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The map label for this gene is trpA

Identifier: 170077187

GI number: 170077187

Start: 588795

End: 589589

Strand: Direct

Name: trpA

Synonym: SYNPCC7002_A0562

Alternate gene names: 170077187

Gene position: 588795-589589 (Clockwise)

Preceding gene: 170077186

Following gene: 170077191

Centisome position: 19.57

GC content: 54.59

Gene sequence:

>795_bases
ATGACCTCTGTTTCTGAACGTTTCCGATCCCTCAAGCAGGCGGGCCAATGTGCGCTGATTCCCTTCATTACAGCGGGTGA
TCCAGATTTAGAAACGACAGAACAGGCCCTCAAAATTTTAGACGCAGCCGGGGCTGATTTTATTGAACTCGGCGTCCCCT
ATTCTGATCCCCTCGCCGATGGGCCGACAATCCAAGCGGCGGCAACCAGGGCCTTGAGCCGGGGCGTCACCCTTGAGCAA
GTTTTAGCGATCGTGCAACGAGTCCATGGGCAATTAACAGCACCGATTATTTTATTCACCTATTACAATCCGATTTTTTA
TCGGGGCATTGATGCTTTTATGGCCCAAGTGGCAGCGGCGGGAGTCAAAGGTTTGGTGATCCCGGATCTGCCCCTAGAGG
AATCCCAGATGGTGCTGGATGCAGCAACAAGTCATGGTCTTGATTTGATTTTATTGGTGGCTCCCACCAGTCCCACGGAA
CGGATCGAGGCGATCGCCAAAGCATCCCAAGGTTTCATTTACCTCGTGAGTGTGACGGGGGTCACGGGGGCGAGAACCTC
TGTGGCCAGCCGTGTCGGGGAACTGTTGCCGAAGTTACGTCAAGTGACCGATAAGCCCATCGGGGTTGGTTTCGGGGTTT
CGGATCCAGCCCAGGCAAGACAGCTAAAAGAATGGGGCGCGGATGGCGTGATCGTCGGCAGTGCGGTAGTCAAACGCCTC
GCCACTGGAACGCCCGCCGAAGGTTTAGCGGCAGTCAAAGAATTTTGTGAGTCCCTCAAGGAAGCGATCGCCTAA

Upstream 100 bases:

>100_bases
ACGGAAGATCAAACTTCGCCAAAAAAGTAACGGCAATCTTTACCGAAGGGGGAGTTGGGGACGTACAATAACCCCTTGTG
TGTTTTTATCGAACAAAATC

Downstream 100 bases:

>100_bases
CGATGGGCCTGTTGTAGATCGAGAAAATGAAAGATCATTCGGGGTCAGTGACGTCTAAGGCCCCCCGAATAATCACCACT
GTGCGGTTTGTCCCCTTGGC

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MTSVSERFRSLKQAGQCALIPFITAGDPDLETTEQALKILDAAGADFIELGVPYSDPLADGPTIQAAATRALSRGVTLEQ
VLAIVQRVHGQLTAPIILFTYYNPIFYRGIDAFMAQVAAAGVKGLVIPDLPLEESQMVLDAATSHGLDLILLVAPTSPTE
RIEAIAKASQGFIYLVSVTGVTGARTSVASRVGELLPKLRQVTDKPIGVGFGVSDPAQARQLKEWGADGVIVGSAVVKRL
ATGTPAEGLAAVKEFCESLKEAIA

Sequences:

>Translated_264_residues
MTSVSERFRSLKQAGQCALIPFITAGDPDLETTEQALKILDAAGADFIELGVPYSDPLADGPTIQAAATRALSRGVTLEQ
VLAIVQRVHGQLTAPIILFTYYNPIFYRGIDAFMAQVAAAGVKGLVIPDLPLEESQMVLDAATSHGLDLILLVAPTSPTE
RIEAIAKASQGFIYLVSVTGVTGARTSVASRVGELLPKLRQVTDKPIGVGFGVSDPAQARQLKEWGADGVIVGSAVVKRL
ATGTPAEGLAAVKEFCESLKEAIA
>Mature_263_residues
TSVSERFRSLKQAGQCALIPFITAGDPDLETTEQALKILDAAGADFIELGVPYSDPLADGPTIQAAATRALSRGVTLEQV
LAIVQRVHGQLTAPIILFTYYNPIFYRGIDAFMAQVAAAGVKGLVIPDLPLEESQMVLDAATSHGLDLILLVAPTSPTER
IEAIAKASQGFIYLVSVTGVTGARTSVASRVGELLPKLRQVTDKPIGVGFGVSDPAQARQLKEWGADGVIVGSAVVKRLA
TGTPAEGLAAVKEFCESLKEAIA

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family

Homologues:

Organism=Escherichia coli, GI1787514, Length=270, Percent_Identity=40.7407407407407, Blast_Score=172, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321412, Length=258, Percent_Identity=40.6976744186046, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPA_SYNP2 (Q8KX32)

Other databases:

- EMBL:   AF381042
- EMBL:   CP000951
- RefSeq:   YP_001733825.1
- ProteinModelPortal:   Q8KX32
- SMR:   Q8KX32
- GeneID:   6055732
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A0562
- HOGENOM:   HBG391690
- OMA:   NPIYIYG
- ProtClustDB:   PRK13111
- HAMAP:   MF_00131
- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00262

Pfam domain/function: PF00290 Trp_syntA; SSF51366 RibP_bind_barrel

EC number: =4.2.1.20

Molecular weight: Translated: 27697; Mature: 27566

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: ACT_SITE 49-49 ACT_SITE 60-60

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSVSERFRSLKQAGQCALIPFITAGDPDLETTEQALKILDAAGADFIELGVPYSDPLAD
CCCHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
GPTIQAAATRALSRGVTLEQVLAIVQRVHGQLTAPIILFTYYNPIFYRGIDAFMAQVAAA
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEHHCHHHHHHHHHHHHHHHHH
GVKGLVIPDLPLEESQMVLDAATSHGLDLILLVAPTSPTERIEAIAKASQGFIYLVSVTG
CCCCEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEEECC
VTGARTSVASRVGELLPKLRQVTDKPIGVGFGVSDPAQARQLKEWGADGVIVGSAVVKRL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHH
ATGTPAEGLAAVKEFCESLKEAIA
HCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSVSERFRSLKQAGQCALIPFITAGDPDLETTEQALKILDAAGADFIELGVPYSDPLAD
CCHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCC
GPTIQAAATRALSRGVTLEQVLAIVQRVHGQLTAPIILFTYYNPIFYRGIDAFMAQVAAA
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEHHCHHHHHHHHHHHHHHHHH
GVKGLVIPDLPLEESQMVLDAATSHGLDLILLVAPTSPTERIEAIAKASQGFIYLVSVTG
CCCCEECCCCCCCHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHCCCEEEEEEECC
VTGARTSVASRVGELLPKLRQVTDKPIGVGFGVSDPAQARQLKEWGADGVIVGSAVVKRL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEHHHHHHHHH
ATGTPAEGLAAVKEFCESLKEAIA
HCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA