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The map label for this gene is nrdA [H]

Identifier: 170077964

GI number: 170077964

Start: 1405818

End: 1408160

Strand: Direct

Name: nrdA [H]

Synonym: SYNPCC7002_A1350

Alternate gene names: 170077964

Gene position: 1405818-1408160 (Clockwise)

Preceding gene: 170077962

Following gene: 170077965

Centisome position: 46.74

GC content: 51.52

Gene sequence:

>2343_bases
TTGTCACTTCACCCCATTAATCCCGTCTGCCCTATGGATCTCCGTCAAGATACTGCCCTCTCCAGAAGCACCCCCAGCGC
TACGGCTACCTACTCTGCTTCCAGGGCGGTAACACCGACGAAACCCCAGACCTATGTGATCAAACGGAGTGGCAAACGGG
CTCCCCTCGATGTCACCAGAATTCGCAACGTGGTGCAGTGGGCCTGTCAAGATTTAGAAGCCAACACCATCGAACTGGAA
GCCGGTCTAAAAACACGCCTCAAAGATGGGGTTACCACCCGCGAAATTCAAGAAAATTTAATTCAATGTGCCCTGGAGAT
GTGCAGTCCCGAAGAACCGGACTGGCGTTATGTGGCTGGGCGTCTCCACATCTGGAGCCTCTGGAAAGATACCCTCGTGG
CGCGTGGTTATCAGTATGGTCAATACCCCCAGCTCGTGGCAGATAAAGTAGCCGCAAAAGCCTACGACGAGCGGCTATTA
CAATACAGTGCGGCGGAGCTAGAAATTGCCAATGGCTGGATCAATCCCGATTGGGATATGGATTATGATTATGCCGGAGC
GGTGTTACTGACAAAGCGTTATCTGCTGGATGATGAACTGCCCCAGGAAGCCTTTTTAACTTGTGCGCTCCTCCTGGCTC
TCCCGGAAAAACCAGAAAATCGGCTCAAGTGGGCGAAAAAATTCTACGAGGCGATCGCCCAGCGGCAGATTTCCTTAGCA
ACGCCGATCCTCGCCAACCTGCGGATTCCCAATGGCTCCCTTTCTTCCTGCTTCATCATTGGCATGGAAGACAACCTCGA
AAGTATTTTCCGCGAAATCACCAATGCCGCCCGGATCTCGAAAAATGGCGGCGGGGTCGGCTGTAATGTCAGTCGGATCC
GCGCCACGGGGAGCCGCGTGATGGGCAAGGCCAATGCCTCCGGGGGCGTTATTCCTTGGATTAAACTCCTCAACGATACG
GCGATCGCCGTTAATCAGGGGGGCCGCCGCGCCGGGGCGATTACTGTTTCCCTCGATGTGTGGCATTTAGATGTGCCAGA
ATTTCTCGAAATGCAGACCGAAAACGGGGATCAGCGGCGCAAAGCCTACGATGTCTTTCCCCAACTGGTAGTCACCGATG
AGTTCATGCGGCGGGTACAACACAAAGAAGCGTGGACTTTGGTGGATCCCTACGAAGTTAAAGAAAATCTCGGCATTGAT
CTCGCGGCCCTCTGGGGCGAAAAATTCGACGCGGCCTACCGTCAAATCGAAGCAAGCCTAGACCAAGACATTAAGCTCTA
CAAAAAAGTCGATGCCCGGCACCTGTTTAAGGAAATTATGCGATCGCAGATCGAAACTGGGATGCCCTACATCGCCTTTA
AAGACACCATCAACCGCGCTAACCCGAACCAACACGAGGGCTACATTCCTGGGGTCAACTTGTGCGTCGAATCTTTTTCC
AATGTGGTGCCGGGTCAGCTCGCCCACACCTGCAATCTCGACTCTTTAAACTTGGCGAATATTGAAGCTGATGAATTAGC
CGATGCCTGCGAAGTGGCGGTGCGCATCCTTGATAACACCATCGAAATTACCAACACTCCCTTTGAAGACAGCAGCATCC
ACAACCAGCGTTACCGCACCATTGGTGTGGGGGCGATGGGTTTGGCAGATTGGCTCGCGAAAAATAAGCTTTCCTATAAA
AATATTGAGGCCATTGATCGCCTCTTTGAAGACATTGGCTACTACTGCACCCGCACCTCTGTAAACCTCGCCCAAGAACG
GGGTGCTTACCCTGGGTTTCCGGGTAGTGAATGGAGTAAGGGACATCTGATTGGCGCGAAACCGATTACTTGGTATCGGG
AAAATGCCCACGCAGTAGACCGCTGGGAACGCCTCAGTGAAGATGTACGAAAGTACGGGATCCGCAATAGCCACATTACG
GCGATCGCCCCCAATACCTCCTCTTCCCTAGTGCAAGGTTGTAGCGCGAGTATTTTGCCGACCTACAGCAAATTTTTCTA
TGACAAATGGGCAAAAGGCACCGTTCCCATTGCCCCACCGTTTATCGGTAAATCTTTCTGGTTCTACCAAGAAAACAAAA
GCATGGATCAGCGTCTTGTGGTCAAAGCCGTTGCGACGATGCAAAAGTGGATCGATACGGGCATCTCGATGGAATTGATT
TTCAATCTCAACCAAGGCATTTATTTCCCGAACGAACCAGAACGGGCCTTAAAAGCAAAGGATATTTTTGAAATCTTGAT
GCTGGCTTGGGCTGAAGGTTGCAAGGCAATTTACTACATCCGCACCGTACAAAAAGATGATTTTAAAGAGGGATCAGAAG
GGTGTGTTGCCTGCGCGAATTAA

Upstream 100 bases:

>100_bases
TGTAAAAAAATTATTTGTTTCCCAAGCTTATCTAGTGTTAGTATATGCAGGCTTCCTGTTTTTCACCATAAATATGGTGC
TATCTCTGAACAGGATTTTT

Downstream 100 bases:

>100_bases
AAAACCTGTATCGACAACGATGGGCTGATCGGGCACTTTTGCTGACCATTGCGGTTCATTAAGCGCCTGGTGGGAAAGGG
ATCAGGGGTTTCGGGGAATT

Product: ribonucleotide reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 780; Mature: 779

Protein sequence:

>780_residues
MSLHPINPVCPMDLRQDTALSRSTPSATATYSASRAVTPTKPQTYVIKRSGKRAPLDVTRIRNVVQWACQDLEANTIELE
AGLKTRLKDGVTTREIQENLIQCALEMCSPEEPDWRYVAGRLHIWSLWKDTLVARGYQYGQYPQLVADKVAAKAYDERLL
QYSAAELEIANGWINPDWDMDYDYAGAVLLTKRYLLDDELPQEAFLTCALLLALPEKPENRLKWAKKFYEAIAQRQISLA
TPILANLRIPNGSLSSCFIIGMEDNLESIFREITNAARISKNGGGVGCNVSRIRATGSRVMGKANASGGVIPWIKLLNDT
AIAVNQGGRRAGAITVSLDVWHLDVPEFLEMQTENGDQRRKAYDVFPQLVVTDEFMRRVQHKEAWTLVDPYEVKENLGID
LAALWGEKFDAAYRQIEASLDQDIKLYKKVDARHLFKEIMRSQIETGMPYIAFKDTINRANPNQHEGYIPGVNLCVESFS
NVVPGQLAHTCNLDSLNLANIEADELADACEVAVRILDNTIEITNTPFEDSSIHNQRYRTIGVGAMGLADWLAKNKLSYK
NIEAIDRLFEDIGYYCTRTSVNLAQERGAYPGFPGSEWSKGHLIGAKPITWYRENAHAVDRWERLSEDVRKYGIRNSHIT
AIAPNTSSSLVQGCSASILPTYSKFFYDKWAKGTVPIAPPFIGKSFWFYQENKSMDQRLVVKAVATMQKWIDTGISMELI
FNLNQGIYFPNEPERALKAKDIFEILMLAWAEGCKAIYYIRTVQKDDFKEGSEGCVACAN

Sequences:

>Translated_780_residues
MSLHPINPVCPMDLRQDTALSRSTPSATATYSASRAVTPTKPQTYVIKRSGKRAPLDVTRIRNVVQWACQDLEANTIELE
AGLKTRLKDGVTTREIQENLIQCALEMCSPEEPDWRYVAGRLHIWSLWKDTLVARGYQYGQYPQLVADKVAAKAYDERLL
QYSAAELEIANGWINPDWDMDYDYAGAVLLTKRYLLDDELPQEAFLTCALLLALPEKPENRLKWAKKFYEAIAQRQISLA
TPILANLRIPNGSLSSCFIIGMEDNLESIFREITNAARISKNGGGVGCNVSRIRATGSRVMGKANASGGVIPWIKLLNDT
AIAVNQGGRRAGAITVSLDVWHLDVPEFLEMQTENGDQRRKAYDVFPQLVVTDEFMRRVQHKEAWTLVDPYEVKENLGID
LAALWGEKFDAAYRQIEASLDQDIKLYKKVDARHLFKEIMRSQIETGMPYIAFKDTINRANPNQHEGYIPGVNLCVESFS
NVVPGQLAHTCNLDSLNLANIEADELADACEVAVRILDNTIEITNTPFEDSSIHNQRYRTIGVGAMGLADWLAKNKLSYK
NIEAIDRLFEDIGYYCTRTSVNLAQERGAYPGFPGSEWSKGHLIGAKPITWYRENAHAVDRWERLSEDVRKYGIRNSHIT
AIAPNTSSSLVQGCSASILPTYSKFFYDKWAKGTVPIAPPFIGKSFWFYQENKSMDQRLVVKAVATMQKWIDTGISMELI
FNLNQGIYFPNEPERALKAKDIFEILMLAWAEGCKAIYYIRTVQKDDFKEGSEGCVACAN
>Mature_779_residues
SLHPINPVCPMDLRQDTALSRSTPSATATYSASRAVTPTKPQTYVIKRSGKRAPLDVTRIRNVVQWACQDLEANTIELEA
GLKTRLKDGVTTREIQENLIQCALEMCSPEEPDWRYVAGRLHIWSLWKDTLVARGYQYGQYPQLVADKVAAKAYDERLLQ
YSAAELEIANGWINPDWDMDYDYAGAVLLTKRYLLDDELPQEAFLTCALLLALPEKPENRLKWAKKFYEAIAQRQISLAT
PILANLRIPNGSLSSCFIIGMEDNLESIFREITNAARISKNGGGVGCNVSRIRATGSRVMGKANASGGVIPWIKLLNDTA
IAVNQGGRRAGAITVSLDVWHLDVPEFLEMQTENGDQRRKAYDVFPQLVVTDEFMRRVQHKEAWTLVDPYEVKENLGIDL
AALWGEKFDAAYRQIEASLDQDIKLYKKVDARHLFKEIMRSQIETGMPYIAFKDTINRANPNQHEGYIPGVNLCVESFSN
VVPGQLAHTCNLDSLNLANIEADELADACEVAVRILDNTIEITNTPFEDSSIHNQRYRTIGVGAMGLADWLAKNKLSYKN
IEAIDRLFEDIGYYCTRTSVNLAQERGAYPGFPGSEWSKGHLIGAKPITWYRENAHAVDRWERLSEDVRKYGIRNSHITA
IAPNTSSSLVQGCSASILPTYSKFFYDKWAKGTVPIAPPFIGKSFWFYQENKSMDQRLVVKAVATMQKWIDTGISMELIF
NLNQGIYFPNEPERALKAKDIFEILMLAWAEGCKAIYYIRTVQKDDFKEGSEGCVACAN

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=675, Percent_Identity=31.5555555555556, Blast_Score=285, Evalue=2e-76,
Organism=Escherichia coli, GI2367133, Length=760, Percent_Identity=28.9473684210526, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI1789030, Length=578, Percent_Identity=31.6608996539792, Blast_Score=236, Evalue=6e-63,
Organism=Caenorhabditis elegans, GI17555242, Length=674, Percent_Identity=31.1572700296736, Blast_Score=289, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6320914, Length=787, Percent_Identity=27.3189326556544, Blast_Score=272, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6322123, Length=781, Percent_Identity=28.9372599231754, Blast_Score=271, Evalue=3e-73,
Organism=Drosophila melanogaster, GI17352481, Length=660, Percent_Identity=29.5454545454545, Blast_Score=273, Evalue=3e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 87828; Mature: 87697

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE ; PS00583 PFKB_KINASES_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLHPINPVCPMDLRQDTALSRSTPSATATYSASRAVTPTKPQTYVIKRSGKRAPLDVTR
CCCCCCCCCCCCCCCCCHHHCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCCHHH
IRNVVQWACQDLEANTIELEAGLKTRLKDGVTTREIQENLIQCALEMCSPEEPDWRYVAG
HHHHHHHHHHCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
RLHIWSLWKDTLVARGYQYGQYPQLVADKVAAKAYDERLLQYSAAELEIANGWINPDWDM
EEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCC
DYDYAGAVLLTKRYLLDDELPQEAFLTCALLLALPEKPENRLKWAKKFYEAIAQRQISLA
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
TPILANLRIPNGSLSSCFIIGMEDNLESIFREITNAARISKNGGGVGCNVSRIRATGSRV
CHHHHEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHH
MGKANASGGVIPWIKLLNDTAIAVNQGGRRAGAITVSLDVWHLDVPEFLEMQTENGDQRR
CCCCCCCCCHHHHHHHHCCCEEEECCCCCEEEEEEEEEEEEECCCHHHHHHHCCCCHHHH
KAYDVFPQLVVTDEFMRRVQHKEAWTLVDPYEVKENLGIDLAALWGEKFDAAYRQIEASL
HHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHH
DQDIKLYKKVDARHLFKEIMRSQIETGMPYIAFKDTINRANPNQHEGYIPGVNLCVESFS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
NVVPGQLAHTCNLDSLNLANIEADELADACEVAVRILDNTIEITNTPFEDSSIHNQRYRT
CCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEE
IGVGAMGLADWLAKNKLSYKNIEAIDRLFEDIGYYCTRTSVNLAQERGAYPGFPGSEWSK
EECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEECCCCHHHHHCCCCCCCCCCCCCC
GHLIGAKPITWYRENAHAVDRWERLSEDVRKYGIRNSHITAIAPNTSSSLVQGCSASILP
CEEECCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCCH
TYSKFFYDKWAKGTVPIAPPFIGKSFWFYQENKSMDQRLVVKAVATMQKWIDTGISMELI
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
FNLNQGIYFPNEPERALKAKDIFEILMLAWAEGCKAIYYIRTVQKDDFKEGSEGCVACAN
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEECC
>Mature Secondary Structure 
SLHPINPVCPMDLRQDTALSRSTPSATATYSASRAVTPTKPQTYVIKRSGKRAPLDVTR
CCCCCCCCCCCCCCCCHHHCCCCCCCCEEECCCCCCCCCCCCEEEEECCCCCCCCCHHH
IRNVVQWACQDLEANTIELEAGLKTRLKDGVTTREIQENLIQCALEMCSPEEPDWRYVAG
HHHHHHHHHHCCCCCEEEEECCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEC
RLHIWSLWKDTLVARGYQYGQYPQLVADKVAAKAYDERLLQYSAAELEIANGWINPDWDM
EEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCC
DYDYAGAVLLTKRYLLDDELPQEAFLTCALLLALPEKPENRLKWAKKFYEAIAQRQISLA
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
TPILANLRIPNGSLSSCFIIGMEDNLESIFREITNAARISKNGGGVGCNVSRIRATGSRV
CHHHHEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCHHH
MGKANASGGVIPWIKLLNDTAIAVNQGGRRAGAITVSLDVWHLDVPEFLEMQTENGDQRR
CCCCCCCCCHHHHHHHHCCCEEEECCCCCEEEEEEEEEEEEECCCHHHHHHHCCCCHHHH
KAYDVFPQLVVTDEFMRRVQHKEAWTLVDPYEVKENLGIDLAALWGEKFDAAYRQIEASL
HHHHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHCCCCCHHHHHCHHHHHHHHHHHHHH
DQDIKLYKKVDARHLFKEIMRSQIETGMPYIAFKDTINRANPNQHEGYIPGVNLCVESFS
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHH
NVVPGQLAHTCNLDSLNLANIEADELADACEVAVRILDNTIEITNTPFEDSSIHNQRYRT
CCCCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCEE
IGVGAMGLADWLAKNKLSYKNIEAIDRLFEDIGYYCTRTSVNLAQERGAYPGFPGSEWSK
EECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCEEECCCCHHHHHCCCCCCCCCCCCCC
GHLIGAKPITWYRENAHAVDRWERLSEDVRKYGIRNSHITAIAPNTSSSLVQGCSASILP
CEEECCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCCH
TYSKFFYDKWAKGTVPIAPPFIGKSFWFYQENKSMDQRLVVKAVATMQKWIDTGISMELI
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEE
FNLNQGIYFPNEPERALKAKDIFEILMLAWAEGCKAIYYIRTVQKDDFKEGSEGCVACAN
EECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]