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The map label for this gene is fbp

Identifier: 170749958

GI number: 170749958

Start: 3777287

End: 3778342

Strand: Reverse

Name: fbp

Synonym: Mrad2831_3559

Alternate gene names: 170749958

Gene position: 3778342-3777287 (Counterclockwise)

Preceding gene: 170749961

Following gene: 170749957

Centisome position: 62.17

GC content: 71.78

Gene sequence:

>1056_bases
ATGGCAATTTCAGCGGCGATCGGGACCCCCCTCGAGACCTGCCTGGCGCAGGCCGTGGACGCCAATCCGGCGCTGAAGGA
CGCCGCCGCGGTGGTCGCGGCCGTGGGGCGGTCGGCGGTGGAGATCAGCGAGCGCATCGGGCGCGGCGCGCTCGGCGGCG
ACCTCGCGGCGGCCGGCGATCACAACAGCGACGGCGACGTCCAGAAGGCCCTCGACGTCATCGCCCACGAGAGCGTGACC
GCGGCGCTGCGGGGCGCCCCGGTCGCCGAGGTCGCCTCCGAGGAGGCCGAGGAGGTGATGCGCCTGAACCCGGACGCGCC
TCTGGCCGTCGCCATCGACCCGCTCGACGGCTCCTCCAACATCGGCGTGAACATGGCCGTCGGGATGATCTTCGGCATCC
GGCCGTCGATCAAGGATCCCGCGAACCCGCTGGCCTCGTTCACGACCCCCGGCTCGACGCAGATCGCCGCGGGCTTCGTC
ACCTACGGCCCGGCCACCGCGCTGATCCTGACGCTCGGCGAGGGCACCCAGTCCTACGTGCTCGACCGTACCGAGGGCCG
GTTCAAGCTGACGAGCCCGGCCATGTCGGTGCCGCCCTCCACCAAGGAGTTCGCCATCAACGCCTCGAACGCCCGGCACT
GGGACGCCCCGGTGAAGGCCTATATCGAGGATTGCCAGCGCGGCACCGAGGGGCCGCGCGACAAGGACTACAACATGCGC
TGGCTCGCCTCCCTGGTGGCCGACATCCAGCGCGTTCTGACCCGCGGCGGCGTGTTCCTCTATCCGGGCGATGCCCGGAA
GAACTACGCCCGCGGCCGCCTGCGGCTGCTCTACGAGGTCGCCCCCGTGGCGATGCTGGTCGAGCAGGCCGGGGGCGCCG
CCACCGACGGCCAGACCCGCATCCTCGACATCGTGGCCAACGGCATCCACGAGCGGGCGCCGCTGGTCTGCGGCTCCACC
GAGGAGGTGACGTGCGTCGCCACCTACTATGCCGGCGGCAAGCCCGATGCCGGCCGCTCGCCGCTCTTCGGCCAGCGCGG
CCTGATGCGGTCATAA

Upstream 100 bases:

>100_bases
GGCGGCAGAGACCGCTATCCTGGCAGCGAGGCGGCCGCTACAGAGCCGGCGCGGAACGCGCGATCCCGGCGGACGGGATC
CGAGCAGGAGGAGTAGGCCG

Downstream 100 bases:

>100_bases
CCGCACCGTGAAGTCGTAAAGGCATGTCGGCGCGGCACCCCATCATCTCGGTGACCGGCTCCTCCGGGGCCGGGACCACC
TCGGTGCGCAACACCTTCGA

Product: inositol phosphatase/fructose-16-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MAISAAIGTPLETCLAQAVDANPALKDAAAVVAAVGRSAVEISERIGRGALGGDLAAAGDHNSDGDVQKALDVIAHESVT
AALRGAPVAEVASEEAEEVMRLNPDAPLAVAIDPLDGSSNIGVNMAVGMIFGIRPSIKDPANPLASFTTPGSTQIAAGFV
TYGPATALILTLGEGTQSYVLDRTEGRFKLTSPAMSVPPSTKEFAINASNARHWDAPVKAYIEDCQRGTEGPRDKDYNMR
WLASLVADIQRVLTRGGVFLYPGDARKNYARGRLRLLYEVAPVAMLVEQAGGAATDGQTRILDIVANGIHERAPLVCGST
EEVTCVATYYAGGKPDAGRSPLFGQRGLMRS

Sequences:

>Translated_351_residues
MAISAAIGTPLETCLAQAVDANPALKDAAAVVAAVGRSAVEISERIGRGALGGDLAAAGDHNSDGDVQKALDVIAHESVT
AALRGAPVAEVASEEAEEVMRLNPDAPLAVAIDPLDGSSNIGVNMAVGMIFGIRPSIKDPANPLASFTTPGSTQIAAGFV
TYGPATALILTLGEGTQSYVLDRTEGRFKLTSPAMSVPPSTKEFAINASNARHWDAPVKAYIEDCQRGTEGPRDKDYNMR
WLASLVADIQRVLTRGGVFLYPGDARKNYARGRLRLLYEVAPVAMLVEQAGGAATDGQTRILDIVANGIHERAPLVCGST
EEVTCVATYYAGGKPDAGRSPLFGQRGLMRS
>Mature_350_residues
AISAAIGTPLETCLAQAVDANPALKDAAAVVAAVGRSAVEISERIGRGALGGDLAAAGDHNSDGDVQKALDVIAHESVTA
ALRGAPVAEVASEEAEEVMRLNPDAPLAVAIDPLDGSSNIGVNMAVGMIFGIRPSIKDPANPLASFTTPGSTQIAAGFVT
YGPATALILTLGEGTQSYVLDRTEGRFKLTSPAMSVPPSTKEFAINASNARHWDAPVKAYIEDCQRGTEGPRDKDYNMRW
LASLVADIQRVLTRGGVFLYPGDARKNYARGRLRLLYEVAPVAMLVEQAGGAATDGQTRILDIVANGIHERAPLVCGSTE
EVTCVATYYAGGKPDAGRSPLFGQRGLMRS

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family

Homologues:

Organism=Homo sapiens, GI189083692, Length=288, Percent_Identity=36.8055555555556, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI16579888, Length=288, Percent_Identity=36.8055555555556, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI22907028, Length=300, Percent_Identity=34.6666666666667, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1790679, Length=323, Percent_Identity=37.7708978328173, Blast_Score=210, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17508131, Length=277, Percent_Identity=36.4620938628159, Blast_Score=172, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6323409, Length=300, Percent_Identity=35.3333333333333, Blast_Score=188, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19921562, Length=275, Percent_Identity=38.1818181818182, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI45550998, Length=275, Percent_Identity=38.1818181818182, Blast_Score=175, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): F16PA_METRJ (B1LUU9)

Other databases:

- EMBL:   CP001001
- RefSeq:   YP_001756218.1
- ProteinModelPortal:   B1LUU9
- SMR:   B1LUU9
- GeneID:   6139612
- GenomeReviews:   CP001001_GR
- KEGG:   mrd:Mrad2831_3559
- HOGENOM:   HBG731261
- OMA:   YSINEGS
- ProtClustDB:   CLSK2330473
- GO:   GO:0005737
- HAMAP:   MF_01855
- InterPro:   IPR000146
- InterPro:   IPR020548
- PANTHER:   PTHR11556
- PRINTS:   PR00115

Pfam domain/function: PF00316 FBPase

EC number: =3.1.3.11

Molecular weight: Translated: 36615; Mature: 36484

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00124 FBPASE

Important sites: BINDING 207-207

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAISAAIGTPLETCLAQAVDANPALKDAAAVVAAVGRSAVEISERIGRGALGGDLAAAGD
CEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEECCC
HNSDGDVQKALDVIAHESVTAALRGAPVAEVASEEAEEVMRLNPDAPLAVAIDPLDGSSN
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
IGVNMAVGMIFGIRPSIKDPANPLASFTTPGSTQIAAGFVTYGPATALILTLGEGTQSYV
CCHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEECCCEEEEEEECCCCHHEE
LDRTEGRFKLTSPAMSVPPSTKEFAINASNARHWDAPVKAYIEDCQRGTEGPRDKDYNMR
EECCCCCEEECCCCCCCCCCCHHEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHH
WLASLVADIQRVLTRGGVFLYPGDARKNYARGRLRLLYEVAPVAMLVEQAGGAATDGQTR
HHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ILDIVANGIHERAPLVCGSTEEVTCVATYYAGGKPDAGRSPLFGQRGLMRS
HHHHHHHHHHHCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AISAAIGTPLETCLAQAVDANPALKDAAAVVAAVGRSAVEISERIGRGALGGDLAAAGD
EECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCEECCC
HNSDGDVQKALDVIAHESVTAALRGAPVAEVASEEAEEVMRLNPDAPLAVAIDPLDGSSN
CCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCC
IGVNMAVGMIFGIRPSIKDPANPLASFTTPGSTQIAAGFVTYGPATALILTLGEGTQSYV
CCHHHHHHHHCCCCCCCCCCCCCHHHCCCCCCCCEEEEEEEECCCEEEEEEECCCCHHEE
LDRTEGRFKLTSPAMSVPPSTKEFAINASNARHWDAPVKAYIEDCQRGTEGPRDKDYNMR
EECCCCCEEECCCCCCCCCCCHHEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHH
WLASLVADIQRVLTRGGVFLYPGDARKNYARGRLRLLYEVAPVAMLVEQAGGAATDGQTR
HHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
ILDIVANGIHERAPLVCGSTEEVTCVATYYAGGKPDAGRSPLFGQRGLMRS
HHHHHHHHHHHCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA