Click here to switch to the map view.

The map label for this gene is mdtA [H]

Identifier: 170078183

GI number: 170078183

Start: 1656773

End: 1658035

Strand: Reverse

Name: mdtA [H]

Synonym: SYNPCC7002_A1574

Alternate gene names: 170078183

Gene position: 1658035-1656773 (Counterclockwise)

Preceding gene: 170078184

Following gene: 170078181

Centisome position: 55.12

GC content: 54.16

Gene sequence:

>1263_bases
ATGGGTGCGTCCCGGAGTGATTGGCGATCGCCAGTGGTCTTAGGTCTAGTTGTCAGCTGTGCCGTGAGCCTTAGTGGTTG
TGGTGGGCCACCGCCCCAAGCCCAAACTCCCCAGGGAGTACCGGTAAAATTTGAAACCTTAGATTCAGATCTGCTCGCCA
CTACCACTGAATACGTGGGGGTTTTAGAAGCGGATAATCTCGTGACCCTCAAGCCAGAAGTAGACGGTATTATTCAAGCC
ATTCAAATCCAAGAGGGGGATACTGTCACGGCAGGAACGCCCATTTTGACCCTCAAGTCAGAACGCAGTCAGGCTTCTTT
GCAACAGGCGATCGCTGGGGTAGAAGCAGCCCGGGCCGCCCAAGCAAATGCCGAAGCCCAACTCAGTGCTGTCAATGCGG
AAAAACTAGAGACCCAAGCCGACTTAAAACTCCGGGAACAGGATCTCCAACGGATTAAAAGCCTAGTGGATACCGGGGCT
TTACCCCAGCGGGATCTCGACCAGAGCCAACGGGATCTAGAGGTGGCCAAGGCGCGGCTAAATACCATCAATCAACGGAT
CAAGGCTGCCCAAGCAAGTGTAAATCAAGCCAAAGCCACCCTCCGCCAATCAAGCAATACGGTGGCGATCGCCAATGAAG
ATCTCCGGGAAACCCAAGTGACAGCCCCCGTTGCGGGCACCATCGGCGACTTAACCGTGCAACAAGGAGACTACCTCGAA
CAGGGAGCCACCATTGCCACCATTGCCCAAAATACACGCCTAAGTCTTAACTTTTTTGTGCCCATCGAGCAGGCCCCCGA
TCTGCGTCTCTCCCTCCCCGTCGAGCTGATCGACTACCGCACCCTCGAAACCGTGGGTCGGGGTCAAGTAAGTTTTATTT
CCCCAGAAGTAGACTTTACCTCCCAAACCATCTTGGCGAAGGCCAGCTTCGATAATCCTGACAATCGCCTTTTCACAGGG
CAACTGGTCAAGGCCAAACTGATTCTGAGTCAGCAAACCGGGGTTTCGGTGCCTGTCACGGCTGTATCCCGCATTGGCGC
AGAAACTTTTGTCTTTGTCACTGCCCCCAATCCCGACGCCCAAGGGGAAAACGATCCCCCCCTGATTGCCGTCCAAAAAT
CCGTCACGTTAGGCGCCATTGAAGGCGATCGCTATCAAGTGTTAGAAGGATTAACCACCGGGGAACAGGTGATTACCACG
GGCATTCTCAATTTGACTGACGGCACCCCTGTCTTCCCCCAAACCGAAGAAGTCTTCCAGTAA

Upstream 100 bases:

>100_bases
GCCTGAATTGCCGACGGATCATCCGCCGGAGTCCCCCAGTTAAGGGAAACTTTGTGTACCCTTGTTAGGAGTGATTTTAT
TCTGGTTGAGGAATTGATGT

Downstream 100 bases:

>100_bases
AGCGTGGGGATTTAGTTAATGCCGATCACATATTTGCGCCATTCGTGGTTGAGATCATCCCGGGTGTATTTCAAAAGCTC
GAAATAAAGGCTACTGTGGG

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Multidrug transporter mdtA [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MGASRSDWRSPVVLGLVVSCAVSLSGCGGPPPQAQTPQGVPVKFETLDSDLLATTTEYVGVLEADNLVTLKPEVDGIIQA
IQIQEGDTVTAGTPILTLKSERSQASLQQAIAGVEAARAAQANAEAQLSAVNAEKLETQADLKLREQDLQRIKSLVDTGA
LPQRDLDQSQRDLEVAKARLNTINQRIKAAQASVNQAKATLRQSSNTVAIANEDLRETQVTAPVAGTIGDLTVQQGDYLE
QGATIATIAQNTRLSLNFFVPIEQAPDLRLSLPVELIDYRTLETVGRGQVSFISPEVDFTSQTILAKASFDNPDNRLFTG
QLVKAKLILSQQTGVSVPVTAVSRIGAETFVFVTAPNPDAQGENDPPLIAVQKSVTLGAIEGDRYQVLEGLTTGEQVITT
GILNLTDGTPVFPQTEEVFQ

Sequences:

>Translated_420_residues
MGASRSDWRSPVVLGLVVSCAVSLSGCGGPPPQAQTPQGVPVKFETLDSDLLATTTEYVGVLEADNLVTLKPEVDGIIQA
IQIQEGDTVTAGTPILTLKSERSQASLQQAIAGVEAARAAQANAEAQLSAVNAEKLETQADLKLREQDLQRIKSLVDTGA
LPQRDLDQSQRDLEVAKARLNTINQRIKAAQASVNQAKATLRQSSNTVAIANEDLRETQVTAPVAGTIGDLTVQQGDYLE
QGATIATIAQNTRLSLNFFVPIEQAPDLRLSLPVELIDYRTLETVGRGQVSFISPEVDFTSQTILAKASFDNPDNRLFTG
QLVKAKLILSQQTGVSVPVTAVSRIGAETFVFVTAPNPDAQGENDPPLIAVQKSVTLGAIEGDRYQVLEGLTTGEQVITT
GILNLTDGTPVFPQTEEVFQ
>Mature_419_residues
GASRSDWRSPVVLGLVVSCAVSLSGCGGPPPQAQTPQGVPVKFETLDSDLLATTTEYVGVLEADNLVTLKPEVDGIIQAI
QIQEGDTVTAGTPILTLKSERSQASLQQAIAGVEAARAAQANAEAQLSAVNAEKLETQADLKLREQDLQRIKSLVDTGAL
PQRDLDQSQRDLEVAKARLNTINQRIKAAQASVNQAKATLRQSSNTVAIANEDLRETQVTAPVAGTIGDLTVQQGDYLEQ
GATIATIAQNTRLSLNFFVPIEQAPDLRLSLPVELIDYRTLETVGRGQVSFISPEVDFTSQTILAKASFDNPDNRLFTGQ
LVKAKLILSQQTGVSVPVTAVSRIGAETFVFVTAPNPDAQGENDPPLIAVQKSVTLGAIEGDRYQVLEGLTTGEQVITTG
ILNLTDGTPVFPQTEEVFQ

Specific function: The mdtABC tripartite complex confers resistance against novobiocin and deoxycholate [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87082036, Length=363, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786668, Length=426, Percent_Identity=26.056338028169, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789665, Length=407, Percent_Identity=26.2899262899263, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022824
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44735; Mature: 44604

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGASRSDWRSPVVLGLVVSCAVSLSGCGGPPPQAQTPQGVPVKFETLDSDLLATTTEYVG
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHE
VLEADNLVTLKPEVDGIIQAIQIQEGDTVTAGTPILTLKSERSQASLQQAIAGVEAARAA
EEECCCEEEECCCCCCCEEEEEECCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHH
QANAEAQLSAVNAEKLETQADLKLREQDLQRIKSLVDTGALPQRDLDQSQRDLEVAKARL
HCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
NTINQRIKAAQASVNQAKATLRQSSNTVAIANEDLRETQVTAPVAGTIGDLTVQQGDYLE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHEECCCCCCCCCCEEECCCCHHH
QGATIATIAQNTRLSLNFFVPIEQAPDLRLSLPVELIDYRTLETVGRGQVSFISPEVDFT
CCCEEEEEECCCEEEEEEEEECCCCCCCEEECCHHHHCCHHHHHCCCCCEEEECCCCCCC
SQTILAKASFDNPDNRLFTGQLVKAKLILSQQTGVSVPVTAVSRIGAETFVFVTAPNPDA
CCEEEEEECCCCCCCEEEECHHEEEEEEEECCCCCCCCHHHHHHCCCEEEEEEECCCCCC
QGENDPPLIAVQKSVTLGAIEGDRYQVLEGLTTGEQVITTGILNLTDGTPVFPQTEEVFQ
CCCCCCCEEEEECCEEEEEECCCHHHHHHCCCCCCHHHHEEEEECCCCCCCCCCCHHHCC
>Mature Secondary Structure 
GASRSDWRSPVVLGLVVSCAVSLSGCGGPPPQAQTPQGVPVKFETLDSDLLATTTEYVG
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHE
VLEADNLVTLKPEVDGIIQAIQIQEGDTVTAGTPILTLKSERSQASLQQAIAGVEAARAA
EEECCCEEEECCCCCCCEEEEEECCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHH
QANAEAQLSAVNAEKLETQADLKLREQDLQRIKSLVDTGALPQRDLDQSQRDLEVAKARL
HCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
NTINQRIKAAQASVNQAKATLRQSSNTVAIANEDLRETQVTAPVAGTIGDLTVQQGDYLE
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHEECCCCCCCCCCEEECCCCHHH
QGATIATIAQNTRLSLNFFVPIEQAPDLRLSLPVELIDYRTLETVGRGQVSFISPEVDFT
CCCEEEEEECCCEEEEEEEEECCCCCCCEEECCHHHHCCHHHHHCCCCCEEEECCCCCCC
SQTILAKASFDNPDNRLFTGQLVKAKLILSQQTGVSVPVTAVSRIGAETFVFVTAPNPDA
CCEEEEEECCCCCCCEEEECHHEEEEEEEECCCCCCCCHHHHHHCCCEEEEEEECCCCCC
QGENDPPLIAVQKSVTLGAIEGDRYQVLEGLTTGEQVITTGILNLTDGTPVFPQTEEVFQ
CCCCCCCEEEEECCEEEEEECCCHHHHHHCCCCCCHHHHEEEEECCCCCCCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA