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The map label for this gene is priA

Identifier: 169629751

GI number: 169629751

Start: 2708260

End: 2708991

Strand: Reverse

Name: priA

Synonym: MAB_2666c

Alternate gene names: 169629751

Gene position: 2708991-2708260 (Counterclockwise)

Preceding gene: 169629752

Following gene: 169629750

Centisome position: 53.46

GC content: 64.48

Gene sequence:

>732_bases
TTGAGTCTCGTTCTATTACCGGCGGTTGATGTCGCGGACGGTCAGGCTGTACGCCTGGTGCAGGGCAAGGCGGGCAGTGA
AACCACGTACGGTTCGCCGCGTGACGCGGCACTGGCGTGGCAGAACGACGGTGCCGAGTGGGTACATCTGGTGGACCTGG
ATGCGGCCTTTGGCCGTGGCTCAAATCGTGAGCTGCTGGCGCAGGTCGTCGGTGAGCTCGACGTCAAGGTGGAGCTCTCG
GGTGGTATCCGTGACGATGAGGCGTTGACCGCGGCGCTCGCCACCGGTTGCGCACGAGTCAATCTCGGTACCGCTGCGCT
GGAGGACCCCGAATGGTGCGCTTCGGCGATCGCCCGGCACGGTGAACGCGTGGCTGTGGGTCTGGATGTCGAAATTGTCG
AGGGCGCACACCGTCTACGCGGCCGTGGCTGGGTGAGTGACGGCGGAGATCTCTGGGAGGTGCTCGAACGTCTGCGTGCA
CAGGGATGTTCGCGCTACGTGGTCACGGATGTAACCAAGGACGGTACCCTGACCGGGCCAAATCTTGAGCTGCTGGCACA
GGTCGCCGGTGTGGCCAACGCTCCGGTCATTGCCTCGGGCGGGGTGTCGAGTCTGGATGATCTGCGTGCCATCGCGGAAT
TGACCGGCGCCGGTGTCGAGGGCGCGATCGTCGGAAAGGCCCTTTACGCAGGCCGTTTCACCCTGCCCGATGCGATAGCA
GCCGTTTCCTGA

Upstream 100 bases:

>100_bases
CGGCGGTGGAGAATGGGCCACTTGCTGCCACACAGTTCCATCCGGAAAAGAGTGGTGACGCGGGGGCCGTGTTGTTGAGC
AATTGGGTGAAGGGAATCTC

Downstream 100 bases:

>100_bases
GATGACCACGACCGCGGAACTGGAAGCTCTGGTGCGCGAGGCGTCCGTGATTCTGGATGCGGCGGCCCAGCGTTTCGTGG
CCGGTCATGGGGCCGAGGGT

Product: phosphoribosyl isomerase A

Products: NA

Alternate protein names: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MSLVLLPAVDVADGQAVRLVQGKAGSETTYGSPRDAALAWQNDGAEWVHLVDLDAAFGRGSNRELLAQVVGELDVKVELS
GGIRDDEALTAALATGCARVNLGTAALEDPEWCASAIARHGERVAVGLDVEIVEGAHRLRGRGWVSDGGDLWEVLERLRA
QGCSRYVVTDVTKDGTLTGPNLELLAQVAGVANAPVIASGGVSSLDDLRAIAELTGAGVEGAIVGKALYAGRFTLPDAIA
AVS

Sequences:

>Translated_243_residues
MSLVLLPAVDVADGQAVRLVQGKAGSETTYGSPRDAALAWQNDGAEWVHLVDLDAAFGRGSNRELLAQVVGELDVKVELS
GGIRDDEALTAALATGCARVNLGTAALEDPEWCASAIARHGERVAVGLDVEIVEGAHRLRGRGWVSDGGDLWEVLERLRA
QGCSRYVVTDVTKDGTLTGPNLELLAQVAGVANAPVIASGGVSSLDDLRAIAELTGAGVEGAIVGKALYAGRFTLPDAIA
AVS
>Mature_242_residues
SLVLLPAVDVADGQAVRLVQGKAGSETTYGSPRDAALAWQNDGAEWVHLVDLDAAFGRGSNRELLAQVVGELDVKVELSG
GIRDDEALTAALATGCARVNLGTAALEDPEWCASAIARHGERVAVGLDVEIVEGAHRLRGRGWVSDGGDLWEVLERLRAQ
GCSRYVVTDVTKDGTLTGPNLELLAQVAGVANAPVIASGGVSSLDDLRAIAELTGAGVEGAIVGKALYAGRFTLPDAIAA
VS

Specific function: Involved in both the histidine and tryptophan biosynthetic pathways

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=247, Percent_Identity=36.8421052631579, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788336, Length=234, Percent_Identity=24.7863247863248, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_MYCA9 (B1MBX5)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703400.1
- ProteinModelPortal:   B1MBX5
- SMR:   B1MBX5
- EnsemblBacteria:   EBMYCT00000006309
- GeneID:   5965175
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2666c
- GeneTree:   EBGT00050000015857
- HOGENOM:   HBG541613
- OMA:   CARYVVT
- ProtClustDB:   PRK14024
- BioCyc:   MABS561007:MAB_2666C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR010188
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR01919

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16; =5.3.1.24

Molecular weight: Translated: 25075; Mature: 24944

Theoretical pI: Translated: 4.33; Mature: 4.33

Prosite motif: NA

Important sites: ACT_SITE 10-10 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVLLPAVDVADGQAVRLVQGKAGSETTYGSPRDAALAWQNDGAEWVHLVDLDAAFGRG
CCEEEEECEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEHHHHCCC
SNRELLAQVVGELDVKVELSGGIRDDEALTAALATGCARVNLGTAALEDPEWCASAIARH
CCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHC
GERVAVGLDVEIVEGAHRLRGRGWVSDGGDLWEVLERLRAQGCSRYVVTDVTKDGTLTGP
CCEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
NLELLAQVAGVANAPVIASGGVSSLDDLRAIAELTGAGVEGAIVGKALYAGRFTLPDAIA
CHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHH
AVS
HCC
>Mature Secondary Structure 
SLVLLPAVDVADGQAVRLVQGKAGSETTYGSPRDAALAWQNDGAEWVHLVDLDAAFGRG
CEEEEECEECCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCEEEEEEEHHHHCCC
SNRELLAQVVGELDVKVELSGGIRDDEALTAALATGCARVNLGTAALEDPEWCASAIARH
CCHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHC
GERVAVGLDVEIVEGAHRLRGRGWVSDGGDLWEVLERLRAQGCSRYVVTDVTKDGTLTGP
CCEEEEECCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCC
NLELLAQVAGVANAPVIASGGVSSLDDLRAIAELTGAGVEGAIVGKALYAGRFTLPDAIA
CHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHH
AVS
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA