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The map label for this gene is slrP [H]

Identifier: 170022993

GI number: 170022993

Start: 817304

End: 819172

Strand: Reverse

Name: slrP [H]

Synonym: YPK_0744

Alternate gene names: 170022993

Gene position: 819172-817304 (Counterclockwise)

Preceding gene: 170022994

Following gene: 170022990

Centisome position: 17.47

GC content: 46.12

Gene sequence:

>1869_bases
ATGAATCTATCAAATATAACCTCGAACACACCAATGCCGAACATAGGGCCAGACCGTGAAATCCATGCTGACCGGGCAGC
AGCAACAACCTTAACTTCGGCTGACTATCATGCAATATGGGAAAAGTGGGAAAGCGAGGCGATACCGGGTGCTAACGAAC
AGCGGGGCCAAGCAGTAGCAAGAATGAAAGAGTGTTTGGAAAACAATGCCGATAAACTCAATCTACATAACCTTGATTTG
ACCTCATTGCCAGATACCCTACCACCTTGTAACGAACTGGAGATATCGAACAATAACATCACTGAGTTGCCTACTTTGCC
AAACAACCTGCAAAGGTTGATGGCAATCTGTAATCAACTGCGTACATTACCCGATACATTACCTGAACATCTATTATCTC
TATATGTGATCTCGAATAAACTCGAACGGCTCCCCGAGAACCTGCCAGAGAGTCTCAATACATTAAATGTTTGCGATAAT
CCGTCACTGCAATTCCCAAACAACTGGCCTTCGAATCTGATGTATCTTAACATTGCAGACTGTGAATTAACTGAACTGCC
TACACTGCCGAACACCTTGACAGAACTGTATGCGGATTTTAATCAACTGCGCACATTGCCCGATACATTGCCGACATCAC
TATTAAAGCTAAGTGTGACCAGTAATCAATTCACACAACTCCCTGAGACATTGCCCGCCTCTCTGTCATTTTTAATGGTA
TTGGGCAATAGTCTCACCGCACTACCGGAAAATTTACCTAGTAGCTTAAGCTGTATCGGCGCTGAATATAATCAATTTTC
CCAACTTCCCGATCTAGCACGTCTGCCCCAAAACTGCGAACTTCTCTTGGAAGGTAACCCTCTTTCTGCCAGCACGCTGT
TGGCACTACAGCATCTCCGTACTAACCCGTATTATCAGGGGCCACAGATTATCTGCCGCGAATTAGACGATCTCCCCCCC
GCGAGTCTCAGTAATATTGTTGCCATCTGGTTGGTTCCCGAACAACAAAACACGTTGGCAGGAGATTGGGCAAATATCGA
GACAGAAGCTAACTCAGCTGCTTTTAGCGTTTTTCTTCACCGTTTGGCTACCACTAAAAACACAGAAAACATCCCTGAAT
TTAAACAACAAATTGCGGCATGGTTGTTGCAACTGGCTGGCTCACCGACTCTACGTGAGCAGACCTTTCTTATCGCTCAG
GAAGCAAGCGCGACCTGTGAAGACCGCATTACCTTGACCTATAACGATATGCAAAAGGCAGTCATGCTCCATGAGGTCGA
AAAGGGACAATATGACACGCAATTACCTGAACTGATGGCGCGTGGCCGGGAGATGTTCCGTCTGGAACAACTTGAGAATA
TTGCCCGCGAAAAAGTAAAAATACTAAAAACACTGAATGTACATTCTGTCGACGACATCGAAGTCTATCTTGCCTATCAG
GTTAAACTACGTGAGTCCTTAGAACTTTTCTCAGTAAGCAAAGAAATGCGCTTCTTTGGCGTATCGCATGTGACAGAAGA
CGATTTACTGAGCGCAGAAAAGAGGGTGAAAACCACGGAAAACCACGATTTCCCGCGCTGGCTATCACAATGGTCCCCAT
GGAAAAGCGTGGTGCAACGTATTGAGCCTGAACGTTATGCTGCTGCGGTCAAAAGGCAATACAGCGCACTGGAGAATATT
TACCCAGATAAACTGGCGGCTGAGCTGGCCGCCAACGGGATGACGGGCGATGTGGATGCCAACCGCATTGTCGGCAAAAG
AATCAACGATGAGATAATGGGGGAGATCGATATGGCCCTGACTCATGAGGTTCTCTCTGCCAAAGGAGCCATCTCCTTAT
TAGATAGTCAGTGGATGGAATATATCTAA

Upstream 100 bases:

>100_bases
CCAGTAAGCTGAAAATACCAGTAGTAGACCTTATGCATCCCCTGTTATTTATCAGCCAAAATAACGCCTCTAAGACTTAT
TAAGGGAGCGGTTTAATACA

Downstream 100 bases:

>100_bases
TCTCGCCTTAATACTGCACGGCCCGCTATGCCATAAAAAACGGCGCATATTCTGTCCTGCAATATGCGCCGTTGATCACC
ACCATGTCGTTAGTGGCTAA

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 622; Mature: 622

Protein sequence:

>622_residues
MNLSNITSNTPMPNIGPDREIHADRAAATTLTSADYHAIWEKWESEAIPGANEQRGQAVARMKECLENNADKLNLHNLDL
TSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQLRTLPDTLPEHLLSLYVISNKLERLPENLPESLNTLNVCDN
PSLQFPNNWPSNLMYLNIADCELTELPTLPNTLTELYADFNQLRTLPDTLPTSLLKLSVTSNQFTQLPETLPASLSFLMV
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCELLLEGNPLSASTLLALQHLRTNPYYQGPQIICRELDDLPP
ASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLHRLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQ
EASATCEDRITLTYNDMQKAVMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQRIEPERYAAAVKRQYSALENI
YPDKLAAELAANGMTGDVDANRIVGKRINDEIMGEIDMALTHEVLSAKGAISLLDSQWMEYI

Sequences:

>Translated_622_residues
MNLSNITSNTPMPNIGPDREIHADRAAATTLTSADYHAIWEKWESEAIPGANEQRGQAVARMKECLENNADKLNLHNLDL
TSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQLRTLPDTLPEHLLSLYVISNKLERLPENLPESLNTLNVCDN
PSLQFPNNWPSNLMYLNIADCELTELPTLPNTLTELYADFNQLRTLPDTLPTSLLKLSVTSNQFTQLPETLPASLSFLMV
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCELLLEGNPLSASTLLALQHLRTNPYYQGPQIICRELDDLPP
ASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLHRLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQ
EASATCEDRITLTYNDMQKAVMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQRIEPERYAAAVKRQYSALENI
YPDKLAAELAANGMTGDVDANRIVGKRINDEIMGEIDMALTHEVLSAKGAISLLDSQWMEYI
>Mature_622_residues
MNLSNITSNTPMPNIGPDREIHADRAAATTLTSADYHAIWEKWESEAIPGANEQRGQAVARMKECLENNADKLNLHNLDL
TSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQLRTLPDTLPEHLLSLYVISNKLERLPENLPESLNTLNVCDN
PSLQFPNNWPSNLMYLNIADCELTELPTLPNTLTELYADFNQLRTLPDTLPTSLLKLSVTSNQFTQLPETLPASLSFLMV
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCELLLEGNPLSASTLLALQHLRTNPYYQGPQIICRELDDLPP
ASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLHRLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQ
EASATCEDRITLTYNDMQKAVMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQRIEPERYAAAVKRQYSALENI
YPDKLAAELAANGMTGDVDANRIVGKRINDEIMGEIDMALTHEVLSAKGAISLLDSQWMEYI

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 70000; Mature: 70000

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLSNITSNTPMPNIGPDREIHADRAAATTLTSADYHAIWEKWESEAIPGANEQRGQAVA
CCCCCCCCCCCCCCCCCCCCHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
RMKECLENNADKLNLHNLDLTSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQL
HHHHHHHCCCCEEEEECCCHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
RTLPDTLPEHLLSLYVISNKLERLPENLPESLNTLNVCDNPSLQFPNNWPSNLMYLNIAD
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECC
CELTELPTLPNTLTELYADFNQLRTLPDTLPTSLLKLSVTSNQFTQLPETLPASLSFLMV
CCHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCHHHHHCHHHHHHHHHHHHH
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCELLLEGNPLSASTLLALQHLR
HCCCHHHHHHCCCCHHHHHCCCHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
TNPYYQGPQIICRELDDLPPASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLH
CCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
RLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQEASATCEDRITLTYNDMQKA
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCCCCCCCEEEEHHHHHHH
VMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEH
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHH
IEPERYAAAVKRQYSALENIYPDKLAAELAANGMTGDVDANRIVGKRINDEIMGEIDMAL
HCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHH
THEVLSAKGAISLLDSQWMEYI
HHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNLSNITSNTPMPNIGPDREIHADRAAATTLTSADYHAIWEKWESEAIPGANEQRGQAVA
CCCCCCCCCCCCCCCCCCCCHHCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHHHHH
RMKECLENNADKLNLHNLDLTSLPDTLPPCNELEISNNNITELPTLPNNLQRLMAICNQL
HHHHHHHCCCCEEEEECCCHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHH
RTLPDTLPEHLLSLYVISNKLERLPENLPESLNTLNVCDNPSLQFPNNWPSNLMYLNIAD
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECC
CELTELPTLPNTLTELYADFNQLRTLPDTLPTSLLKLSVTSNQFTQLPETLPASLSFLMV
CCHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHEEEECCHHHHHCHHHHHHHHHHHHH
LGNSLTALPENLPSSLSCIGAEYNQFSQLPDLARLPQNCELLLEGNPLSASTLLALQHLR
HCCCHHHHHHCCCCHHHHHCCCHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHH
TNPYYQGPQIICRELDDLPPASLSNIVAIWLVPEQQNTLAGDWANIETEANSAAFSVFLH
CCCCCCCHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHH
RLATTKNTENIPEFKQQIAAWLLQLAGSPTLREQTFLIAQEASATCEDRITLTYNDMQKA
HHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHEEEECCCCCCCCCCEEEEHHHHHHH
VMLHEVEKGQYDTQLPELMARGREMFRLEQLENIAREKVKILKTLNVHSVDDIEVYLAYQ
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEH
VKLRESLELFSVSKEMRFFGVSHVTEDDLLSAEKRVKTTENHDFPRWLSQWSPWKSVVQR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHH
IEPERYAAAVKRQYSALENIYPDKLAAELAANGMTGDVDANRIVGKRINDEIMGEIDMAL
HCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHH
THEVLSAKGAISLLDSQWMEYI
HHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]