| Definition | Methylobacterium radiotolerans JCM 2831 chromosome, complete genome. |
|---|---|
| Accession | NC_010505 |
| Length | 6,077,833 |
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The map label for this gene is topA [H]
Identifier: 170747437
GI number: 170747437
Start: 1061250
End: 1063934
Strand: Reverse
Name: topA [H]
Synonym: Mrad2831_1005
Alternate gene names: 170747437
Gene position: 1063934-1061250 (Counterclockwise)
Preceding gene: 170747440
Following gene: 170747435
Centisome position: 17.51
GC content: 71.06
Gene sequence:
>2685_bases ATGAAAGTCGTCGTCGTCGAGTCGCCGGCCAAAGCCAAGACGATCAATAAGTATCTCGGCCGCGACTATGAAGTCATCGC CTCCTTCGGGCACATCCGCGACCTGCCGCCCAAGGACGGCTCGGTGGATCCCGAGCAGGATTTCCGCATGGTCTGGGAAC TGGCCGACCGCGGGGCGAGCCGGGTCTCCGAGATCGCCAAGGCGGTCAAGGGCGCCGACAAGCTGATCCTCGCCACCGAC CCGGATCGCGAGGGCGAGGCGATCTCCTGGCACGTGCTGGAGGCGCTCACCGCCCGCAAGGCGCTCAAGGGCATCCCGGT CGAGCGCGTGACCTTCAACGCCATCACCAAGGCGTCGGTCGAGCAGGCGATGCGCAAGCCGCGCGAGATCGACCAGGCGC TGGTCGACGCCTACCTGGCGCGCCGGGCGCTCGACTATCTCGTCGGCTTCAATCTCTCGCCGGTCCTGTGGCGCAAGCTG CCGGGCGCCCGCTCGGCCGGGCGCGTGCAGTCCGTGGCGCTCCGGCTCGTGGTCGAGCGCGAGATGGAGATCGAGCGGTT CAAGCCGCGCGAGTACTGGACGCTCATCGCGACCCTGACGACCGCCGACGGCGCGACCTTCGAGGCCCGGCTCGTGGGCG CGGACGGCAAGCGGATCCAGCGCCTCGACGTCGGCACGGGCGAGGAGGCGGCCGCCTTCAGGCGCGACCTCGAGCTCGCG ACCTTCCAGGTGGCGAGCGTCGAGGCCAAGCCCGCCAAGCGCCACCCGCAGCCGCCCTTCACCACCTCGACCCTCCAGCA GGAGGCCTCCCGCAAGCTCGGCATGGCGCCGGCCCAGACCATGCGGGTCGCCCAGCGGCTCTACGAGGGCGTCGACATCG GCGGCGAGACGGTCGGCATCATCACCTACATGCGGACCGACGGCGTCGACATGGCGCCGGAGGCGATCCAGGACGCCCGC CGGGTCATCGGCAAGGAGTTCGGCGACCGCTACGTGCCGGACGTGCCGCGCAAGTACAGCGTCAAGGCCAAGAACGCCCA GGAGGCCCACGAGGCGGTGCGTCCCACCGACATGGGCCGCCTGCCCAAGACGGTGGCGCGCCACCTGGAGCCCGAGCAGG CCCGGCTCTACGAGCTGATCTGGACCCGCACCATGGCGAGCCAGATGGAATCGGCCGAGCTGGAGCGGACCACCGTCGAC GTCACCGCCAAGGTCGGGCCGCGGACCATCGACCTGCGCGCCACCGGCCAGGTGGTGAAGTTCGACGGCTTCCTGACCCT CTACCAGGAGGGCAAGGACGACGAGGAGGACGAGGAGAGCCGCCGCCTGCCGCCCATGAAGGCCGGCGACCCCCTCACCC GCGAGCGCATCAGCGCGACCCAGCACTTCACCGAGCCGCCGCCGCGCTACTCCGAGGCGAGCCTCGTGAAGCGCATGGAG GAGCTCGGCATCGGCCGGCCCTCGACCTACGCCGCGGTGCTCCAGACCTTGCGGGACCGCGAGTACGTCAAGATCGAGAA GAAGCGGCTGCAGCCGGAGGACAAGGGGCGGCTCGTCACGGGCTTCCTGGAGAGCTTCTTCCGGCGCTACGTCGAGTACG ACTTCACCGCCGGCCTCGAGGAGCAGCTCGACCGGGTCTCCAACGCCGAGATCGACTGGCGGGCGGTGCTGCGCGACTTC TGGCGCGACTTCTCCGCGGCGATCGGCGAGACCAAGGAGCTGCGCGTCGCCGACGTGCTGGAGGCGCTGAACGGCCTTCT CGGGCCGCACATCTTCCCCGACAAGGGCGACGGCTCGAACCCGCGCACCTGCCCGACCTGCGGCTCGGGCCAGCTGTCGC TGAAGCTCGGCAAGTTCGGCGCCTTCATCGGCTGCTCGAACTACCCGGAGTGCAAGTACACCCGCCAGCTCTCGGCCACG GGCATCGACGGCGACGGGGACGGCTCCTCGGCCGAGGGCGGCCAGCCGGGCGTGCGCGTGCTGGGCGACGATCCCGCGAC CGGCCTGCCGGTGACGCTCCGCGACGGCCGCTTCGGGCCGTTCCTCCAGCTCGGCGAGGCCTCCACCGAGAAGGGCGCGG AGAAGCCGAAGCGCTCGTCGCTGCCGAAGGGGCTGAGCCCCTCGGACGTGGATCTGAACAAGGCGCTGGCCCTGCTCGCG CTGCCCCGCGAGGTGGCGCGCCACCCCGAGACCGGCGAGCCGATCCTGGCCAATCTCGGCCGGTTCGGGCCCTACGTGCA GCACGGGAAGACCTACGCCAATCTCGGCAAGGACGACGACGTGCTGGAGATCGGGGCCAACCGCGCCATCGACCTGATCG TCGCCAAGGAGCAGGGCGGCGGCCGCGGCCGCCTGGCCGCCGATCCGGGCCGGCCGCTCGGCAAGGACGAGGCTAGCGGC CGAGACCTCGTGGTCAAGGCCGGCAAGTACGGGCCCTACGTCACCGACGGCGAGGTCAACGCCACGCTGCCGAAGACGAT GAGCGCCGAGGCGCTGACGCTGGACGAGGCGATCGCCCTGGTGAACGCCAAGCGCGCCGCGGGCGGCGGCAAGCCGGCGA AGCGGGGGGCGGCCCGGAAGAGTTCGGCGCGCGCCGCGAGCGGCGACAAGCCGGCGGCGAAGAAGACCGCCACGAAGAAG CCGGCGGCCAAGAAGGCGGCGACCAAGAAATCGAGCTCGGGCTGA
Upstream 100 bases:
>100_bases CCGGCGCGCGGCCCCGGCCCGACGGCGGGCATACGTCCCACGCGAATCTCGAACAGAATTCGTCCGTCGCGCCCAGGCCC CGTCAGGGGCAGAGGTCTGA
Downstream 100 bases:
>100_bases GGGGCTCGCGGGCGGGGGCCGGGAGCGGCCGCCCCGTCCGCGCGCGCGGAGCGGGGCGATCCGGGACAGCCCGGGGCCGC CGAGCGTGGCGCCGACCGGT
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 894; Mature: 894
Protein sequence:
>894_residues MKVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDGSVDPEQDFRMVWELADRGASRVSEIAKAVKGADKLILATD PDREGEAISWHVLEALTARKALKGIPVERVTFNAITKASVEQAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKL PGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEARLVGADGKRIQRLDVGTGEEAAAFRRDLELA TFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDAR RVIGKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIWTRTMASQMESAELERTTVD VTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRME ELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLEEQLDRVSNAEIDWRAVLRDF WRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGSNPRTCPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSAT GIDGDGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFLQLGEASTEKGAEKPKRSSLPKGLSPSDVDLNKALALLA LPREVARHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRLAADPGRPLGKDEASG RDLVVKAGKYGPYVTDGEVNATLPKTMSAEALTLDEAIALVNAKRAAGGGKPAKRGAARKSSARAASGDKPAAKKTATKK PAAKKAATKKSSSG
Sequences:
>Translated_894_residues MKVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDGSVDPEQDFRMVWELADRGASRVSEIAKAVKGADKLILATD PDREGEAISWHVLEALTARKALKGIPVERVTFNAITKASVEQAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKL PGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEARLVGADGKRIQRLDVGTGEEAAAFRRDLELA TFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDAR RVIGKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIWTRTMASQMESAELERTTVD VTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRME ELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLEEQLDRVSNAEIDWRAVLRDF WRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGSNPRTCPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSAT GIDGDGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFLQLGEASTEKGAEKPKRSSLPKGLSPSDVDLNKALALLA LPREVARHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRLAADPGRPLGKDEASG RDLVVKAGKYGPYVTDGEVNATLPKTMSAEALTLDEAIALVNAKRAAGGGKPAKRGAARKSSARAASGDKPAAKKTATKK PAAKKAATKKSSSG >Mature_894_residues MKVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDGSVDPEQDFRMVWELADRGASRVSEIAKAVKGADKLILATD PDREGEAISWHVLEALTARKALKGIPVERVTFNAITKASVEQAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKL PGARSAGRVQSVALRLVVEREMEIERFKPREYWTLIATLTTADGATFEARLVGADGKRIQRLDVGTGEEAAAFRRDLELA TFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDIGGETVGIITYMRTDGVDMAPEAIQDAR RVIGKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGRLPKTVARHLEPEQARLYELIWTRTMASQMESAELERTTVD VTAKVGPRTIDLRATGQVVKFDGFLTLYQEGKDDEEDEESRRLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRME ELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLEEQLDRVSNAEIDWRAVLRDF WRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGSNPRTCPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSAT GIDGDGDGSSAEGGQPGVRVLGDDPATGLPVTLRDGRFGPFLQLGEASTEKGAEKPKRSSLPKGLSPSDVDLNKALALLA LPREVARHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGGGRGRLAADPGRPLGKDEASG RDLVVKAGKYGPYVTDGEVNATLPKTMSAEALTLDEAIALVNAKRAAGGGKPAKRGAARKSSARAASGDKPAAKKTATKK PAAKKAATKKSSSG
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=700, Percent_Identity=25.8571428571429, Blast_Score=130, Evalue=6e-30, Organism=Homo sapiens, GI4507635, Length=506, Percent_Identity=26.4822134387352, Blast_Score=120, Evalue=6e-27, Organism=Escherichia coli, GI1787529, Length=669, Percent_Identity=40.0597907324365, Blast_Score=453, Evalue=1e-128, Organism=Escherichia coli, GI1788061, Length=549, Percent_Identity=24.2258652094718, Blast_Score=114, Evalue=2e-26, Organism=Caenorhabditis elegans, GI32563869, Length=574, Percent_Identity=28.0487804878049, Blast_Score=137, Evalue=4e-32, Organism=Caenorhabditis elegans, GI17555378, Length=476, Percent_Identity=27.1008403361345, Blast_Score=116, Evalue=5e-26, Organism=Saccharomyces cerevisiae, GI6323263, Length=551, Percent_Identity=25.4083484573503, Blast_Score=105, Evalue=2e-23, Organism=Drosophila melanogaster, GI24585251, Length=621, Percent_Identity=26.8921095008052, Blast_Score=141, Evalue=2e-33, Organism=Drosophila melanogaster, GI24640096, Length=582, Percent_Identity=24.0549828178694, Blast_Score=107, Evalue=3e-23,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 97591; Mature: 97591
Theoretical pI: Translated: 9.50; Mature: 9.50
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.0 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDGSVDPEQDFRMVWELADRGAS CEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH RVSEIAKAVKGADKLILATDPDREGEAISWHVLEALTARKALKGIPVERVTFNAITKASV HHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCHHHEEHHHHHHHHH EQAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVER HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH EMEIERFKPREYWTLIATLTTADGATFEARLVGADGKRIQRLDVGTGEEAAAFRRDLELA HHHHHHCCCHHHEEEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHH TFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDIGGETVGI EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEE ITYMRTDGVDMAPEAIQDARRVIGKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGR EEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHCCCCCCCC LPKTVARHLEPEQARLYELIWTRTMASQMESAELERTTVDVTAKVGPRTIDLRATGQVVK CHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEEECCCEEE FDGFLTLYQEGKDDEEDEESRRLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRME ECCEEEEEECCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH ELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLE HHCCCCCHHHHHHHHHHHCCHHEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH EQLDRVSNAEIDWRAVLRDFWRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGSN HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC PRTCPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSATGIDGDGDGSSAEGGQPGVRV CCCCCCCCCCCEEEEECCCEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEE LGDDPATGLPVTLRDGRFGPFLQLGEASTEKGAEKPKRSSLPKGLSPSDVDLNKALALLA ECCCCCCCCEEEEECCCCCCCEECCCCCCHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHH LPREVARHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGG CCHHHHCCCCCCCHHHHHHHHCCCHHHCCCHHHCCCCCCCEEEECCCCEEEEEEEECCCC GRGRLAADPGRPLGKDEASGRDLVVKAGKYGPYVTDGEVNATLPKTMSAEALTLDEAIAL CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHH VNAKRAAGGGKPAKRGAARKSSARAASGDKPAAKKTATKKPAAKKAATKKSSSG HHHHHHCCCCCHHHHCCCHHHCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCCC >Mature Secondary Structure MKVVVVESPAKAKTINKYLGRDYEVIASFGHIRDLPPKDGSVDPEQDFRMVWELADRGAS CEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH RVSEIAKAVKGADKLILATDPDREGEAISWHVLEALTARKALKGIPVERVTFNAITKASV HHHHHHHHHCCCCEEEEEECCCCCCCEEHHHHHHHHHHHHHHHCCCHHHEEHHHHHHHHH EQAMRKPREIDQALVDAYLARRALDYLVGFNLSPVLWRKLPGARSAGRVQSVALRLVVER HHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHH EMEIERFKPREYWTLIATLTTADGATFEARLVGADGKRIQRLDVGTGEEAAAFRRDLELA HHHHHHCCCHHHEEEEEEEEECCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHH TFQVASVEAKPAKRHPQPPFTTSTLQQEASRKLGMAPAQTMRVAQRLYEGVDIGGETVGI EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCEEEE ITYMRTDGVDMAPEAIQDARRVIGKEFGDRYVPDVPRKYSVKAKNAQEAHEAVRPTDMGR EEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHCCCCCCCC LPKTVARHLEPEQARLYELIWTRTMASQMESAELERTTVDVTAKVGPRTIDLRATGQVVK CHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCCEEEEEEECCCEEE FDGFLTLYQEGKDDEEDEESRRLPPMKAGDPLTRERISATQHFTEPPPRYSEASLVKRME ECCEEEEEECCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHH ELGIGRPSTYAAVLQTLRDREYVKIEKKRLQPEDKGRLVTGFLESFFRRYVEYDFTAGLE HHCCCCCHHHHHHHHHHHCCHHEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH EQLDRVSNAEIDWRAVLRDFWRDFSAAIGETKELRVADVLEALNGLLGPHIFPDKGDGSN HHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC PRTCPTCGSGQLSLKLGKFGAFIGCSNYPECKYTRQLSATGIDGDGDGSSAEGGQPGVRV CCCCCCCCCCCEEEEECCCEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEE LGDDPATGLPVTLRDGRFGPFLQLGEASTEKGAEKPKRSSLPKGLSPSDVDLNKALALLA ECCCCCCCCEEEEECCCCCCCEECCCCCCHHCCCCCCHHCCCCCCCCCCCCHHHHHHHHH LPREVARHPETGEPILANLGRFGPYVQHGKTYANLGKDDDVLEIGANRAIDLIVAKEQGG CCHHHHCCCCCCCHHHHHHHHCCCHHHCCCHHHCCCCCCCEEEECCCCEEEEEEEECCCC GRGRLAADPGRPLGKDEASGRDLVVKAGKYGPYVTDGEVNATLPKTMSAEALTLDEAIAL CCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHH VNAKRAAGGGKPAKRGAARKSSARAASGDKPAAKKTATKKPAAKKAATKKSSSG HHHHHHCCCCCHHHHCCCHHHCCCCCCCCCCCHHHHCCCCCHHHHHHCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA