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The map label for this gene is hexR [H]

Identifier: 170024369

GI number: 170024369

Start: 2365876

End: 2366781

Strand: Direct

Name: hexR [H]

Synonym: YPK_2135

Alternate gene names: 170024369

Gene position: 2365876-2366781 (Clockwise)

Preceding gene: 170024363

Following gene: 170024370

Centisome position: 50.45

GC content: 47.24

Gene sequence:

>906_bases
ATGAAATCGGTAAAACCCATGGGTGGCTCTCGTTATATGAATACGCTGGAAAATATCCAAAATAGTATGGACCTTCTGAG
CAAATCAGAAAGGAAAGTCGCCGAGGTAATCCTTGCCTCCCCGCAAACGGCCATCCATTCTAGTATCGCTACACTTGCCA
AAATGGCGAATGTCAGCGAACCGACAGTCAACCGTTTTTGCCGTCGTCTGGAGACCAAAGGTTTCCCTGATTTTAAACTG
CATTTGGCGCAAAGTCTGGCGAACGGTACACCCTATGTGAATCGTAACGTCGAAGAAGATGATAGTGTAGCTGCGTACAC
CGGAAAAATTTTTGAATCGACGATGGCCAGCTTGGACCGCGTAAAAAACAATCTGGATATCGCCGCCATTAACCGGGCTG
TCGATTTATTGACTCAAGCGAAAAAAATCTCGTTCTTTGGCCTGGGTTCCTCCGCTGCCGTTGCTCATGATGCGATGAAT
AAGTTTTTCCGCTTTAATATCCCGGTAATTTATTTCGATGACATCGTTATGCAACGCATGAGTTGTATGAACTCAAGCGA
AGGCGATGTGGTAGTGTTGATCTCCCACACAGGGCGAACCAAAAGCCTGGTGGAGCTGGCGCAGTTGGCTCGTGAAAATG
ATGCTGCCGTGATTGCCATAACTTCATGTGATACGCCACTGGCCAACGAAGCAACCTTATCGCTGTTGCTGGATGTGCCG
GAAGATACCGATATGTATATGCCAATGGTGTCACGCATCGCCCAGCTCACGTTGATTGATGTGCTGGCAACGGGCTTCAC
CCTACGGCGCGGAGCAAAATTTAGGGATAATTTGAAGCGGGTCAAAGAGGCATTGAAAGAATCTCGTTTTGATAAGGATT
CTTTGCCAGTAAACAACGGTGATTAA

Upstream 100 bases:

>100_bases
ATATTATGGTGAAAAAGGCTTACTTCTCACCCTATGCCACTGCCAACGGGTACCAGCTCGTAGTATATTTTCATTAAACC
GGCATAGATTTCTCCTTTAT

Downstream 100 bases:

>100_bases
CATCATGAGCGGAAGTCACGTTGCCTTGTGTTAGCGCATCTTTTGTCGTAATAACTTGACGTATTATTGAGAGATAATCG
TCGTCATGGCCCGGAGAGGG

Product: DNA-binding transcriptional regulator HexR

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKSVKPMGGSRYMNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRRLETKGFPDFKL
HLAQSLANGTPYVNRNVEEDDSVAAYTGKIFESTMASLDRVKNNLDIAAINRAVDLLTQAKKISFFGLGSSAAVAHDAMN
KFFRFNIPVIYFDDIVMQRMSCMNSSEGDVVVLISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVP
EDTDMYMPMVSRIAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNGD

Sequences:

>Translated_301_residues
MKSVKPMGGSRYMNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRRLETKGFPDFKL
HLAQSLANGTPYVNRNVEEDDSVAAYTGKIFESTMASLDRVKNNLDIAAINRAVDLLTQAKKISFFGLGSSAAVAHDAMN
KFFRFNIPVIYFDDIVMQRMSCMNSSEGDVVVLISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVP
EDTDMYMPMVSRIAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNGD
>Mature_301_residues
MKSVKPMGGSRYMNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRRLETKGFPDFKL
HLAQSLANGTPYVNRNVEEDDSVAAYTGKIFESTMASLDRVKNNLDIAAINRAVDLLTQAKKISFFGLGSSAAVAHDAMN
KFFRFNIPVIYFDDIVMQRMSCMNSSEGDVVVLISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVP
EDTDMYMPMVSRIAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=283, Percent_Identity=82.6855123674912, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI87082369, Length=238, Percent_Identity=25.6302521008403, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788767, Length=262, Percent_Identity=27.0992366412214, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI87082130, Length=195, Percent_Identity=29.2307692307692, Blast_Score=79, Evalue=2e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 33206; Mature: 33206

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVKPMGGSRYMNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
PTVNRFCRRLETKGFPDFKLHLAQSLANGTPYVNRNVEEDDSVAAYTGKIFESTMASLDR
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VKNNLDIAAINRAVDLLTQAKKISFFGLGSSAAVAHDAMNKFFRFNIPVIYFDDIVMQRM
HHCCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
SCMNSSEGDVVVLISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVP
HHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECC
EDTDMYMPMVSRIAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNG
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
D
C
>Mature Secondary Structure
MKSVKPMGGSRYMNTLENIQNSMDLLSKSERKVAEVILASPQTAIHSSIATLAKMANVSE
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
PTVNRFCRRLETKGFPDFKLHLAQSLANGTPYVNRNVEEDDSVAAYTGKIFESTMASLDR
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
VKNNLDIAAINRAVDLLTQAKKISFFGLGSSAAVAHDAMNKFFRFNIPVIYFDDIVMQRM
HHCCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHH
SCMNSSEGDVVVLISHTGRTKSLVELAQLARENDAAVIAITSCDTPLANEATLSLLLDVP
HHCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEECC
EDTDMYMPMVSRIAQLTLIDVLATGFTLRRGAKFRDNLKRVKEALKESRFDKDSLPVNNG
CCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]