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The map label for this gene is mmlH [H]

Identifier: 170748029

GI number: 170748029

Start: 1715809

End: 1717158

Strand: Reverse

Name: mmlH [H]

Synonym: Mrad2831_1611

Alternate gene names: 170748029

Gene position: 1717158-1715809 (Counterclockwise)

Preceding gene: 170748030

Following gene: 170748026

Centisome position: 28.25

GC content: 72.0

Gene sequence:

>1350_bases
ATGGACGCGGGCGACGTGGGCTTGCGCGGGGCGGCCAGCGCCCCGTGGTACGCGGGTCTCACCCGGCGCCACTGGCGGAT
CCTGTGGGGCAGCTATCTCGGCTGGATCTTCGACGGCTACGAGGCGGTGGCCCTGGTCTACGCCCTGCGCCCGGCCCTGG
CCTCGATCCTCACCCCCGAGCAGGCCCAGGCCCCGGCCTTCTACGTGGGTCTCGCCATCGGCATCACCCTGCTGGGCTGG
GGGATCGGCGGCCTGATGGGTGGGATCGCGGCCGACTATATCGGCCGCAAGCGCATGATGATGGTGTCGATCCTGGGCTA
CGCGCTGTTCACGGGGCTCACCGCCTTCGCGGAGAGCTTCGCGCAGCTCGCCGTGCTGCGCTTCATCACCGGGCTCGCCA
TCGGCTCGGAATGGTCCACCGGCATCGCCCTCGTGGCCGAGACCTGGCCGAACCGGGCGCGCCCGAAGGGCTGCGGCTTC
CTGCAATCGGGCTTCGGCGGCGGCGCCGTGCTGGCCGCCATCGTGTGGGCCGTGCTCGCCGCCACCGAGCCGCTGGGCCC
GGAATCCTGGCGGATCCTGTTCGCGCTGGGCGCGCTCCCCGCCTTCGTGTGCCTGTACCTGCGGCGGGCGCTGGAGGAAT
CCGAGCAGTGGATGCGGGCGCTCAGGGCGCAGCGCTGGGCGGCCACCGCGGAGGACGCGAACCGCGCCCCGCGGAGCGCG
CGGCGCCCGTTCTCCCTGACGGAGATCTTCCGCGAGCCCGAGAGCCGGCGGCGGGTCCTGCTCGCCACGCTGCTGTCCTT
CGCCACCACGGTGGGCTGGTGGGCGGTCTCGTCCTGGCTGCCGGCCTACACGGAGGGGCTCGCCAAGGCCGCGGGCGCGC
CGGCCAATCTCTGGGGCCCGCGCATGGGCATCGTCTACAATATCGGGGCGATCACCGCCTACGTGATCTCCGGCTTCGTG
GCCGACGCGATCGGCCGCCGCGCCTTCCTGCTGGTCACCTATGTCGGCTGCATCGCCACGTCGCTCGCCTGCTACCTCTG
GACCGGCGGGCTGGTGCCGTTCATGGCGCTCGCTTTCCTGAACGGGTTCTTCACCCTGGGCTTCGCCTTCTCGTGGATGG
CGATCTACCTCGCGGAGCTGTTCACCCCGGCGGTCCGGGCGACGGCGGCGAGCGTCGTGTTCAACGGCGCGCGGCTGATC
GCCTGGATCTTCCCGATCATCGCCGGGCAGATCGTGACCGCCTTCGGGGGCGTCGCCGCGGCGGCGCTGACGCTCTCCAG
CGTCTACGTGATCGGCCTCGTCGTGCCGTGGTTCATGCCGGAGACGCGGGGCCGGCCGCTGCCGGAATAG

Upstream 100 bases:

>100_bases
TGCCGGGCCGGCCAGCCGGATATGGTCGACCCGATGCCACAACCGACCTATCAGGGCGGGGCGGGCGCCGCCGACGCGTC
CCGGGCGGGAGGAACGGGCG

Downstream 100 bases:

>100_bases
GGCGATCCCGTTTCCGCCCCGCCCTCGGGCGCGCCCGGGTCCGGCCGGACGCGGAGCGGCCCCCGACTCCGCGGGAGCCG
GGGGCCGCGTCCTGCACGGG

Product: major facilitator transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MDAGDVGLRGAASAPWYAGLTRRHWRILWGSYLGWIFDGYEAVALVYALRPALASILTPEQAQAPAFYVGLAIGITLLGW
GIGGLMGGIAADYIGRKRMMMVSILGYALFTGLTAFAESFAQLAVLRFITGLAIGSEWSTGIALVAETWPNRARPKGCGF
LQSGFGGGAVLAAIVWAVLAATEPLGPESWRILFALGALPAFVCLYLRRALEESEQWMRALRAQRWAATAEDANRAPRSA
RRPFSLTEIFREPESRRRVLLATLLSFATTVGWWAVSSWLPAYTEGLAKAAGAPANLWGPRMGIVYNIGAITAYVISGFV
ADAIGRRAFLLVTYVGCIATSLACYLWTGGLVPFMALAFLNGFFTLGFAFSWMAIYLAELFTPAVRATAASVVFNGARLI
AWIFPIIAGQIVTAFGGVAAAALTLSSVYVIGLVVPWFMPETRGRPLPE

Sequences:

>Translated_449_residues
MDAGDVGLRGAASAPWYAGLTRRHWRILWGSYLGWIFDGYEAVALVYALRPALASILTPEQAQAPAFYVGLAIGITLLGW
GIGGLMGGIAADYIGRKRMMMVSILGYALFTGLTAFAESFAQLAVLRFITGLAIGSEWSTGIALVAETWPNRARPKGCGF
LQSGFGGGAVLAAIVWAVLAATEPLGPESWRILFALGALPAFVCLYLRRALEESEQWMRALRAQRWAATAEDANRAPRSA
RRPFSLTEIFREPESRRRVLLATLLSFATTVGWWAVSSWLPAYTEGLAKAAGAPANLWGPRMGIVYNIGAITAYVISGFV
ADAIGRRAFLLVTYVGCIATSLACYLWTGGLVPFMALAFLNGFFTLGFAFSWMAIYLAELFTPAVRATAASVVFNGARLI
AWIFPIIAGQIVTAFGGVAAAALTLSSVYVIGLVVPWFMPETRGRPLPE
>Mature_449_residues
MDAGDVGLRGAASAPWYAGLTRRHWRILWGSYLGWIFDGYEAVALVYALRPALASILTPEQAQAPAFYVGLAIGITLLGW
GIGGLMGGIAADYIGRKRMMMVSILGYALFTGLTAFAESFAQLAVLRFITGLAIGSEWSTGIALVAETWPNRARPKGCGF
LQSGFGGGAVLAAIVWAVLAATEPLGPESWRILFALGALPAFVCLYLRRALEESEQWMRALRAQRWAATAEDANRAPRSA
RRPFSLTEIFREPESRRRVLLATLLSFATTVGWWAVSSWLPAYTEGLAKAAGAPANLWGPRMGIVYNIGAITAYVISGFV
ADAIGRRAFLLVTYVGCIATSLACYLWTGGLVPFMALAFLNGFFTLGFAFSWMAIYLAELFTPAVRATAASVVFNGARLI
AWIFPIIAGQIVTAFGGVAAAALTLSSVYVIGLVVPWFMPETRGRPLPE

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI148664184, Length=403, Percent_Identity=22.0843672456576, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI87082404, Length=318, Percent_Identity=28.3018867924528, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI87082231, Length=253, Percent_Identity=29.2490118577075, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1790550, Length=386, Percent_Identity=25.1295336787565, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1786229, Length=445, Percent_Identity=26.2921348314607, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87082159, Length=284, Percent_Identity=30.2816901408451, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788292, Length=426, Percent_Identity=24.1784037558685, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1788068, Length=396, Percent_Identity=23.4848484848485, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48276; Mature: 48276

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAGDVGLRGAASAPWYAGLTRRHWRILWGSYLGWIFDGYEAVALVYALRPALASILTPE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QAQAPAFYVGLAIGITLLGWGIGGLMGGIAADYIGRKRMMMVSILGYALFTGLTAFAESF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLAVLRFITGLAIGSEWSTGIALVAETWPNRARPKGCGFLQSGFGGGAVLAAIVWAVLA
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHH
ATEPLGPESWRILFALGALPAFVCLYLRRALEESEQWMRALRAQRWAATAEDANRAPRSA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
RRPFSLTEIFREPESRRRVLLATLLSFATTVGWWAVSSWLPAYTEGLAKAAGAPANLWGP
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
RMGIVYNIGAITAYVISGFVADAIGRRAFLLVTYVGCIATSLACYLWTGGLVPFMALAFL
CCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
NGFFTLGFAFSWMAIYLAELFTPAVRATAASVVFNGARLIAWIFPIIAGQIVTAFGGVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALTLSSVYVIGLVVPWFMPETRGRPLPE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDAGDVGLRGAASAPWYAGLTRRHWRILWGSYLGWIFDGYEAVALVYALRPALASILTPE
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QAQAPAFYVGLAIGITLLGWGIGGLMGGIAADYIGRKRMMMVSILGYALFTGLTAFAESF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLAVLRFITGLAIGSEWSTGIALVAETWPNRARPKGCGFLQSGFGGGAVLAAIVWAVLA
HHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHH
ATEPLGPESWRILFALGALPAFVCLYLRRALEESEQWMRALRAQRWAATAEDANRAPRSA
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHHH
RRPFSLTEIFREPESRRRVLLATLLSFATTVGWWAVSSWLPAYTEGLAKAAGAPANLWGP
CCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCC
RMGIVYNIGAITAYVISGFVADAIGRRAFLLVTYVGCIATSLACYLWTGGLVPFMALAFL
CCCCEEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
NGFFTLGFAFSWMAIYLAELFTPAVRATAASVVFNGARLIAWIFPIIAGQIVTAFGGVAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALTLSSVYVIGLVVPWFMPETRGRPLPE
HHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]