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The map label for this gene is gnd [H]

Identifier: 170076852

GI number: 170076852

Start: 232392

End: 233810

Strand: Direct

Name: gnd [H]

Synonym: SYNPCC7002_A0221

Alternate gene names: 170076852

Gene position: 232392-233810 (Clockwise)

Preceding gene: 170076851

Following gene: 170076853

Centisome position: 7.73

GC content: 51.52

Gene sequence:

>1419_bases
ATGACTAAACGAACCTTTGGCGTCATCGGCCTCGCGGTAATGGGCGAAAACCTAGCCCTCAACGTTGAACGTAATGGCTT
CCCGATTGCCGTGTACAACCGCACCGCCAGCAAAACAGAAGAATTTATGGCGACCCGCGCCGTCGGCAAGGACATCAAAG
CCGCCTATAGCCTCGAAGAATTTGTCCAACTCCTCGAACGTCCCCGCAAAATTTTGGTGATGGTTAAAGCCGGGGCTCCC
GTTGACTATGTAATCAATGACCTCAAACCGCTTCTAGAAGAAGGCGACATGATCATTGATGGCGGTAATTCCCTCTATGA
AGACACTGAACGTCGCACCAAGGATCTTGAAGCCACGGGCTTAGGTTTTGTCGGCATGGGAGTCAGTGGTGGCGAAGAAG
GTGCCCTCAACGGCCCCAGTCTGATGCCCGGTGGGACAGAAGCCGCTTACAGGGAGCTCGAACCGATCCTGACAAAAGTT
GCCGCCCAGGTAAACGATGGCCCCTGCGTTACCTTTATTGGGCCAGGTGGTGCGGGTCACTACGTCAAAATGGTGCACAA
CGGCATTGAGTACGGTGATATGCAGCTGATCGCCGAAGCCTACGATCTCTTAGCAAACGCCGCAAAGCTAAACCATACGG
AACTCCATGAGGTCTTTACGGAATGGAATCAAACCGATGAGCTCAATTCTTTCTTAATTGAGATTACCGCTGATATTTTC
AAAAAAATTGACCCTGAAACCAATCAACCCCTGGTAGAACTAATCCTCGACAGTGCAGGGCAAAAGGGTACCGGACGCTG
GACAGTGGTGAGTTCCCTGGAGTTGGGTGTGCCAATTCCAACGATCTATGCCGCCGTGAATGCCCGCGTGATGTCAGCCT
ATAAAGATGAACGGAAAGCCGCATCCTTGGAGTTACCCTCACCGGAGCGCGTTTATCGGGGTGATATTAAAACCTTTATT
AACCAAGTACGGGATGCGTTGTATTGCTCGAAGATGTGTTCCTATGCCCAAGGAATGGCCCTGCTGGGTAAAGCTTCGGC
GGAGTATGGCTACAACCTAGACCTCGGTGAAACGGCGCGGATCTGGAAGGGGGGCTGTATCATTCGGGCGGGCTTCCTCG
ACAAGATTAAGGCGGCCTATGTGGAAAATCCGAATTTACCGAATTTGTTACTGGCGCCGGAATTTAAACAGTCAATTATT
GATCGCCAAACTGCGTGGCGGACAGTTATTTTGGCGGCAAATGAATTGGGGATTGCTGTACCAGCTTTTAGCGCCTCGTT
AGATTATTTTGATAGCTATCGTCGGGCGCGTTTACCCCAAAACCTGACCCAAGCCCAGCGGGATTACTTTGGGGCCCACA
CCTACGAACGAACCGATAAATCCCGGGGTGAGTTTTTCCATACGGCCTGGGCAGAGTAA

Upstream 100 bases:

>100_bases
ACGACAAATAATGACCGAATTCTGAGCAAGATCAGACCCACACGCTAACGTAAAAGAAAAGAAGACCTCACACGCTTAGA
AAAACAACTCAACACTCAAT

Downstream 100 bases:

>100_bases
GTCCTGTATTGGGCCAACAGATTCAATGAGCGGCTATTCATTTAGATGACCTAAATATTTTCCGCAAAACATTCTCCCTT
CTATCGACTGCGGTGGAAGG

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MTKRTFGVIGLAVMGENLALNVERNGFPIAVYNRTASKTEEFMATRAVGKDIKAAYSLEEFVQLLERPRKILVMVKAGAP
VDYVINDLKPLLEEGDMIIDGGNSLYEDTERRTKDLEATGLGFVGMGVSGGEEGALNGPSLMPGGTEAAYRELEPILTKV
AAQVNDGPCVTFIGPGGAGHYVKMVHNGIEYGDMQLIAEAYDLLANAAKLNHTELHEVFTEWNQTDELNSFLIEITADIF
KKIDPETNQPLVELILDSAGQKGTGRWTVVSSLELGVPIPTIYAAVNARVMSAYKDERKAASLELPSPERVYRGDIKTFI
NQVRDALYCSKMCSYAQGMALLGKASAEYGYNLDLGETARIWKGGCIIRAGFLDKIKAAYVENPNLPNLLLAPEFKQSII
DRQTAWRTVILAANELGIAVPAFSASLDYFDSYRRARLPQNLTQAQRDYFGAHTYERTDKSRGEFFHTAWAE

Sequences:

>Translated_472_residues
MTKRTFGVIGLAVMGENLALNVERNGFPIAVYNRTASKTEEFMATRAVGKDIKAAYSLEEFVQLLERPRKILVMVKAGAP
VDYVINDLKPLLEEGDMIIDGGNSLYEDTERRTKDLEATGLGFVGMGVSGGEEGALNGPSLMPGGTEAAYRELEPILTKV
AAQVNDGPCVTFIGPGGAGHYVKMVHNGIEYGDMQLIAEAYDLLANAAKLNHTELHEVFTEWNQTDELNSFLIEITADIF
KKIDPETNQPLVELILDSAGQKGTGRWTVVSSLELGVPIPTIYAAVNARVMSAYKDERKAASLELPSPERVYRGDIKTFI
NQVRDALYCSKMCSYAQGMALLGKASAEYGYNLDLGETARIWKGGCIIRAGFLDKIKAAYVENPNLPNLLLAPEFKQSII
DRQTAWRTVILAANELGIAVPAFSASLDYFDSYRRARLPQNLTQAQRDYFGAHTYERTDKSRGEFFHTAWAE
>Mature_471_residues
TKRTFGVIGLAVMGENLALNVERNGFPIAVYNRTASKTEEFMATRAVGKDIKAAYSLEEFVQLLERPRKILVMVKAGAPV
DYVINDLKPLLEEGDMIIDGGNSLYEDTERRTKDLEATGLGFVGMGVSGGEEGALNGPSLMPGGTEAAYRELEPILTKVA
AQVNDGPCVTFIGPGGAGHYVKMVHNGIEYGDMQLIAEAYDLLANAAKLNHTELHEVFTEWNQTDELNSFLIEITADIFK
KIDPETNQPLVELILDSAGQKGTGRWTVVSSLELGVPIPTIYAAVNARVMSAYKDERKAASLELPSPERVYRGDIKTFIN
QVRDALYCSKMCSYAQGMALLGKASAEYGYNLDLGETARIWKGGCIIRAGFLDKIKAAYVENPNLPNLLLAPEFKQSIID
RQTAWRTVILAANELGIAVPAFSASLDYFDSYRRARLPQNLTQAQRDYFGAHTYERTDKSRGEFFHTAWAE

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=51.4830508474576, Blast_Score=459, Evalue=1e-129,
Organism=Escherichia coli, GI1788341, Length=471, Percent_Identity=56.687898089172, Blast_Score=521, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17542558, Length=474, Percent_Identity=52.7426160337553, Blast_Score=495, Evalue=1e-140,
Organism=Saccharomyces cerevisiae, GI6321695, Length=452, Percent_Identity=51.5486725663717, Blast_Score=466, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6321977, Length=452, Percent_Identity=52.4336283185841, Blast_Score=456, Evalue=1e-129,
Organism=Drosophila melanogaster, GI24639279, Length=464, Percent_Identity=51.0775862068966, Blast_Score=440, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51977; Mature: 51846

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRTFGVIGLAVMGENLALNVERNGFPIAVYNRTASKTEEFMATRAVGKDIKAAYSLEE
CCCCHHHHEEHEEECCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHH
FVQLLERPRKILVMVKAGAPVDYVINDLKPLLEEGDMIIDGGNSLYEDTERRTKDLEATG
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCHHCC
LGFVGMGVSGGEEGALNGPSLMPGGTEAAYRELEPILTKVAAQVNDGPCVTFIGPGGAGH
CCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
YVKMVHNGIEYGDMQLIAEAYDLLANAAKLNHTELHEVFTEWNQTDELNSFLIEITADIF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
KKIDPETNQPLVELILDSAGQKGTGRWTVVSSLELGVPIPTIYAAVNARVMSAYKDERKA
HHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
ASLELPSPERVYRGDIKTFINQVRDALYCSKMCSYAQGMALLGKASAEYGYNLDLGETAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
IWKGGCIIRAGFLDKIKAAYVENPNLPNLLLAPEFKQSIIDRQTAWRTVILAANELGIAV
HCCCCEEEEECHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHEEEEEEECCCCEEE
PAFSASLDYFDSYRRARLPQNLTQAQRDYFGAHTYERTDKSRGEFFHTAWAE
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCCCEEHHCCCC
>Mature Secondary Structure 
TKRTFGVIGLAVMGENLALNVERNGFPIAVYNRTASKTEEFMATRAVGKDIKAAYSLEE
CCCHHHHEEHEEECCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHH
FVQLLERPRKILVMVKAGAPVDYVINDLKPLLEEGDMIIDGGNSLYEDTERRTKDLEATG
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHCCHHCC
LGFVGMGVSGGEEGALNGPSLMPGGTEAAYRELEPILTKVAAQVNDGPCVTFIGPGGAGH
CCEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCH
YVKMVHNGIEYGDMQLIAEAYDLLANAAKLNHTELHEVFTEWNQTDELNSFLIEITADIF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
KKIDPETNQPLVELILDSAGQKGTGRWTVVSSLELGVPIPTIYAAVNARVMSAYKDERKA
HHCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
ASLELPSPERVYRGDIKTFINQVRDALYCSKMCSYAQGMALLGKASAEYGYNLDLGETAR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
IWKGGCIIRAGFLDKIKAAYVENPNLPNLLLAPEFKQSIIDRQTAWRTVILAANELGIAV
HCCCCEEEEECHHHHHHHHHCCCCCCCCEEECCHHHHHHHHHHHHHEEEEEEECCCCEEE
PAFSASLDYFDSYRRARLPQNLTQAQRDYFGAHTYERTDKSRGEFFHTAWAE
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCCCCCEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]