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The map label for this gene is bioA [H]

Identifier: 169629773

GI number: 169629773

Start: 2729748

End: 2731073

Strand: Reverse

Name: bioA [H]

Synonym: MAB_2688c

Alternate gene names: 169629773

Gene position: 2731073-2729748 (Counterclockwise)

Preceding gene: 169629776

Following gene: 169629772

Centisome position: 53.9

GC content: 65.69

Gene sequence:

>1326_bases
GTGCCGAAGTTGACACCAGAAGAGGTCGAAGCCGTCGACGCCGCGCATTTGTGGCATCCGTATAGCGGGATCGGCATCCC
CGCGGCGGCCCAGCGACCGCTGGTGGTGACAGGTGCCAGTGGCCCCAACATCACGGTCGTGCGCGATGGCCGATCCGTCG
AGGTGCTTGACGGGATGAGCTCGTGGTGGTCCTGCATCCATGGTCACGGTCACCCGGTGCTGGACCGCGCGGTGACCGAC
CAGCTGGCCTCGATGAGCCATGTGATGTTCGGGGGCTTGACCCATGAGCCGGCAGCCCGGCTGGCTCAGCTGCTGGTCGA
GCTCACACCGGCGGGGCTGGAGACGGTCTTCTTCTGCGACTCCGGATCGGTGTCGGTGGAAGTGGCGATCAAGATGGCGC
TGCAATATTGGCGCAGCCTCGGACTGCCGGCCAAGCATCGGTTGATGACGTGGCGTGGCGGCTATCACGGGGACACCTTC
GCGCCGATGAGTGTCTGTGATCCCGAGGGCGGCATGCACTCACTGTGGACCGACGTGCTGGTCGAGCAGATCTTTGCCGA
CCGTGTCCCCGGCGCCTACGACGGCGAGTACATGAGGCGTTTCGAAGCGGAGCTGACCGAACACGCTGCCGAACTTGCGG
CGGTCATCGTCGAGCCCATGGTGCAGGGCGCCGGTGGGATGCGATTTCACGATCCGCGGTATCTCGCAGAGCTGCGCGCC
ATCTGCGACAGGCATGGTGTGCTGCTGATCTTCGACGAGATCGCCACCGGGTTCGGGCGTACCGGCGAGCTGTTCGCCGC
CGACCATGCCGGGGTGAGTCCGGACATCATGTGCGTCGGCAAGGCGATCACCGGCGGCTACCTCACCCTGGCTGCCACGC
TGTGTACGGCCAAGATCGCGCAGACAATCAGCGACAGCCCCGCCGGTGCGTTGATGCACGGACCGACTTTCATGGCCAAT
CCGTTGGCGTGCGCTGTGGCTGTCGCTTCCATCGAGCTGTTGCTGTCTGGAGACTGGAAGACTCGGGTCGCCCGGATAGC
AGCGGGCCTGCGCGAGGGCCTGGCGCCCGCAGCGGATCTCGAGGGCGTCGCCGACGTGCGGGTCTGCGGGGCCATCGGCG
TCATCGATATGGAGCATCCGTTGGGTGAGCAGGGCATGCGAATTGCTACGGGTGCGGCACTGGACGAGGGCGTTTGGCTG
CGTCCCTTCCGAACGCTGATTTATACGATGCCGCCGTACATCTGCGACGAGGGCGAAATCCGCCGAATCACCCGTGCGAT
GGTCCGGGCGGCGACGGCGGTAGTAGCCGGCCGACAGGTGCGCTAA

Upstream 100 bases:

>100_bases
GTACCCATGGTTGCCGAGAGTCTTGGCAGTTGCGCGCCAACGGCGTGTGCGCGAGAGGCGAATGGCCCAATGCCGGGGGC
CTGTGACAGGCTCGCTGACT

Downstream 100 bases:

>100_bases
CCTGAACACCGTTCAGGAGAGGAGGTGCCGGTGGTCGAGGCATCATCACCGCTTGCCTGGTTGGGTGAGGTCGAGCGGCA
ACGGGAAGCTGCCGGGCTGC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 441; Mature: 440

Protein sequence:

>441_residues
MPKLTPEEVEAVDAAHLWHPYSGIGIPAAAQRPLVVTGASGPNITVVRDGRSVEVLDGMSSWWSCIHGHGHPVLDRAVTD
QLASMSHVMFGGLTHEPAARLAQLLVELTPAGLETVFFCDSGSVSVEVAIKMALQYWRSLGLPAKHRLMTWRGGYHGDTF
APMSVCDPEGGMHSLWTDVLVEQIFADRVPGAYDGEYMRRFEAELTEHAAELAAVIVEPMVQGAGGMRFHDPRYLAELRA
ICDRHGVLLIFDEIATGFGRTGELFAADHAGVSPDIMCVGKAITGGYLTLAATLCTAKIAQTISDSPAGALMHGPTFMAN
PLACAVAVASIELLLSGDWKTRVARIAAGLREGLAPAADLEGVADVRVCGAIGVIDMEHPLGEQGMRIATGAALDEGVWL
RPFRTLIYTMPPYICDEGEIRRITRAMVRAATAVVAGRQVR

Sequences:

>Translated_441_residues
MPKLTPEEVEAVDAAHLWHPYSGIGIPAAAQRPLVVTGASGPNITVVRDGRSVEVLDGMSSWWSCIHGHGHPVLDRAVTD
QLASMSHVMFGGLTHEPAARLAQLLVELTPAGLETVFFCDSGSVSVEVAIKMALQYWRSLGLPAKHRLMTWRGGYHGDTF
APMSVCDPEGGMHSLWTDVLVEQIFADRVPGAYDGEYMRRFEAELTEHAAELAAVIVEPMVQGAGGMRFHDPRYLAELRA
ICDRHGVLLIFDEIATGFGRTGELFAADHAGVSPDIMCVGKAITGGYLTLAATLCTAKIAQTISDSPAGALMHGPTFMAN
PLACAVAVASIELLLSGDWKTRVARIAAGLREGLAPAADLEGVADVRVCGAIGVIDMEHPLGEQGMRIATGAALDEGVWL
RPFRTLIYTMPPYICDEGEIRRITRAMVRAATAVVAGRQVR
>Mature_440_residues
PKLTPEEVEAVDAAHLWHPYSGIGIPAAAQRPLVVTGASGPNITVVRDGRSVEVLDGMSSWWSCIHGHGHPVLDRAVTDQ
LASMSHVMFGGLTHEPAARLAQLLVELTPAGLETVFFCDSGSVSVEVAIKMALQYWRSLGLPAKHRLMTWRGGYHGDTFA
PMSVCDPEGGMHSLWTDVLVEQIFADRVPGAYDGEYMRRFEAELTEHAAELAAVIVEPMVQGAGGMRFHDPRYLAELRAI
CDRHGVLLIFDEIATGFGRTGELFAADHAGVSPDIMCVGKAITGGYLTLAATLCTAKIAQTISDSPAGALMHGPTFMANP
LACAVAVASIELLLSGDWKTRVARIAAGLREGLAPAADLEGVADVRVCGAIGVIDMEHPLGEQGMRIATGAALDEGVWLR
PFRTLIYTMPPYICDEGEIRRITRAMVRAATAVVAGRQVR

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=420, Percent_Identity=27.6190476190476, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI284507298, Length=245, Percent_Identity=32.6530612244898, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI13994255, Length=387, Percent_Identity=28.1653746770026, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI37574042, Length=364, Percent_Identity=25, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI226442705, Length=359, Percent_Identity=24.7910863509749, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI226442709, Length=328, Percent_Identity=24.390243902439, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI1786991, Length=424, Percent_Identity=54.0094339622642, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI145693181, Length=320, Percent_Identity=33.4375, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789759, Length=286, Percent_Identity=34.965034965035, Blast_Score=142, Evalue=6e-35,
Organism=Escherichia coli, GI1788044, Length=309, Percent_Identity=33.9805825242718, Blast_Score=138, Evalue=6e-34,
Organism=Escherichia coli, GI1789016, Length=385, Percent_Identity=27.7922077922078, Blast_Score=135, Evalue=7e-33,
Organism=Escherichia coli, GI1787560, Length=385, Percent_Identity=30.1298701298701, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1786349, Length=393, Percent_Identity=27.9898218829517, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=309, Percent_Identity=27.831715210356, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=150, Percent_Identity=38, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI32564660, Length=374, Percent_Identity=25.9358288770053, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71992977, Length=439, Percent_Identity=25.0569476082005, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17541228, Length=286, Percent_Identity=27.6223776223776, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=469, Percent_Identity=39.4456289978678, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6323470, Length=433, Percent_Identity=28.8683602771363, Blast_Score=133, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=333, Percent_Identity=26.1261261261261, Blast_Score=99, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=26.2019230769231, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161085790, Length=383, Percent_Identity=26.1096605744125, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574759, Length=383, Percent_Identity=26.1096605744125, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21356575, Length=340, Percent_Identity=23.8235294117647, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 47210; Mature: 47079

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLTPEEVEAVDAAHLWHPYSGIGIPAAAQRPLVVTGASGPNITVVRDGRSVEVLDGMS
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEECCCEEEEHHHHH
SWWSCIHGHGHPVLDRAVTDQLASMSHVMFGGLTHEPAARLAQLLVELTPAGLETVFFCD
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEC
SGSVSVEVAIKMALQYWRSLGLPAKHRLMTWRGGYHGDTFAPMSVCDPEGGMHSLWTDVL
CCCEEEHHHHHHHHHHHHHCCCCHHHCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VEQIFADRVPGAYDGEYMRRFEAELTEHAAELAAVIVEPMVQGAGGMRFHDPRYLAELRA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ICDRHGVLLIFDEIATGFGRTGELFAADHAGVSPDIMCVGKAITGGYLTLAATLCTAKIA
HHCCCCEEEEEHHHHHCCCCCCCEEEECCCCCCCCEEEECCHHCCHHHHHHHHHHHHHHH
QTISDSPAGALMHGPTFMANPLACAVAVASIELLLSGDWKTRVARIAAGLREGLAPAADL
HHHCCCCCCCEEECCCHHCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCCCCC
EGVADVRVCGAIGVIDMEHPLGEQGMRIATGAALDEGVWLRPFRTLIYTMPPYICDEGEI
CCCHHHHHHCEECEEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHH
RRITRAMVRAATAVVAGRQVR
HHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PKLTPEEVEAVDAAHLWHPYSGIGIPAAAQRPLVVTGASGPNITVVRDGRSVEVLDGMS
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEECCCEEEEHHHHH
SWWSCIHGHGHPVLDRAVTDQLASMSHVMFGGLTHEPAARLAQLLVELTPAGLETVFFCD
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEC
SGSVSVEVAIKMALQYWRSLGLPAKHRLMTWRGGYHGDTFAPMSVCDPEGGMHSLWTDVL
CCCEEEHHHHHHHHHHHHHCCCCHHHCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
VEQIFADRVPGAYDGEYMRRFEAELTEHAAELAAVIVEPMVQGAGGMRFHDPRYLAELRA
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
ICDRHGVLLIFDEIATGFGRTGELFAADHAGVSPDIMCVGKAITGGYLTLAATLCTAKIA
HHCCCCEEEEEHHHHHCCCCCCCEEEECCCCCCCCEEEECCHHCCHHHHHHHHHHHHHHH
QTISDSPAGALMHGPTFMANPLACAVAVASIELLLSGDWKTRVARIAAGLREGLAPAADL
HHHCCCCCCCEEECCCHHCCHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHCCCCCCCC
EGVADVRVCGAIGVIDMEHPLGEQGMRIATGAALDEGVWLRPFRTLIYTMPPYICDEGEI
CCCHHHHHHCEECEEECCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHH
RRITRAMVRAATAVVAGRQVR
HHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]