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The map label for this gene is slrP [H]

Identifier: 170022995

GI number: 170022995

Start: 820886

End: 822733

Strand: Reverse

Name: slrP [H]

Synonym: YPK_0746

Alternate gene names: 170022995

Gene position: 822733-820886 (Counterclockwise)

Preceding gene: 170022996

Following gene: 170022994

Centisome position: 17.54

GC content: 46.43

Gene sequence:

>1848_bases
ATGCCGAACATAGGACCAGACCGTGAAATCCATGCTGACCGGGCAGCAGCAACAGCCTTAACTCCGGCTGACTATTATGC
AATATGGGAAAAATGGGAAAATGATCCAAGAACTGTTGCTGGTGAACAACGGGGCCAGGCCGTAGCGAGAATGAAAGAGT
GTTTGGAAAACAATACCGAACGCCTCGATCTCGATGAGCTTGGTTTGACCTCATTACCCGACACCCTGCCGCCGTGTAAT
GAACTGAATATTATGGCTAATAATTTAACTGAGTTGCCGACAACACTGCCCGACAACCTGCAAAAACTGAATGTTTCTTT
TAATCAACTGCGTGCATTACCGAATACATTACCGGCCTCGCTGTTATCTCTAAATGTGTTTATGAATAAACTGGAACGGC
TCCCTGAGTCGCTACCTGAAGGGCTAAAAGAATTAGACGTTAATGATAATGAGTCACTGCAACTCCCAAATCGCTTGCCC
CAGAATCTGGAGTCTCTTGGTATTGTAAGCTGTGGCTTAACTGAACTGCCTACACTGCCGAACAGTTTGAAAAGACTGGA
TGCGGATAGTAATCAACTGCGCACATTGCCCGAGACATTGCCAATATCGCTGTTAAGGTTAAGTGTAACCAGTAATCAAC
TCACACAACTCCCCGAGACATTGCCCGCCTCGCTGTCACTTTTAATGGTATTGGGCAATAGGCTCACCGCACTACCGGAA
AATTTACCCGGTAGTTTAAGATGTATCAGCGCTGAATATAATCAATTATCCCAACTTCCCGACCTGGCCCGTCTGCCCCA
AAACTGTGAAATTCTCTTGGAAGGTAACCCTCTTTCTACCAGCACACTGCAGGTACTACAACATCTCCGTACTAACCCGT
ATTATCAGGGGCCACGGATTAACTGCAGCGAATTAGACAATCTACCACCAGCGAGTCTCAGTAACATTGTTGCCACCTGG
TTGCCGCCGGAACAACAAAATAGGTTGGCAGGAGATTGGGCAAATATCGAGACAGAAGCTAACTCAGCCGCTTTTAGCGT
TTTTCTTCACCGTTTGACTACAACTCAAAACGCAAATAATATCCCTGAATTTAAACAACAAATTGCGGCATGGTTGTTGC
AACTGGCTGACTCACCTACTCTACGTGAGCAGACCTTTCTTATTGCTCAGGAAGCAAGCGCGACCTGTGAAGACCGCATT
ACCTTGACGCATAACGATATGCAAAAGGCAGTCATGCTCCATGAGGTCGAAAAGGGGAAATATGATGAAAAACTACCTGA
ACTGATGGCGCGTGGCCGAGAGATGTTCCGTCTGGAACAACTTGAGAATATTGCCCGCGAAAAAGTAAAAATACTAAAAA
CACTGAATGTAAATTCAGTCGATGATATCGAAGTCTATCTCGCCTATCAGGTCAAACTGCTCAATTCCTTACAGCTCTCC
TCGGTAAACAAAGAAATGCGCTTCTTTGGCGTATCACATGTGACAGCAGACGATTTACTGAGCGCAGAAACCCGGGTGAA
AACTGCGGAAAACCACGATTTCTCACGCTGGCTATCACAATGGTCCCCGTGGAAAAGCGTGGTGCAACGTATTGAGCCTG
AACGTTATGCTGCTGCGGTCGAAAAGCAGTACCACGCACTGGAAAATATTTACCCAGATAAACTGGCGGCTGAATTGGCC
GCCAACGGGATGACGGGCGATGTGGATGCCAACCGCATTGTCGGCAAAAGAATCAACGATGAGATAATGGAGGAGATCGA
TATGGCCCTGACTCATGAGGTTCTCTCTGCCAAAGGAGCCTCCTCCTTATTAGATAATCTGTGGATGGAATCTCTAATCT
CGTTTTAA

Upstream 100 bases:

>100_bases
CCACCCCCTGTTATTTATCAGCCAAAATAATGCTTCTAAAGCTTATTAAGGGAGTGGTTTTAATACAATGTCTCTATCAA
ATGTAACCTCGTACATGTCA

Downstream 100 bases:

>100_bases
TACTACACAACCCGTTATCCCATAAAAACGGCGCATATTCTGTCCTGCAATATGCGCCGCAGATAGGTCATTCTTCACCC
TCCACACCTCCCGCTCTTTT

Product: leucine-rich repeat-containing protein

Products: NA

Alternate protein names: Secreted effector protein slrP [H]

Number of amino acids: Translated: 615; Mature: 614

Protein sequence:

>615_residues
MPNIGPDREIHADRAAATALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENNTERLDLDELGLTSLPDTLPPCN
ELNIMANNLTELPTTLPDNLQKLNVSFNQLRALPNTLPASLLSLNVFMNKLERLPESLPEGLKELDVNDNESLQLPNRLP
QNLESLGIVSCGLTELPTLPNSLKRLDADSNQLRTLPETLPISLLRLSVTSNQLTQLPETLPASLSLLMVLGNRLTALPE
NLPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHLRTNPYYQGPRINCSELDNLPPASLSNIVATW
LPPEQQNRLAGDWANIETEANSAAFSVFLHRLTTTQNANNIPEFKQQIAAWLLQLADSPTLREQTFLIAQEASATCEDRI
TLTHNDMQKAVMLHEVEKGKYDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAYQVKLLNSLQLS
SVNKEMRFFGVSHVTADDLLSAETRVKTAENHDFSRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALENIYPDKLAAELA
ANGMTGDVDANRIVGKRINDEIMEEIDMALTHEVLSAKGASSLLDNLWMESLISF

Sequences:

>Translated_615_residues
MPNIGPDREIHADRAAATALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENNTERLDLDELGLTSLPDTLPPCN
ELNIMANNLTELPTTLPDNLQKLNVSFNQLRALPNTLPASLLSLNVFMNKLERLPESLPEGLKELDVNDNESLQLPNRLP
QNLESLGIVSCGLTELPTLPNSLKRLDADSNQLRTLPETLPISLLRLSVTSNQLTQLPETLPASLSLLMVLGNRLTALPE
NLPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHLRTNPYYQGPRINCSELDNLPPASLSNIVATW
LPPEQQNRLAGDWANIETEANSAAFSVFLHRLTTTQNANNIPEFKQQIAAWLLQLADSPTLREQTFLIAQEASATCEDRI
TLTHNDMQKAVMLHEVEKGKYDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAYQVKLLNSLQLS
SVNKEMRFFGVSHVTADDLLSAETRVKTAENHDFSRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALENIYPDKLAAELA
ANGMTGDVDANRIVGKRINDEIMEEIDMALTHEVLSAKGASSLLDNLWMESLISF
>Mature_614_residues
PNIGPDREIHADRAAATALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENNTERLDLDELGLTSLPDTLPPCNE
LNIMANNLTELPTTLPDNLQKLNVSFNQLRALPNTLPASLLSLNVFMNKLERLPESLPEGLKELDVNDNESLQLPNRLPQ
NLESLGIVSCGLTELPTLPNSLKRLDADSNQLRTLPETLPISLLRLSVTSNQLTQLPETLPASLSLLMVLGNRLTALPEN
LPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHLRTNPYYQGPRINCSELDNLPPASLSNIVATWL
PPEQQNRLAGDWANIETEANSAAFSVFLHRLTTTQNANNIPEFKQQIAAWLLQLADSPTLREQTFLIAQEASATCEDRIT
LTHNDMQKAVMLHEVEKGKYDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAYQVKLLNSLQLSS
VNKEMRFFGVSHVTADDLLSAETRVKTAENHDFSRWLSQWSPWKSVVQRIEPERYAAAVEKQYHALENIYPDKLAAELAA
NGMTGDVDANRIVGKRINDEIMEEIDMALTHEVLSAKGASSLLDNLWMESLISF

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host TXN (Thioredoxin).

COG id: COG4886

COG function: function code S; Leucine-rich repeat (LRR) protein

Gene ontology:

Cell location: Secreted. Host cytoplasm. Note=Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 10 LRR (leucine-rich) repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001611 [H]

Pfam domain/function: PF00560 LRR_1 [H]

EC number: NA

Molecular weight: Translated: 68941; Mature: 68810

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNIGPDREIHADRAAATALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENNTE
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
RLDLDELGLTSLPDTLPPCNELNIMANNLTELPTTLPDNLQKLNVSFNQLRALPNTLPAS
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHCCHHHHHH
LLSLNVFMNKLERLPESLPEGLKELDVNDNESLQLPNRLPQNLESLGIVSCGLTELPTLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHCCCHHCCCCC
NSLKRLDADSNQLRTLPETLPISLLRLSVTSNQLTQLPETLPASLSLLMVLGNRLTALPE
HHHHHCCCCCHHHHCCHHHHCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NLPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHLRTNPYYQGPRI
CCCCCEEEECHHHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCC
NCSELDNLPPASLSNIVATWLPPEQQNRLAGDWANIETEANSAAFSVFLHRLTTTQNANN
CHHHHCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
IPEFKQQIAAWLLQLADSPTLREQTFLIAQEASATCEDRITLTHNDMQKAVMLHEVEKGK
CHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCCCHHCCEEEEHHHHHHHHHHHHHHCCC
YDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAYQVKLLNSLQLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
SVNKEMRFFGVSHVTADDLLSAETRVKTAENHDFSRWLSQWSPWKSVVQRIEPERYAAAV
HHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCHHHHHHHH
EKQYHALENIYPDKLAAELAANGMTGDVDANRIVGKRINDEIMEEIDMALTHEVLSAKGA
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCH
SSLLDNLWMESLISF
HHHHHHHHHHHHHCC
>Mature Secondary Structure 
PNIGPDREIHADRAAATALTPADYYAIWEKWENDPRTVAGEQRGQAVARMKECLENNTE
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
RLDLDELGLTSLPDTLPPCNELNIMANNLTELPTTLPDNLQKLNVSFNQLRALPNTLPAS
CCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHCCHHHHHH
LLSLNVFMNKLERLPESLPEGLKELDVNDNESLQLPNRLPQNLESLGIVSCGLTELPTLP
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCHHCCCHHCCCCC
NSLKRLDADSNQLRTLPETLPISLLRLSVTSNQLTQLPETLPASLSLLMVLGNRLTALPE
HHHHHCCCCCHHHHCCHHHHCHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NLPGSLRCISAEYNQLSQLPDLARLPQNCEILLEGNPLSTSTLQVLQHLRTNPYYQGPRI
CCCCCEEEECHHHHHHHCCCHHHHCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCCCC
NCSELDNLPPASLSNIVATWLPPEQQNRLAGDWANIETEANSAAFSVFLHRLTTTQNANN
CHHHHCCCCCHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
IPEFKQQIAAWLLQLADSPTLREQTFLIAQEASATCEDRITLTHNDMQKAVMLHEVEKGK
CHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCCCHHCCEEEEHHHHHHHHHHHHHHCCC
YDEKLPELMARGREMFRLEQLENIAREKVKILKTLNVNSVDDIEVYLAYQVKLLNSLQLS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
SVNKEMRFFGVSHVTADDLLSAETRVKTAENHDFSRWLSQWSPWKSVVQRIEPERYAAAV
HHHHHHHHHCCHHCCHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHCHHHHHHHH
EKQYHALENIYPDKLAAELAANGMTGDVDANRIVGKRINDEIMEEIDMALTHEVLSAKGA
HHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCCH
SSLLDNLWMESLISF
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10861017 [H]