Click here to switch to the map view.

The map label for this gene is mcl1 [H]

Identifier: 169628460

GI number: 169628460

Start: 1366803

End: 1367765

Strand: Direct

Name: mcl1 [H]

Synonym: MAB_1369

Alternate gene names: 169628460

Gene position: 1366803-1367765 (Clockwise)

Preceding gene: 169628459

Following gene: 169628462

Centisome position: 26.97

GC content: 66.15

Gene sequence:

>963_bases
GTGACAGCACCCGCGTACCGTCCACGCCGCACCACGCTGGCTGTGCCCGGCAGCAGCCAGAAGATGATCGACAAGGCGAA
AACCCTTCCGGCGGACGAGGTCTTCCTGGACCTTGAAGACGCTGTCGCCGCACCCGCCAAGGTAGAGGCGCGCCGGCGCA
TCGCCGAGGCGCTCAACGCTCCGGGATGGTCCGGCCAGCTGCTGTCGGTGCGCGTCAATGACTGGACCACCGAATGGACC
TACGCCGATCTGGTGGAGATTGTTTCCCGGGCGGGCGCCAACATCGACAACATCCTGCTACCCAAGGTCACCGCCGCCTC
ACACGTGACGGCTCTTGATCTGCTGCTCACCCAGCTGGAGCGATCACACGGGCTGCAGGTGGGTGCCATCGGCATCCAGG
CCCAGATCGAGAACGCCGAGGGGCTCACCAATATCGACGCGATCGCATCGGCCAGCCCGCGCATGCGCTCACTCGTCTTC
GGTCCGGCCGACTTCATGGCCAGCCTCGGCATGCGCACGCTGGTGGTGGGCGAACAGCCGCCCGGCTACGACGGCGAGGC
TTATCACCATGTGCTGATGACCATCCTGGTCGCCGCGCGGGCGCACGGAATCGATGCCATCGACGGTCCCTATTTGAAGG
TGCGTGACGTCGATGCCTTCCGAACTGCGGCAGCCCGATCGGCCGCACTCGGTTTCGACGGGAAATGGGTGCTACACCCC
GCACAGATCGAGGCGGGCAACGAGATATTCAGCCCGCGGCAAGACGACTACGACAGGGCCGAGCTGATCCTGGACGCCTA
CGAGTGGCACACCTCGGTCGCCGGTGGTGCCCGGGGAGCGGTAATGCTCGGAGACGAGATGATCGACGAGGCCAGCCGCA
AGATGGCGCTGGTGATCGCGGGCAAGGGACGTGCCGCGGGAATGGCTCGCCAGGCGGCCCCTTACGAGCCTCCGACGGGC
TAG

Upstream 100 bases:

>100_bases
CCAAGGCGCCGCTGCGGCCCGTCACCGTCACGCCGGCCGAGGCCAAGGAGCGGTACGGGAGGCGAGCCACCGCATAGGGC
GGCGCCTACGCTGACTATCT

Downstream 100 bases:

>100_bases
AAAGACCCCGACGTGCTGCTGCTCCCCGCGGCTATCACGATGAGGACCAATATCCACAGCACGGGGATCACCGCGCCCAG
GATGATGCCGGCAATCGCTA

Product: citrate lyase beta chain

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MTAPAYRPRRTTLAVPGSSQKMIDKAKTLPADEVFLDLEDAVAAPAKVEARRRIAEALNAPGWSGQLLSVRVNDWTTEWT
YADLVEIVSRAGANIDNILLPKVTAASHVTALDLLLTQLERSHGLQVGAIGIQAQIENAEGLTNIDAIASASPRMRSLVF
GPADFMASLGMRTLVVGEQPPGYDGEAYHHVLMTILVAARAHGIDAIDGPYLKVRDVDAFRTAAARSAALGFDGKWVLHP
AQIEAGNEIFSPRQDDYDRAELILDAYEWHTSVAGGARGAVMLGDEMIDEASRKMALVIAGKGRAAGMARQAAPYEPPTG

Sequences:

>Translated_320_residues
MTAPAYRPRRTTLAVPGSSQKMIDKAKTLPADEVFLDLEDAVAAPAKVEARRRIAEALNAPGWSGQLLSVRVNDWTTEWT
YADLVEIVSRAGANIDNILLPKVTAASHVTALDLLLTQLERSHGLQVGAIGIQAQIENAEGLTNIDAIASASPRMRSLVF
GPADFMASLGMRTLVVGEQPPGYDGEAYHHVLMTILVAARAHGIDAIDGPYLKVRDVDAFRTAAARSAALGFDGKWVLHP
AQIEAGNEIFSPRQDDYDRAELILDAYEWHTSVAGGARGAVMLGDEMIDEASRKMALVIAGKGRAAGMARQAAPYEPPTG
>Mature_319_residues
TAPAYRPRRTTLAVPGSSQKMIDKAKTLPADEVFLDLEDAVAAPAKVEARRRIAEALNAPGWSGQLLSVRVNDWTTEWTY
ADLVEIVSRAGANIDNILLPKVTAASHVTALDLLLTQLERSHGLQVGAIGIQAQIENAEGLTNIDAIASASPRMRSLVFG
PADFMASLGMRTLVVGEQPPGYDGEAYHHVLMTILVAARAHGIDAIDGPYLKVRDVDAFRTAAARSAALGFDGKWVLHPA
QIEAGNEIFSPRQDDYDRAELILDAYEWHTSVAGGARGAVMLGDEMIDEASRKMALVIAGKGRAAGMARQAAPYEPPTG

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=292, Percent_Identity=30.1369863013699, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI87081764, Length=252, Percent_Identity=35.3174603174603, Blast_Score=129, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI17557458, Length=299, Percent_Identity=29.0969899665552, Blast_Score=101, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 34260; Mature: 34129

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPAYRPRRTTLAVPGSSQKMIDKAKTLPADEVFLDLEDAVAAPAKVEARRRIAEALNA
CCCCCCCCCCEEEECCCCCHHHHHHHHCCCHHHEEEEHHHHHCCCHHHHHHHHHHHHHCC
PGWSGQLLSVRVNDWTTEWTYADLVEIVSRAGANIDNILLPKVTAASHVTALDLLLTQLE
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHH
RSHGLQVGAIGIQAQIENAEGLTNIDAIASASPRMRSLVFGPADFMASLGMRTLVVGEQP
HHCCCEEEEEEEEEEECCCCCCCCHHHHHCCCCHHHHEEECCHHHHHHCCCEEEEECCCC
PGYDGEAYHHVLMTILVAARAHGIDAIDGPYLKVRDVDAFRTAAARSAALGFDGKWVLHP
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEH
AQIEAGNEIFSPRQDDYDRAELILDAYEWHTSVAGGARGAVMLGDEMIDEASRKMALVIA
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCEEEEEEE
GKGRAAGMARQAAPYEPPTG
CCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure 
TAPAYRPRRTTLAVPGSSQKMIDKAKTLPADEVFLDLEDAVAAPAKVEARRRIAEALNA
CCCCCCCCCEEEECCCCCHHHHHHHHCCCHHHEEEEHHHHHCCCHHHHHHHHHHHHHCC
PGWSGQLLSVRVNDWTTEWTYADLVEIVSRAGANIDNILLPKVTAASHVTALDLLLTQLE
CCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHHHHHHHH
RSHGLQVGAIGIQAQIENAEGLTNIDAIASASPRMRSLVFGPADFMASLGMRTLVVGEQP
HHCCCEEEEEEEEEEECCCCCCCCHHHHHCCCCHHHHEEECCHHHHHHCCCEEEEECCCC
PGYDGEAYHHVLMTILVAARAHGIDAIDGPYLKVRDVDAFRTAAARSAALGFDGKWVLHP
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEEEEH
AQIEAGNEIFSPRQDDYDRAELILDAYEWHTSVAGGARGAVMLGDEMIDEASRKMALVIA
HHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHCCEEEEEEE
GKGRAAGMARQAAPYEPPTG
CCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA