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The map label for this gene is kbl [C]

Identifier: 169629772

GI number: 169629772

Start: 2728572

End: 2729723

Strand: Reverse

Name: kbl [C]

Synonym: MAB_2687c

Alternate gene names: 169629772

Gene position: 2729723-2728572 (Counterclockwise)

Preceding gene: 169629773

Following gene: 169629771

Centisome position: 53.87

GC content: 69.1

Gene sequence:

>1152_bases
GTGCCGGTGGTCGAGGCATCATCACCGCTTGCCTGGTTGGGTGAGGTCGAGCGGCAACGGGAAGCTGCCGGGCTGCGTCG
ACGGCTGCGTACGCGCAGCGCGGCAGAACCCGAAATCGACCTGGCTTCCAATGACTACCTGGGCCTTTCCCGGCATCCGC
AGGTCATCGAGGCAGGTGTCGAGGCGTTGCGGATATGGGGTGCCGGATCCACCGGCTCACGTCTGGTCACCGGTAACACC
GAGCTGCATGAAGAACTCGAGCAAGAGCTCGCGACCTTCATGGGTACGGAGTCGGCGCTGGTCTTCTCCTCGGGATACAC
CGCCAACCTCGGGGCGGTGGTCGCCCTGTCCGGCCCGGGGACCCTCATCGTCTCCGATGCGCGCACGCATGCCTCGCTGA
TCGATGCCTGCCGTTTGTCGCGCGCGCGGGTGGTGGTGACCCCCTACCGCGACACGCAAGCGGTGGCGGCGGCCCTGGCG
CAGCGCCCCGAAGAACGTGCGCTGGTGCTCACCGACGCGGTCTTCAGCGCCGACGGTGCGCTGGCCCCGTTGGCCGAACT
GTATGGCGTGTGCCGCCGCCACGGCGCAGTGCTGCTGGTCGACGAGGCGCACGGGCTTGGTGTGCGTGGGTCGGGTGGCC
GCGGTCTGGTCGCCGAAATGAACCTGGCGGGCCGGGATGACCTCGTCGTGACCGTGACGCTTTCCAAGGCGCTGGGTAGT
CAGGGCGGGGCCGTGCTCGGATCGGCGGCGGTGCGTGCGCACCTCATTGACGCCGCCCGTCCGTTCATCTTCGACACTGG
GCTCGCGCCCGCGGCGGTCGGGTCGGCGTTGGCGGCCCTGCGCCTGATGATCGACGAACCCGCGCGGATACGTGCTGTCC
TGGCGCATGCGGCGGCGCTGGGGCAGTGGTGCGGCGTGCCCGATAAGCCGGAATCGGCGGTGGTGCCGGTGGTTCTCGGT
GATCCCACGGTCGCGTTCAATGCCGCGCGGTCATGTTTGGAGCAGGGCGTTCGGGTGGGTTGTTTTCGTCCGCCCTCCGT
CCCGGAAGGTCAGTCGCTGTTGCGACTGACGGCCCGCGCCTCGCTCACCGAGGCCGATATGGAACGCGTGCACGAGGTGC
TTGCCGGGGTGCTGACGCTGGCGCGGCGATGA

Upstream 100 bases:

>100_bases
GGGCGAAATCCGCCGAATCACCCGTGCGATGGTCCGGGCGGCGACGGCGGTAGTAGCCGGCCGACAGGTGCGCTAACCTG
AACACCGTTCAGGAGAGGAG

Downstream 100 bases:

>100_bases
CGATTTTGCTGGTCACCGGCACATCGACCGGGGTGGGCAAGACGGTGGCGACGGCTGCGCTGGCCGCCGCGGCTGTCCGT
CAGGGCATCGACGTGACGGT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MPVVEASSPLAWLGEVERQREAAGLRRRLRTRSAAEPEIDLASNDYLGLSRHPQVIEAGVEALRIWGAGSTGSRLVTGNT
ELHEELEQELATFMGTESALVFSSGYTANLGAVVALSGPGTLIVSDARTHASLIDACRLSRARVVVTPYRDTQAVAAALA
QRPEERALVLTDAVFSADGALAPLAELYGVCRRHGAVLLVDEAHGLGVRGSGGRGLVAEMNLAGRDDLVVTVTLSKALGS
QGGAVLGSAAVRAHLIDAARPFIFDTGLAPAAVGSALAALRLMIDEPARIRAVLAHAAALGQWCGVPDKPESAVVPVVLG
DPTVAFNAARSCLEQGVRVGCFRPPSVPEGQSLLRLTARASLTEADMERVHEVLAGVLTLARR

Sequences:

>Translated_383_residues
MPVVEASSPLAWLGEVERQREAAGLRRRLRTRSAAEPEIDLASNDYLGLSRHPQVIEAGVEALRIWGAGSTGSRLVTGNT
ELHEELEQELATFMGTESALVFSSGYTANLGAVVALSGPGTLIVSDARTHASLIDACRLSRARVVVTPYRDTQAVAAALA
QRPEERALVLTDAVFSADGALAPLAELYGVCRRHGAVLLVDEAHGLGVRGSGGRGLVAEMNLAGRDDLVVTVTLSKALGS
QGGAVLGSAAVRAHLIDAARPFIFDTGLAPAAVGSALAALRLMIDEPARIRAVLAHAAALGQWCGVPDKPESAVVPVVLG
DPTVAFNAARSCLEQGVRVGCFRPPSVPEGQSLLRLTARASLTEADMERVHEVLAGVLTLARR
>Mature_382_residues
PVVEASSPLAWLGEVERQREAAGLRRRLRTRSAAEPEIDLASNDYLGLSRHPQVIEAGVEALRIWGAGSTGSRLVTGNTE
LHEELEQELATFMGTESALVFSSGYTANLGAVVALSGPGTLIVSDARTHASLIDACRLSRARVVVTPYRDTQAVAAALAQ
RPEERALVLTDAVFSADGALAPLAELYGVCRRHGAVLLVDEAHGLGVRGSGGRGLVAEMNLAGRDDLVVTVTLSKALGSQ
GGAVLGSAAVRAHLIDAARPFIFDTGLAPAAVGSALAALRLMIDEPARIRAVLAHAAALGQWCGVPDKPESAVVPVVLGD
PTVAFNAARSCLEQGVRVGCFRPPSVPEGQSLLRLTARASLTEADMERVHEVLAGVLTLARR

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=354, Percent_Identity=34.4632768361582, Blast_Score=184, Evalue=8e-47,
Organism=Homo sapiens, GI284448556, Length=354, Percent_Identity=34.4632768361582, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI83977442, Length=377, Percent_Identity=35.5437665782493, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI83977444, Length=377, Percent_Identity=35.5437665782493, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI83977440, Length=377, Percent_Identity=35.5437665782493, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI4502025, Length=356, Percent_Identity=32.3033707865169, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI40316939, Length=356, Percent_Identity=32.3033707865169, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI4758668, Length=357, Percent_Identity=27.1708683473389, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI119220554, Length=395, Percent_Identity=25.0632911392405, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI5454084, Length=267, Percent_Identity=26.9662921348315, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI1790046, Length=348, Percent_Identity=34.4827586206897, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1786993, Length=348, Percent_Identity=38.5057471264368, Blast_Score=181, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI71994529, Length=357, Percent_Identity=34.1736694677871, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI32566772, Length=366, Percent_Identity=25.1366120218579, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17560912, Length=377, Percent_Identity=24.9336870026525, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71982625, Length=269, Percent_Identity=25.2788104089219, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17560914, Length=377, Percent_Identity=24.9336870026525, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71982617, Length=269, Percent_Identity=25.2788104089219, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320438, Length=350, Percent_Identity=30.5714285714286, Blast_Score=128, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6323954, Length=256, Percent_Identity=30.078125, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6320267, Length=374, Percent_Identity=25.1336898395722, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24662918, Length=336, Percent_Identity=32.4404761904762, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI17137420, Length=325, Percent_Identity=33.2307692307692, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17136286, Length=260, Percent_Identity=28.0769230769231, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24653280, Length=276, Percent_Identity=25.3623188405797, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653276, Length=276, Percent_Identity=25.3623188405797, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI24653278, Length=276, Percent_Identity=25.3623188405797, Blast_Score=115, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 40009; Mature: 39878

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVVEASSPLAWLGEVERQREAAGLRRRLRTRSAAEPEIDLASNDYLGLSRHPQVIEAGV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHH
EALRIWGAGSTGSRLVTGNTELHEELEQELATFMGTESALVFSSGYTANLGAVVALSGPG
HHEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCC
TLIVSDARTHASLIDACRLSRARVVVTPYRDTQAVAAALAQRPEERALVLTDAVFSADGA
EEEEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEHHHHCCCCC
LAPLAELYGVCRRHGAVLLVDEAHGLGVRGSGGRGLVAEMNLAGRDDLVVTVTLSKALGS
HHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCEEEEECCCCCCCEEEEEEEHHHHCC
QGGAVLGSAAVRAHLIDAARPFIFDTGLAPAAVGSALAALRLMIDEPARIRAVLAHAAAL
CCCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GQWCGVPDKPESAVVPVVLGDPTVAFNAARSCLEQGVRVGCFRPPSVPEGQSLLRLTARA
HHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHH
SLTEADMERVHEVLAGVLTLARR
HCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PVVEASSPLAWLGEVERQREAAGLRRRLRTRSAAEPEIDLASNDYLGLSRHPQVIEAGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCHHHHHHHH
EALRIWGAGSTGSRLVTGNTELHEELEQELATFMGTESALVFSSGYTANLGAVVALSGPG
HHEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCC
TLIVSDARTHASLIDACRLSRARVVVTPYRDTQAVAAALAQRPEERALVLTDAVFSADGA
EEEEECCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHCCCCCEEEEEHHHHCCCCC
LAPLAELYGVCRRHGAVLLVDEAHGLGVRGSGGRGLVAEMNLAGRDDLVVTVTLSKALGS
HHHHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCEEEEECCCCCCCEEEEEEEHHHHCC
QGGAVLGSAAVRAHLIDAARPFIFDTGLAPAAVGSALAALRLMIDEPARIRAVLAHAAAL
CCCCHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GQWCGVPDKPESAVVPVVLGDPTVAFNAARSCLEQGVRVGCFRPPSVPEGQSLLRLTARA
HHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHH
SLTEADMERVHEVLAGVLTLARR
HCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA