Click here to switch to the map view.

The map label for this gene is hflC [H]

Identifier: 170750917

GI number: 170750917

Start: 4805993

End: 4806970

Strand: Direct

Name: hflC [H]

Synonym: Mrad2831_4528

Alternate gene names: 170750917

Gene position: 4805993-4806970 (Clockwise)

Preceding gene: 170750916

Following gene: 170750918

Centisome position: 79.07

GC content: 69.02

Gene sequence:

>978_bases
ATGAAGCAGGCTCTCCGCACCGGCCTGATCGTGGTCGCGGCGATCGTCGCGATCGGCCTCTACGCCTCGATCTTCACCGT
CGGCCAGATGCAGCAGGCGCTCGTCCTGCAGTTCGGCCGCGTCCGCGCCGTCCTCAACGCCACCGGCGAGGACAAGCCCG
GCCTCTACTTCAAGATCCCGTTCATGGAGAACGTGGTCATCTTCGACAAGCGCGTCCTCGACCTCGACCTGCCGGTGCAG
ACGGTGCTCACCGCCGACCGCCAGAACCTGGAGGTGGACGCCTTCGCCCGCTACCGGATCGTCGATCCGCTGCGCTTCTA
CCAGGCGGTGGGCAATATCGCGCTGGCCAACCAGCGGCTCGCGAGCTTCACCAATTCCGGCCTGCGCAACGTGCTCGCCC
GCTCGACCCGCGACGCGATCGTGAAGACCGATCGCGGGCAGCTGATGCACCAGATCCAGGAGGACGTGAACCGGCAGGCC
AAGGCGCTCGGCATCGAGATCGTCGACCTGCGCATGACCCGCGTCGACCTGCCCGCGCAGAACTCGGCCGCCGTCTACCG
GCGGATGAAGACCGAGCGCGAGCGCGAGGCCGCCGACATCCGCGCCAACGGCGACCAGATCGCCGCCACGATCCGCGCCA
AGGCCGACCGCGAGGTCACGGTGATCCTCGCCGAGGCGACGCAGAAGTCCGAGCAGCTGCGCGGACAGGGTGACGCGGAC
AAGAACCGCATCCTCGCCGACGCGTTCGGCAAGGACGCGGACTTCTTCAGCTTCTACCGCTCGATGCAGGCCTACGAGAG
CGGGCTGAAGGGATCCGACACCCGCCTGGTGATCAGCCCGAACACGGACTTCTTCCGCTTCTTCAGCGATCCGCAGGGCC
GGGCACCCGCCCCGGCAGCCCGCGGACCGCGCGGACCGGCCGATCCGAGCGCCACCACCGGGTCGACGACCGGCTCCACG
GCCGGGACGGCGCGCTGA

Upstream 100 bases:

>100_bases
ACGGGACGCAGCCCGGCGGCGCGACCGCGGCCGGCGTGCTGCCGGTGCTGCCGCTCTCCGAGTTCGGCGCCCGCGCCCAG
ACCCAGACGGGAGCCGCCCG

Downstream 100 bases:

>100_bases
GGGAGCCCGTTGGCGCCCCGGCGCCCGGGGATTACCGTGCAGGACAACCCGCGGGCGATCGACCGTCGGTCGAGGCCCGC
GGGACCGGAAACGCGTTCTT

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKQALRTGLIVVAAIVAIGLYASIFTVGQMQQALVLQFGRVRAVLNATGEDKPGLYFKIPFMENVVIFDKRVLDLDLPVQ
TVLTADRQNLEVDAFARYRIVDPLRFYQAVGNIALANQRLASFTNSGLRNVLARSTRDAIVKTDRGQLMHQIQEDVNRQA
KALGIEIVDLRMTRVDLPAQNSAAVYRRMKTEREREAADIRANGDQIAATIRAKADREVTVILAEATQKSEQLRGQGDAD
KNRILADAFGKDADFFSFYRSMQAYESGLKGSDTRLVISPNTDFFRFFSDPQGRAPAPAARGPRGPADPSATTGSTTGST
AGTAR

Sequences:

>Translated_325_residues
MKQALRTGLIVVAAIVAIGLYASIFTVGQMQQALVLQFGRVRAVLNATGEDKPGLYFKIPFMENVVIFDKRVLDLDLPVQ
TVLTADRQNLEVDAFARYRIVDPLRFYQAVGNIALANQRLASFTNSGLRNVLARSTRDAIVKTDRGQLMHQIQEDVNRQA
KALGIEIVDLRMTRVDLPAQNSAAVYRRMKTEREREAADIRANGDQIAATIRAKADREVTVILAEATQKSEQLRGQGDAD
KNRILADAFGKDADFFSFYRSMQAYESGLKGSDTRLVISPNTDFFRFFSDPQGRAPAPAARGPRGPADPSATTGSTTGST
AGTAR
>Mature_325_residues
MKQALRTGLIVVAAIVAIGLYASIFTVGQMQQALVLQFGRVRAVLNATGEDKPGLYFKIPFMENVVIFDKRVLDLDLPVQ
TVLTADRQNLEVDAFARYRIVDPLRFYQAVGNIALANQRLASFTNSGLRNVLARSTRDAIVKTDRGQLMHQIQEDVNRQA
KALGIEIVDLRMTRVDLPAQNSAAVYRRMKTEREREAADIRANGDQIAATIRAKADREVTVILAEATQKSEQLRGQGDAD
KNRILADAFGKDADFFSFYRSMQAYESGLKGSDTRLVISPNTDFFRFFSDPQGRAPAPAARGPRGPADPSATTGSTTGST
AGTAR

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI38016911, Length=209, Percent_Identity=26.7942583732057, Blast_Score=75, Evalue=6e-14,
Organism=Escherichia coli, GI1790617, Length=313, Percent_Identity=34.185303514377, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1786697, Length=286, Percent_Identity=23.0769230769231, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17569493, Length=188, Percent_Identity=27.1276595744681, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI193209764, Length=188, Percent_Identity=27.1276595744681, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17569497, Length=218, Percent_Identity=27.5229357798165, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI32566490, Length=218, Percent_Identity=26.1467889908257, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25153583, Length=211, Percent_Identity=27.4881516587678, Blast_Score=68, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI71987621, Length=242, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71987612, Length=209, Percent_Identity=27.7511961722488, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45556022, Length=171, Percent_Identity=26.9005847953216, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI18860517, Length=263, Percent_Identity=23.9543726235741, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356845, Length=233, Percent_Identity=24.4635193133047, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 35686; Mature: 35686

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: PS00104 EPSP_SYNTHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQALRTGLIVVAAIVAIGLYASIFTVGQMQQALVLQFGRVRAVLNATGEDKPGLYFKIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
FMENVVIFDKRVLDLDLPVQTVLTADRQNLEVDAFARYRIVDPLRFYQAVGNIALANQRL
CCCCEEEECCEEEECCCCHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHH
ASFTNSGLRNVLARSTRDAIVKTDRGQLMHQIQEDVNRQAKALGIEIVDLRMTRVDLPAQ
HHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEECCCCC
NSAAVYRRMKTEREREAADIRANGDQIAATIRAKADREVTVILAEATQKSEQLRGQGDAD
CHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCEEEEEEECHHHHHHHHCCCCCCC
KNRILADAFGKDADFFSFYRSMQAYESGLKGSDTRLVISPNTDFFRFFSDPQGRAPAPAA
HHCEEHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCC
RGPRGPADPSATTGSTTGSTAGTAR
CCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKQALRTGLIVVAAIVAIGLYASIFTVGQMQQALVLQFGRVRAVLNATGEDKPGLYFKIP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
FMENVVIFDKRVLDLDLPVQTVLTADRQNLEVDAFARYRIVDPLRFYQAVGNIALANQRL
CCCCEEEECCEEEECCCCHHHHHHCCCCCCCCHHHHHHHHCCHHHHHHHHCCHHHHHHHH
ASFTNSGLRNVLARSTRDAIVKTDRGQLMHQIQEDVNRQAKALGIEIVDLRMTRVDLPAQ
HHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHCEEEEEEEEEEECCCCC
NSAAVYRRMKTEREREAADIRANGDQIAATIRAKADREVTVILAEATQKSEQLRGQGDAD
CHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCEEEEEEECHHHHHHHHCCCCCCC
KNRILADAFGKDADFFSFYRSMQAYESGLKGSDTRLVISPNTDFFRFFSDPQGRAPAPAA
HHCEEHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCCCCCC
RGPRGPADPSATTGSTTGSTAGTAR
CCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]