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The map label for this gene is gltR [H]

Identifier: 170749750

GI number: 170749750

Start: 3556554

End: 3557447

Strand: Direct

Name: gltR [H]

Synonym: Mrad2831_3349

Alternate gene names: 170749750

Gene position: 3556554-3557447 (Clockwise)

Preceding gene: 170749749

Following gene: 170749751

Centisome position: 58.52

GC content: 71.03

Gene sequence:

>894_bases
ATGGCGGATTTCCGCAGCTTGGAGGTGTTCTACTGGGTCGCGAAACTCTCGAGCTTCCGGCGCGCCAGCGAGAAGGTGAA
CACCACCCAGCCGGCGGTTTCCCAGCGCATCGCGGCCCTGGAGCATGAGTACGGGACGCTGTTCGAGCGCCGCAGCCGGG
ACGTCGCGCTGACGGAGCGGGGGCGTCTGCTCCTCGGCTTCGCCGAGCGGTTCCTGGCGCTCCAGACCGAGATGAGCGCG
GCCCTGCACGAGACCGGCCGGACGCGGGGCACCCTGCGGCTCGGCGTGTCCGAGACGATCGTCCACCTGTGGCTGTCGCG
CTTCATCGAGCGCATGCGCGCCGCCCATCCCGGGATCGGCGTCGACATCACGGTCGACATCTCGCCGAACATGCAGGCCG
CCCTGGTCGCCGACGAGATCGACCTCGCTTTCCTCGTCGGCCCGATCACCCTGCCGAGCTTCGCCAACCGCGCGCTGTTC
AGCACTCCCGTCGCCTGGATCGCCGCGCCGGGCCTGCTGCCGGGCGACGAGCCCCTGAGCCTCGGCGCGCTGCTGCACCA
CCCGCTCATCACCTACCCGCGCAACACCAGCCCCTACGTCGAGCTGCGCGACCTCGTCCTGCAGGAGAACCTCCTGCCGA
GCCAGATCCACACGAGCGCCTCGCTGGCCACCATCGTGAAGATGGGCGTCGAGGGCCTCGGGATCTGCGTGATCCCGCCG
GCCGTGGTCGAGGCCGAACTCCGCGCCGGCACCCTGCGGGTCCTGCCGGCCGAGCCGACGCTCTCGGACCTGACCTTCAC
GGCGATGCACACGAAGCGGCCGGCCCACCACTTCGTGGCGGACGCGGCCCGCCTCGCCCAGGAGGTCGCCGAGACCTGGG
CCGCCGGCCGATAA

Upstream 100 bases:

>100_bases
TCAGGTCGTCCACCCAGGACGAGAGCAGCCGCACGCTTGCGCTTCCGCGCGCCGGGGCGCGATATGACCGGACACGACGG
CGGCGCGGGACGATCGCGGG

Downstream 100 bases:

>100_bases
GACGGGTTTATCGCGCCCCATTCGCAATCACGATTGGCGCGCCCCGCGGCGCGATGGGATCGTTGCCGCAGGAAATGAAT
CGCTGAAGCGATCGCGATCT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MADFRSLEVFYWVAKLSSFRRASEKVNTTQPAVSQRIAALEHEYGTLFERRSRDVALTERGRLLLGFAERFLALQTEMSA
ALHETGRTRGTLRLGVSETIVHLWLSRFIERMRAAHPGIGVDITVDISPNMQAALVADEIDLAFLVGPITLPSFANRALF
STPVAWIAAPGLLPGDEPLSLGALLHHPLITYPRNTSPYVELRDLVLQENLLPSQIHTSASLATIVKMGVEGLGICVIPP
AVVEAELRAGTLRVLPAEPTLSDLTFTAMHTKRPAHHFVADAARLAQEVAETWAAGR

Sequences:

>Translated_297_residues
MADFRSLEVFYWVAKLSSFRRASEKVNTTQPAVSQRIAALEHEYGTLFERRSRDVALTERGRLLLGFAERFLALQTEMSA
ALHETGRTRGTLRLGVSETIVHLWLSRFIERMRAAHPGIGVDITVDISPNMQAALVADEIDLAFLVGPITLPSFANRALF
STPVAWIAAPGLLPGDEPLSLGALLHHPLITYPRNTSPYVELRDLVLQENLLPSQIHTSASLATIVKMGVEGLGICVIPP
AVVEAELRAGTLRVLPAEPTLSDLTFTAMHTKRPAHHFVADAARLAQEVAETWAAGR
>Mature_296_residues
ADFRSLEVFYWVAKLSSFRRASEKVNTTQPAVSQRIAALEHEYGTLFERRSRDVALTERGRLLLGFAERFLALQTEMSAA
LHETGRTRGTLRLGVSETIVHLWLSRFIERMRAAHPGIGVDITVDISPNMQAALVADEIDLAFLVGPITLPSFANRALFS
TPVAWIAAPGLLPGDEPLSLGALLHHPLITYPRNTSPYVELRDLVLQENLLPSQIHTSASLATIVKMGVEGLGICVIPPA
VVEAELRAGTLRVLPAEPTLSDLTFTAMHTKRPAHHFVADAARLAQEVAETWAAGR

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788626, Length=249, Percent_Identity=30.1204819277108, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788481, Length=251, Percent_Identity=28.6852589641434, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1789173, Length=260, Percent_Identity=29.2307692307692, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789639, Length=263, Percent_Identity=26.2357414448669, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI157672245, Length=192, Percent_Identity=27.0833333333333, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786401, Length=281, Percent_Identity=25.6227758007117, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI145693105, Length=189, Percent_Identity=27.5132275132275, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87081904, Length=258, Percent_Identity=25.968992248062, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787879, Length=295, Percent_Identity=23.728813559322, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790208, Length=172, Percent_Identity=28.4883720930233, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789283, Length=256, Percent_Identity=26.953125, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1788887, Length=253, Percent_Identity=24.5059288537549, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32537; Mature: 32406

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADFRSLEVFYWVAKLSSFRRASEKVNTTQPAVSQRIAALEHEYGTLFERRSRDVALTER
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GRLLLGFAERFLALQTEMSAALHETGRTRGTLRLGVSETIVHLWLSRFIERMRAAHPGIG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCC
VDITVDISPNMQAALVADEIDLAFLVGPITLPSFANRALFSTPVAWIAAPGLLPGDEPLS
EEEEEEECCCCCEEEEECCCCEEEEECCCCCHHHHCCHHHHCCHHHHCCCCCCCCCCCHH
LGALLHHPLITYPRNTSPYVELRDLVLQENLLPSQIHTSASLATIVKMGVEGLGICVIPP
HHHHHHCCCEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECH
AVVEAELRAGTLRVLPAEPTLSDLTFTAMHTKRPAHHFVADAARLAQEVAETWAAGR
HHHHHHHCCCEEEEEECCCCHHHEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADFRSLEVFYWVAKLSSFRRASEKVNTTQPAVSQRIAALEHEYGTLFERRSRDVALTER
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCC
GRLLLGFAERFLALQTEMSAALHETGRTRGTLRLGVSETIVHLWLSRFIERMRAAHPGIG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCC
VDITVDISPNMQAALVADEIDLAFLVGPITLPSFANRALFSTPVAWIAAPGLLPGDEPLS
EEEEEEECCCCCEEEEECCCCEEEEECCCCCHHHHCCHHHHCCHHHHCCCCCCCCCCCHH
LGALLHHPLITYPRNTSPYVELRDLVLQENLLPSQIHTSASLATIVKMGVEGLGICVIPP
HHHHHHCCCEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEEEECH
AVVEAELRAGTLRVLPAEPTLSDLTFTAMHTKRPAHHFVADAARLAQEVAETWAAGR
HHHHHHHCCCEEEEEECCCCHHHEEEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]