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The map label for this gene is impA [H]

Identifier: 169629750

GI number: 169629750

Start: 2707443

End: 2708258

Strand: Reverse

Name: impA [H]

Synonym: MAB_2665c

Alternate gene names: 169629750

Gene position: 2708258-2707443 (Counterclockwise)

Preceding gene: 169629751

Following gene: 169629749

Centisome position: 53.45

GC content: 65.2

Gene sequence:

>816_bases
ATGACCACGACCGCGGAACTGGAAGCTCTGGTGCGCGAGGCGTCCGTGATTCTGGATGCGGCGGCCCAGCGTTTCGTGGC
CGGTCATGGGGCCGAGGGTGTGGTCTTCAAGGGCGGCAAGGATTTTGCCACCGAGGAAGACCTCGCCATCGAGCGGATGG
TGGTGCAGGCACTGACCGAGCGCACCGGAATCGGGGTGCACGGTGAGGAATTCGGCGGCCCGGCGGTGGATTCCGGATTG
GTCTGGGTAGTCGACCCGATAGACGGCACCGTCAACTACGCGGCGGGTTCTCCGATGGCCGCAATTCTGCTCGGGCTGAT
GTCCGACGGTGTGCCGGTGGCCGGGCTGACCTGGTTGCCGTTCATGGGGGAGAAGTATGCCGCCGTGACGGGCGGTCCGT
TGTTCCGCAACGGAGTTGCGATGCCACCCTTGCCGCGCACCGATCTTGCGGACGTGGCCGTGGGCCTGGGCACCTTCAAT
GTTGATTGGAAGGGCCGGGTTCCGGGGCGGTACCGCCTGACCGTGCTGGAGAAACTGAGCCGCATCACCTCGCGGCTGCG
TATGCATGGCAGTACCGGAATCGATTTGGCGTTCACCGCCGGCGGAATATTGGGTGGTGCGGTGAGCTTCGGTGCGCATG
TCTGGGATCACGCCGCTGGTATCGCATTGGTACAGGCCGCGGGCGGCCATGCGAGCGACCTGAACGGTGAGCCCTGGACC
CCGGAATCGCCCTCGCTACTGGTGGCGGCACCGGGCGTGCAGGAGCAGATCTTGGAAGTACTGGCTGAGGTCGGAGATCC
GGAGGACTACCGATGA

Upstream 100 bases:

>100_bases
GCGGAATTGACCGGCGCCGGTGTCGAGGGCGCGATCGTCGGAAAGGCCCTTTACGCAGGCCGTTTCACCCTGCCCGATGC
GATAGCAGCCGTTTCCTGAG

Downstream 100 bases:

>100_bases
GTGTTGCCACCCGCGTCATCGCATGCCTGGACGTCGACGACGGCCGGGTGGTCAAGGGCGTGAATTTCGAAAACCTCCGG
GATGCGGGCGATCCGGTCGA

Product: inositol monophosphatase family protein

Products: NA

Alternate protein names: I-1-Pase; IMPase; Inositol-1-phosphatase [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTTTAELEALVREASVILDAAAQRFVAGHGAEGVVFKGGKDFATEEDLAIERMVVQALTERTGIGVHGEEFGGPAVDSGL
VWVVDPIDGTVNYAAGSPMAAILLGLMSDGVPVAGLTWLPFMGEKYAAVTGGPLFRNGVAMPPLPRTDLADVAVGLGTFN
VDWKGRVPGRYRLTVLEKLSRITSRLRMHGSTGIDLAFTAGGILGGAVSFGAHVWDHAAGIALVQAAGGHASDLNGEPWT
PESPSLLVAAPGVQEQILEVLAEVGDPEDYR

Sequences:

>Translated_271_residues
MTTTAELEALVREASVILDAAAQRFVAGHGAEGVVFKGGKDFATEEDLAIERMVVQALTERTGIGVHGEEFGGPAVDSGL
VWVVDPIDGTVNYAAGSPMAAILLGLMSDGVPVAGLTWLPFMGEKYAAVTGGPLFRNGVAMPPLPRTDLADVAVGLGTFN
VDWKGRVPGRYRLTVLEKLSRITSRLRMHGSTGIDLAFTAGGILGGAVSFGAHVWDHAAGIALVQAAGGHASDLNGEPWT
PESPSLLVAAPGVQEQILEVLAEVGDPEDYR
>Mature_270_residues
TTTAELEALVREASVILDAAAQRFVAGHGAEGVVFKGGKDFATEEDLAIERMVVQALTERTGIGVHGEEFGGPAVDSGLV
WVVDPIDGTVNYAAGSPMAAILLGLMSDGVPVAGLTWLPFMGEKYAAVTGGPLFRNGVAMPPLPRTDLADVAVGLGTFNV
DWKGRVPGRYRLTVLEKLSRITSRLRMHGSTGIDLAFTAGGILGGAVSFGAHVWDHAAGIALVQAAGGHASDLNGEPWTP
ESPSLLVAAPGVQEQILEVLAEVGDPEDYR

Specific function: Catalyzes the dephosphorylation of inositol-1-phosphate (I-1-P) to yield free myo-inositol, a key metabolite in mycobacteria (Probable) [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI5031789, Length=219, Percent_Identity=26.9406392694064, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI221625487, Length=219, Percent_Identity=26.9406392694064, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1788882, Length=204, Percent_Identity=28.921568627451, Blast_Score=79, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193202572, Length=218, Percent_Identity=32.5688073394495, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193202570, Length=220, Percent_Identity=32.2727272727273, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320493, Length=208, Percent_Identity=25.9615384615385, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357329, Length=281, Percent_Identity=27.0462633451957, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21357303, Length=217, Percent_Identity=27.6497695852535, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.25 [H]

Molecular weight: Translated: 28179; Mature: 28048

Theoretical pI: Translated: 4.45; Mature: 4.45

Prosite motif: PS00630 IMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTAELEALVREASVILDAAAQRFVAGHGAEGVVFKGGKDFATEEDLAIERMVVQALTE
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
RTGIGVHGEEFGGPAVDSGLVWVVDPIDGTVNYAAGSPMAAILLGLMSDGVPVAGLTWLP
HCCCCCCCHHCCCCCCCCCCEEEECCCCCCEECCCCCCHHHHHHHHHHCCCCCCCEEECC
FMGEKYAAVTGGPLFRNGVAMPPLPRTDLADVAVGLGTFNVDWKGRVPGRYRLTVLEKLS
CCCCCEEEEECCCHHHCCCCCCCCCCCCHHHHHHHCCEEECCCCCCCCCCEEHHHHHHHH
RITSRLRMHGSTGIDLAFTAGGILGGAVSFGAHVWDHAAGIALVQAAGGHASDLNGEPWT
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCC
PESPSLLVAAPGVQEQILEVLAEVGDPEDYR
CCCCCEEEECCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TTTAELEALVREASVILDAAAQRFVAGHGAEGVVFKGGKDFATEEDLAIERMVVQALTE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
RTGIGVHGEEFGGPAVDSGLVWVVDPIDGTVNYAAGSPMAAILLGLMSDGVPVAGLTWLP
HCCCCCCCHHCCCCCCCCCCEEEECCCCCCEECCCCCCHHHHHHHHHHCCCCCCCEEECC
FMGEKYAAVTGGPLFRNGVAMPPLPRTDLADVAVGLGTFNVDWKGRVPGRYRLTVLEKLS
CCCCCEEEEECCCHHHCCCCCCCCCCCCHHHHHHHCCEEECCCCCCCCCCEEHHHHHHHH
RITSRLRMHGSTGIDLAFTAGGILGGAVSFGAHVWDHAAGIALVQAAGGHASDLNGEPWT
HHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCCCCC
PESPSLLVAAPGVQEQILEVLAEVGDPEDYR
CCCCCEEEECCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9401044 [H]