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The map label for this gene is aphA [H]

Identifier: 170748030

GI number: 170748030

Start: 1717351

End: 1718376

Strand: Reverse

Name: aphA [H]

Synonym: Mrad2831_1612

Alternate gene names: 170748030

Gene position: 1718376-1717351 (Counterclockwise)

Preceding gene: 170748031

Following gene: 170748029

Centisome position: 28.27

GC content: 77.1

Gene sequence:

>1026_bases
ATGCGCATCGTCCACACGCCCGATTCGAGCCGGCACGACCCCGAACGCTACATGCGGCGCGGCGCGGCGATCCCGCATCC
CGAGCAGGCGGCCCGCTACGCGATCCTGCGGGACGCGGCCGCCCGGGGCGGCCACGCCCTCGCCGAGCCGGCCGATCACG
GCCTCGAGCCGATCCGCGCGGTGCACGACCCGGACTACGTGGCGTTCCTGGCCGAGGCCTGGGCGCGCCGGGACGCGATC
CCCGGCATCGGCGACGAGATCCTGACCGGGTCCTTCGCCCGGCCGCAGATGCACCGGAAGCCCCCCGGCCTCCTCGGGCG
CCTCGGCCTCTACACCGCCGACACCTCGACGCCGATCCGCGCCGGCACCTGGGCGGCGGTCTACGGGTCGGCGCAGTGCG
CGGTCGCGGCCGCCGACGCGGCGCTGGCGGCGGGGCACGCCTACGCCCTGTGCCGCCCGCCCGGCCACCACGCCTACGCG
GACTCCGCGGGCGGCTTCTGCTTCCTCAACAACAGCGCCATCGCGGCCGAGCGGATGCGCGCCGCGACCGGCGGCCCGGT
GGCGATCCTCGACATCGACGTCCATCACGGCAACGGCACGCAGGGGATCTTCTACGCCCGCGCCGACGTGCTGACCGTCT
CGGTCCACGCCGACCCGTCCGACTACTTCCCGTTCTTCGCCGGCTACGCCGACGAGACCGGCGCCGGGGCGGGGGCGGGG
TTCAACCGCAACCTGCCGCTGCCGCCGGGCTCGGGCGACGCGCCCTGGCTCGAGGCCGTGGCGGCGGGCCTCGCGGCCAT
CGCCGCATACCGGCCCCGGGCCCTCGTGGTGGCCCTGGGCCTCGACGCCGCCGCGGACGATCCGATCGGCGCCCTCGCGG
TCTCTCGCGCGGGCTTCGTCGGGGCCGCGGAGCGGATCGCCCGGGCCGGGCTGCCCACGGCCCTGGTCCAGGAGGGCGGC
TACCTCTGCGCGGCCCTGCCGGACAACCTCGCGGCCTTCCTCGCCGCCTTCGACGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
CGTCCGGGTGCGCCCGTCGCGGGTGCGTCCCACGCGGGTGCGCCCCGCGAGTCCGTGCCGGGCGGATGACGCCGGTCCCG
GCGGGCCCTAACCTGCCCGC

Downstream 100 bases:

>100_bases
GACGCGCACCGCGCGCCGGCCCCGCGCCGGCCTCGCGCCGGCGCGACGCGCGGACACGATCCGCCGGCGTGATGCGATCG
TGATCGCCGGAATGCCGGGC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MRIVHTPDSSRHDPERYMRRGAAIPHPEQAARYAILRDAAARGGHALAEPADHGLEPIRAVHDPDYVAFLAEAWARRDAI
PGIGDEILTGSFARPQMHRKPPGLLGRLGLYTADTSTPIRAGTWAAVYGSAQCAVAAADAALAAGHAYALCRPPGHHAYA
DSAGGFCFLNNSAIAAERMRAATGGPVAILDIDVHHGNGTQGIFYARADVLTVSVHADPSDYFPFFAGYADETGAGAGAG
FNRNLPLPPGSGDAPWLEAVAAGLAAIAAYRPRALVVALGLDAAADDPIGALAVSRAGFVGAAERIARAGLPTALVQEGG
YLCAALPDNLAAFLAAFDAAR

Sequences:

>Translated_341_residues
MRIVHTPDSSRHDPERYMRRGAAIPHPEQAARYAILRDAAARGGHALAEPADHGLEPIRAVHDPDYVAFLAEAWARRDAI
PGIGDEILTGSFARPQMHRKPPGLLGRLGLYTADTSTPIRAGTWAAVYGSAQCAVAAADAALAAGHAYALCRPPGHHAYA
DSAGGFCFLNNSAIAAERMRAATGGPVAILDIDVHHGNGTQGIFYARADVLTVSVHADPSDYFPFFAGYADETGAGAGAG
FNRNLPLPPGSGDAPWLEAVAAGLAAIAAYRPRALVVALGLDAAADDPIGALAVSRAGFVGAAERIARAGLPTALVQEGG
YLCAALPDNLAAFLAAFDAAR
>Mature_341_residues
MRIVHTPDSSRHDPERYMRRGAAIPHPEQAARYAILRDAAARGGHALAEPADHGLEPIRAVHDPDYVAFLAEAWARRDAI
PGIGDEILTGSFARPQMHRKPPGLLGRLGLYTADTSTPIRAGTWAAVYGSAQCAVAAADAALAAGHAYALCRPPGHHAYA
DSAGGFCFLNNSAIAAERMRAATGGPVAILDIDVHHGNGTQGIFYARADVLTVSVHADPSDYFPFFAGYADETGAGAGAG
FNRNLPLPPGSGDAPWLEAVAAGLAAIAAYRPRALVVALGLDAAADDPIGALAVSRAGFVGAAERIARAGLPTALVQEGG
YLCAALPDNLAAFLAAFDAAR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI148539870, Length=331, Percent_Identity=32.6283987915408, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI169234807, Length=337, Percent_Identity=32.9376854599407, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI17158039, Length=218, Percent_Identity=34.8623853211009, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI13128864, Length=193, Percent_Identity=39.3782383419689, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI30795202, Length=225, Percent_Identity=34.6666666666667, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI30795204, Length=225, Percent_Identity=34.6666666666667, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI153085395, Length=339, Percent_Identity=30.9734513274336, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI8923769, Length=167, Percent_Identity=31.1377245508982, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI20070354, Length=229, Percent_Identity=33.6244541484716, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI262073088, Length=177, Percent_Identity=30.5084745762712, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI62750347, Length=209, Percent_Identity=35.8851674641148, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI62750349, Length=209, Percent_Identity=35.8851674641148, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI13128860, Length=170, Percent_Identity=31.1764705882353, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI13128862, Length=170, Percent_Identity=31.1764705882353, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI293336691, Length=155, Percent_Identity=29.6774193548387, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI226529806, Length=141, Percent_Identity=38.2978723404255, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI262073092, Length=103, Percent_Identity=33.0097087378641, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17540334, Length=191, Percent_Identity=37.17277486911, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI193206283, Length=194, Percent_Identity=37.1134020618557, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17540332, Length=194, Percent_Identity=37.1134020618557, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17537347, Length=213, Percent_Identity=34.2723004694836, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI193209491, Length=283, Percent_Identity=30.7420494699647, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17508561, Length=167, Percent_Identity=32.9341317365269, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=266, Percent_Identity=28.1954887218045, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561978, Length=169, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324307, Length=200, Percent_Identity=36.5, Blast_Score=113, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6323999, Length=170, Percent_Identity=33.5294117647059, Blast_Score=89, Evalue=7e-19,
Organism=Saccharomyces cerevisiae, GI6321244, Length=168, Percent_Identity=29.1666666666667, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6325325, Length=156, Percent_Identity=26.9230769230769, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325141, Length=100, Percent_Identity=33, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI281360801, Length=193, Percent_Identity=41.9689119170984, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360799, Length=193, Percent_Identity=41.9689119170984, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641720, Length=193, Percent_Identity=41.9689119170984, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360899, Length=208, Percent_Identity=37.5, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24642142, Length=208, Percent_Identity=37.5, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24642146, Length=208, Percent_Identity=37.5, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24642144, Length=208, Percent_Identity=37.5, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24644244, Length=170, Percent_Identity=34.7058823529412, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24657891, Length=221, Percent_Identity=28.5067873303167, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 35222; Mature: 35222

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVHTPDSSRHDPERYMRRGAAIPHPEQAARYAILRDAAARGGHALAEPADHGLEPIRA
CEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHH
VHDPDYVAFLAEAWARRDAIPGIGDEILTGSFARPQMHRKPPGLLGRLGLYTADTSTPIR
HCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHCCCCCHHHHCEEEECCCCCCCC
AGTWAAVYGSAQCAVAAADAALAAGHAYALCRPPGHHAYADSAGGFCFLNNSAIAAERMR
CCCEEEEECCCCEEEEHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEECCCHHHHHHHH
AATGGPVAILDIDVHHGNGTQGIFYARADVLTVSVHADPSDYFPFFAGYADETGAGAGAG
HCCCCCEEEEEEEEECCCCCCEEEEEEEEEEEEEEECCCCCCCCHHCCCCCCCCCCCCCC
FNRNLPLPPGSGDAPWLEAVAAGLAAIAAYRPRALVVALGLDAAADDPIGALAVSRAGFV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCH
GAAERIARAGLPTALVQEGGYLCAALPDNLAAFLAAFDAAR
HHHHHHHHCCCCHHHHHCCCEEEEECHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIVHTPDSSRHDPERYMRRGAAIPHPEQAARYAILRDAAARGGHALAEPADHGLEPIRA
CEEEECCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCHHHHH
VHDPDYVAFLAEAWARRDAIPGIGDEILTGSFARPQMHRKPPGLLGRLGLYTADTSTPIR
HCCCHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHCCCCCHHHHCEEEECCCCCCCC
AGTWAAVYGSAQCAVAAADAALAAGHAYALCRPPGHHAYADSAGGFCFLNNSAIAAERMR
CCCEEEEECCCCEEEEHHHHHHHCCCEEEEECCCCCCCCCCCCCCEEEECCCHHHHHHHH
AATGGPVAILDIDVHHGNGTQGIFYARADVLTVSVHADPSDYFPFFAGYADETGAGAGAG
HCCCCCEEEEEEEEECCCCCCEEEEEEEEEEEEEEECCCCCCCCHHCCCCCCCCCCCCCC
FNRNLPLPPGSGDAPWLEAVAAGLAAIAAYRPRALVVALGLDAAADDPIGALAVSRAGFV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHCCCH
GAAERIARAGLPTALVQEGGYLCAALPDNLAAFLAAFDAAR
HHHHHHHHCCCCHHHHHCCCEEEEECHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]