Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 170023535

GI number: 170023535

Start: 1418581

End: 1419009

Strand: Direct

Name: ndk [H]

Synonym: YPK_1289

Alternate gene names: 170023535

Gene position: 1418581-1419009 (Clockwise)

Preceding gene: 170023534

Following gene: 170023536

Centisome position: 30.25

GC content: 47.55

Gene sequence:

>429_bases
ATGGCTTTAGAACGTACTTTCTCGATTATCAAACCAAACGCTGTTGCCAATAACAACATCGGTGCCATTTATGCGCGTTT
TGAAAGTGCTGGTTTCAAAATCATCGCCGCAAAGATGTTGCACCTGACCAAAGAACAGGCCGAAGGTTTTTACGCTGAAC
ATAAAGGCCGCCCGTTCTTTGATGGTTTGGTTGAATTTATGACCTCTGGCCCCATTATTGTTCAGGTTCTGGAAGGCGAA
AATGCAGTACAGCGCCATCGCGATATTATGGGGGCGACTAACCCAGATAATGCGCTGGCCGGTACGCTACGTGCTGATTT
TGCCGACAGCTTCACCGCGAATGCGGTACATGGCTCTGATGCTGTTGAATCTGCTCAACGCGAAATCGCGTATTTCTTTG
CGGCAGATGAAATTTTTCCCCGTAGCTAA

Upstream 100 bases:

>100_bases
CATCATTTTAGTGTAAAGGAACGGGCTGCCAGCCAAGTAAATACGCTTATCAGAGCAGGTTCCGAGTCCGGTTAATATTA
GAAATCCAATAGAGGTTATT

Downstream 100 bases:

>100_bases
TGCGTTAATTTAAGCGACTAGTGGGTTGATTCAATGCAGGAAAGTGGGGGGATTTAATCAACTGAAACAATAAAGTTGCC
CAGACCCGTTTCCATTCATG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 142; Mature: 141

Protein sequence:

>142_residues
MALERTFSIIKPNAVANNNIGAIYARFESAGFKIIAAKMLHLTKEQAEGFYAEHKGRPFFDGLVEFMTSGPIIVQVLEGE
NAVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSDAVESAQREIAYFFAADEIFPRS

Sequences:

>Translated_142_residues
MALERTFSIIKPNAVANNNIGAIYARFESAGFKIIAAKMLHLTKEQAEGFYAEHKGRPFFDGLVEFMTSGPIIVQVLEGE
NAVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSDAVESAQREIAYFFAADEIFPRS
>Mature_141_residues
ALERTFSIIKPNAVANNNIGAIYARFESAGFKIIAAKMLHLTKEQAEGFYAEHKGRPFFDGLVEFMTSGPIIVQVLEGEN
AVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSDAVESAQREIAYFFAADEIFPRS

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=45.5882352941176, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=44.1176470588235, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=44.1176470588235, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=44.1176470588235, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=44.1176470588235, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=44.1176470588235, Blast_Score=132, Evalue=1e-31,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=41.9117647058824, Blast_Score=126, Evalue=7e-30,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=41.9117647058824, Blast_Score=125, Evalue=9e-30,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=37.037037037037, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=41.9117647058824, Blast_Score=98, Evalue=2e-21,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=34.8148148148148, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=34.8148148148148, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI4505413, Length=139, Percent_Identity=33.8129496402878, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=35.7664233576642, Blast_Score=79, Evalue=9e-16,
Organism=Homo sapiens, GI148839372, Length=137, Percent_Identity=31.3868613138686, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1788866, Length=142, Percent_Identity=78.169014084507, Blast_Score=236, Evalue=5e-64,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=45.1851851851852, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=44.4444444444444, Blast_Score=132, Evalue=2e-32,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=48.1481481481481, Blast_Score=139, Evalue=5e-34,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=38.0597014925373, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15527; Mature: 15395

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALERTFSIIKPNAVANNNIGAIYARFESAGFKIIAAKMLHLTKEQAEGFYAEHKGRPFF
CCCCHHHHEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHH
DGLVEFMTSGPIIVQVLEGENAVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
AVESAQREIAYFFAADEIFPRS
HHHHHHHHHHHHEECCCCCCCC
>Mature Secondary Structure 
ALERTFSIIKPNAVANNNIGAIYARFESAGFKIIAAKMLHLTKEQAEGFYAEHKGRPFF
CCCHHHHEECCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHCCCCCHH
DGLVEFMTSGPIIVQVLEGENAVQRHRDIMGATNPDNALAGTLRADFADSFTANAVHGSD
HHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
AVESAQREIAYFFAADEIFPRS
HHHHHHHHHHHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA