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The map label for this gene is clpP2 [H]

Identifier: 169628672

GI number: 169628672

Start: 1611927

End: 1612580

Strand: Direct

Name: clpP2 [H]

Synonym: MAB_1582

Alternate gene names: 169628672

Gene position: 1611927-1612580 (Clockwise)

Preceding gene: 169628671

Following gene: 169628673

Centisome position: 31.81

GC content: 64.68

Gene sequence:

>654_bases
GTGATCTCGAAGCACCTCAACCCGGAACTTGCCCCGCAGGCCCGGTACATCCTGCCCTCGTTCATCGAGCACTCGAGCTT
CGGTGTCAAGGAGTCGAACCCCTACAACAAGCTGTTCGAGGAGCGCATCATCTTCCTCGGCGTGCAGGTCGACGACGCCT
CGGCCAACGACATCATGGCCCAGCTGCTGGTGCTGGAGTCGCTGGATCCCGACCGCGAGATCACCATGTACATCAACTCC
CCGGGTGGCTCGTTCACCTCGTTGATGGCGATCTACGACACCATGCAGTACGTCCGCTCCGACATCCGCACCGTGGTGCT
GGGTCAGGCCGCGTCCGCGGCTGCGGTGCTGCTCGCTGCCGGCACCCCGGGCAAGCGGATGGCTCTGCCGAACGCACGCG
TGCTCATCCACCAGCCCGCACTGTCCGGTGTCATCCAGGGGCAGTTCACCGACCTGGAGATCCAGGCCGCCGAGATCGAG
CGCATGCGCGTGCTGCAGGAGACCACGCTGGCCCGCCACACCGGCAGGCCGGCCGAGGAAATCCGCAAGGACACCGACCG
CGACAAGATCTTCACGGCCGAGGAGGCCAAGGAGTACGGGATCATCGATGTCGTGCTGGAGTACCGCAAGCTCTCCGCTC
AGACAGCTTCGTAG

Upstream 100 bases:

>100_bases
ACCGCGATCGCTGGTTCACCGCTCCCGAGGCACTCGAGTACGGGTTCGTCGACAAGATCATCACCCGCGGCAATCTGAAC
GGCAGCAAGGGAGCCTCCAA

Downstream 100 bases:

>100_bases
CTGCCGGACGCGAGCCCGGATAACAGTTGCAACACACCGGTCTCCGGTGCGCGTCATCCGGGGCTGCAGTCGGTGTGAGG
CGATATGTTCTCCAGCACGG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2 [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MISKHLNPELAPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDREITMYINS
PGGSFTSLMAIYDTMQYVRSDIRTVVLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPALSGVIQGQFTDLEIQAAEIE
RMRVLQETTLARHTGRPAEEIRKDTDRDKIFTAEEAKEYGIIDVVLEYRKLSAQTAS

Sequences:

>Translated_217_residues
MISKHLNPELAPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDREITMYINS
PGGSFTSLMAIYDTMQYVRSDIRTVVLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPALSGVIQGQFTDLEIQAAEIE
RMRVLQETTLARHTGRPAEEIRKDTDRDKIFTAEEAKEYGIIDVVLEYRKLSAQTAS
>Mature_217_residues
MISKHLNPELAPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMAQLLVLESLDPDREITMYINS
PGGSFTSLMAIYDTMQYVRSDIRTVVLGQAASAAAVLLAAGTPGKRMALPNARVLIHQPALSGVIQGQFTDLEIQAAEIE
RMRVLQETTLARHTGRPAEEIRKDTDRDKIFTAEEAKEYGIIDVVLEYRKLSAQTAS

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=43.8775510204082, Blast_Score=164, Evalue=8e-41,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=48.4536082474227, Blast_Score=196, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI17538017, Length=191, Percent_Identity=42.4083769633508, Blast_Score=158, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=44.2708333333333, Blast_Score=162, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 24066; Mature: 24066

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKHLNPELAPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEEEEEEEECCCCHHHHHH
QLLVLESLDPDREITMYINSPGGSFTSLMAIYDTMQYVRSDIRTVVLGQAASAAAVLLAA
HHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEC
GTPGKRMALPNARVLIHQPALSGVIQGQFTDLEIQAAEIERMRVLQETTLARHTGRPAEE
CCCCCEEECCCCEEEEECCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHH
IRKDTDRDKIFTAEEAKEYGIIDVVLEYRKLSAQTAS
HHCCCCHHHEEEHHHHHHCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MISKHLNPELAPQARYILPSFIEHSSFGVKESNPYNKLFEERIIFLGVQVDDASANDIMA
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHEEEEEEEEECCCCHHHHHH
QLLVLESLDPDREITMYINSPGGSFTSLMAIYDTMQYVRSDIRTVVLGQAASAAAVLLAA
HHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEECCCCCCCEEEEEEC
GTPGKRMALPNARVLIHQPALSGVIQGQFTDLEIQAAEIERMRVLQETTLARHTGRPAEE
CCCCCEEECCCCEEEEECCHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCCHHH
IRKDTDRDKIFTAEEAKEYGIIDVVLEYRKLSAQTAS
HHCCCCHHHEEEHHHHHHCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]