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The map label for this gene is nadC [H]

Identifier: 169629757

GI number: 169629757

Start: 2713286

End: 2714182

Strand: Reverse

Name: nadC [H]

Synonym: MAB_2672c

Alternate gene names: 169629757

Gene position: 2714182-2713286 (Counterclockwise)

Preceding gene: 169629758

Following gene: 169629755

Centisome position: 53.56

GC content: 64.21

Gene sequence:

>897_bases
ATGCGAAGTTGCGCTACCGTCTGGAGTGCCATGTTGACCGGAACACTGACGGAAACCGAACTCGCGGAGGCGCGTTCGGT
GGTGGAGCGCGCTCTTGCCGAGGACCTGCATTACGGCCCGGACATCACCAGTCGGGCGACCGTGCCCGCAGATGCCGAAT
GCACCGCATCGATGGTGACCCGGGCGGGCGGGGTGATCGCCGGAGTCGACATCGCCCTCATCGTGCTCGACCAGGTTGTC
GGTGCCGGTAATTACCGAGTGGACAGTCGCCTCACCGATGGGGCTCGGGTGGGAACCGGCGTATCGCTGCTTACCGTCAC
CGCGCCGACGCGTGACCTATTGACCGCCGAACGCACCATGTTGAATCTGGTGTGTCATCTCTCTGGCATCGCTACCACCA
CTGCCGCCTGGGTGGATGCCGTCGACGGCACCGGTGCGCGGATCCGCGATACCAGGAAAACCCTTCCCGGACTTCGCCTT
TTGCAGAAATATGCGGTACGTGCCGGAGGTGGGGTCAACCATCGGCTCGGCCTCGGAGACGCGGCGCTGATCAAGGACAA
CCATGTGGTGGCCGCGGGCTCGGTCGTTGCTGCGCTGCGCGCGGTCCGCGCGGTAGCGCCGGACATCGAGTGCGAGGTCG
AAGTGGACTCGCTGGAACAACTTGACGAGGTCATGGCCGAAGGGGCAGAACTGGTGCTCCTGGACAACTTCCCGGTGTGG
CAGGCTCAAGTTGCGGTGCAACGGCGCGACGCCCGCGCACCGCAACTCAAGCTCGAAGCCTCCGGCGGGTTATCCCTGGA
AACCGCCGCTGCGTACGCCAAGACAGGTGTCGATTACCTTGCGGTTGGGGCATTGACCCACTCCGCACGGGTGCTCGACA
TCGGTTTGGACATGTAA

Upstream 100 bases:

>100_bases
CGGCACGCACAGAATCGCGCGGCTGCCATGCCCGTTCGGACTGGCCCCGAACCGATTCGCATTTTGCCGTCAGCCTTCCG
GTGCGCCGCGACGCGGATGG

Downstream 100 bases:

>100_bases
CTCGCGCACCAGCGTGTGGCGCCGGGAGTACCGGCTTACTGTGCGATCTCGGCCACGAAGACGCCGGCGCGCTTGTTCAC
CTGACGCGTGGCGCGTGTCA

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MRSCATVWSAMLTGTLTETELAEARSVVERALAEDLHYGPDITSRATVPADAECTASMVTRAGGVIAGVDIALIVLDQVV
GAGNYRVDSRLTDGARVGTGVSLLTVTAPTRDLLTAERTMLNLVCHLSGIATTTAAWVDAVDGTGARIRDTRKTLPGLRL
LQKYAVRAGGGVNHRLGLGDAALIKDNHVVAAGSVVAALRAVRAVAPDIECEVEVDSLEQLDEVMAEGAELVLLDNFPVW
QAQVAVQRRDARAPQLKLEASGGLSLETAAAYAKTGVDYLAVGALTHSARVLDIGLDM

Sequences:

>Translated_298_residues
MRSCATVWSAMLTGTLTETELAEARSVVERALAEDLHYGPDITSRATVPADAECTASMVTRAGGVIAGVDIALIVLDQVV
GAGNYRVDSRLTDGARVGTGVSLLTVTAPTRDLLTAERTMLNLVCHLSGIATTTAAWVDAVDGTGARIRDTRKTLPGLRL
LQKYAVRAGGGVNHRLGLGDAALIKDNHVVAAGSVVAALRAVRAVAPDIECEVEVDSLEQLDEVMAEGAELVLLDNFPVW
QAQVAVQRRDARAPQLKLEASGGLSLETAAAYAKTGVDYLAVGALTHSARVLDIGLDM
>Mature_298_residues
MRSCATVWSAMLTGTLTETELAEARSVVERALAEDLHYGPDITSRATVPADAECTASMVTRAGGVIAGVDIALIVLDQVV
GAGNYRVDSRLTDGARVGTGVSLLTVTAPTRDLLTAERTMLNLVCHLSGIATTTAAWVDAVDGTGARIRDTRKTLPGLRL
LQKYAVRAGGGVNHRLGLGDAALIKDNHVVAAGSVVAALRAVRAVAPDIECEVEVDSLEQLDEVMAEGAELVLLDNFPVW
QAQVAVQRRDARAPQLKLEASGGLSLETAAAYAKTGVDYLAVGALTHSARVLDIGLDM

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=276, Percent_Identity=34.7826086956522, Blast_Score=131, Evalue=6e-31,
Organism=Escherichia coli, GI1786299, Length=273, Percent_Identity=42.1245421245421, Blast_Score=180, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6321162, Length=287, Percent_Identity=29.9651567944251, Blast_Score=118, Evalue=9e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31178; Mature: 31178

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSCATVWSAMLTGTLTETELAEARSVVERALAEDLHYGPDITSRATVPADAECTASMVT
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
RAGGVIAGVDIALIVLDQVVGAGNYRVDSRLTDGARVGTGVSLLTVTAPTRDLLTAERTM
HCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
LNLVCHLSGIATTTAAWVDAVDGTGARIRDTRKTLPGLRLLQKYAVRAGGGVNHRLGLGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCC
AALIKDNHVVAAGSVVAALRAVRAVAPDIECEVEVDSLEQLDEVMAEGAELVLLDNFPVW
EEEEECCCEEEHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCCCH
QAQVAVQRRDARAPQLKLEASGGLSLETAAAYAKTGVDYLAVGALTHSARVLDIGLDM
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCC
>Mature Secondary Structure
MRSCATVWSAMLTGTLTETELAEARSVVERALAEDLHYGPDITSRATVPADAECTASMVT
CCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
RAGGVIAGVDIALIVLDQVVGAGNYRVDSRLTDGARVGTGVSLLTVTAPTRDLLTAERTM
HCCCEEEHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHH
LNLVCHLSGIATTTAAWVDAVDGTGARIRDTRKTLPGLRLLQKYAVRAGGGVNHRLGLGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHHHHCCCCCCCCCCCCC
AALIKDNHVVAAGSVVAALRAVRAVAPDIECEVEVDSLEQLDEVMAEGAELVLLDNFPVW
EEEEECCCEEEHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCCCH
QAQVAVQRRDARAPQLKLEASGGLSLETAAAYAKTGVDYLAVGALTHSARVLDIGLDM
HHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCCHHHHHHHHHCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]