Click here to switch to the map view.

The map label for this gene is argH

Identifier: 169629429

GI number: 169629429

Start: 2398010

End: 2399431

Strand: Direct

Name: argH

Synonym: MAB_2343

Alternate gene names: 169629429

Gene position: 2398010-2399431 (Clockwise)

Preceding gene: 169629428

Following gene: 169629430

Centisome position: 47.32

GC content: 66.17

Gene sequence:

>1422_bases
GTGAGCACCAACGAAGGCTCGCTGTGGGGCGGCCGGTTCGCCGGCGGCCCAGCCCCGGCGCTGGCGGCATTGAGCAAATC
CACTCATTTCGATTGGGCGCTGGCGCCTTACGACATTCAGGCGTCGGTTGCTCATGCCCGAGTGCTCCGCAAGGCGGGCC
TGCTCACCGATGAACAACTCGGTGCCCTGGTCGAGGGCTTAGAGCAGCTGGGTCGGGATGTCGCGTCGGGCGTGTTCGTC
CCAGCCGATACCGACGAGGACGTACACGGTGCCCTCGAACGCGGGTTGATCGAACGGGTGGGCCCTGACATCGGCGGCCG
TCTCCGTGCCGGCCGATCCCGAAACGATCAGGTGGCCACACTGTTTCGGATGTGGCTGCGCGACGCGGCCGGACGCATCT
CCGAGGGCGTGCTCGACGTCGTGCAGGCATTGGCGGATCAGGCCGGGGCACATCCGGATGCGATCATGCCGGGCAAGACT
CATTTGCAGGCCGCCCAACCGGTGCTGCTTGCGCATCATCTGCTCGCGCACGCGCAGCCGCTGCTGCGCGACGTCGACCG
GCTCGTGGACTGGGACCGGCGCACCGCCGTCTCGCCCTACGGCGCCGGGGCGCTGGCGGGTTCCTCGTTGGGCCTAGACC
CCGATGCCATCGCGCTGGATCTGGGTTTCACCGCGGCCGCGGACAATTCGATCGATGCGACGTCGTCACGCGATTTCGCT
GCCGAGGCTGGCTTTGTTTTCGCGATGATCGGCATCGATTTGTCGCGGCTGTCCGAAGACATCATTTTGTGGGGCACCAC
CGAATTCGGGTACGTCACCCTCGACGACTCATGGTCTACCGGCAGTTCGATCATGCCGCAGAAGAAGAACCCCGATATCG
CCGAGCTGGCGCGCGGCAAGACGGGGAGGTTGATCGGTAATCTCACCGGCTTGCTCGCCACTTTGAAAGCGCAACCGTTG
GCGTACAACCGGGACCTGCAGGAGGACAAGGAGCCCCTGTTCGATTCGGTGTCCCAGTTGGAGCTGCTGCTACCCGCGAT
GGCGGGGCTCGTCGCCACGCTGCGGTTCCACACCGAACGGATGGCGCAGCTCGCGCCCGCCGGATTCACGCTGGCCACCG
ATCTAGCGGAATGGATGGTGCGACAAGGCATTCCGTTCCGCGTCGCGCATGAGGCGGCGGGGGAGGCGGTTCGGGTGGCC
GAGGCACGTGGTGTCGGACTGGAGGACCTTACCGACGAGGAGTTCGCAGCCATTCATCCGGAACTGACCGGAGATGTACG
CGCCGTGCTCACCACGGCCGGCTCTGTCGCCTCGCGCGATGCACGCGGTGGCACCGCCCCAGAGCGGGTAGCGGAGCAGC
GTGAACTGGTGCTGGCCCGTCTGAACGTGCTTCGCGGTCAGAACGGCCGCCATCCAGGCTAA

Upstream 100 bases:

>100_bases
ACGACGAGGGCGACAGCTTCGATCAGTCCAGCGCCAAGGGCTTCGTGCATATTCACGGTCTGTCCTCCAAGATCTCCGCG
CAGAGGGACCTCTCGGGCAA

Downstream 100 bases:

>100_bases
TATCCAGCCATGGACGGTGAGCCGGACCCGACATTGTCGGGCCCCGGTCCGGGGGGAGAGACGCCGGACGACCCGAACGC
GGTATGGCGCCGCCCCGGTG

Product: argininosuccinate lyase ArgH

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MSTNEGSLWGGRFAGGPAPALAALSKSTHFDWALAPYDIQASVAHARVLRKAGLLTDEQLGALVEGLEQLGRDVASGVFV
PADTDEDVHGALERGLIERVGPDIGGRLRAGRSRNDQVATLFRMWLRDAAGRISEGVLDVVQALADQAGAHPDAIMPGKT
HLQAAQPVLLAHHLLAHAQPLLRDVDRLVDWDRRTAVSPYGAGALAGSSLGLDPDAIALDLGFTAAADNSIDATSSRDFA
AEAGFVFAMIGIDLSRLSEDIILWGTTEFGYVTLDDSWSTGSSIMPQKKNPDIAELARGKTGRLIGNLTGLLATLKAQPL
AYNRDLQEDKEPLFDSVSQLELLLPAMAGLVATLRFHTERMAQLAPAGFTLATDLAEWMVRQGIPFRVAHEAAGEAVRVA
EARGVGLEDLTDEEFAAIHPELTGDVRAVLTTAGSVASRDARGGTAPERVAEQRELVLARLNVLRGQNGRHPG

Sequences:

>Translated_473_residues
MSTNEGSLWGGRFAGGPAPALAALSKSTHFDWALAPYDIQASVAHARVLRKAGLLTDEQLGALVEGLEQLGRDVASGVFV
PADTDEDVHGALERGLIERVGPDIGGRLRAGRSRNDQVATLFRMWLRDAAGRISEGVLDVVQALADQAGAHPDAIMPGKT
HLQAAQPVLLAHHLLAHAQPLLRDVDRLVDWDRRTAVSPYGAGALAGSSLGLDPDAIALDLGFTAAADNSIDATSSRDFA
AEAGFVFAMIGIDLSRLSEDIILWGTTEFGYVTLDDSWSTGSSIMPQKKNPDIAELARGKTGRLIGNLTGLLATLKAQPL
AYNRDLQEDKEPLFDSVSQLELLLPAMAGLVATLRFHTERMAQLAPAGFTLATDLAEWMVRQGIPFRVAHEAAGEAVRVA
EARGVGLEDLTDEEFAAIHPELTGDVRAVLTTAGSVASRDARGGTAPERVAEQRELVLARLNVLRGQNGRHPG
>Mature_472_residues
STNEGSLWGGRFAGGPAPALAALSKSTHFDWALAPYDIQASVAHARVLRKAGLLTDEQLGALVEGLEQLGRDVASGVFVP
ADTDEDVHGALERGLIERVGPDIGGRLRAGRSRNDQVATLFRMWLRDAAGRISEGVLDVVQALADQAGAHPDAIMPGKTH
LQAAQPVLLAHHLLAHAQPLLRDVDRLVDWDRRTAVSPYGAGALAGSSLGLDPDAIALDLGFTAAADNSIDATSSRDFAA
EAGFVFAMIGIDLSRLSEDIILWGTTEFGYVTLDDSWSTGSSIMPQKKNPDIAELARGKTGRLIGNLTGLLATLKAQPLA
YNRDLQEDKEPLFDSVSQLELLLPAMAGLVATLRFHTERMAQLAPAGFTLATDLAEWMVRQGIPFRVAHEAAGEAVRVAE
ARGVGLEDLTDEEFAAIHPELTGDVRAVLTTAGSVASRDARGGTAPERVAEQRELVLARLNVLRGQNGRHPG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=463, Percent_Identity=44.7084233261339, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI68303542, Length=463, Percent_Identity=44.7084233261339, Blast_Score=384, Evalue=1e-106,
Organism=Homo sapiens, GI68303549, Length=463, Percent_Identity=42.3326133909287, Blast_Score=350, Evalue=2e-96,
Organism=Homo sapiens, GI68303547, Length=463, Percent_Identity=42.1166306695464, Blast_Score=348, Evalue=6e-96,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=41.8859649122807, Blast_Score=324, Evalue=7e-90,
Organism=Saccharomyces cerevisiae, GI6321806, Length=464, Percent_Identity=40.7327586206897, Blast_Score=342, Evalue=5e-95,
Organism=Drosophila melanogaster, GI221473854, Length=455, Percent_Identity=41.3186813186813, Blast_Score=326, Evalue=2e-89,
Organism=Drosophila melanogaster, GI78706858, Length=455, Percent_Identity=41.3186813186813, Blast_Score=326, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_MYCA9 (B1MB03)

