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The map label for this gene is clpP [H]

Identifier: 169628671

GI number: 169628671

Start: 1611337

End: 1611930

Strand: Direct

Name: clpP [H]

Synonym: MAB_1581

Alternate gene names: 169628671

Gene position: 1611337-1611930 (Clockwise)

Preceding gene: 169628670

Following gene: 169628672

Centisome position: 31.8

GC content: 61.78

Gene sequence:

>594_bases
ATGCGTTCGGCGACAGCCGGGCTCAACCTGATCGACTCGGTGTATGAGCGCCTGCTCTCCGAGCGCATCATTTTCCTGGG
TCAGCAGGTGGACGACGACATCGCCAACAAGCTGTGCGCGCAGATTCTGCTGCTGACGGCGGAGGACCCCACCAAGGACA
TCCACCTGTACATCAACTCTCCGGGTGGATCGATCAGCGCGGGCATGGCGATCTTCGACACCATGCAGCTCTCGGAGTGC
GATATCGCCACCTACGCGATGGGCATGGCCGCATCGATGGGTGAGTTCCTGCTTGCCGCCGGAACCAAGGGCAAGCGCCA
CGCGTTGCCGCACGCCCGCATCCTGATGCACCAGCCGCTCGGTGGTGTCACCGGTAGCGCCTCGGACATCGCCATCCAGG
CCGAGCAGTTCCAGGTGATCAAGAAGGAAATGTTCCGTCTCAACGCCGAATTCACCGGCAAGAGCATCGAACAGATCGAG
CAGGACTCGGACCGCGATCGCTGGTTCACCGCTCCCGAGGCACTCGAGTACGGGTTCGTCGACAAGATCATCACCCGCGG
CAATCTGAACGGCAGCAAGGGAGCCTCCAAGTGA

Upstream 100 bases:

>100_bases
CCGATGTTGGTTAATGTCGGCAGTACGCAAGATGGTTCTCAAGATTGGTTTCAAGCGAACCCCGAAGAGCTAGACGAAGG
CAGGTTGCACAGTGACTGAA

Downstream 100 bases:

>100_bases
TCTCGAAGCACCTCAACCCGGAACTTGCCCCGCAGGCCCGGTACATCCTGCCCTCGTTCATCGAGCACTCGAGCTTCGGT
GTCAAGGAGTCGAACCCCTA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1 [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MRSATAGLNLIDSVYERLLSERIIFLGQQVDDDIANKLCAQILLLTAEDPTKDIHLYINSPGGSISAGMAIFDTMQLSEC
DIATYAMGMAASMGEFLLAAGTKGKRHALPHARILMHQPLGGVTGSASDIAIQAEQFQVIKKEMFRLNAEFTGKSIEQIE
QDSDRDRWFTAPEALEYGFVDKIITRGNLNGSKGASK

Sequences:

>Translated_197_residues
MRSATAGLNLIDSVYERLLSERIIFLGQQVDDDIANKLCAQILLLTAEDPTKDIHLYINSPGGSISAGMAIFDTMQLSEC
DIATYAMGMAASMGEFLLAAGTKGKRHALPHARILMHQPLGGVTGSASDIAIQAEQFQVIKKEMFRLNAEFTGKSIEQIE
QDSDRDRWFTAPEALEYGFVDKIITRGNLNGSKGASK
>Mature_197_residues
MRSATAGLNLIDSVYERLLSERIIFLGQQVDDDIANKLCAQILLLTAEDPTKDIHLYINSPGGSISAGMAIFDTMQLSEC
DIATYAMGMAASMGEFLLAAGTKGKRHALPHARILMHQPLGGVTGSASDIAIQAEQFQVIKKEMFRLNAEFTGKSIEQIE
QDSDRDRWFTAPEALEYGFVDKIITRGNLNGSKGASK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=178, Percent_Identity=47.752808988764, Blast_Score=183, Evalue=9e-47,
Organism=Escherichia coli, GI1786641, Length=175, Percent_Identity=57.7142857142857, Blast_Score=216, Evalue=8e-58,
Organism=Caenorhabditis elegans, GI17538017, Length=179, Percent_Identity=49.1620111731844, Blast_Score=180, Evalue=3e-46,
Organism=Drosophila melanogaster, GI20129427, Length=171, Percent_Identity=45.0292397660819, Blast_Score=162, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 21470; Mature: 21470

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSATAGLNLIDSVYERLLSERIIFLGQQVDDDIANKLCAQILLLTAEDPTKDIHLYINS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
PGGSISAGMAIFDTMQLSECDIATYAMGMAASMGEFLLAAGTKGKRHALPHARILMHQPL
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCC
GGVTGSASDIAIQAEQFQVIKKEMFRLNAEFTGKSIEQIEQDSDRDRWFTAPEALEYGFV
CCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEECCHHHHHHHHH
DKIITRGNLNGSKGASK
HHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRSATAGLNLIDSVYERLLSERIIFLGQQVDDDIANKLCAQILLLTAEDPTKDIHLYINS
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
PGGSISAGMAIFDTMQLSECDIATYAMGMAASMGEFLLAAGTKGKRHALPHARILMHQPL
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHEECCC
GGVTGSASDIAIQAEQFQVIKKEMFRLNAEFTGKSIEQIEQDSDRDRWFTAPEALEYGFV
CCCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCEECCHHHHHHHHH
DKIITRGNLNGSKGASK
HHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]