Click here to switch to the map view.

The map label for this gene is slrP [H]

Identifier: 170022994

GI number: 170022994

Start: 819734

End: 820639

Strand: Reverse

Name: slrP [H]

Synonym: YPK_0745

Alternate gene names: 170022994

Gene position: 820639-819734 (Counterclockwise)

Preceding gene: 170022995

Following gene: 170022993

Centisome position: 17.5

GC content: 46.69

Gene sequence:

>906_bases
ATGCCGAACATCGAGCCAGACCGTGAAATCCATTCTGCACGGACATCAACAGCAGCCTTAACTCCGGCTGACTATTATGC
AATATGGGAAAAATGGGAAAATGATCCAAGAACTGTTGCTGGTGAACAACGGGGCCAGGCCGTAGCGAGAATGAAAGAGT
GTTTGGAAAACAGTGCAGATTATCTCGATCTCGATGAGCTTGGTTTGACCTCATTACCCGACACCCTGCCGCCGTGTAAT
GAACTGAATATTATGGCTAATAATTTAACTGAGTTGCCGACAACACTGCCAGACAACCTGCAAGAACTGAATGCTTATTA
TAATCAACTGCGTACATTACCGAATACATTACCGGCCTCGCTGTTATTTCTAAAGGTGTACAGAAATGAACTGGAACGAC
TCCCTGAGTTACTGCCTGAAGGGCTGAAAGCATTAAATGTTGGTCATAATACGTCACTGCAACTCCCAAACCGCTGGCCC
CCGGTTCTGGAGTCTCTTGGTATTGCAAACTGTAACTTAACTGAACTGCCTACACTGCCGAACAGTTTGAAAGGACTGGA
GGCGGAGGGTAATCAACTGCGCACATTGCCCGAGACATTGCCGATATCGCTGTTAATATTAGATGTGTCCGGTAATCAAC
TCACACAACTCCCCGAGACATTGCCCGCCTCGCTGTCACTTTTAATGGTAAAGGGTAATAGCCTCACAGCACTACCGGAA
AATTTACCCGGTAGTTTAAAGTGTATAAACGCTCAATATAATCAATTATCCCAGCTTCCCGACCTGGCCCATCTGCGCCA
AAATTGTAACATTTGCTTAGACGGTAACCCTCTTTCTCCCAGCACGCTGCTGGCACTACTACGTCTCAGTACTAACCCGA
ATTATCAGGGGCCACGGATTAGCTGA

Upstream 100 bases:

>100_bases
CCACCCCCTGTTATTTATCAGCCAAAATAATACCTCTAAGGCTTATTAAGGGAGCGGTTTTAATACAATGAATCTATCAA
ATATAATGTCGAACGTGTCA

Downstream 100 bases:

>100_bases
ATCGACTTAAACAATATACAAAAGCAGTCATGAATCATCGGGGCTAGAAGGGAAAGTATGATGAAAAATCACCTGAACTG
ATGGCGCGTGGCCGGGAGAT

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MPNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENSADYLDLDELGLTSLPDTLPPCN
ELNIMANNLTELPTTLPDNLQELNAYYNQLRTLPNTLPASLLFLKVYRNELERLPELLPEGLKALNVGHNTSLQLPNRWP
PVLESLGIANCNLTELPTLPNSLKGLEAEGNQLRTLPETLPISLLILDVSGNQLTQLPETLPASLSLLMVKGNSLTALPE
NLPGSLKCINAQYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTNPNYQGPRIS

Sequences:

>Translated_301_residues
MPNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENSADYLDLDELGLTSLPDTLPPCN
ELNIMANNLTELPTTLPDNLQELNAYYNQLRTLPNTLPASLLFLKVYRNELERLPELLPEGLKALNVGHNTSLQLPNRWP
PVLESLGIANCNLTELPTLPNSLKGLEAEGNQLRTLPETLPISLLILDVSGNQLTQLPETLPASLSLLMVKGNSLTALPE
NLPGSLKCINAQYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTNPNYQGPRIS
>Mature_300_residues
PNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENSADYLDLDELGLTSLPDTLPPCNE
LNIMANNLTELPTTLPDNLQELNAYYNQLRTLPNTLPASLLFLKVYRNELERLPELLPEGLKALNVGHNTSLQLPNRWPP
VLESLGIANCNLTELPTLPNSLKGLEAEGNQLRTLPETLPISLLILDVSGNQLTQLPETLPASLSLLMVKGNSLTALPEN
LPGSLKCINAQYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTNPNYQGPRIS

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 33192; Mature: 33061

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENSAD
CCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
YLDLDELGLTSLPDTLPPCNELNIMANNLTELPTTLPDNLQELNAYYNQLRTLPNTLPAS
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
LLFLKVYRNELERLPELLPEGLKALNVGHNTSLQLPNRWPPVLESLGIANCNLTELPTLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCCC
NSLKGLEAEGNQLRTLPETLPISLLILDVSGNQLTQLPETLPASLSLLMVKGNSLTALPE
CHHCCCCCCCCHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCEEECCC
NLPGSLKCINAQYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTNPNYQGPRI
CCCCCEEEECHHHHHHHHCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
S
C
>Mature Secondary Structure 
PNIEPDREIHSARTSTAALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENSAD
CCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
YLDLDELGLTSLPDTLPPCNELNIMANNLTELPTTLPDNLQELNAYYNQLRTLPNTLPAS
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
LLFLKVYRNELERLPELLPEGLKALNVGHNTSLQLPNRWPPVLESLGIANCNLTELPTLP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHCCCCCCCCCCCCCCC
NSLKGLEAEGNQLRTLPETLPISLLILDVSGNQLTQLPETLPASLSLLMVKGNSLTALPE
CHHCCCCCCCCHHHCCCCCCCEEEEEEECCCCHHHHHHHHHCCCEEEEEEECCCEEECCC
NLPGSLKCINAQYNQLSQLPDLAHLRQNCNICLDGNPLSPSTLLALLRLSTNPNYQGPRI
CCCCCEEEECHHHHHHHHCHHHHHHHHCCCEEECCCCCCHHHHHHHHHHCCCCCCCCCCC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]