Other databases:

- EMBL:   CU458896
- RefSeq:   YP_001703078.1
- ProteinModelPortal:   B1MB03
- SMR:   B1MB03
- EnsemblBacteria:   EBMYCT00000007826
- GeneID:   5964853
- GenomeReviews:   CU458896_GR
- KEGG:   mab:MAB_2343
- GeneTree:   EBGT00050000016253
- HOGENOM:   HBG539632
- OMA:   MPGRTHL
- BioCyc:   MABS561007:MAB_2343-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 50270; Mature: 50139

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTNEGSLWGGRFAGGPAPALAALSKSTHFDWALAPYDIQASVAHARVLRKAGLLTDEQL
CCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHH
GALVEGLEQLGRDVASGVFVPADTDEDVHGALERGLIERVGPDIGGRLRAGRSRNDQVAT
HHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LFRMWLRDAAGRISEGVLDVVQALADQAGAHPDAIMPGKTHLQAAQPVLLAHHLLAHAQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLRDVDRLVDWDRRTAVSPYGAGALAGSSLGLDPDAIALDLGFTAAADNSIDATSSRDFA
HHHHHHHHHCCHHHCCCCCCCCCHHCCCCCCCCCCCEEEECCCEECCCCCCCCCCCCCHH
AEAGFVFAMIGIDLSRLSEDIILWGTTEFGYVTLDDSWSTGSSIMPQKKNPDIAELARGK
HHCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCC
TGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPLFDSVSQLELLLPAMAGLVATLRFHTER
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAQLAPAGFTLATDLAEWMVRQGIPFRVAHEAAGEAVRVAEARGVGLEDLTDEEFAAIHP
HHHHCCCCHHHHHHHHHHHHHCCCCEEEHHHHCCCCEEHHHHCCCCCCCCCCCHHHHCCC
ELTGDVRAVLTTAGSVASRDARGGTAPERVAEQRELVLARLNVLRGQNGRHPG
CCCCHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
STNEGSLWGGRFAGGPAPALAALSKSTHFDWALAPYDIQASVAHARVLRKAGLLTDEQL
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHCCCCHHHH
GALVEGLEQLGRDVASGVFVPADTDEDVHGALERGLIERVGPDIGGRLRAGRSRNDQVAT
HHHHHHHHHHHHHHHCCEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LFRMWLRDAAGRISEGVLDVVQALADQAGAHPDAIMPGKTHLQAAQPVLLAHHLLAHAQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLRDVDRLVDWDRRTAVSPYGAGALAGSSLGLDPDAIALDLGFTAAADNSIDATSSRDFA
HHHHHHHHHCCHHHCCCCCCCCCHHCCCCCCCCCCCEEEECCCEECCCCCCCCCCCCCHH
AEAGFVFAMIGIDLSRLSEDIILWGTTEFGYVTLDDSWSTGSSIMPQKKNPDIAELARGK
HHCCHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHCCC
TGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPLFDSVSQLELLLPAMAGLVATLRFHTER
CCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MAQLAPAGFTLATDLAEWMVRQGIPFRVAHEAAGEAVRVAEARGVGLEDLTDEEFAAIHP
HHHHCCCCHHHHHHHHHHHHHCCCCEEEHHHHCCCCEEHHHHCCCCCCCCCCCHHHHCCC
ELTGDVRAVLTTAGSVASRDARGGTAPERVAEQRELVLARLNVLRGQNGRHPG
CCCCHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA