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The map label for this gene is argG [H]

Identifier: 169629428

GI number: 169629428

Start: 2396799

End: 2398013

Strand: Direct

Name: argG [H]

Synonym: MAB_2342

Alternate gene names: 169629428

Gene position: 2396799-2398013 (Clockwise)

Preceding gene: 169629427

Following gene: 169629429

Centisome position: 47.3

GC content: 63.46

Gene sequence:

>1215_bases
ATGCCCGTAGAACACTCTGACCGCGTAATCCTCGCCTACTCGGGCGGTCTCGATACTTCCGTGGCGATCAGCTGGATCGG
CAAGGAGACCGGCCGTGAGGTCGTCGCCGTCGCCATCGATCTGGGCCAGGGCGGCGAGGACATGGAAGTGGTGCGCCAGC
GCGCCCTGGACTGCGGCGCGGTTGAGGCCGTTGTGGTGGACGCACGCGACGAATTCGCCGAGGAATACTGCCTACCCACG
ATCCAATCCAACGCGCTGTACATGGATCGGTACCCGCTGGTGTCCGCGATCAGCCGTCCGCTGATCGTCAAGCACCTGGT
TGCCGCGGCACGCGAGCACGGTGGCGGGATCGTCGCTCACGGCTGCACCGGCAAGGGCAACGATCAGGTGCGCTTCGAGG
TTGGCTTTGCCTCGCTAGCACCAGATTTGGAAGTACTGGCGCCGGTGCGTGACTACGCGTGGACCCGCGAGAAGGCGATC
GCGTTCGCGGCAGAGAACGAGATTCCGATCAACGTGACGAAGAAGTCGCCGTTCTCGATCGATCAGAACGTATGGGGACG
CGCGGTGGAAACCGGCTTCCTGGAAGACCTTTGGAACGCGCCGACCAAAGATGTGTACGACTACACCGAAGACCCGACCC
TGAACTGGGGCGCACCCGACGAGCTGATCGTCACCTTCGACAAGGGTGTACCAACTGCCATCGACGGCCACCCGGTCAGC
GTGTTGGAGGCCATCGTCGAGCTCAACCGCCGGGCGGGTGCACAGGGCGTGGGTCGCCTGGACGTGGTCGAAGACCGGCT
GGTCGGCATCAAGAGCCGTGAAATCTATGAGGCGCCGGGTGCGATGGTTCTGATCACCGCACACGAGGAGCTCGAACACG
TCACCCTGGAGCGCGAACTTGGCCGCTACAAGCGACGCACGGACCAGAAGTGGGCCGAGCTGGTGTACGACGGGCTCTGG
TACTCGCCGCTGAAGCGTTCACTGGAGGCCTTTGTCGCCGATACCCAGCAGCATGTGTCCGGCGACATCCGGCTGGTGCT
GCACGGCGGCAACATCGCCGTCAATGGCCGCCGCAGTCCTGAATCCCTGTACGACTTCAACCTGGCGACCTACGACGAGG
GCGACAGCTTCGATCAGTCCAGCGCCAAGGGCTTCGTGCATATTCACGGTCTGTCCTCCAAGATCTCCGCGCAGAGGGAC
CTCTCGGGCAAGTGA

Upstream 100 bases:

>100_bases
GATGACACCATTGCGGTGATCGCCCGCGAACCCTTGACCGGAGCCCAGCTCGCCGCACAGTTCGAACAGCTTGCCTAGAA
ACTAGAAAGAAGAAGTAGGA

Downstream 100 bases:

>100_bases
GCACCAACGAAGGCTCGCTGTGGGGCGGCCGGTTCGCCGGCGGCCCAGCCCCGGCGCTGGCGGCATTGAGCAAATCCACT
CATTTCGATTGGGCGCTGGC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MPVEHSDRVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVVRQRALDCGAVEAVVVDARDEFAEEYCLPT
IQSNALYMDRYPLVSAISRPLIVKHLVAAAREHGGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAI
AFAAENEIPINVTKKSPFSIDQNVWGRAVETGFLEDLWNAPTKDVYDYTEDPTLNWGAPDELIVTFDKGVPTAIDGHPVS
VLEAIVELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHEELEHVTLERELGRYKRRTDQKWAELVYDGLW
YSPLKRSLEAFVADTQQHVSGDIRLVLHGGNIAVNGRRSPESLYDFNLATYDEGDSFDQSSAKGFVHIHGLSSKISAQRD
LSGK

Sequences:

>Translated_404_residues
MPVEHSDRVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVVRQRALDCGAVEAVVVDARDEFAEEYCLPT
IQSNALYMDRYPLVSAISRPLIVKHLVAAAREHGGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAI
AFAAENEIPINVTKKSPFSIDQNVWGRAVETGFLEDLWNAPTKDVYDYTEDPTLNWGAPDELIVTFDKGVPTAIDGHPVS
VLEAIVELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHEELEHVTLERELGRYKRRTDQKWAELVYDGLW
YSPLKRSLEAFVADTQQHVSGDIRLVLHGGNIAVNGRRSPESLYDFNLATYDEGDSFDQSSAKGFVHIHGLSSKISAQRD
LSGK
>Mature_403_residues
PVEHSDRVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVVRQRALDCGAVEAVVVDARDEFAEEYCLPTI
QSNALYMDRYPLVSAISRPLIVKHLVAAAREHGGGIVAHGCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIA
FAAENEIPINVTKKSPFSIDQNVWGRAVETGFLEDLWNAPTKDVYDYTEDPTLNWGAPDELIVTFDKGVPTAIDGHPVSV
LEAIVELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHEELEHVTLERELGRYKRRTDQKWAELVYDGLWY
SPLKRSLEAFVADTQQHVSGDIRLVLHGGNIAVNGRRSPESLYDFNLATYDEGDSFDQSSAKGFVHIHGLSSKISAQRDL
SGK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 1 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=409, Percent_Identity=40.5867970660147, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI16950633, Length=409, Percent_Identity=40.5867970660147, Blast_Score=281, Evalue=8e-76,
Organism=Escherichia coli, GI1789563, Length=409, Percent_Identity=30.3178484107579, Blast_Score=124, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6324514, Length=403, Percent_Identity=35.7320099255583, Blast_Score=251, Evalue=1e-67,
Organism=Drosophila melanogaster, GI21358151, Length=405, Percent_Identity=36.5432098765432, Blast_Score=258, Evalue=4e-69,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 44370; Mature: 44239

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVEHSDRVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVVRQRALDCGA
CCCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCC
VEAVVVDARDEFAEEYCLPTIQSNALYMDRYPLVSAISRPLIVKHLVAAAREHGGGIVAH
EEEEEEECHHHHHHHHCCCCCCCCEEEEECCHHHHHHCCHHHHHHHHHHHHHCCCEEEEE
GCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAAENEIPINVTKKSPFSI
CCCCCCCCEEEEEECHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCCCC
DQNVWGRAVETGFLEDLWNAPTKDVYDYTEDPTLNWGAPDELIVTFDKGVPTAIDGHPVS
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHH
VLEAIVELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHEELEHVTLEREL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCEEEEEECHHHHHHHHHHHH
GRYKRRTDQKWAELVYDGLWYSPLKRSLEAFVADTQQHVSGDIRLVLHGGNIAVNGRRSP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCC
ESLYDFNLATYDEGDSFDQSSAKGFVHIHGLSSKISAQRDLSGK
CHHHCCCEEECCCCCCCCCCCCCCEEEEECCCCHHCCCCCCCCC
>Mature Secondary Structure 
PVEHSDRVILAYSGGLDTSVAISWIGKETGREVVAVAIDLGQGGEDMEVVRQRALDCGA
CCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHHCCCCC
VEAVVVDARDEFAEEYCLPTIQSNALYMDRYPLVSAISRPLIVKHLVAAAREHGGGIVAH
EEEEEEECHHHHHHHHCCCCCCCCEEEEECCHHHHHHCCHHHHHHHHHHHHHCCCEEEEE
GCTGKGNDQVRFEVGFASLAPDLEVLAPVRDYAWTREKAIAFAAENEIPINVTKKSPFSI
CCCCCCCCEEEEEECHHHHCCCHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCCCC
DQNVWGRAVETGFLEDLWNAPTKDVYDYTEDPTLNWGAPDELIVTFDKGVPTAIDGHPVS
CHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHH
VLEAIVELNRRAGAQGVGRLDVVEDRLVGIKSREIYEAPGAMVLITAHEELEHVTLEREL
HHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHCCCCCCEEEEEECHHHHHHHHHHHH
GRYKRRTDQKWAELVYDGLWYSPLKRSLEAFVADTQQHVSGDIRLVLHGGNIAVNGRRSP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCEEEECCCCCC
ESLYDFNLATYDEGDSFDQSSAKGFVHIHGLSSKISAQRDLSGK
CHHHCCCEEECCCCCCCCCCCCCCEEEEECCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA