGGACA
GGCAGGAGACGACGGCTAGG

Downstream 100 bases:

>100_bases
AGCAGGCTCTCCGCACCGGCCTGATCGTGGTCGCGGCGATCGTCGCGATCGGCCTCTACGCCTCGATCTTCACCGTCGGC
CAGATGCAGCAGGCGCTCGT

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MPWSNQSGGGGPWGRPGGNGGGPWGGGGGGGKTPPNLEDLLRRGQDRLRGLIPGGGGSGGGYGGGGSTGVGGGRSAAVIA
VLAIAIWLATGFYTVYPRQVGIETIFGRYVGTKGEGLRYNFPYPIGGVVKPDVGSQNSIQIGFRAGPNGQGRTRDVPDES
LMLTGDENIVDLDFEVQWRVNPLKASDFVFNLQNPEGTIKAISESAMREVIGRRNIQAILTNDQSSIAQEVKEMVQKALD
EYGAGVRIEVVQLVSVNPPPEVRPAFIDVNAAQQDADTAQNEAKTYASREVPQARGKASQIVQQAEAYRTKATADATGQA
ARFSEVYASYKAAPAISRERIFLETMEKVLGSVNKVIIDQNGTQPGGATAAGVLPVLPLSEFGARAQTQTGAAR

Sequences:

>Translated_394_residues
MPWSNQSGGGGPWGRPGGNGGGPWGGGGGGGKTPPNLEDLLRRGQDRLRGLIPGGGGSGGGYGGGGSTGVGGGRSAAVIA
VLAIAIWLATGFYTVYPRQVGIETIFGRYVGTKGEGLRYNFPYPIGGVVKPDVGSQNSIQIGFRAGPNGQGRTRDVPDES
LMLTGDENIVDLDFEVQWRVNPLKASDFVFNLQNPEGTIKAISESAMREVIGRRNIQAILTNDQSSIAQEVKEMVQKALD
EYGAGVRIEVVQLVSVNPPPEVRPAFIDVNAAQQDADTAQNEAKTYASREVPQARGKASQIVQQAEAYRTKATADATGQA
ARFSEVYASYKAAPAISRERIFLETMEKVLGSVNKVIIDQNGTQPGGATAAGVLPVLPLSEFGARAQTQTGAAR
>Mature_393_residues
PWSNQSGGGGPWGRPGGNGGGPWGGGGGGGKTPPNLEDLLRRGQDRLRGLIPGGGGSGGGYGGGGSTGVGGGRSAAVIAV
LAIAIWLATGFYTVYPRQVGIETIFGRYVGTKGEGLRYNFPYPIGGVVKPDVGSQNSIQIGFRAGPNGQGRTRDVPDESL
MLTGDENIVDLDFEVQWRVNPLKASDFVFNLQNPEGTIKAISESAMREVIGRRNIQAILTNDQSSIAQEVKEMVQKALDE
YGAGVRIEVVQLVSVNPPPEVRPAFIDVNAAQQDADTAQNEAKTYASREVPQARGKASQIVQQAEAYRTKATADATGQAA
RFSEVYASYKAAPAISRERIFLETMEKVLGSVNKVIIDQNGTQPGGATAAGVLPVLPLSEFGARAQTQTGAAR

Specific function: HflC and HflK govern the stability of phage lambda cII protein and have been proposed to encode or regulate a cII- specific protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=390, Percent_Identity=33.5897435897436, Blast_Score=171, Evalue=7e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 41299; Mature: 41168

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWSNQSGGGGPWGRPGGNGGGPWGGGGGGGKTPPNLEDLLRRGQDRLRGLIPGGGGSGG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCEECCCCCCCCC
GYGGGGSTGVGGGRSAAVIAVLAIAIWLATGFYTVYPRQVGIETIFGRYVGTKGEGLRYN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCCCEEEE
FPYPIGGVVKPDVGSQNSIQIGFRAGPNGQGRTRDVPDESLMLTGDENIVDLDFEVQWRV
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEEEEEEEEE
NPLKASDFVFNLQNPEGTIKAISESAMREVIGRRNIQAILTNDQSSIAQEVKEMVQKALD
CCEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHH
EYGAGVRIEVVQLVSVNPPPEVRPAFIDVNAAQQDADTAQNEAKTYASREVPQARGKASQ
HHCCCCEEEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHCCHHHH
IVQQAEAYRTKATADATGQAARFSEVYASYKAAPAISRERIFLETMEKVLGSVNKVIIDQ
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
NGTQPGGATAAGVLPVLPLSEFGARAQTQTGAAR
CCCCCCCCCHHCHHHCCCHHHHCCCHHCCCCCCC
>Mature Secondary Structure 
PWSNQSGGGGPWGRPGGNGGGPWGGGGGGGKTPPNLEDLLRRGQDRLRGLIPGGGGSGG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCEECCCCCCCCC
GYGGGGSTGVGGGRSAAVIAVLAIAIWLATGFYTVYPRQVGIETIFGRYVGTKGEGLRYN
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCCCCCEEEE
FPYPIGGVVKPDVGSQNSIQIGFRAGPNGQGRTRDVPDESLMLTGDENIVDLDFEVQWRV
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCCEEEEEEEEEEEE
NPLKASDFVFNLQNPEGTIKAISESAMREVIGRRNIQAILTNDQSSIAQEVKEMVQKALD
CCEECCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHH
EYGAGVRIEVVQLVSVNPPPEVRPAFIDVNAAQQDADTAQNEAKTYASREVPQARGKASQ
HHCCCCEEEEEEEEECCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCHHCCHHHH
IVQQAEAYRTKATADATGQAARFSEVYASYKAAPAISRERIFLETMEKVLGSVNKVIIDQ
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEEEEC
NGTQPGGATAAGVLPVLPLSEFGARAQTQTGAAR
CCCCCCCCCHHCHHHCCCHHHHCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]