| Definition | Mycobacterium abscessus ATCC 19977 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010397 |
| Length | 5,067,172 |
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The map label for this gene is hisD [H]
Identifier: 169629755
GI number: 169629755
Start: 2711382
End: 2712722
Strand: Reverse
Name: hisD [H]
Synonym: MAB_2670c
Alternate gene names: 169629755
Gene position: 2712722-2711382 (Counterclockwise)
Preceding gene: 169629757
Following gene: 169629754
Centisome position: 53.54
GC content: 67.79
Gene sequence:
>1341_bases GTGAATGACGCCGCGCCCGTCCTGCTTCGCCGTATCGATATGCGTGGTGCGAGCCTGTCGCCGTCGCACCTGCGCGCTGC CCTGCCCAGGGGTGGCACGGACGTCGACGCGGTATTACCGCGGGTGCGGCCCGTCGTAGAGGCAGTTCGTGACCGCGGCG CGGAGGCCGCACTGGATTTCTGTGCCGAATTCGATGGTGTCCGTCCCGGCACCGTCCGGGTTCCCGCGGCAGAGCTGGAC CGCGCCCTCGCCGATCTAGACCCCGCCGTGCGCGACGCGCTCGAGGTGGCGATTCTGCGTGCCCGGGCCGTACACGCCGA TCAGCGCCGCCAGGACACCGTAACCACGGTTGCCGACGGCGCGACGGTGACCGAGCGGTGGGTACCTGTCGAGCGGGTGG GCCTATACGTGCCCGGTGGCAACGCCGTGTACCCATCGAGCGTCGTGATGAACGTTGTGCCCGCGCAAACAGCGGGAGTG GGATCGCTCGTCATAGCGTCGCCGCCCCAAGCGCAGTTCGGCGGTCTGCCGCATCCGACCATTTTGGCGGCGGCGCAGTT GCTCGGTGTCCAAGAAGTCTGGGCGGTCGGTGGCGCACAGGGCGTGGCGCTGCTGGCGCACGGCGGCACCGATACCGATG GGGCTGAGCTCGCACCGGTCGACATGATCACCGGGCCCGGAAACATCTATGTCACCGCTGCCAAGCGGTTGTGCCGATCG CTGGTGGGCATCGACGCGGAGGCCGGCCCTACGGAGATCGCGATTCTCGCTGACGAGACCGCCGATCCGGTGCATGTGGC CGCCGACCTGATCAGCCAGGCCGAACACGATGTGTTGGCGGCCAGCGTCTTGGTCACCGACAGTGCGGCACTTGCCGACG CGGTGGTCAAGGAGACCTCTGCGCAATTGGCGACCACGGTGCACGCCGAACGCGTCACCGCTGCGCTGACCGGCACGCAA TCCGGGATCGTGCTTGTCGACGACATCGACGCGGGCATCAAGGTGGTAAACGCCTACGCGGCCGAGCACCTGGAGATTCA CACGGTGGAACCGGTGCCGGTGGCCGCGCGGGTGCGCAATGCCGGTGCGATTTTCCTGGGGCCGTGGTCGCCGGTGAGCC TCGGCGACTACTGCGCCGGCTCCAACCACGTACTACCCACCGCCGGATGCGCGCGGCATTCCAGCGGGTTGTCCGTGCAG ACCTTCCTGCGCGGTATCCACATCGTGGACTACACCGAAGCGGCACTCAAAGAGGTCGCCGGGCATGTGATCACACTGGC TAACGCCGAGAATCTGCCCGCGCACGGTGAGGCCGTCCGACGCAGGTTCGAGCGATCATGA
Upstream 100 bases:
>100_bases GGTGCGGGAATCTCGCGCACGAGTCTAGTTAGACGTGCGTCACATACAACCGGTGACTGCGTGGTAAATGCTGTTGAGCA GCTCTGGGAGAATGGCTTAT
Downstream 100 bases:
>100_bases GCGTGCCGATCGGTGGCTCGGCCCGGCTGGAGGACCTGCCGCTGCGGGACAGCCTGCGCGGCAAGAGTCCCTACGGCGCG CCGCAATTGACAGTGCCGGT
Product: histidinol dehydrogenase
Products: NA
Alternate protein names: HDH [H]
Number of amino acids: Translated: 446; Mature: 446
Protein sequence:
>446_residues MNDAAPVLLRRIDMRGASLSPSHLRAALPRGGTDVDAVLPRVRPVVEAVRDRGAEAALDFCAEFDGVRPGTVRVPAAELD RALADLDPAVRDALEVAILRARAVHADQRRQDTVTTVADGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGV GSLVIASPPQAQFGGLPHPTILAAAQLLGVQEVWAVGGAQGVALLAHGGTDTDGAELAPVDMITGPGNIYVTAAKRLCRS LVGIDAEAGPTEIAILADETADPVHVAADLISQAEHDVLAASVLVTDSAALADAVVKETSAQLATTVHAERVTAALTGTQ SGIVLVDDIDAGIKVVNAYAAEHLEIHTVEPVPVAARVRNAGAIFLGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQ TFLRGIHIVDYTEAALKEVAGHVITLANAENLPAHGEAVRRRFERS
Sequences:
>Translated_446_residues MNDAAPVLLRRIDMRGASLSPSHLRAALPRGGTDVDAVLPRVRPVVEAVRDRGAEAALDFCAEFDGVRPGTVRVPAAELD RALADLDPAVRDALEVAILRARAVHADQRRQDTVTTVADGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGV GSLVIASPPQAQFGGLPHPTILAAAQLLGVQEVWAVGGAQGVALLAHGGTDTDGAELAPVDMITGPGNIYVTAAKRLCRS LVGIDAEAGPTEIAILADETADPVHVAADLISQAEHDVLAASVLVTDSAALADAVVKETSAQLATTVHAERVTAALTGTQ SGIVLVDDIDAGIKVVNAYAAEHLEIHTVEPVPVAARVRNAGAIFLGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQ TFLRGIHIVDYTEAALKEVAGHVITLANAENLPAHGEAVRRRFERS >Mature_446_residues MNDAAPVLLRRIDMRGASLSPSHLRAALPRGGTDVDAVLPRVRPVVEAVRDRGAEAALDFCAEFDGVRPGTVRVPAAELD RALADLDPAVRDALEVAILRARAVHADQRRQDTVTTVADGATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGV GSLVIASPPQAQFGGLPHPTILAAAQLLGVQEVWAVGGAQGVALLAHGGTDTDGAELAPVDMITGPGNIYVTAAKRLCRS LVGIDAEAGPTEIAILADETADPVHVAADLISQAEHDVLAASVLVTDSAALADAVVKETSAQLATTVHAERVTAALTGTQ SGIVLVDDIDAGIKVVNAYAAEHLEIHTVEPVPVAARVRNAGAIFLGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQ TFLRGIHIVDYTEAALKEVAGHVITLANAENLPAHGEAVRRRFERS
Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]
COG id: COG0141
COG function: function code E; Histidinol dehydrogenase
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the histidinol dehydrogenase family [H]
Homologues:
Organism=Escherichia coli, GI1788331, Length=411, Percent_Identity=36.4963503649635, Blast_Score=224, Evalue=1e-59, Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=34.8729792147806, Blast_Score=236, Evalue=7e-63,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR016161 - InterPro: IPR022695 - InterPro: IPR001692 - InterPro: IPR012131 [H]
Pfam domain/function: PF00815 Histidinol_dh [H]
EC number: =1.1.1.23 [H]
Molecular weight: Translated: 46189; Mature: 46189
Theoretical pI: Translated: 5.03; Mature: 5.03
Prosite motif: PS00611 HISOL_DEHYDROGENASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.9 %Cys (Translated Protein) 0.9 %Met (Translated Protein) 1.8 %Cys+Met (Translated Protein) 0.9 %Cys (Mature Protein) 0.9 %Met (Mature Protein) 1.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNDAAPVLLRRIDMRGASLSPSHLRAALPRGGTDVDAVLPRVRPVVEAVRDRGAEAALDF CCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH CAEFDGVRPGTVRVPAAELDRALADLDPAVRDALEVAILRARAVHADQRRQDTVTTVADG HHHHCCCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECC ATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGVGSLVIASPPQAQFGGLPHPT CCHHHHCCCHHHEEEEECCCCCCCCCHHHHEECCCCCCCCCEEEEECCCCHHHCCCCCHH ILAAAQLLGVQEVWAVGGAQGVALLAHGGTDTDGAELAPVDMITGPGNIYVTAAKRLCRS HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCEEEHHHHHHHHH LVGIDAEAGPTEIAILADETADPVHVAADLISQAEHDVLAASVLVTDSAALADAVVKETS HHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEHHEEECCHHHHHHHHHHHH AQLATTVHAERVTAALTGTQSGIVLVDDIDAGIKVVNAYAAEHLEIHTVEPVPVAARVRN HHHHHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHHCC AGAIFLGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHIVDYTEAALKEVA CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHC GHVITLANAENLPAHGEAVRRRFERS CCEEEEECCCCCCCCHHHHHHHHCCC >Mature Secondary Structure MNDAAPVLLRRIDMRGASLSPSHLRAALPRGGTDVDAVLPRVRPVVEAVRDRGAEAALDF CCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHH CAEFDGVRPGTVRVPAAELDRALADLDPAVRDALEVAILRARAVHADQRRQDTVTTVADG HHHHCCCCCCEEECCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECC ATVTERWVPVERVGLYVPGGNAVYPSSVVMNVVPAQTAGVGSLVIASPPQAQFGGLPHPT CCHHHHCCCHHHEEEEECCCCCCCCCHHHHEECCCCCCCCCEEEEECCCCHHHCCCCCHH ILAAAQLLGVQEVWAVGGAQGVALLAHGGTDTDGAELAPVDMITGPGNIYVTAAKRLCRS HHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCEEEHHHHHHHHH LVGIDAEAGPTEIAILADETADPVHVAADLISQAEHDVLAASVLVTDSAALADAVVKETS HHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHEEHHEEECCHHHHHHHHHHHH AQLATTVHAERVTAALTGTQSGIVLVDDIDAGIKVVNAYAAEHLEIHTVEPVPVAARVRN HHHHHHHHHHHHHEEEECCCCCEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHHCC AGAIFLGPWSPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHIVDYTEAALKEVA CCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCEEEEHHHHHHHHHC GHVITLANAENLPAHGEAVRRRFERS CCEEEEECCCCCCCCHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 1435262 [H]