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The map label for this gene is ilvA [H]

Identifier: 169629776

GI number: 169629776

Start: 2735556

End: 2736815

Strand: Reverse

Name: ilvA [H]

Synonym: MAB_2691c

Alternate gene names: 169629776

Gene position: 2736815-2735556 (Counterclockwise)

Preceding gene: 169629777

Following gene: 169629773

Centisome position: 54.01

GC content: 65.71

Gene sequence:

>1260_bases
TTGAGCACGTCCGAGGTGGTGACGGCCGCCGATATCGATGCCGCGGCCAAGCGCATCGACGAGGTCGTCCATCCCACACC
GCTGCAGCACGCCGATCGGCTCTCGGCCCTCACCCGCGCCGAGGTGTATCTGAAGCGTGAAGATCTGCAGTCGGTCCGCT
CCTACAAGGTGCGCGGTGCGTTCAACCTGCTGATGCAGCTCAGCGATGAGGAGAAGGCCGCCGGCGTGGTGTGTTCCAGT
GCCGGTAACCACGCTCAGGGATTCGCGCTGGCGTGCAAGTCGATGGGCGTGCACGGCCGGGTGTACATCCCCAGTAAAAC
CCCTAAGCAGAAGCGGCAGCGAATCATCTACCACGGCAATGGGTTTGTGGAGCTGATCGCGGTCGGGCACGGCTATGACG
AGGCTGCGGCCGCGGCCAAGGCCGATGCCGCGCGTACCGGTGCCACCCTGGTGCCGGCCTTTGACGATGTGCGAACGATC
GCGGGCCAGGGCACCATCGCCGCGGAGATACTCGATCAATTGGATAGTCCGCCCGACGTGGTGGTGGTACCGGTCGGCGG
TGGCGGCTGCATCTCGGGGATCGTCACCTACCTGCGCGAGCGTGCCCCTGAGGTTCGCGTGGTGGGGGTGGAACCCGCCG
GTGCTGCCTGTATGGCCGCGGCCTTGCGGGCCGGCGGTCCGGTTCCGCTCGACCATGTGGATCCCTTTGTCGACGGCTGT
GCCGTACAGGTAGCCGGGGCTGCTCCATATCGGGTGCTTGCCGCGGCGGGGGAGATGCTCACGCTCACGACAGTCGATGA
GGGTGCCGCCTGCACCGCGATGCTGGAGCTTTACCAGAACGAGGGGATCATCGCTGAGCCCGCCGGTGCGCTGTCGGTGG
CCGCGCTGGCGGAGATGGCGATCGAGCCGGGCGCCACCGTCGTCTGCCTGATTTCCGGTGGCAACAATGATGTTTCGCGG
TACGGCGAGATCCTGGAACGCTCGTTGGTGCACCTGGGGCTCAAGCACTACTTCCTGGTGGACTTCCCGCAGGAACCGGG
TGCGCTGCGGCGCTTTCTCGGCGAGGTGCTGGGGCCCAACGACGACATCACGCTGTTCGAGTACGTCAAGCGGAACAACC
GCGAGATGGGTGCCGCTTTGGTGGGCATCGAGCTCAGCTACGCGGATGACCTGTCGGGTCTGCTGGATCGGATGCGGTTT
TCCGGGCTGGATATCGAACGGCTGGAGCCGGACTCGCCGGCCTTCCGCTATCTGACATAG

Upstream 100 bases:

>100_bases
CCACGTGGTGGGATCGTGCCGTCGAGGCCTACCCGCCCTATGCGGAATACCAGACCAAGACCGACCGTCAGATCCCGGTT
TTCGTGCTGACACCTGTCTC

Downstream 100 bases:

>100_bases
GGCGGCTACCCGCTTTTACGCAGCACCACTAGGGCGCGGTCTTGTACGCGCACTGCTTCGCCAGCCTTGACCACGGTCGA
GCATTGGCCATTGGGTGTGG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSTSEVVTAADIDAAAKRIDEVVHPTPLQHADRLSALTRAEVYLKREDLQSVRSYKVRGAFNLLMQLSDEEKAAGVVCSS
AGNHAQGFALACKSMGVHGRVYIPSKTPKQKRQRIIYHGNGFVELIAVGHGYDEAAAAAKADAARTGATLVPAFDDVRTI
AGQGTIAAEILDQLDSPPDVVVVPVGGGGCISGIVTYLRERAPEVRVVGVEPAGAACMAAALRAGGPVPLDHVDPFVDGC
AVQVAGAAPYRVLAAAGEMLTLTTVDEGAACTAMLELYQNEGIIAEPAGALSVAALAEMAIEPGATVVCLISGGNNDVSR
YGEILERSLVHLGLKHYFLVDFPQEPGALRRFLGEVLGPNDDITLFEYVKRNNREMGAALVGIELSYADDLSGLLDRMRF
SGLDIERLEPDSPAFRYLT

Sequences:

>Translated_419_residues
MSTSEVVTAADIDAAAKRIDEVVHPTPLQHADRLSALTRAEVYLKREDLQSVRSYKVRGAFNLLMQLSDEEKAAGVVCSS
AGNHAQGFALACKSMGVHGRVYIPSKTPKQKRQRIIYHGNGFVELIAVGHGYDEAAAAAKADAARTGATLVPAFDDVRTI
AGQGTIAAEILDQLDSPPDVVVVPVGGGGCISGIVTYLRERAPEVRVVGVEPAGAACMAAALRAGGPVPLDHVDPFVDGC
AVQVAGAAPYRVLAAAGEMLTLTTVDEGAACTAMLELYQNEGIIAEPAGALSVAALAEMAIEPGATVVCLISGGNNDVSR
YGEILERSLVHLGLKHYFLVDFPQEPGALRRFLGEVLGPNDDITLFEYVKRNNREMGAALVGIELSYADDLSGLLDRMRF
SGLDIERLEPDSPAFRYLT
>Mature_418_residues
STSEVVTAADIDAAAKRIDEVVHPTPLQHADRLSALTRAEVYLKREDLQSVRSYKVRGAFNLLMQLSDEEKAAGVVCSSA
GNHAQGFALACKSMGVHGRVYIPSKTPKQKRQRIIYHGNGFVELIAVGHGYDEAAAAAKADAARTGATLVPAFDDVRTIA
GQGTIAAEILDQLDSPPDVVVVPVGGGGCISGIVTYLRERAPEVRVVGVEPAGAACMAAALRAGGPVPLDHVDPFVDGCA
VQVAGAAPYRVLAAAGEMLTLTTVDEGAACTAMLELYQNEGIIAEPAGALSVAALAEMAIEPGATVVCLISGGNNDVSRY
GEILERSLVHLGLKHYFLVDFPQEPGALRRFLGEVLGPNDDITLFEYVKRNNREMGAALVGIELSYADDLSGLLDRMRFS
GLDIERLEPDSPAFRYLT

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=332, Percent_Identity=28.3132530120482, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI19923959, Length=319, Percent_Identity=30.0940438871473, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI33469958, Length=303, Percent_Identity=29.042904290429, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790207, Length=369, Percent_Identity=35.230352303523, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=34.7003154574132, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17537387, Length=374, Percent_Identity=32.0855614973262, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71991565, Length=327, Percent_Identity=33.3333333333333, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17508781, Length=247, Percent_Identity=28.3400809716599, Blast_Score=85, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6320930, Length=418, Percent_Identity=33.2535885167464, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6322631, Length=321, Percent_Identity=30.8411214953271, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319788, Length=214, Percent_Identity=29.9065420560748, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355833, Length=346, Percent_Identity=33.5260115606936, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24645328, Length=250, Percent_Identity=33.2, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44311; Mature: 44180

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSEVVTAADIDAAAKRIDEVVHPTPLQHADRLSALTRAEVYLKREDLQSVRSYKVRGA
CCCCCEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNLLMQLSDEEKAAGVVCSSAGNHAQGFALACKSMGVHGRVYIPSKTPKQKRQRIIYHGN
HHHHHHCCCCCHHCCEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHCEEEEECC
GFVELIAVGHGYDEAAAAAKADAARTGATLVPAFDDVRTIAGQGTIAAEILDQLDSPPDV
CEEEEEEECCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCCHHHHHHHHHCCCCCE
VVVPVGGGGCISGIVTYLRERAPEVRVVGVEPAGAACMAAALRAGGPVPLDHVDPFVDGC
EEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHCCHHHCCC
AVQVAGAAPYRVLAAAGEMLTLTTVDEGAACTAMLELYQNEGIIAEPAGALSVAALAEMA
EEEEECCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHH
IEPGATVVCLISGGNNDVSRYGEILERSLVHLGLKHYFLVDFPQEPGALRRFLGEVLGPN
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCC
DDITLFEYVKRNNREMGAALVGIELSYADDLSGLLDRMRFSGLDIERLEPDSPAFRYLT
CCCHHHHHHHHCCCHHCEEEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STSEVVTAADIDAAAKRIDEVVHPTPLQHADRLSALTRAEVYLKREDLQSVRSYKVRGA
CCCCEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FNLLMQLSDEEKAAGVVCSSAGNHAQGFALACKSMGVHGRVYIPSKTPKQKRQRIIYHGN
HHHHHHCCCCCHHCCEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHCEEEEECC
GFVELIAVGHGYDEAAAAAKADAARTGATLVPAFDDVRTIAGQGTIAAEILDQLDSPPDV
CEEEEEEECCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHCCCCCHHHHHHHHHCCCCCE
VVVPVGGGGCISGIVTYLRERAPEVRVVGVEPAGAACMAAALRAGGPVPLDHVDPFVDGC
EEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHCCHHHCCC
AVQVAGAAPYRVLAAAGEMLTLTTVDEGAACTAMLELYQNEGIIAEPAGALSVAALAEMA
EEEEECCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHH
IEPGATVVCLISGGNNDVSRYGEILERSLVHLGLKHYFLVDFPQEPGALRRFLGEVLGPN
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHCCC
DDITLFEYVKRNNREMGAALVGIELSYADDLSGLLDRMRFSGLDIERLEPDSPAFRYLT
CCCHHHHHHHHCCCHHCEEEEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]