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The map label for this gene is tdcB [H]

Identifier: 169628292

GI number: 169628292

Start: 1213811

End: 1215055

Strand: Direct

Name: tdcB [H]

Synonym: MAB_1199

Alternate gene names: 169628292

Gene position: 1213811-1215055 (Clockwise)

Preceding gene: 169628290

Following gene: 169628293

Centisome position: 23.95

GC content: 69.32

Gene sequence:

>1245_bases
ATGGCCATGGAGACATCGGGAGCAATAGGGTTGGTAACGGTCCAGGAGATCCAGGAGGTAGCCGAGCGGCTGGCCCCTGT
GATACGGCGCACACCGATGGTGGCCTTCCGTGCGCTGAGTGACCGCTGCGGGCACGAGGTGCGGCTCAAATGTGAAAACC
TGCAACGCACAGGATCTTTCAAACCGCGTGGTGCCTACAACCGGATCAGCCAGCTGCCCGGCGAGCAGCGCGTCAATGGT
GTGGTGGCAGCCAGCGCGGGCAATCATGCCCAGGGCGTGGCCTGGGCGGCGACCACCCTGGGCATCCCGTCGACGGTGTT
CATGCCGGTGGGGGCGGCGTTGCCCAAGATCGTCGCCACCCGTGCGTACGGCGCGACCGTGCACCTCACCGGCTCCACCA
TCGACGACGCGCTGTTGGCCGCGACCGAGTTCGCGGCGGAAACCGGTGCGGTGCTCATCCATCCGTTCGACCATCGCGAT
GTGGTGGCCGGGCAGGCCACCGTCGGGCTTGAGATCCTGGAGCAGCTTCCGGAGGTGGGCACCATTGTGGTGCCCGCGGG
CGGCGGCGGCTTGGTGGCAGGGGTCGCCGCGGTGGTCAAGGCGGCGCGACCGGCGGTTCGGATCGTCGCGGTGCAGGCCG
CCGGTGCGGCGGCCTGGCCGGTGTCGCTCAAAGCCGGGCACCCGGTGGCACTGGAATCCATGGACACCATGGCCGACGGC
ATCGCCGTCGGTAAGCCCGGGGCGGTGCCCTTTGAGCACGTGGCCGCCCTGGTCGACGACGTGGTCACGGTCAGCGAGGA
AGCGCTGTCGCGGGGCCTGCTGTTGTGCCTGGAGCGCGCCAAGCTGGTGGTGGAACCTGCCGGCGCCGCCGCGGTAGCGG
CGCTGCTCACCCTGTCCGCCGAGGAATTGGGCCTCACCGGGCCGGTGTGTGCGGTGCTTTCGGGCGGCAACATCGACCCG
TTGCTGCTTACCCATGTCATCACCCATGGATTGCGGGCCGCCGGTCGCTATCTGACGGTTCGGGTCACCGTCGCCGACGC
GCCGGGCGGACTGTCGGGTCTGCTGGATGTCTTCCGGGCCTCCGGTGCCAGCGTCGTCGACGTCACGCACTGGCGGAACA
GCGAGCGGCTGCGTCTGGGCGAGGTGGATGTGCTGGCGACCGTCGAGACGCGGGGGCCCGAACACCGTCAGGCGGTCCTC
GACGCAATTGTCGCGGCCGGCCTGACGGTCCAAGAAGAGCGGTAG

Upstream 100 bases:

>100_bases
GGCCGTCCCGACGCGTTGTTCAGCAACAGAAGCAGGAGGTCCTCCGCAATCTGTGGCATGAGGGGACAATAGCGGCAGAA
CTGGTGACATGATGCCTGGC

Downstream 100 bases:

>100_bases
CCCCCGCCCCCAGCCCTCAACGAGTGCGAGCCTGACGCGGAAATCTGCCCTGAAACCCGCGTGAGGCTCGCACTCGATCG
GGGGCGGATGGGTTGTCGGT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MAMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGHEVRLKCENLQRTGSFKPRGAYNRISQLPGEQRVNG
VVAASAGNHAQGVAWAATTLGIPSTVFMPVGAALPKIVATRAYGATVHLTGSTIDDALLAATEFAAETGAVLIHPFDHRD
VVAGQATVGLEILEQLPEVGTIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPVALESMDTMADG
IAVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLCLERAKLVVEPAGAAAVAALLTLSAEELGLTGPVCAVLSGGNIDP
LLLTHVITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRASGASVVDVTHWRNSERLRLGEVDVLATVETRGPEHRQAVL
DAIVAAGLTVQEER

Sequences:

>Translated_414_residues
MAMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGHEVRLKCENLQRTGSFKPRGAYNRISQLPGEQRVNG
VVAASAGNHAQGVAWAATTLGIPSTVFMPVGAALPKIVATRAYGATVHLTGSTIDDALLAATEFAAETGAVLIHPFDHRD
VVAGQATVGLEILEQLPEVGTIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPVALESMDTMADG
IAVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLCLERAKLVVEPAGAAAVAALLTLSAEELGLTGPVCAVLSGGNIDP
LLLTHVITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRASGASVVDVTHWRNSERLRLGEVDVLATVETRGPEHRQAVL
DAIVAAGLTVQEER
>Mature_413_residues
AMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGHEVRLKCENLQRTGSFKPRGAYNRISQLPGEQRVNGV
VAASAGNHAQGVAWAATTLGIPSTVFMPVGAALPKIVATRAYGATVHLTGSTIDDALLAATEFAAETGAVLIHPFDHRDV
VAGQATVGLEILEQLPEVGTIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPVALESMDTMADGI
AVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLCLERAKLVVEPAGAAAVAALLTLSAEELGLTGPVCAVLSGGNIDPL
LLTHVITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRASGASVVDVTHWRNSERLRLGEVDVLATVETRGPEHRQAVLD
AIVAAGLTVQEER

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=309, Percent_Identity=36.5695792880259, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI19923959, Length=311, Percent_Identity=33.1189710610932, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI33469958, Length=289, Percent_Identity=31.4878892733564, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1789505, Length=308, Percent_Identity=41.8831168831169, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1790207, Length=384, Percent_Identity=33.0729166666667, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71991565, Length=388, Percent_Identity=39.9484536082474, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17537387, Length=381, Percent_Identity=37.7952755905512, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=31.2101910828025, Blast_Score=160, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6322631, Length=307, Percent_Identity=37.4592833876222, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6320930, Length=357, Percent_Identity=35.8543417366947, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=290, Percent_Identity=27.2413793103448, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322024, Length=154, Percent_Identity=30.5194805194805, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355833, Length=345, Percent_Identity=39.4202898550725, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24645328, Length=265, Percent_Identity=37.7358490566038, Blast_Score=130, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 42551; Mature: 42419

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGHEVRLKCENLQRTGSF
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEEHHHHHCCCC
KPRGAYNRISQLPGEQRVNGVVAASAGNHAQGVAWAATTLGIPSTVFMPVGAALPKIVAT
CCCCHHHHHHHCCCCHHCCEEEEECCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHH
RAYGATVHLTGSTIDDALLAATEFAAETGAVLIHPFDHRDVVAGQATVGLEILEQLPEVG
HCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCEECCCHHHHHHHHHHCCCCC
TIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPVALESMDTMADG
EEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEECCCEECEEEECCCCCEEHHHHHHHHCC
IAVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLCLERAKLVVEPAGAAAVAALLTLSA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHH
EELGLTGPVCAVLSGGNIDPLLLTHVITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRA
HHCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHC
SGASVVDVTHWRNSERLRLGEVDVLATVETRGPEHRQAVLDAIVAAGLTVQEER
CCCCEEEEEECCCCCCEEECCEEEEEEEECCCCHHHHHHHHHHHHCCCEEECCC
>Mature Secondary Structure 
AMETSGAIGLVTVQEIQEVAERLAPVIRRTPMVAFRALSDRCGHEVRLKCENLQRTGSF
CCCCCCCEEEEEHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCEEEEEEHHHHHCCCC
KPRGAYNRISQLPGEQRVNGVVAASAGNHAQGVAWAATTLGIPSTVFMPVGAALPKIVAT
CCCCHHHHHHHCCCCHHCCEEEEECCCCCCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHH
RAYGATVHLTGSTIDDALLAATEFAAETGAVLIHPFDHRDVVAGQATVGLEILEQLPEVG
HCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEEECCCCCCEECCCHHHHHHHHHHCCCCC
TIVVPAGGGGLVAGVAAVVKAARPAVRIVAVQAAGAAAWPVSLKAGHPVALESMDTMADG
EEEEECCCCHHHHHHHHHHHHCCCEEEEEEEEECCCEECEEEECCCCCEEHHHHHHHHCC
IAVGKPGAVPFEHVAALVDDVVTVSEEALSRGLLLCLERAKLVVEPAGAAAVAALLTLSA
EECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHH
EELGLTGPVCAVLSGGNIDPLLLTHVITHGLRAAGRYLTVRVTVADAPGGLSGLLDVFRA
HHCCCCCCHHEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHC
SGASVVDVTHWRNSERLRLGEVDVLATVETRGPEHRQAVLDAIVAAGLTVQEER
CCCCEEEEEECCCCCCEEECCEEEEEEEECCCCHHHHHHHHHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA