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The map label for this gene is purM

Identifier: 170076973

GI number: 170076973

Start: 363498

End: 364523

Strand: Direct

Name: purM

Synonym: SYNPCC7002_A0345

Alternate gene names: 170076973

Gene position: 363498-364523 (Clockwise)

Preceding gene: 170076970

Following gene: 170076974

Centisome position: 12.08

GC content: 55.65

Gene sequence:

>1026_bases
ATGGACTACCAACAAGCAGGAGTAGATATCGAAGCAGGGCGTTCCTTCGTCAAAACCATCAAGGATAACGTCGAAAGCAC
ATACCGACCGGGGGTACTGGGTGGCCTCGGTGGTTTTGGTGGCTGCTTTGAAATTCCCGCTGGCTATCGTCAACCGGTGC
TAATTTCCGGTACGGATGGGGTGGGCACAAAGCTCAAAATCGCCCACCAGACCGATCAGCACCACACCGTCGGCATTGAT
TTGGTGGCAATGTGTGTCAACGATATCCTCACCTCTGGGGCCGAACCGCTCTTTTTCCTCGACTATTTAGCGACGGGCAA
GCTCGAGCCTGAACAACTGGCCCAGGTGGTCGCCGGAATTGTTGAAGGGTGTAAGCAGAGTGGTTGTGCGCTTCTGGGGG
GCGAAACAGCGGAGATGCCGGGTTTTTACCAAGCAGGGGAATATGATCTTGCGGGCTTCTGTGTGGGGATCGTCGAAAAA
AGCGAAATTTTAGACGGCTCCCAAGTGCAGGTCGGCGATGTGGCGATCGCCTTACCCAGTAGCGGTGTCCACAGCAATGG
TTTTTCCCTAGTGCGGAAAATCATCGAAATGAATCAATTGTCCTGGGACGACAAGCCCGCAGCATTTCAGGGCAAAACCC
TCGGTGAAGTCTTCCTTACGCCCACCCAAATCTATGTCCAGGCGATCCAAGGTGCCCTCAAGGCCAAGATGGAAATCCAC
GGTATGGCCCACATCACCGGGGGCGGTCTCCCCGAAAATCTGCCCCGGTGTCTCCAAGCCAATCAATCCATGGCCATTGA
TCCGAGCACCTGGGAAATCCCCACCCTCTTCCAGTGGCTGCAAACCATGGGCGATGTCCCCCAAGCAGCCATGTGGGACA
CCTTCAATATGGGGGTGGGCTATGTGGTAATTGTGCCGGCCCCCAAAGCGGCGGAAAATGTTGCTTGGTTTAAGGCCCAG
GGGATCGCGGCTTGGCAAGTGGGTACGGTGGTCGCAGGTCAAGGGGAAGTCCTCGGGCTACAATAG

Upstream 100 bases:

>100_bases
AAATGGCAACGAATAAAGTTAAAGCACGGTAAAATCTGCTTTTCGAGTTTTGTCAGACTCGACAATTTCCCTTGACCAAT
TCATAAAGAATTTTTATCGC

Downstream 100 bases:

>100_bases
CTACGGTCATCCTTGCCAACGATTAATAGTTACTGATATTGGGTTTGAGTTCATGTTTTCCTCCTTCGACAATCAAGGCC
CGCAACCCAGGGAAAAATGG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MDYQQAGVDIEAGRSFVKTIKDNVESTYRPGVLGGLGGFGGCFEIPAGYRQPVLISGTDGVGTKLKIAHQTDQHHTVGID
LVAMCVNDILTSGAEPLFFLDYLATGKLEPEQLAQVVAGIVEGCKQSGCALLGGETAEMPGFYQAGEYDLAGFCVGIVEK
SEILDGSQVQVGDVAIALPSSGVHSNGFSLVRKIIEMNQLSWDDKPAAFQGKTLGEVFLTPTQIYVQAIQGALKAKMEIH
GMAHITGGGLPENLPRCLQANQSMAIDPSTWEIPTLFQWLQTMGDVPQAAMWDTFNMGVGYVVIVPAPKAAENVAWFKAQ
GIAAWQVGTVVAGQGEVLGLQ

Sequences:

>Translated_341_residues
MDYQQAGVDIEAGRSFVKTIKDNVESTYRPGVLGGLGGFGGCFEIPAGYRQPVLISGTDGVGTKLKIAHQTDQHHTVGID
LVAMCVNDILTSGAEPLFFLDYLATGKLEPEQLAQVVAGIVEGCKQSGCALLGGETAEMPGFYQAGEYDLAGFCVGIVEK
SEILDGSQVQVGDVAIALPSSGVHSNGFSLVRKIIEMNQLSWDDKPAAFQGKTLGEVFLTPTQIYVQAIQGALKAKMEIH
GMAHITGGGLPENLPRCLQANQSMAIDPSTWEIPTLFQWLQTMGDVPQAAMWDTFNMGVGYVVIVPAPKAAENVAWFKAQ
GIAAWQVGTVVAGQGEVLGLQ
>Mature_341_residues
MDYQQAGVDIEAGRSFVKTIKDNVESTYRPGVLGGLGGFGGCFEIPAGYRQPVLISGTDGVGTKLKIAHQTDQHHTVGID
LVAMCVNDILTSGAEPLFFLDYLATGKLEPEQLAQVVAGIVEGCKQSGCALLGGETAEMPGFYQAGEYDLAGFCVGIVEK
SEILDGSQVQVGDVAIALPSSGVHSNGFSLVRKIIEMNQLSWDDKPAAFQGKTLGEVFLTPTQIYVQAIQGALKAKMEIH
GMAHITGGGLPENLPRCLQANQSMAIDPSTWEIPTLFQWLQTMGDVPQAAMWDTFNMGVGYVVIVPAPKAAENVAWFKAQ
GIAAWQVGTVVAGQGEVLGLQ

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=335, Percent_Identity=48.3582089552239, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI209869995, Length=335, Percent_Identity=48.3582089552239, Blast_Score=309, Evalue=2e-84,
Organism=Homo sapiens, GI209869993, Length=335, Percent_Identity=48.3582089552239, Blast_Score=309, Evalue=2e-84,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=54.1666666666667, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17567511, Length=321, Percent_Identity=41.7445482866044, Blast_Score=232, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6321203, Length=333, Percent_Identity=48.6486486486487, Blast_Score=308, Evalue=8e-85,
Organism=Drosophila melanogaster, GI24582400, Length=302, Percent_Identity=45.6953642384106, Blast_Score=248, Evalue=3e-66,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_SYNP2 (B1XNH7)

Other databases:

- EMBL:   CP000951
- RefSeq:   YP_001733611.1
- ProteinModelPortal:   B1XNH7
- SMR:   B1XNH7
- GeneID:   6056914
- GenomeReviews:   CP000951_GR
- KEGG:   syp:SYNPCC7002_A0345
- HOGENOM:   HBG531222
- OMA:   HYDLAGF
- ProtClustDB:   PRK05385
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36161; Mature: 36161

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYQQAGVDIEAGRSFVKTIKDNVESTYRPGVLGGLGGFGGCFEIPAGYRQPVLISGTDG
CCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCEEEECCCC
VGTKLKIAHQTDQHHTVGIDLVAMCVNDILTSGAEPLFFLDYLATGKLEPEQLAQVVAGI
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHHH
VEGCKQSGCALLGGETAEMPGFYQAGEYDLAGFCVGIVEKSEILDGSQVQVGDVAIALPS
HHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHEEHHHHHHCCCCCCEEECEEEEECCC
SGVHSNGFSLVRKIIEMNQLSWDDKPAAFQGKTLGEVFLTPTQIYVQAIQGALKAKMEIH
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHE
GMAHITGGGLPENLPRCLQANQSMAIDPSTWEIPTLFQWLQTMGDVPQAAMWDTFNMGVG
EEEEECCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCC
YVVIVPAPKAAENVAWFKAQGIAAWQVGTVVAGQGEVLGLQ
EEEEECCCCCHHCCEEEEECCEEEEEECEEEECCCCEECCC
>Mature Secondary Structure
MDYQQAGVDIEAGRSFVKTIKDNVESTYRPGVLGGLGGFGGCFEIPAGYRQPVLISGTDG
CCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCEEEECCCC
VGTKLKIAHQTDQHHTVGIDLVAMCVNDILTSGAEPLFFLDYLATGKLEPEQLAQVVAGI
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCHHHHHHHHHHH
VEGCKQSGCALLGGETAEMPGFYQAGEYDLAGFCVGIVEKSEILDGSQVQVGDVAIALPS
HHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHEEHHHHHHCCCCCCEEECEEEEECCC
SGVHSNGFSLVRKIIEMNQLSWDDKPAAFQGKTLGEVFLTPTQIYVQAIQGALKAKMEIH
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHE
GMAHITGGGLPENLPRCLQANQSMAIDPSTWEIPTLFQWLQTMGDVPQAAMWDTFNMGVG
EEEEECCCCCHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCC
YVVIVPAPKAAENVAWFKAQGIAAWQVGTVVAGQGEVLGLQ
EEEEECCCCCHHCCEEEEECCEEEEEECEEEECCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA