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The map label for this gene is tesB [H]

Identifier: 169629975

GI number: 169629975

Start: 2943190

End: 2944041

Strand: Reverse

Name: tesB [H]

Synonym: MAB_2891c

Alternate gene names: 169629975

Gene position: 2944041-2943190 (Counterclockwise)

Preceding gene: 169629976

Following gene: 169629974

Centisome position: 58.1

GC content: 62.91

Gene sequence:

>852_bases
ATGGCCGATATCGAGGAGATCCTTACTCTCGAGCAGCTGGAGAAGGACATCTTCCGGGGCAACGTGACCCCCAGCAATCT
TCGTCGCACCTTCGGCGGGCAGGTCGCTGGGCAGTCACTGGTGTCCGCGGTTCGCACCGTGGAACCGGAGTATCTGGTGC
ACTCGTTGCACGGATACTTTCTGCGGCCCGGAAATCCCAACGAGCCCACCGTGTTTCTCGTCGACCGGGTCCGCGACGGT
AGATCGTTCGTAACGCGCCGAGTCACCGCGATCCAGGACGGGCAGGCCATCTTCAGCATGTCGGCCTCATTTCAGACACT
GGACACCGGTATCGAGCATCAGGATCTGATGCCGCCGGTACCCGATCCGGAGGATCTGCCCGACGCACAGGAACAGGATT
CGTTCAACCGGGATCTTTTCCGGCAGTTCGCCGAGTGGGATATCCGGATCGTGCCGGACGAGCTCATGGACAGGAATCCC
CGGCTGGCCGCCCAGCAGCGGGTGTGGTTCCGCTGCCGTAAGCACCTGCCCGACGACCCGGTGCTACACATCTGCGCGCT
GGCGTATATGAGCGACCTGACGTTGCTGAGTTCTTCGAAGGTGCCGCATCGGGATACCGTGCTGCAGACGGCTTCATTGG
ACCACGCGCTGTGGTTCCTGCGGCCCTTCCGTGCCGACGAGTGGATGTTGTACGACGAGACATCCCCGTCGGCAGGGTTC
GGGCGCGCGTTGACGCAGGGCCGGATCTTCAACCGGGACGGAACCATGGTGGCTGCGGTGGTGCAAGAGGGGCTTACCCG
CATTGAGCGTAACCCCGAGCAGGCGTCGGTGGCCCGAGGGAATATGGCGTGA

Upstream 100 bases:

>100_bases
CAAGGTGTCGCGTGGCCTGGGCGAGGCGATGGTCGGTATCAATGTGGAGGACATCGCGCAGCCGCACAGGCTCGCCGAGC
GCGGCTGGTAGAACTAGCGG

Downstream 100 bases:

>100_bases
GTCCCCTTGTGGGTGTGCTGGCATTGCAGGGCGATGTCAGGGAACATGTTGCGGCGCTGAAAGATTCGGGGGCCGAGGCG
CTTGGTGTGCGTCGCCCCGA

Product: acyl-CoA thioesterase II TesB2

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MADIEEILTLEQLEKDIFRGNVTPSNLRRTFGGQVAGQSLVSAVRTVEPEYLVHSLHGYFLRPGNPNEPTVFLVDRVRDG
RSFVTRRVTAIQDGQAIFSMSASFQTLDTGIEHQDLMPPVPDPEDLPDAQEQDSFNRDLFRQFAEWDIRIVPDELMDRNP
RLAAQQRVWFRCRKHLPDDPVLHICALAYMSDLTLLSSSKVPHRDTVLQTASLDHALWFLRPFRADEWMLYDETSPSAGF
GRALTQGRIFNRDGTMVAAVVQEGLTRIERNPEQASVARGNMA

Sequences:

>Translated_283_residues
MADIEEILTLEQLEKDIFRGNVTPSNLRRTFGGQVAGQSLVSAVRTVEPEYLVHSLHGYFLRPGNPNEPTVFLVDRVRDG
RSFVTRRVTAIQDGQAIFSMSASFQTLDTGIEHQDLMPPVPDPEDLPDAQEQDSFNRDLFRQFAEWDIRIVPDELMDRNP
RLAAQQRVWFRCRKHLPDDPVLHICALAYMSDLTLLSSSKVPHRDTVLQTASLDHALWFLRPFRADEWMLYDETSPSAGF
GRALTQGRIFNRDGTMVAAVVQEGLTRIERNPEQASVARGNMA
>Mature_282_residues
ADIEEILTLEQLEKDIFRGNVTPSNLRRTFGGQVAGQSLVSAVRTVEPEYLVHSLHGYFLRPGNPNEPTVFLVDRVRDGR
SFVTRRVTAIQDGQAIFSMSASFQTLDTGIEHQDLMPPVPDPEDLPDAQEQDSFNRDLFRQFAEWDIRIVPDELMDRNPR
LAAQQRVWFRCRKHLPDDPVLHICALAYMSDLTLLSSSKVPHRDTVLQTASLDHALWFLRPFRADEWMLYDETSPSAGFG
RALTQGRIFNRDGTMVAAVVQEGLTRIERNPEQASVARGNMA

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known [H]

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family [H]

Homologues:

Organism=Homo sapiens, GI34577075, Length=284, Percent_Identity=39.7887323943662, Blast_Score=200, Evalue=1e-51,
Organism=Escherichia coli, GI1786657, Length=280, Percent_Identity=40.3571428571429, Blast_Score=202, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI71988741, Length=266, Percent_Identity=37.9699248120301, Blast_Score=178, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17558508, Length=317, Percent_Identity=35.6466876971609, Blast_Score=176, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI115532456, Length=301, Percent_Identity=31.8936877076412, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17531889, Length=301, Percent_Identity=31.8936877076412, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI17531885, Length=301, Percent_Identity=31.8936877076412, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI71982224, Length=301, Percent_Identity=29.5681063122924, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI212645202, Length=262, Percent_Identity=29.7709923664122, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322480, Length=331, Percent_Identity=23.8670694864048, Blast_Score=83, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003703 [H]

Pfam domain/function: PF02551 Acyl_CoA_thio [H]

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32121; Mature: 31989

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIEEILTLEQLEKDIFRGNVTPSNLRRTFGGQVAGQSLVSAVRTVEPEYLVHSLHGYF
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCEE
LRPGNPNEPTVFLVDRVRDGRSFVTRRVTAIQDGQAIFSMSASFQTLDTGIEHQDLMPPV
ECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCCCHHCCCCCC
PDPEDLPDAQEQDSFNRDLFRQFAEWDIRIVPDELMDRNPRLAAQQRVWFRCRKHLPDDP
CCCCCCCCCHHHHHCCHHHHHHHHHCCEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCCH
VLHICALAYMSDLTLLSSSKVPHRDTVLQTASLDHALWFLRPFRADEWMLYDETSPSAGF
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
GRALTQGRIFNRDGTMVAAVVQEGLTRIERNPEQASVARGNMA
HHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCC
>Mature Secondary Structure 
ADIEEILTLEQLEKDIFRGNVTPSNLRRTFGGQVAGQSLVSAVRTVEPEYLVHSLHGYF
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHCCEE
LRPGNPNEPTVFLVDRVRDGRSFVTRRVTAIQDGQAIFSMSASFQTLDTGIEHQDLMPPV
ECCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHHCCCCHHCCCCCC
PDPEDLPDAQEQDSFNRDLFRQFAEWDIRIVPDELMDRNPRLAAQQRVWFRCRKHLPDDP
CCCCCCCCCHHHHHCCHHHHHHHHHCCEEECCHHHHCCCCCHHHHHHHHHHHHHCCCCCH
VLHICALAYMSDLTLLSSSKVPHRDTVLQTASLDHALWFLRPFRADEWMLYDETSPSAGF
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCH
GRALTQGRIFNRDGTMVAAVVQEGLTRIERNPEQASVARGNMA
HHHHHCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]