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The map label for this gene is ubiB [C]

Identifier: 169630396

GI number: 169630396

Start: 3353251

End: 3354654

Strand: Direct

Name: ubiB [C]

Synonym: MAB_3315

Alternate gene names: 169630396

Gene position: 3353251-3354654 (Clockwise)

Preceding gene: 169630395

Following gene: 169630397

Centisome position: 66.18

GC content: 61.61

Gene sequence:

>1404_bases
ATGAGTGACCGTCACATTCCCCGGGGACGGATCCGGCGCACCATGCCACTGGCAGGCTTCACCGCCCGTGCAGCAGGCGG
CCGACTCGTCGCGGGCCTACGTGAAAAAGCTGGCGACACCGGAGCCATCAACCGTTTCCACGAGAGAACAGCCGAGCGCT
ACACCGAACTCCTCGGGCACTCCAAAGGTGTCCTGATGAAAGCCGGGCAGATCTTCTCGGTCGCCGATATCGCTTCCCAT
GGATATGCCCAACTCACGCCATATCAGAACGCATTAACGCGCCTACAGGCCGACGCACCGCCAATGCATCCGCTCTTGGC
ACGGCAAGCCTTGGAGGAGGACCTGGGGCGGCCCGTGGAGGATCTGTTCTCCGCCTTCTGCGACGATCCCATCGCTGCGG
CATCGATCGGCCAGGTGCACCGGGCGACCCTGCACGACGGTCGGCAGGTCGCGGTCAAGATTCAGTATCCGGGTGTGGCC
CAAGCCATTAGGCATGACCTGTCGAACGCCGAACTCATGGCCACCTTCCTGCGCTTCGCGACCGGCATCGCCGGGCCCAA
GCCACAACTGGATCATCGCCAGATGGCCGACGAGGTTGCCGCGCGTATATCCGAGGAACTGGACTACCGGCACGAGGCTG
CCAATATCCAGGCGTTCGCCGCCTTGTACGACGGCCATCCCTTTATCCGGATACCCGAGGTGATTTCCGGAGCATCCGGA
AATCGGGTGCTCACCATGACCTACCTGGACGGTCTGGACTGGACGGCTGCACAGCAGGCCGACCAGGATCTCAAGAACGT
TTGGGTTGAAGCTATCTGGCGCTTCAGCACTGGGTCGTTTCGGCATGCCAACCTGTTTCATGCCGATCCGCACCCGGGCA
ACTATCGGTTCGGGTTGGACGGGTCAGTCGGTTTTGTCGATTTCGGCTGCATCAAAGTAGTCCCCGAGCCCCTCCGGTAT
CGGCTTGTCCGAATGATCCGTGCCGCCGCCGACGAACGTCGGGAAGACCTGCGCCAGTTGATGGTCGACGCTGGCTACTT
CGCCGCCGACTCGCCGCTTTCGTCCCAGGACGTCTTTGACTGGCTCGGGTCAACCGTGCAAGACATCCGTGCTCCTCAAC
CCGTCACTTTTACCCGTGAGGTTTCCACCAGCGCCACCCGGTCGCTGCTGAATTTCCAGACGCTGCATCAAATGTCGATA
CCCAGTGACTTGGTATTCCTAGCACGGATCAACCTCAATATCAGCGCGCTGTCGGCCACGCTCAACGCGACGGGGCACAC
GCGCGCACTGCTCGATGATCTCGACGGGGTCGGCGAACCCGTTTCCCCGTTAGGTAGACAGCATATCGCGTGGGTGCGTG
ACCGCGGCCTACCCTTCGGATTGGATCGCCATGACCACTGCTAA

Upstream 100 bases:

>100_bases
CAGATACCGCCCTTGGCATTCGACATGTTGCCTGGGTGAAGGAACGCGGCCTACCGTTCGGTCTGGACCCACGCGAGCAG
TCAGAGGTTGGTGCCCGGTT

Downstream 100 bases:

>100_bases
CCCCGTCACCCCGCGAATCCCCTGGGATTCCCGAGATCCTTATGTCTACCTCGAAGACTTACGAGCCCACGGTGACGTGG
TCTTAGACGAAAATGCCGGT

Product: putative ABC transporter ATP-binding protein

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MSDRHIPRGRIRRTMPLAGFTARAAGGRLVAGLREKAGDTGAINRFHERTAERYTELLGHSKGVLMKAGQIFSVADIASH
GYAQLTPYQNALTRLQADAPPMHPLLARQALEEDLGRPVEDLFSAFCDDPIAAASIGQVHRATLHDGRQVAVKIQYPGVA
QAIRHDLSNAELMATFLRFATGIAGPKPQLDHRQMADEVAARISEELDYRHEAANIQAFAALYDGHPFIRIPEVISGASG
NRVLTMTYLDGLDWTAAQQADQDLKNVWVEAIWRFSTGSFRHANLFHADPHPGNYRFGLDGSVGFVDFGCIKVVPEPLRY
RLVRMIRAAADERREDLRQLMVDAGYFAADSPLSSQDVFDWLGSTVQDIRAPQPVTFTREVSTSATRSLLNFQTLHQMSI
PSDLVFLARINLNISALSATLNATGHTRALLDDLDGVGEPVSPLGRQHIAWVRDRGLPFGLDRHDHC

Sequences:

>Translated_467_residues
MSDRHIPRGRIRRTMPLAGFTARAAGGRLVAGLREKAGDTGAINRFHERTAERYTELLGHSKGVLMKAGQIFSVADIASH
GYAQLTPYQNALTRLQADAPPMHPLLARQALEEDLGRPVEDLFSAFCDDPIAAASIGQVHRATLHDGRQVAVKIQYPGVA
QAIRHDLSNAELMATFLRFATGIAGPKPQLDHRQMADEVAARISEELDYRHEAANIQAFAALYDGHPFIRIPEVISGASG
NRVLTMTYLDGLDWTAAQQADQDLKNVWVEAIWRFSTGSFRHANLFHADPHPGNYRFGLDGSVGFVDFGCIKVVPEPLRY
RLVRMIRAAADERREDLRQLMVDAGYFAADSPLSSQDVFDWLGSTVQDIRAPQPVTFTREVSTSATRSLLNFQTLHQMSI
PSDLVFLARINLNISALSATLNATGHTRALLDDLDGVGEPVSPLGRQHIAWVRDRGLPFGLDRHDHC
>Mature_466_residues
SDRHIPRGRIRRTMPLAGFTARAAGGRLVAGLREKAGDTGAINRFHERTAERYTELLGHSKGVLMKAGQIFSVADIASHG
YAQLTPYQNALTRLQADAPPMHPLLARQALEEDLGRPVEDLFSAFCDDPIAAASIGQVHRATLHDGRQVAVKIQYPGVAQ
AIRHDLSNAELMATFLRFATGIAGPKPQLDHRQMADEVAARISEELDYRHEAANIQAFAALYDGHPFIRIPEVISGASGN
RVLTMTYLDGLDWTAAQQADQDLKNVWVEAIWRFSTGSFRHANLFHADPHPGNYRFGLDGSVGFVDFGCIKVVPEPLRYR
LVRMIRAAADERREDLRQLMVDAGYFAADSPLSSQDVFDWLGSTVQDIRAPQPVTFTREVSTSATRSLLNFQTLHQMSIP
SDLVFLARINLNISALSATLNATGHTRALLDDLDGVGEPVSPLGRQHIAWVRDRGLPFGLDRHDHC

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI34147522, Length=446, Percent_Identity=26.2331838565022, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI27363457, Length=359, Percent_Identity=30.3621169916435, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI40254938, Length=261, Percent_Identity=30.6513409961686, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI217416386, Length=256, Percent_Identity=32.8125, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI217035081, Length=190, Percent_Identity=30.5263157894737, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI41393593, Length=223, Percent_Identity=30.4932735426009, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI2367309, Length=342, Percent_Identity=25.1461988304094, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17559152, Length=259, Percent_Identity=32.4324324324324, Blast_Score=118, Evalue=7e-27,
Organism=Caenorhabditis elegans, GI32565180, Length=406, Percent_Identity=25.8620689655172, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=366, Percent_Identity=26.775956284153, Blast_Score=123, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6323282, Length=274, Percent_Identity=26.6423357664234, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI22024280, Length=263, Percent_Identity=30.0380228136882, Blast_Score=110, Evalue=3e-24,
Organism=Drosophila melanogaster, GI18859849, Length=390, Percent_Identity=25.3846153846154, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24662575, Length=286, Percent_Identity=25.5244755244755, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 51576; Mature: 51445

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDRHIPRGRIRRTMPLAGFTARAAGGRLVAGLREKAGDTGAINRFHERTAERYTELLGH
CCCCCCCHHHHHHCCCCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
SKGVLMKAGQIFSVADIASHGYAQLTPYQNALTRLQADAPPMHPLLARQALEEDLGRPVE
CCCCEEECCCCHHHHHHHHCCCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
DLFSAFCDDPIAAASIGQVHRATLHDGRQVAVKIQYPGVAQAIRHDLSNAELMATFLRFA
HHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHH
TGIAGPKPQLDHRQMADEVAARISEELDYRHEAANIQAFAALYDGHPFIRIPEVISGASG
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEECHHHHCCCCC
NRVLTMTYLDGLDWTAAQQADQDLKNVWVEAIWRFSTGSFRHANLFHADPHPGNYRFGLD
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECEEEECCCCCCCEEECCC
GSVGFVDFGCIKVVPEPLRYRLVRMIRAAADERREDLRQLMVDAGYFAADSPLSSQDVFD
CCCCEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
WLGSTVQDIRAPQPVTFTREVSTSATRSLLNFQTLHQMSIPSDLVFLARINLNISALSAT
HHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHH
LNATGHTRALLDDLDGVGEPVSPLGRQHIAWVRDRGLPFGLDRHDHC
HCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SDRHIPRGRIRRTMPLAGFTARAAGGRLVAGLREKAGDTGAINRFHERTAERYTELLGH
CCCCCCHHHHHHCCCCCCCHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCC
SKGVLMKAGQIFSVADIASHGYAQLTPYQNALTRLQADAPPMHPLLARQALEEDLGRPVE
CCCCEEECCCCHHHHHHHHCCCEEECCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHH
DLFSAFCDDPIAAASIGQVHRATLHDGRQVAVKIQYPGVAQAIRHDLSNAELMATFLRFA
HHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHCCCHHHHHHHHHHH
TGIAGPKPQLDHRQMADEVAARISEELDYRHEAANIQAFAALYDGHPFIRIPEVISGASG
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEECHHHHCCCCC
NRVLTMTYLDGLDWTAAQQADQDLKNVWVEAIWRFSTGSFRHANLFHADPHPGNYRFGLD
CEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECEEEECCCCCCCEEECCC
GSVGFVDFGCIKVVPEPLRYRLVRMIRAAADERREDLRQLMVDAGYFAADSPLSSQDVFD
CCCCEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
WLGSTVQDIRAPQPVTFTREVSTSATRSLLNFQTLHQMSIPSDLVFLARINLNISALSAT
HHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEHHHH
LNATGHTRALLDDLDGVGEPVSPLGRQHIAWVRDRGLPFGLDRHDHC
HCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]